Nicotinic effects on cognitive function: behavioral characterization, pharmacological specification, and anatomic localization
Abstract
Rationale Nicotine has been shown in a variety of studies in humans and experimental animals to improve cognitive function. Nicotinic treatments are being developed as therapeutic treatments for cognitive dysfunction.Objectives Critical for the development of nicotinic therapeutics is an understanding of the neurobehavioral bases for nicotinic involvement in cognitive function.Methods Specific and diverse cognitive functions affected by nicotinic treatments are reviewed, including attention, learning, and memory. The neural substrates for these behavioral actions involve the identification of the critical pharmacologic receptor targets, in particular brain locations, and how those incipient targets integrate with broader neural systems involved with cognitive function.Results Nicotine and nicotinic agonists can improve working memory function, learning, and attention. Both alpha4beta2 and alpha7 nicotinic receptors appear to be critical for memory function. The hippocampus and the amygdala in particular have been found to be important for memory, with decreased nicotinic activity in these areas impairing memory. Nicotine and nicotinic analogs have shown promise for inducing cognitive improvement. Positive therapeutic effects have been seen in initial studies with a variety of cognitive dysfunctions, including Alzheimer's disease, age-associated memory impairment, schizophrenia, and attention deficit hyperactivity disorder.Conclusions Discovery of the behavioral, pharmacological, and anatomic specificity of nicotinic effects on learning, memory, and attention not only aids the understanding of nicotinic involvement in the basis of cognitive function, but also helps in the development of novel nicotinic treatments for cognitive dysfunction. Nicotinic treatments directed at specific receptor subtypes and nicotinic cotreatments with drugs affecting interacting transmitter systems may provide cognitive benefits most relevant to different syndromes of cognitive impairment such as Alzheimer's disease, schizophrenia, and attention deficit hyperactivity disorder. Further research is necessary in order to determine the efficacy and safety of nicotinic treatments of these cognitive disorders.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Craving and cognitive impairments are reliable markers of nicotine withdrawal.
“Although craving and cognitive impairments are reliable markers of nicotine withdrawal (Kenney and Gould, 2008; Levin et al, 2006; McClernon et al, 2004; Rezvani and Levin, 2001), anxiety has been shown to impact relapse rate as well (Dani and Harris, 2005; DiMatteo et al, 2000).”
From Divergent Functional Effects of Sazetidine-A and Varenicline During Nicotine Withdrawal (2013) · cites this paper as Levin et al, 2006
Cites
Psychopharmacology: The third generation of progress
O’Connell, R. A. (1988) · Comprehensive Psychiatry · doi:10.1016/0010-440x(88)90057-0 · Cited by 3,014 · see citing works
Smoking and Mental Illness: A Population-Based Prevalence Study
Lasser, K., Boyd, J. W., Woolhandler, S., Himmelstein, D. U., McCormick, D., & Bor, D. H. (2000) · JAMA · doi:10.1001/jama.284.20.2606 · Cited by 2,508 · see citing works
Psychopharmacology: The Third Generation of Progress.
(1988) · Annals of Internal Medicine · doi:10.7326/0003-4819-108-3-509_2 · Cited by 2,021 · see citing works
Neuroscience of attention-deficit/hyperactivity disorder: the search for endophenotypes
Castellanos, F. X., & Tannock, R. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn896 · Cited by 1,827 · see citing works
The 5-choice serial reaction time task: behavioural pharmacology and functional neurochemistry
Robbins, T. (2002) · Psychopharmacology · doi:10.1007/s00213-002-1154-7 · Cited by 1,282 · see citing works
Corrigall, W. A., Coen, K. M., & Adamson, K. L. (1994) · Brain Research · doi:10.1016/0006-8993(94)90401-4 · Cited by 740 · see citing works
Schizophrenia, sensory gating, and nicotinic receptors
Adler, L. E., Olincy, A., Waldo, M., Harris, J. G., Griffith, J., Stevens, K., Flach, K., Nagamoto, H., Bickford, P., Leonard, S., et al. (1998) · Schizophrenia Bulletin · doi:10.1093/oxfordjournals.schbul.a033320 · Cited by 690 · see citing works
Normalization of auditory physiology by cigarette smoking in schizophrenic patients
Adler, L. E., Hoffer, L., Wiser, A., & Freedman, R. (1993) · American Journal of Psychiatry · doi:10.1176/ajp.150.12.1856 · Cited by 679 · see citing works
Nicotinic acetylcholine involvement in cognitive function in animals
Levin, E. D., & Simon, B. B. (1998) · Psychopharmacology · doi:10.1007/s002130050667 · Cited by 675 · see citing works
Self-citationGranon, S., Passetti, F., Thomas, K. L., Dalley, J. W., Everitt, B. J., & Robbins, T. W. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-03-01208.2000 · Cited by 546 · see citing works
Decker, M. W., & McGaugh, J. L. (1991) · Synapse · doi:10.1002/syn.890070209 · Cited by 524 · see citing works
Rezvani, A. H., & Levin, E. D. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(00)01094-5 · Cited by 519 · see citing works
Self-citationNicotinic systems and cognitive function
Levin, E. D. (1992) · Psychopharmacology · doi:10.1007/bf02247415 · Cited by 511 · see citing works
Self-citationNicotinic receptors in the brain: correlating physiology with function
Jones, S., Sudweeks, S. N., & Yakel, J. L. (1999) · Trends in Neurosciences · doi:10.1016/s0166-2236(99)01471-x · Cited by 447 · see citing works
Schizophrenia and smoking: an epidemiological survey in a state hospital
de León, J., Dadvand, M., Canuso, C. M., Odom-White, A., Stanilla, J. K., & Simpson, G. M. (1995) · American Journal of Psychiatry · doi:10.1176/ajp.152.3.453 · Cited by 417 · see citing works
Sofouglu, M., Herman, A. I., Robinson, C. D., & Waters, A. J. (2014) · Lincoln (University of Nebraska) · Cited by 417 · see citing works
Nicotine effects on adults with attention-deficit/hyperactivity disorder
Levin, E. D., Conners, C. K., Sparrow, E., Hinton, S. C., Erhardt, D., Meck, W. H., Rose, J. E., & March, J. (1996) · Psychopharmacology · doi:10.1007/bf02246281 · Cited by 415 · see citing works
Self-citationNormalization by nicotine of deficient auditory sensory gating in the relatives of schizophrenics
Adler, L. E., Hoffer, L., Griffith, J. M., Waldo, M. C., & Freedman, R. (1992) · Biological Psychiatry · doi:10.1016/0006-3223(92)90073-9 · Cited by 412 · see citing works
Kollins, S. H., McClernon, F. J., & Fuemmeler, B. F. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.10.1142 · Cited by 369 · see citing works
Self-citationCigarette smoking and protection from Parkinson's disease
Morens, D. M., Grandinetti, A., REED, D. M., White, L. R., & Ross, G. W. (1995) · Neurology · doi:10.1212/wnl.45.6.1041 · Cited by 368 · see citing works
Nicotine and smoking: A review of effects on human performance.
Heishma, S. J., Taylor, R. C., & Henningfield, J. E. (1994) · Experimental and Clinical Psychopharmacology · doi:10.1037/1064-1297.2.4.345 · Cited by 366 · see citing works
Attention-deficit/hyperactivity disorder: a life-span perspective.
Biederman, J. (1998) · PubMed · Cited by 361 · see citing works
Smoking-induced ventral striatum dopamine release.
Brody, A., Olmstead, R., London, E., Farahi, J., Meyer, J., Grossman, P., Lee, G. S., Huang, J., Hahn, E. L., & Mandelkern, M. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.7.1211 · Cited by 356 · see citing works
Nicotinic receptor subtypes and cognitive function
Levin, E. D. (2002) · Journal of Neurobiology · doi:10.1002/neu.10151 · Cited by 354 · see citing works
Self-citationCigarette smoking in adult patients diagnosed with attention deficit hyperactivity disorder
Pomerleau, O. F., Downey, K. K., Stelson, F. W., & Pomerleau, C. S. (1995) · Journal of Substance Abuse · doi:10.1016/0899-3289(95)90030-6 · Cited by 349 · see citing works
Nicotine-Haloperidol Interactions and Cognitive Performance in Schizophrenics
Levin, E. D. (1996) · Neuropsychopharmacology · doi:10.1016/s0893-133x(96)00018-8 · Cited by 342 · see citing works
Self-citationBrain nicotinic receptors: structure and regulation, role in learning and reinforcement
Changeux, J.-P., Bertrand, D., Corringer, P.-J., Dehaene, S., Edelstein, S., Léna, C., Le Novère, N., Marubio, L., Picciotto, M., & Zoli, M. (1998) · Brain Research Reviews · doi:10.1016/s0165-0173(97)00040-4 · Cited by 322 · see citing works
Cognitive Mechanisms of Nicotine on Visual Attention
Lawrence, N., Ross, T. J., & Stein, E. A. (2002) · Neuron · doi:10.1016/s0896-6273(02)01004-8 · Cited by 321 · see citing works
Intravenous nicotine in Alzheimer's disease: a pilot study
NEWHOUSE, P. A., Sunderland, T., Tariot, P. N., Blumhardt, C. L., Weingartner, H., Mellow, A. M., & Murphy, D. L. (1988) · Psychopharmacology · doi:10.1007/bf00174504 · Cited by 308 · see citing works
Guan, Z., Zhang, X., Blennow, K., & Nordberg, A. K. (1999) · Neuroreport · doi:10.1097/00001756-199906030-00028 · Cited by 286 · see citing works
Amygdala Modulation of Memory Consolidation: Interaction with Other Brain Systems
McGaugh, J. (2002) · Neurobiology of Learning and Memory · doi:10.1006/nlme.2002.4082 · Cited by 279 · see citing works
Poor P50 Suppression Among Schizophrenia Patients and Their First-Degree Biological Relatives
Clementz, B. A., Geyer, M. A., & BRAFF, D. L. (1998) · American Journal of Psychiatry · doi:10.1176/ajp.155.12.1691 · Cited by 276 · see citing works
Four-week nicotine skin patch treatment effects on cognitive performance in Alzheimer's disease
White, H. K., & Levin, E. D. (1999) · Psychopharmacology · doi:10.1007/s002130050931 · Cited by 273 · see citing works
Self-citationCholinergic gating of response to auditory stimuli in rat hippocampus
Luntz‐Leybman, V., Bickford, P. C., & Freedman, R. (1992) · Brain Research · doi:10.1016/0006-8993(92)91437-j · Cited by 266 · see citing works
Decker, M. W., Brioni, J. D., Bannon, A. W., & Arnerić, S. P. (1995) · Life Sciences · doi:10.1016/0024-3205(94)00488-e · Cited by 260 · see citing works
Neuronal Nicotinic Receptors in Dementia with Lewy Bodies and Schizophrenia
COURT, J. A., Spurden, D., Lloyd, S. R., McKeith, I. G., Ballard, C. G., Cairns, N. J., Kerwin, R. W., Perry, R., & Perry, E. K. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.0731590.x · Cited by 254 · see citing works
What does the hippocampus really do?
Jarrard, L. E. (1995) · Behavioural Brain Research · doi:10.1016/0166-4328(95)00034-8 · Cited by 249 · see citing works
Smith, R. (2002) · Neuropsychopharmacology · doi:10.1016/s0893-133x(02)00324-x · Cited by 247 · see citing works
Grottick, A. J., & Higgins, G. A. (2000) · Behavioural Brain Research · doi:10.1016/s0166-4328(00)00305-3 · Cited by 240 · see citing works
Effects of Nicotine on Cognitive Deficits in Schizophrenia
Harris, J. G., Kongs, S., Allensworth, D., Martín, L., Tregellas, J. R., Sullivan, B. F., Zerbe, G. O., & Freedman, R. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300450 · Cited by 237 · see citing works
Cognitive effects of nicotine in humans: an fMRI study
Kumari, V., Gray, J. A., Ffytche, D. H., Mitterschiffthaler, M. T., Das, M., Zachariah, E., Vythelingum, G. N., Williams, S., Simmons, A., & Sharma, T. (2003) · NeuroImage · doi:10.1016/s1053-8119(03)00110-1 · Cited by 237 · see citing works
Nicotine self-administration in rats: strain and nicotine pre-exposure effects on acquisition
Shoaib, M., Schindler, C. W., & Goldberg, S. R. (1997) · Psychopharmacology · doi:10.1007/s002130050159 · Cited by 233 · see citing works
Nicotinic receptor abnormalities in Alzheimer’s disease
COURT, J. A., Martin-Ruiz, C. M., Piggott, M. A., Spurden, D., Griffiths, M., & Perry, E. K. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(00)01116-1 · Cited by 232 · see citing works
Wilens, T. E., Biederman, J., Spencer, T. J., Bostic, J., Prince, J., Monuteaux, M. C., Soriano, J., Fine, C., Abrams, A., Rater, M., et al. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.12.1931 · Cited by 230 · see citing works
Haloperidol increases smoking in patients with schizophrenia
McEvoy, J. P., Freudenreich, O., Levin, E. D., & Rose, J. E. (1995) · Psychopharmacology · doi:10.1007/bf02246063 · Cited by 225 · see citing works
Self-citationSmoking and Parkinson’s disease
Gorell, J. M., Rybicki, B. A., Johnson, C. C., & Peterson, E. L. (1999) · Neurology · doi:10.1212/wnl.52.1.115 · Cited by 224 · see citing works
Young, J. W., Finlayson, K., Spratt, C., Marston, H. M., Crawford, N., Kelly, J. S., & Sharkey, J. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300393 · Cited by 218 · see citing works
Everitt, B. J., Robbins, T. W., & Muir, J. L. (1995) · Psychopharmacology · doi:10.1007/bf02245253 · Cited by 214 · see citing works
Methods in Behavioral Pharmacology
(1993) · Techniques in the behavioral and neural sciences · doi:10.1016/c2009-0-00507-8 · Cited by 213 · see citing works
Cognitive Effects of Neonatal Hippocampal Lesions in a Rat Model of Schizophrenia
Chambers, R. (1996) · Neuropsychopharmacology · doi:10.1016/s0893-133x(96)00132-7 · Cited by 210 · see citing works
Hippocampal α7 and α4β2 nicotinic receptors and working memory
Levin, E. D., Bradley, A., Addy, N., & Sigurani, N. (2002) · Neuroscience · doi:10.1016/s0306-4522(01)00538-3 · Cited by 202 · see citing works
Self-citationChapter 15 Presynaptic modulation of transmitter release by nicotinic receptors
Wonnacott, S., Irons, J., RAPIER, C. M., Thorne, B., & Lunt, G. G. (1989) · Progress in brain research · doi:10.1016/s0079-6123(08)62475-9 · Cited by 200 · see citing works
Arendash, G. W., Sengstock, G. J., Sanberg, P. R., & Kem, W. R. (1995) · Brain Research · doi:10.1016/0006-8993(94)01449-r · Cited by 198 · see citing works
Nicotine patches in Alzheimer's disease: Pilot study on learning, memory, and safety
Wilson, A. L., Langley, L. K., Monley, J., Bauer, T., Rottunda, S. J., McFalls, E. O., Kovera, C. A., & McCarten, J. R. (1995) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(95)00043-v · Cited by 196 · see citing works
AR-R 17779, an α7 nicotinic agonist, improves learning and memory in rats
Levin, E. D., Bettegowda, C., Blosser, J. C., & Gordon, J. C. (1999) · Behavioural Pharmacology · doi:10.1097/00008877-199911000-00014 · Cited by 193 · see citing works
Self-citationSmoking and Parkinson's disease: Systematic review of prospective studies
Allam, M. F., Campbell, M. J., Albert Hofman, D., del Castillo, A. S., & Navajas, R. F. (2004) · Movement Disorders · doi:10.1002/mds.20029 · Cited by 191 · see citing works
Brenner, D. E., Kukull, W. A., van Belle, G., Bowen, J. D., McCormick, W. C., Teri, L. L., & Larson, E. B. (1993) · Neurology · doi:10.1212/wnl.43.2.293 · Cited by 183 · see citing works
Nicotine enhances sustained attention in the rat under specific task conditions
Mirza, N. R., & Stolerman, I. P. (1998) · Psychopharmacology · doi:10.1007/s002130050671 · Cited by 181 · see citing works
The effects of nicotine on Parkinson's disease.
Kelton, M., Kahn, H. J., Conrath, C. L., & NEWHOUSE, P. A. (2000) · PubMed · Cited by 180 · see citing works
Nicotinic receptors in human brain: topography and pathology
Court, J. A., Martin-Ruiz, C., Graham, A., & Perry, E. (2000) · Journal of Chemical Neuroanatomy · doi:10.1016/s0891-0618(00)00110-1 · Cited by 180 · see citing works
Potter, A., & NEWHOUSE, P. A. (2004) · Psychopharmacology · doi:10.1007/s00213-004-1874-y · Cited by 180 · see citing works
Dépatie, L. (2002) · Neuropsychopharmacology · doi:10.1016/s0893-133x(02)00372-x · Cited by 175 · see citing works
Almeida, O. P., Hulse, G. K., Lawrence, D. M., & Flicker, L. A. (2002) · Addiction · doi:10.1046/j.1360-0443.2002.00016.x · Cited by 175 · see citing works
Nicotine as a cognitive enhancer
Warburton, D. M. (1992) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/0278-5846(92)90069-q · Cited by 175 · see citing works
Gould, E. A., Woolf, N. J., & Butcher, L. L. (1989) · Neuroscience · doi:10.1016/0306-4522(89)90008-0 · Cited by 171 · see citing works
Weiser, M., Reichenberg, A., Grotto, I., Yasvitzky, R., Rabinowitz, J., Lubin, G., Nahon, D., Knobler, H. Y., & Davidson, M. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.7.1219 · Cited by 171 · see citing works
Levin, E. D., Conners, C. K., Silva, D., Canu, W. H., & March, J. S. (2001) · Experimental and Clinical Psychopharmacology · doi:10.1037/1064-1297.9.1.83 · Cited by 169 · see citing works
Self-citationHigh Levels of Dopamine Activity in the Basal Ganglia of Cigarette Smokers
Salokangas, R. K. R., Vilkman, H., Ilonen, T., Taiminen, T., Bergman, J., Haaparanta, M., Solin, O., Alanen, A., Syvã«¡hti, E., & Hietala, J. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.4.632 · Cited by 164 · cited 2× · see citing works
“Consistent with this conceptualization, human neuroimaging studies have found evidence of greater dopamine precursor uptake in the basal ganglia in smokers compared to nonsmokers (Salokangas et al. 2000) and in the ventral striatum of smokers following smoking a single”
BackgroundResultBuccafusco, J. J., & Jackson, W. J. (1991) · Neurobiology of Aging · doi:10.1016/0197-4580(91)90102-p · Cited by 164 · see citing works
Potter, A., Corwin, J., Lang, J., Piasecki, M., Lenox, R., & Newhouse, P. A. (1999) · Psychopharmacology · doi:10.1007/s002130050897 · Cited by 163 · see citing works
AR-R 17779 improves social recognition in rats by activation of nicotinic α7 receptors
van Kampen, M., Selbach, K., Schneider, R., Schiegel, E., Boess, F., & Schreiber, R. (2004) · Psychopharmacology · doi:10.1007/s00213-003-1668-7 · Cited by 161 · see citing works
Nicotinic antagonist administration into the ventral hippocampus and spatial working memory in rats
Felix, R. A., & Levin, E. D. (1997) · Neuroscience · doi:10.1016/s0306-4522(97)00224-8 · Cited by 160 · see citing works
Self-citationCOURT, J. A., Piggott, M. A., Lloyd, S. R., Cookson, N., Ballard, C. G., McKeith, I. G., Perry, R. H., & Perry, E. K. (2000) · Neuroscience · doi:10.1016/s0306-4522(00)00071-3 · Cited by 156 · see citing works
Nicotine may relieve symptoms of Parkinson's disease
Fagerström, K. O., Pomerleau, O. F., Giordani, B., & Stelson, F. W. (1994) · Psychopharmacology · doi:10.1007/bf02244882 · Cited by 155 · see citing works
Acute and chronic nicotine effects on working memory in aged rats
Levin, E. D., & Torry, D. J. (1996) · Psychopharmacology · doi:10.1007/bf02246285 · Cited by 150 · see citing works
Self-citationNicotinic involvement in memory function in zebrafish
Levin, E. D., & Chen, E. Y. (2004) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2004.06.010 · Cited by 148 · see citing works
Self-citationNicotine in an animal model of attention
Stolerman, I. P., Mirza, N. R., Hahn, B., & Shoaib, M. C. (2000) · European Journal of Pharmacology · doi:10.1016/s0014-2999(99)00886-9 · Cited by 144 · see citing works
Nicotine enhances delayed matching-to-sample performance by primates
Elrod, K., Buccafusco, J. J., & Jackson, W. J. (1988) · Life Sciences · doi:10.1016/0024-3205(88)90318-9 · Cited by 142 · see citing works
RJR-2403: a nicotinic agonist with CNS selectivity I. In vitro characterization.
Bencherif, M., Lovette, M. E., Fowler, K., Arrington, S. R., Reeves, L., Caldwell, W. S., & Lippiello, P. M. (1996) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)21302-7 · Cited by 141 · see citing works
Effects of nicotine on spatial memory deficits in rats with septal lesions
Decker, M. W., Majchrzak, M. J., & Anderson, D. J. (1992) · Brain Research · doi:10.1016/0006-8993(92)90485-r · Cited by 140 · see citing works
Hodges, H., Allen, Y. S., Sinden, J. D., et al. (1991) · Behavioural Brain Research · doi:10.1016/s0166-4328(05)80048-8 · Cited by 138 · see citing works
The Pharmacology of (-)-Nicotine and Novel Cholinergic Channel Modulators
Brioni, J. D., Decker, M. W., Sullivan, J. P., & Arnerić, S. P. (1996) · Advances in pharmacology · doi:10.1016/s1054-3589(08)60950-3 · Cited by 137 · see citing works
Changeux, J. (1990) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(90)90049-e · Cited by 135 · see citing works
Attentional effects of nicotinic agonists in rats
Hahn, B., Sharples, C. G. V., Wonnacott, S., Shoaib, M., & Stolerman, I. P. (2003) · Neuropharmacology · doi:10.1016/s0028-3908(03)00099-6 · Cited by 135 · see citing works
Distribution of Nicotinic Receptors in the Human Hippocampus and Thalamus
Rubboli, F., COURT, J. A., Sala, C., Morris, C. M., Chini, B., Perry, E. K., & Clementi, F. (1994) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1994.tb00550.x · Cited by 134 · see citing works
Chronic nicotine and withdrawal effects on radial-arm maze performance in rats
Levin, E. D., Lee, C. K., Rose, J. E., Reyes, A., Ellison, G. D., Jarvik, M. E., & Gritz, E. R. (1990) · Behavioral and Neural Biology · doi:10.1016/0163-1047(90)90509-5 · Cited by 130 · see citing works
Self-citationMcGaughy, J., Decker, M. W., & Sarter, M. (1999) · Psychopharmacology · doi:10.1007/s002130050991 · Cited by 128 · see citing works
Passetti, F., Dalley, J. W., & Robbins, T. W. (2003) · Psychopharmacology · doi:10.1007/s00213-002-1227-7 · Cited by 121 · see citing works
Investigating the Association Between Cigarette Smoking and Schizophrenia in a Cohort Study
Zammit, S., Allebeck, P., Dalman, C., Lundberg, I., Hemmingsson, T., & Lewis, G. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.12.2216 · Cited by 121 · see citing works
Nicotinic receptors in the brain
Vidal, C. (1996) · Molecular and Chemical Neuropathology · doi:10.1007/bf02815199 · Cited by 118 · see citing works
Nicotine breaks down preformed Alzheimer’s β-amyloid fibrils in vitro
Ono, K., Hasegawa, K., Yamada, M., & Naiki, H. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01417-8 · Cited by 116 · see citing works
White, H. K., & Levin, E. D. (2004) · Psychopharmacology · doi:10.1007/s00213-003-1614-8 · Cited by 116 · see citing works
Self-citationNicotine enhances morris water maze performance of young and aged rats
Socci, D. J., Sanberg, P. R., & Arendash, G. W. (1995) · Neurobiology of Aging · doi:10.1016/0197-4580(95)00091-r · Cited by 115 · see citing works
Effects of smoking in patients with early-onset Parkinson's disease
Ishikawa, A., & Miyatake, T. (1993) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(93)90150-w · Cited by 115 · see citing works
Kim, J. S., & Levin, E. D. (1996) · Brain Research · doi:10.1016/0006-8993(96)00213-2 · Cited by 115 · see citing works
Self-citationAggleton, J. P., Keith, A. B., & Sahgal, A. (1991) · Behavioural Brain Research · doi:10.1016/s0166-4328(05)80020-8 · Cited by 113 · see citing works
Gatto, G. J., Bohme, G. A., Caldwell, W. S., Letchworth, S. R., Traina, V. M., Obinu, M. C., Laville, M., Reibaud, M., Pradier, L., Dunbar, G., et al. (2004) · CNS Drug Reviews · doi:10.1111/j.1527-3458.2004.tb00010.x · Cited by 111 · see citing works
Levin, E. D., Christopher, N. C., Briggs, S. J., & Rose, J. E. (1993) · Cognitive Brain Research · doi:10.1016/0926-6410(93)90021-v · Cited by 111 · see citing works
Self-citationEd, L., Kaplan, S., & Boardman, A. (1997) · PubMed · Cited by 110 · see citing works
Nicotine improves memory in an object recognition task in rats
Puma, C., Deschaux, O., Molimard, R., & Bizot, J. (1999) · European Neuropsychopharmacology · doi:10.1016/s0924-977x(99)00002-4 · Cited by 107 · see citing works
Selective effects of nicotine on attentional processes
Mancuso, G., Sherwood, N., Tirelli, E., Warburton, D. M., & M�len, M. (1999) · Psychopharmacology · doi:10.1007/s002130051107 · Cited by 106 · see citing works
Warburton, E. C., Baird, A. L., Morgan, A., Muir, J. L., & Aggleton, J. P. (2000) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2000.00039.x · Cited by 106 · see citing works
Timing of nicotine effects on learning in zebrafish
Levin, E. D., Limpuangthip, J., Rachakonda, T. D., & Peterson, M. (2005) · Psychopharmacology · doi:10.1007/s00213-005-0162-9 · Cited by 104 · see citing works
Self-citationNicotine psychopharmacology: Addiction, cognition and neuroadaptation
Stolerman, I. P., Mirza, N. R., & Shoaib, M. (1995) · Medicinal Research Reviews · doi:10.1002/med.2610150105 · Cited by 102 · see citing works
Effects of histamine and opioid systems on memory retention of passive avoidance learning in rats
Zarrindast, M., Eidi, M., Eidi, A., et al. (2002) · European Journal of Pharmacology · doi:10.1016/s0014-2999(02)02269-0 · Cited by 101 · see citing works
Buccafusco, J. J., Jackson, W. J., Terry, A. V., Marsh, K. C., Decker, M. W., & Arnerić, S. P. (1995) · Psychopharmacology · doi:10.1007/bf02311172 · Cited by 100 · see citing works
Lemay, S., Chouinard, S., Blanchet, P. J., Masson, H., Soland, V., Beuter, A. C., & Bédard, M. (2003) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/s0278-5846(03)00172-6 · Cited by 99 · see citing works
Blockade of hippocampal nicotinic receptors impairs working memory but not reference memory in rats
Ohno, M., Yamamoto, T., & Watanabe, S. (1993) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(93)90091-7 · Cited by 96 · see citing works
Neurotransmitter Interactions and Cognitive Function
Levin, E., Decker, M. W., & Butcher, L. (1992) · Birkhäuser Boston · doi:10.1007/978-1-4615-9843-5 · Cited by 93 · see citing works
Self-citationChronic nicotinic stimulation and blockade effects on working memory
Levin, E. D., Briggs, S. J., Christopher, N. C., & Rose, J. E. (1993) · Behavioural Pharmacology · doi:10.1097/00008877-199304000-00010 · Cited by 92 · see citing works
Self-citationFu, Y.-T., Matta, S. G., James, T. J., & Sharp, B. M. (1998) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)37341-0 · Cited by 92 · see citing works
Nicotinic and muscarinic interactions and choice accuracy in the radial-arm maze
Levin, E. D., & Rose, J. E. (1991) · Brain Research Bulletin · doi:10.1016/0361-9230(91)90293-s · Cited by 91 · see citing works
Self-citationNicotine enhances the learning and memory of aged rats
Aren-, G. W., Sanberg, P. R., & Sengstock, G. J. (1995) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(95)00119-h · Cited by 90 · see citing works
Interactions between histaminergic and cholinergic systems in learning and memory
Bacciottini, L. (2001) · Behavioural Brain Research · doi:10.1016/s0166-4328(01)00230-3 · Cited by 89 · see citing works
Ventral hippocampal α4β2 nicotinic receptors and chronic nicotine effects on memory
Bancroft, A., & Levin, E. D. (2000) · Neuropharmacology · doi:10.1016/s0028-3908(00)00099-x · Cited by 89 · see citing works
Self-citationLevin, E. D. (1998) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(98)00109-9 · Cited by 89 · see citing works
Self-citationAcetylcholine, Histamine, and Cognition: Two Sides of the Same CoinPreprint
Blandina, P., Efoudebe, M., Cenni, G., Mannaioni, P. F., & Passani, M. B. (2004) · Learning & Memory · doi:10.1101/lm.68004 · Cited by 88 · see citing works
Krause, K.-H., Dresel, S. H., Krause, J., Kung, H. F., Tatsch, K., & Ackenheil, M. (2002) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145702002821 · Cited by 88 · see citing works
Nicotine improves delayed recognition in schizophrenic patients
Myers, C. S., Robles, O., Kakoyannis, A. N., Sherr, J. D., Avila, M. T., Blaxton, T. A., & Thaker, G. K. (2004) · Psychopharmacology · doi:10.1007/s00213-003-1764-8 · Cited by 87 · see citing works
Bettany, J. H., & Levin, E. D. (2001) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(01)00643-8 · Cited by 84 · see citing works
Self-citationReduced levels of Aβ 40 and Aβ 42 in brains of smoking controls and Alzheimer's patients
Hellström‐Lindahl, E., Mousavi, M. T., Ravid, R., & Nordberg, A. K. (2004) · Neurobiology of Disease · doi:10.1016/j.nbd.2003.11.024 · Cited by 83 · see citing works
Levin, E. D., Kim, P. M., & Meray, R. (1996) · Psychopharmacology · doi:10.1007/bf02805971 · Cited by 82 · see citing works
Self-citationPersistence of chronic nicotine-induced cognitive facilitation
Levin, E. D., Briggs, S. J., Christopher, N. C., & Rose, J. E. (1992) · Behavioral and Neural Biology · doi:10.1016/0163-1047(92)90399-o · Cited by 82 · see citing works
Self-citationRezvani, A. H., Bushnell, P. J., & Levin, E. D. (2002) · Psychopharmacology · doi:10.1007/s00213-002-1221-0 · Cited by 79 · see citing works
Self-citationPersonality differences related to smoking and adult attention deficit hyperactivity disorder
Downey, K. K., Pomerleau, C. S., & Pomerleau, O. F. (1996) · Journal of Substance Abuse · doi:10.1016/s0899-3289(96)90139-x · Cited by 77 · see citing works
Addy, N., Nakijama, A., & Levin, E. D. (2003) · Cognitive Brain Research · doi:10.1016/s0926-6410(02)00209-4 · Cited by 76 · see citing works
Self-citationNicotinic receptors and Parkinson's disease
Quik, M., & Jeyarasasingam, G. (2000) · European Journal of Pharmacology · doi:10.1016/s0014-2999(99)00888-2 · Cited by 74 · see citing works
Grigoryan, G. A., Mitchell, S. N., Hodges, H. M., Sinden, J. D., & Gray, J. A. (1994) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(94)90063-9 · Cited by 74 · see citing works
Addy, N. (2002) · Neuropsychopharmacology · doi:10.1016/s0893-133x(02)00327-5 · Cited by 73 · see citing works
Effects of ABT-418, a novel cholinergic channel ligand, on place learning in septal-lesioned rats
Decker, M. W., Curzon, P., Brioni, J. D., et al. (1994) · European Journal of Pharmacology · doi:10.1016/0014-2999(94)90323-9 · Cited by 72 · see citing works
Mediodorsal thalamic lesions impair radial maze performance in the rat.
Stokes, K. A., & Best, P. J. (1988) · Behavioral Neuroscience · doi:10.1037//0735-7044.102.2.294 · Cited by 71 · see citing works
Decker, M. W., & Majchrzak, M. J. (1992) · Psychopharmacology · doi:10.1007/bf02245267 · Cited by 69 · see citing works
Effects of combined muscarinic and nicotinic blockade on choice accuracy in the radial-arm maze
Levin, E. D., McGurk, S. R., South, D. A., et al. (1989) · Behavioral and Neural Biology · doi:10.1016/s0163-1047(89)90917-5 · Cited by 69 · see citing works
Self-citationMirza, N., & Bright, J. (2001) · Psychopharmacology · doi:10.1007/s002130000605 · Cited by 65 · see citing works
Acute and Chronic Nicotinic Interactions with Dopamine Systems and Working Memory Performancea
Levin, E. D., & Rose, J. E. (1995) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1995.tb17481.x · Cited by 64 · see citing works
Self-citationLevin, E. D., Briggs, S. J., Christopher, N. C., & Auman, J. T. (1994) · Brain Research · doi:10.1016/0006-8993(94)90964-4 · Cited by 63 · see citing works
Self-citationPapke, R. L., Webster, J. C., Lippiello, P. M., Bencherif, M., & Francis, M. M. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0750204.x · Cited by 63 · see citing works
Novel Approaches to the Treatment of Alzheimer’s Disease
Meyer, E. M., Simpkins, J. W., & Yamamoto, J. (1989) · Advances in behavioral biology · doi:10.1007/978-1-4684-5727-8 · Cited by 61 · see citing works
Terry, A. V., Risbrough, V. B., Buccafusco, J. J., & Menzaghi, F. (2002) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.301.1.284 · Cited by 61 · see citing works
Cholinergic drugs regulate passive avoidance performance via the amygdala.
Riekkinen, P. J., Riekkinen, M., & Sirviö, J. (1993) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)39599-6 · Cited by 60 · see citing works
Spatial Working Memory and the Brainstem Cholinergic Innervation to the Anterior Thalamus
Mitchell, A. S., Dalrymple‐Alford, J. C., & Christie, M. A. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-05-01922.2002 · Cited by 60 · see citing works
Eidi, M., Zarrindast, M., Eidi, A., et al. (2003) · European Journal of Pharmacology · doi:10.1016/s0014-2999(03)01440-7 · Cited by 60 · see citing works
Mediodorsal thalamic lesions impair radial maze performance in the rat.
Stokes, K. A., & Best, P. J. (1988) · Behavioral Neuroscience · doi:10.1037/0735-7044.102.2.294 · Cited by 60 · see citing works
Rezvani, A. H., & Levin, E. D. (2003) · European Journal of Pharmacology · doi:10.1016/s0014-2999(03)01439-0 · Cited by 59 · see citing works
Self-citationMcGurk, S. R., Levin, E. D., & Butcher, L. L. (1989) · Psychopharmacology · doi:10.1007/bf00445560 · Cited by 59 · see citing works
Self-citationRezvani, A. H. (2003) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(03)00193-x · Cited by 59 · see citing works
Self-citationInvolvement of pallidothalamic circuitry in working memory
Kalivas, P. W., Jackson, D., Romanidies, A., Wyndham, L., & Duffy, P. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00054-9 · Cited by 58 · see citing works
Characterization of the cognitive effects of combined muscarinic and nicotinic blockade
Levin, E. D., Rose, J. E., McGurk, S. R., et al. (1990) · Behavioral and Neural Biology · doi:10.1016/0163-1047(90)90865-4 · Cited by 58 · see citing works
Self-citationNicotine–antipsychotic drug interactions and attentional performance in female rats
Rezvani, A. H., & Levin, E. D. (2004) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2003.12.021 · Cited by 58 · see citing works
Self-citationSahakian, B. J., & Coull, J. T. (1994) · Drug Development Research · doi:10.1002/ddr.430310112 · Cited by 58 · see citing works
Clinical and attentional effects of acute nicotine treatment in Tourette’s syndrome
Howson, A. L., Batth, S., Ilivitsky, V., Boisjoli, A., Jaworski, M., Mahoney, C., & Knott, V. (2004) · European Psychiatry · doi:10.1016/j.eurpsy.2003.11.002 · Cited by 57 · see citing works
Attentional effects of nicotine and amphetamine in rats at different levels of motivation
Bizarro, L., & Stolerman, I. P. (2003) · Psychopharmacology · doi:10.1007/s00213-003-1543-6 · Cited by 56 · see citing works
Shytle, R. D., Silver, A. A., Wilkinson, B. J., & Sanberg, P. R. (2002) · The World Journal of Biological Psychiatry · doi:10.3109/15622970209150616 · Cited by 55 · see citing works
Reversal of a mecamylamine-induced cognitive deficit with the D2 agonist, LY 171555
Levin, E. D., McGurk, S. R., Rose, J. E., et al. (1989) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(89)90494-2 · Cited by 54 · see citing works
Self-citationLevin, E. D., Christopher, N. C., Weaver, T., Moore, J., & Brucato, F. H. (1999) · Cognitive Brain Research · doi:10.1016/s0926-6410(98)00044-5 · Cited by 54 · see citing works
Self-citationUtsuki, T., Shoaib, M. C., Holloway, H. W., Ingram, D. K., Wallace, W., Haroutunian, V. H., Sambamurti, K., Lahiri, D. K., & Greig, N. H. (2002) · Journal of Alzheimer s Disease · doi:10.3233/jad-2002-4507 · Cited by 53 · see citing works
Nicotinic Receptors in the Nervous System
Levin, E. D. (2001) · CRC Press eBooks · doi:10.1201/9781420038521 · Cited by 51 · see citing works
Self-citationNicotinic—dopaminergic relationships and radial-arm maze performance in rats
McGurk, S. R., Levin, E. D., & Butcher, L. L. (1989) · Behavioral and Neural Biology · doi:10.1016/s0163-1047(89)90182-9 · Cited by 50 · see citing works
Self-citationArthur, D. B., & Levin, E. (2002) · Psychopharmacology · doi:10.1007/s00213-001-0961-6 · Cited by 49 · see citing works
Self-citationRuotsalainen, S., Miettinen, R., MacDonald, E., Koivisto, E., & Sirviö, J. (2000) · Psychopharmacology · doi:10.1007/s002130050032 · Cited by 49 · see citing works
Effect of nicotine and nicotinic receptor agonists on latent inhibition in the rat.
Rochford, J. M., Sen, A. P., & Quirion, R. (1996) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)13072-3 · Cited by 46 · see citing works
Moragrega, I., Carrasco, M. C., Vicens, P., & Redolat, R. (2003) · Behavioural Brain Research · doi:10.1016/s0166-4328(03)00112-8 · Cited by 46 · see citing works
The Effects of Nicotine on Learning and Memory
Attaway, C. M., Compton, D. M., & Turner, M. D. (1999) · Physiology & Behavior · doi:10.1016/s0031-9384(99)00081-5 · Cited by 43 · see citing works
Effects of MK-801 and nicotine combinations on memory consolidation in CD1 mice
Ciamei, A., Aversano, M., Cestari, V., et al. (2001) · Psychopharmacology · doi:10.1007/s002130000584 · Cited by 43 · see citing works
The Effects of Nicotine in Dermal Plaster on Cognitive Functions in Patients with Alzheimers Disease
Snædal, J., Jóhannesson, T., Jonsson, J., et al. (1996) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000106852 · Cited by 43 · see citing works
Effects of nicotine on active avoidance learning in rats: sex differences.
Yilmaz, O., Kanıt, L., Okur, B. E., & Pöğün, Ş. (1997) · PubMed · Cited by 42 · see citing works
Risk Factors for Alzheimer’s Disease: A Case-Control Study
Wang, P., Wang, S., Hong, C., et al. (1997) · Neuroepidemiology · doi:10.1159/000109692 · Cited by 40 · see citing works
Levin, E. D., Rose, J. E., & Abood, L. G. (1995) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(94)00406-9 · Cited by 40 · see citing works
Self-citationYamazaki, Y., Hamaue, N., & Sumikawa, K. (2002) · Brain Research · doi:10.1016/s0006-8993(02)02935-9 · Cited by 39 · see citing works
Grilly, D. M. (2000) · Experimental and Clinical Psychopharmacology · doi:10.1037//1064-1297.8.1.14 · Cited by 37 · see citing works
Ventral hippocampal NMDA blockade and nicotinic effects on memory function
Levin, E. D., Sledge, D., Baruah, A., & Addy, N. (2003) · Brain Research Bulletin · doi:10.1016/s0361-9230(03)00183-7 · Cited by 36 · see citing works
Self-citationTerry, A. V., Buccafusco, J. J., Zagrodnik, S., et al. (1996) · Psychopharmacology · doi:10.1007/bf02246174 · Cited by 34 · see citing works
Nicotinic–serotonergic drug interactions and attentional performance in rats
Rezvani, A. H., Caldwell, D. P., & Levin, E. D. (2005) · Psychopharmacology · doi:10.1007/s00213-004-2060-y · Cited by 34 · see citing works
Self-citationGrilly, D. M. (2000) · Experimental and Clinical Psychopharmacology · doi:10.1037/1064-1297.8.1.14 · Cited by 34 · see citing works
Persistence of nicotinic agonist RJR 2403‐induced working memory improvement in rats
Levin, E. D., & Christopher, N. C. (2002) · Drug Development Research · doi:10.1002/ddr.10024 · Cited by 33 · see citing works
Self-citationJackson, W. J., Elrod, K., & Buccafusco, J. J. (1989) · Advances in behavioral biology · doi:10.1007/978-1-4684-5727-8_5 · Cited by 32 · see citing works
Baclofen interactions with nicotine in rats: effects on memory
Levin, E. D., Weber, E., & Icenogle, L. (2004) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2004.08.013 · Cited by 32 · see citing works
Self-citationEffects of transdermal nicotine on lateralized identification and memory interference
McClernon, F. J., Gilbert, D. G., & Radtke, R. C. (2003) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.488 · Cited by 31 · see citing works
Self-citationLevin, E. D. (1997) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(97)00052-x · Cited by 30 · see citing works
Self-citationVicens, P., Carrasco, M. C., & Redolat, R. (2003) · Neural Plasticity · doi:10.1155/np.2003.303 · Cited by 30 · see citing works
Nicotine attenuates spatial learning deficits induced in the rat by perinatal lead exposure
Zhou, M., & Suszkiw, J. B. (2004) · Brain Research · doi:10.1016/j.brainres.2003.10.068 · Cited by 28 · see citing works
Nicotine interactions with dopamine agonists: Effects on working memory function
Levin, E. D., & Eisner, B. (1994) · Drug Development Research · doi:10.1002/ddr.430310106 · Cited by 27 · see citing works
Self-citationNicotine in Psychiatry Psychopathology and Emerging Therapeutics
Weinstein, D. D. (2001) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v62n0613d · Cited by 25 · see citing works
Effects of transdermal nicotine on cognitive performance in Down's syndrome
Seidl, R., Tiefenthaler, M., Hauser, E., & Lübec, G. (2000) · The Lancet · doi:10.1016/s0140-6736(00)02848-8 · Cited by 24 · see citing works
Nicotine imptoves cognitive disturbance in senescence-accelerated mice
Meguro, K., Yamaguchi, S., Arai, H., Nakagawa, T., Doi, C., Yamada, M., Ikarashi, Y., Maruyama, Y., & Sasaki, H. (1994) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(94)90100-7 · Cited by 24 · see citing works
Green, J. T. (2000) · Experimental Aging Research · doi:10.1080/036107300750015723 · Cited by 24 · see citing works
Chen, Z. (2000) · PubMed · Cited by 24 · see citing works
Effect of H1-antagonists on spatial memory deficit evaluated by 8-arm radial maze in rats.
Chen, Z., Chen, J. Q., & KAMEI, C. (2001) · PubMed · Cited by 23 · see citing works
NMDA systems in the amygdala and piriform cortex and nicotinic effects on memory function
May‐Simera, H., & Levin, E. D. (2003) · Cognitive Brain Research · doi:10.1016/s0926-6410(03)00163-0 · Cited by 23 · see citing works
Self-citationBjugstad, K. B., Mahnir, V. M., Kem, W. R., Socci, D. J., & Arendash, G. W. (1996) · Drug Development Research · doi:10.1002/(sici)1098-2299(19960901)39:1 · Cited by 22 · see citing works
Effects of the dopamine D-2 receptor agonist, LY 171555, on radial arm maze performance in rats
Levin, E. D., & Bowman, R. E. (1986) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(86)90095-x · Cited by 19 · see citing works
Self-citationNicotine in Psychiatry: Psychopathology and Emerging Therapeutics
Melissa, P., & Paul, A. (2000) · Cited by 19 · see citing works
Taukulis, H. K. (1986) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(86)90234-0 · Cited by 18 · see citing works
Lobeline-induced learning improvement of rats in the radial-arm maze
Levin, E. D. (2003) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(03)00216-8 · Cited by 18 · see citing works
Self-citationNicotine-induced catecholamine synthesis after lesions to the dorsal or ventral noradrenergic bundle
Mitchell, S. N., Brazell, M. P., Schugens, M. M., et al. (1990) · European Journal of Pharmacology · doi:10.1016/0014-2999(90)90179-a · Cited by 17 · see citing works
Levin, E. D., & Rose, J. E. (1992) · Birkhäuser Boston eBooks · doi:10.1007/978-1-4615-9843-5_9 · Cited by 15 · see citing works
Self-citationHiramatsu, M., Yamatsu, T., Kameyama, T., et al. (2002) · Journal of Neural Transmission · doi:10.1007/s007020200029 · Cited by 15 · see citing works
The Role of Nicotinic Acetylcholine Receptors in Cognitive Function
Levin, E. D. (2000) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-57079-7_23 · Cited by 12 · see citing works
Self-citationEffects of a single transdermal nicotine dose on cognitive performance in adults with Down syndrome
Bernert, G., Šustrová, M., Sovcikova, E., Seidl, R., & Lübec, G. (2001) · Springer eBooks · doi:10.1007/978-3-7091-6262-0_19 · Cited by 10 · see citing works
Nicotine Effects on Attention Deficit Hyperactivity Disorder
Levin, E. D. (2001) · Frontiers in neuroscience · doi:10.1201/9781420038521.ch13 · Cited by 1 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
The role of acetylcholine in learning and memory
Hasselmo, M. E. (2006) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2006.09.002 · Cited by 1,693 · see citing works
Genome-wide meta-analyses identify multiple loci associated with smoking behavior
The Tobacco and Genetics Consortium (2010) · Nature Genetics · doi:10.1038/ng.571 · Cited by 1,098 · see citing works
Brain nicotinic acetylcholine receptors: native subtypes and their relevance
Gotti, C., Zoli, M., & Clementi, F. (2006) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2006.07.004 · Cited by 882 · see citing works
Modes and models of forebrain cholinergic neuromodulation of cognition
Hasselmo, M. E., & Sarter, M. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2010.104 · Cited by 733 · see citing works
Logue, S. F., & Gould, T. J. (2014) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2013.08.007 · Cited by 477 · see citing works
Nicotine addiction and nicotinic receptors: lessons from genetically modified mice
Changeux, J.-P. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2849 · Cited by 453 · see citing works
Lecourtier, L., & Kelly, P. H. (2007) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2007.01.004 · Cited by 283 · see citing works
Couey, J. J., Meredith, R. M., Spijker, S., Poorthuis, R. B., Smit, A. B., Brussaard, A. B., & Mansvelder, H. D. (2007) · Neuron · doi:10.1016/j.neuron.2007.03.006 · Cited by 253 · see citing works
The subtypes of nicotinic acetylcholine receptors on dopaminergic terminals of mouse striatum
Grady, S. R., Salminen, O., Laverty, D. C., Whiteaker, P., McIntosh, J. M., Collins, A. C., & Marks, M. J. (2007) · Biochemical Pharmacology · doi:10.1016/j.bcp.2007.07.032 · Cited by 252 · see citing works
McNaughton, N., Kocsis, B., & Hajós, M. (2007) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e3282ee82e3 · Cited by 187 · see citing works
Cognitive function during nicotine withdrawal: Implications for nicotine dependence treatment
Ashare, R. L., Falcone, M., & Lerman, C. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.04.034 · Cited by 170 · see citing works
Wilens, T. E., & Decker, M. W. (2007) · Biochemical Pharmacology · doi:10.1016/j.bcp.2007.07.002 · Cited by 164 · see citing works
Dose-Related Enhancement of Mood and Cognition in Smokers Administered Nicotine Nasal Spray
Myers, C. S., Taylor, R. C., Moolchan, E. T., & Heishman, S. J. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301425 · Cited by 143 · see citing works
Livingstone, P. D., Srinivasan, J., Kew, J. N. C., Dawson, L. A., Gotti, C., Moretti, M., Shoaib, M., & Wonnacott, S. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06613.x · Cited by 133 · see citing works
Levin, E. D., & Rezvani, A. H. (2007) · Biochemical Pharmacology · doi:10.1016/j.bcp.2007.07.019 · Cited by 129 · see citing works
Self-citationRole of nicotinic acetylcholine receptors in regulating dopamine neuron activity
Faure, P., Tolu, S., Valverde, S., & Naudé, J. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.05.040 · Cited by 125 · see citing works
Mateos, B., Borcel, E., Loriga, R., Luesu, W., Bini, V, Llorente, R., Castelli, M., & Viveros, M.-P. (2011) · Journal of Psychopharmacology · doi:10.1177/0269881110370503 · Cited by 108 · see citing works
McClernon, F. J., Hiott, F. B., Westman, E. C., Rose, J. E., & Levin, E. D. (2006) · Psychopharmacology · doi:10.1007/s00213-006-0516-y · Cited by 106 · see citing works
Self-citationNicotine and cannabinoids: parallels, contrasts and interactions
VIVEROS, M., MARCO, E., & FILE, S. (2006) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2006.08.002 · Cited by 106 · see citing works
Semenova, S., Stolerman, I. P., & Markou, A. (2007) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2007.05.009 · Cited by 104 · see citing works
Nicotinic actions on neuronal networks for cognition: General principles and long-term consequences
Poorthuis, R. B., Goriounova, N. A., Couey, J. J., & Mansvelder, H. D. (2009) · Biochemical Pharmacology · doi:10.1016/j.bcp.2009.04.031 · Cited by 102 · see citing works
Brunzell, D. H., Boschen, K. E., Hendrick, E. S., Beardsley, P. M., & McIntosh, J. M. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.171 · Cited by 95 · see citing works
P50 gating deficit in Alzheimer dementia correlates to frontal neuropsychological function
Thomas, C., vom Berg, I., Rupp, A., Seidl, U., Schröder, J., Roesch-Ely, D., Kreisel, S. H., Mundt, C., & Weisbrod, M. (2010) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2008.05.002 · Cited by 88 · see citing works
Nicotinic mechanisms influencing synaptic plasticity in the hippocampus
Placzek, A. N., Zhang, T. A., & Dani, J. A. (2009) · Acta Pharmacologica Sinica · doi:10.1038/aps.2009.39 · Cited by 77 · see citing works
The visinin-like proteins VILIP-1 and VILIP-3 in Alzheimer’s disease—old wine in new bottles
Braunewell, K. H. (2012) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2012.00020 · Cited by 66 · see citing works
Kenney, J. W., Adoff, M. D., Wilkinson, D. S., & Gould, T. J. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2283-7 · Cited by 67 · see citing works
Hippocampal nAChRs mediate nicotine withdrawal-related learning deficits
Davis, J. A., & Gould, T. J. (2009) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2009.02.003 · Cited by 60 · see citing works
Nicotinic receptor activation in perirhinal cortex and hippocampus enhances object memory in rats
Melichercik, A. M., Elliott, K. S., Bianchi, C., Ernst, S. M., & Winters, B. D. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.01.008 · Cited by 54 · see citing works
Taylor, G. M. J., & Treur, J. L. (2023) · International Journal of Clinical and Health Psychology · doi:10.1016/j.ijchp.2022.100335 · Cited by 50 · see citing works
“These shortterm effects of nicotine appear to be particularly important in reducing negative symptoms in schizophrenia (Levin et al., 2005), and have some salience amongst people with attention deficit hyperactivity disorder (Kollins et al., 2020).”
BackgroundRezvani, A. H., Cauley, M., Sexton, H., Xiao, Y., Brown, M. L., Paige, M. A., McDowell, B. E., Kellar, K. J., & Levin, E. D. (2011) · Psychopharmacology · doi:10.1007/s00213-010-2161-8 · Cited by 50 · see citing works
Self-citationGiessing, C., Fink, G. R., Rösler, F., & Thiel, C. M. (2007) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.2007.19.4.658 · Cited by 51 · see citing works
Froeliger, B., Kozink, R. V., Rose, J. E., Behm, F. M., Salley, A. N., & McClernon, F. J. (2010) · Psychopharmacology · doi:10.1007/s00213-010-1862-3 · Cited by 49 · see citing works
Self-citationCholinergic Circuits and Signaling in the Pathophysiology of Schizophrenia
Berman, J. A., Talmage, D. A., & Role, L. W. (2007) · International Review of Neurobiology · doi:10.1016/s0074-7742(06)78007-2 · Cited by 47 · see citing works
Andreasen, J. T., Henningsen, K., Bate, S., Christiansen, S., & Wiborg, O. (2011) · Journal of Psychopharmacology · doi:10.1177/0269881110391831 · Cited by 46 · see citing works
Sabec, M. H., Wonnacott, S., Warburton, E. C., & Bashir, Z. I. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.03.016 · Cited by 42 · see citing works
Andreasen, J. T., Redrobe, J. P., & Nielsen, E. Ø. (2012) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2011.11.004 · Cited by 43 · see citing works
Nicotine and extinction of fear conditioning
Elias, G. A., Gulick, D., Wilkinson, D. S., & Gould, T. J. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2009.11.022 · Cited by 36 · see citing works
André, J. M., Leach, P. T., & Gould, T. J. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2010.12.004 · Cited by 32 · see citing works
β2 Nicotinic acetylcholine receptor availability in post-traumatic stress disorder
Czermak, C., Staley, J. K., Kasserman, S., Bois, F., Young, T., Henry, S., Tamagnan, G. D., Seibyl, J. P., Krystal, J. H., & Neumeister, A. (2008) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145707008152 · Cited by 31 · see citing works
Chen, G.-J., Xiong, Z., & Yan, Z. (2013) · Molecular Neurodegeneration · doi:10.1186/1750-1326-8-3 · Cited by 30 · see citing works
Divergent Functional Effects of Sazetidine-A and Varenicline During Nicotine Withdrawal
Turner, J. R., Wilkinson, D. S., Poole, R. L., Gould, T. J., Carlson, G. C., & Blendy, J. A. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.105 · Cited by 29 · see citing works
Luberto, C. M., McLeish, A. C., Robertson, S. A., Avallone, K. M., Kraemer, K. M., & Jeffries, E. R. (2014) · The American Journal on Addictions · doi:10.1111/j.1521-0391.2013.12096.x · Cited by 25 · see citing works
The effects of nicotine on intrusive memories in nonsmokers
Hawkins, K. A., & Cougle, J. R. (2013) · Experimental and Clinical Psychopharmacology · doi:10.1037/a0033966 · Cited by 24 · see citing works
Askew, C., Intskirveli, I., & Metherate, R. (2017) · eneuro · doi:10.1523/eneuro.0192-17.2017 · Cited by 18 · see citing works
Stojanovic, T., Velarde Gamez, D., Schuld, G. J., Bormann, D., Cabatic, M., Uhrin, P., Lubec, G., & Monje, F. J. (2022) · Cells · doi:10.3390/cells11020261 · Cited by 8 · see citing works
- Authors
- Levin, E. D., McClernon, F. J., & Rezvani, A. H.
- Affiliations
- Duke University (US)
- Duke Medical Center (US)
- Corresponding author
- Levin, Edward D.
- Venue
- Psychopharmacology
- Published
- 2005-10-12
- Volume
- 184
- Issue
- 3-4
- Pages
- 523-539
- ISSN
- 0033-3158 (ISSN-L)
- 1432-2072
- OpenAlex
- W2059495695
- Cited by
- 820
- References
- 200
- Citations by year
- 2026: 10 · 2025: 22 · 2024: 38 · 2023: 6 · 2022: 14 · 2021: 14 · 2020: 42 · 2019: 20 · 2018: 34 · 2017: 45 · 2016: 43 · 2015: 41 · 2014: 68 · 2013: 60 · 2012: 57
- FWCI
- 15.83
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of Mental Health (MH 64494, R01MH064494)
- National Institute on Drug Abuse (R01DA015756, DA015756)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- nicotine, nicotinic agonists, nicotinic acetylcholine receptors, alpha4beta2 nicotinic receptor, alpha7 nicotinic acetylcholine receptor, cognitive function, working memory, learning, attention, hippocampus, amygdala, Alzheimer's disease, schizophrenia, attention deficit hyperactivity disorder, age-associated memory impairment, cognitive impairment
- MeSH terms
- Alzheimer Disease, Amygdala, Animals, Attention, Cognition, Hippocampus, Humans, Learning, Memory, Nicotine, Receptors, Nicotinic, Schizophrenia, Mice, Rats, alpha7 Nicotinic Acetylcholine Receptor
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review