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Interferon beta‐1b is effective in relapsing‐remitting multiple sclerosis: II. MRI analysis results of a multicenter, randomized, double‐blind, placebo‐controlled trial
Open accessAbstract
We performed yearly MRI analyses on 327 of the total 372 patients in a multicenter, randomized, double-blind, placebo-controlled trial of interferon beta-1b (IFNB). Clinical results are presented in the preceding companion paper. Baseline MRI characteristics were the same in all treatment groups. Fifty-two patients at one center formed a cohort for frequent MRIs (one every 6 weeks) for analysis of disease activity. The MRI results support the clinical results in showing a significant reduction in disease activity as measured by numbers of active scans (median 80% reduction, p = 0.0082) and appearance of new lesions. In addition, there was an equally significant reduction in MRI-detected burden of disease in the treatment as compared with placebo groups (mean group difference of 23%, p = 0.001). These results demonstrate that IFNB has made a significant impact on the natural history of MS in these patients.
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Citations
Cites
Rating neurologic impairment in multiple sclerosis: An expanded disability status scale (EDSS)
Kurtzke, J. F. (1983) · Neurology · doi:10.1212/wnl.33.11.1444 · Cited by 15,011
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External validity of randomised controlled trials: “To whom do the results of this trial apply?”
Rothwell, P. M. (2005) · The Lancet · doi:10.1016/s0140-6736(04)17670-8 · Cited by 2,544
Protein Therapeutics: A Summary and Pharmacological Classification
Leader, B., Baca, Q. J., & Golan, D. E. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2399 · Cited by 2,161
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Multiple Sclerosis: An Immune or Neurodegenerative Disorder?
Trapp, B. D., & Nave, K.-A. (2008) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.30.051606.094313 · Cited by 1,724
Metadata
- Authors
- Paty, D. W., Li, D. K. B., the UBC MS/MRI Study Group, & the IFNB Multiple Sclerosis Study Group
- Venue
- Neurology
- Published
- 1993-04
- Volume
- 43
- Issue
- 4
- Pages
- 662-662
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2165547142
- Cited by
- 1,967
- References
- 1
- FWCI
- 58.48
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Interferon beta‐1b is effective in relapsing‐remitting multiple sclerosis: II. MRI analysis results of a multicenter, randomized, double‐blind, placebo‐controlled trial. https://app.cochat.ai/papers/10.1212/wnl.43.4.662
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- Paty, D. W., Li, D. K. B., the UBC MS/MRI Study Group, & the IFNB Multiple Sclerosis Study Group. (1993). Interferon beta‐1b is effective in relapsing‐remitting multiple sclerosis: II. MRI analysis results of a multicenter, randomized, double‐blind, placebo‐controlled trial. Neurology. https://doi.org/10.1212/wnl.43.4.662
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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