The DOI matches its Crossref record.
The natural history of amyotrophic lateral sclerosis
Abstract
Using 42 strength and functional assessments recorded monthly, the natural history of amyotrophic lateral sclerosis (ALS) is described in 167 patients (98 men, 67 women) followed in five medical centers in the western United States. The mean age at onset was 57.4 years, and symptoms were present for 2.64 years before study entry. Although there was a highly variable rate of decline within the group of patients, there were no differences in rate of decline by age or gender. Older patients and women were weaker on entry. Forty-eight patients died during the study. The median survival was 4.0 years for the study cohort but 2.1 years for newly diagnosed cases. Decline in pulmonary function most closely correlated with death. Our results emphasize the importance of considering clinical variability in planning clinical trials. One possible strategy is to identify and stratify patients by rate of decline in pulmonary function since prospectively identifying homogeneous subgroups allows investigators to substantially reduce sample size in therapeutic trials.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Kiernan, M. C., Vucic, S., Cheah, B. C., Turner, M. R., Eisen, A., Hardiman, O., Burrell, J. R., & Zoing, M. C. (2011) · The Lancet · doi:10.1016/s0140-6736(10)61156-7 · Cited by 2,603
Prognostic factors in ALS: A critical review
Chiò, A., Logroscino, G., Hardiman, O., Swingler, R., Mitchell, D., Beghi, E., Traynor, B. G., & On Behalf of the Eurals Consortium (2009) · Amyotrophic Lateral Sclerosis · doi:10.3109/17482960802566824 · Cited by 1,172
Energy metabolism in amyotrophic lateral sclerosis
Dupuis, L., Pradat, P.-F., Ludolph, A. C., & Loeffler, J.-P. (2011) · The Lancet Neurology · doi:10.1016/s1474-4422(10)70224-6 · Cited by 537
Prognosis in amyotrophic lateral sclerosis: A population-based study
del Aguila, M. A., Longstreth, W. T., McGuire, V., Koepsell, T. D., & van Belle, G. (2003) · Neurology · doi:10.1212/01.wnl.0000049472.47709.3b · Cited by 469
Rate of familial amyotrophic lateral sclerosis: a systematic review and meta-analysis
Byrne, S., Walsh, C., Lynch, C., Bede, P., Elamin, M., Kenna, K., McLaughlin, R., & Hardiman, O. (2011) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.2010.224501 · Cited by 351
Metadata
- Authors
- Ringel, S. P., Murphy, J. R., Alderson, M. K., Bryan, W., England, J. D., Miller, R. G., Petajan, J. H., Smith, S. A., Roelofs, R. I., Ziter, F., Lee, M. Y., Brinkmann, J. R., Almada, A., Gappmaier, E., Graves, J., Herbelin, L., Mendoza, M., Mylar, D., Smith, P., & Yu, P.
- Venue
- Neurology
- Published
- 1993-07
- Volume
- 43
- Issue
- 7
- Pages
- 1316-1316
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2062321724
- Cited by
- 243
- References
- 0
- FWCI
- 5.45
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: The natural history of amyotrophic lateral sclerosis. https://app.cochat.ai/papers/10.1212/wnl.43.7.1316
- The paper
- Ringel, S. P., Murphy, J. R., Alderson, M. K., Bryan, W., England, J. D., Miller, R. G., Petajan, J. H., Smith, S. A., Roelofs, R. I., Ziter, F., Lee, M. Y., Brinkmann, J. R., Almada, A., Gappmaier, E., Graves, J., Herbelin, L., Mendoza, M., Mylar, D., Smith, P., & Yu, P. (1993). The natural history of amyotrophic lateral sclerosis. Neurology. https://doi.org/10.1212/wnl.43.7.1316
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
