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Cited by 384

Prognosis in amyotrophic lateral sclerosis: A population-based study

del Aguila, M.A., Longstreth, W.T., McGuire, V., Koepsell, T.D., van Belle, G.·2003·Neurology
DOI 10.1212/01.wnl.0000049472.47709.3b
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Abstract

Background Accurate information on prognosis of ALS is useful to patients, families, and clinicians. Methods In a population-based study of ALS in western Washington, the authors assembled a cohort of 180 patients with incident ALS between 1990 and 1994. Information on potential prognostic factors was collected during an in-person interview. Patients also completed the Medical Outcomes Study Short Form 36 (SF-36). Vital status through December 1999 was known for all patients. Results Median survival was 32 months from onset of symptoms and 19 months from diagnosis. The 5-year survival after diagnosis was 7%. Older age and female sex were strongly associated with poor survival. In multivariable Cox proportional hazards regression models, factors significantly and independently associated with a worse prognosis included older age, any bulbar features at onset, shorter time from symptom onset to diagnosis, lack of a marital partner, and residence in King County. Recursive partitioning identified age, time from symptom onset to diagnosis, and marital status as the strongest predictors of survival. Good summary scores for physical health on the SF-36, but not for mental health, were significantly associated with longer survival than poor scores. Conclusion These findings are consistent with other population-based studies of ALS and confirm its pernicious nature. Older age, female sex, any bulbar features at onset, short time from symptom onset to diagnosis, lack of a marital partn…

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Crossref · 10.1212/01.wnl.0000049472.47709.3b

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  • The median survival time is well within the range reported by several population-based studies, which extends from 16 months to 28 months, with most studies reporting values between 19 and 23 months.

    “it is well within the range reported by several population-based studies, which extends from 16 months (65;66) to 28 months (67), with most studies reporting values between 19 and 23 months (68–70).”

    From Association of ALS with head injury, cigarette smoking and APOE genotypes (2010) · cites this paper as [70]

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Authors
del Aguila, M. A., Longstreth, W. T., McGuire, V., Koepsell, T. D., & van Belle, G.
Affiliations
From the Departments of Dental Public Health Sciences (Dr. del Aguila), Neurology (Dr. Longstreth), Epidemiology (Drs. del Aguila, Longstreth, McGuire, and Koepsell), Health Services (Dr. Koepsell), Environmental Health (Dr. van Belle), and Biostatistics (Dr. van Belle), University of Washington, Seattle.
Venue
Neurology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2003-03-11
Volume
60
Issue
5
Pages
813-819
ISSN
  • 0028-3878
  • 1526-632X
DOI
10.1212/01.wnl.0000049472.47709.3b
Cited by
384
References
1
Language
en

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