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Cytokine mRNA levels in mononuclear blood cells from patients with multiple sclerosis
Abstract
We determined the cytokine messenger RNA (mRNA) expression pattern of blood mononuclear cells in 45 patients with the relapsing-remitting form of MS and 32 patients with other neurologic diseases. Using a semiquantitative polymerase chain reaction method, we detected significantly higher levels of tumor necrosis factor-alpha and lymphotoxin mRNA in patients with relapsing compared to those with stable disease (p < 0.001), but transforming growth factor-beta and interleukin-10 mRNA expressions were higher in patients with stable disease.
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Citations
Cited by
Kallmann, B. A. (2000) · Brain · doi:10.1093/brain/123.4.687 · Cited by 106
Kallaur, A. P., Oliveira, S. R., Simão, A. N. C., Alfieri, D. F., Flauzino, T., Lopes, J., de Carvalho Jennings Pereira, W. L., de Meleck Proença, C., Borelli, S. D., Kaimen-Maciel, D. R., et al. (2017) · Molecular Neurobiology · doi:10.1007/s12035-016-9846-x · Cited by 75
Astroglial‐derived lymphotoxin‐α exacerbates inflammation and demyelination, but not remyelination
Plant, S. R., Arnett, H. A., & Ting, J. P. (2005) · Glia · doi:10.1002/glia.20089 · Cited by 60
Plasma Biomarkers Discriminate Clinical Forms of Multiple Sclerosis
Tejera-Alhambra, M., Casrouge, A., de Andrés, C., Seyfferth, A., Ramos-Medina, R., Alonso, B., Vega, J., Fernández-Paredes, L., Albert, M. L., & Sánchez-Ramón, S. (2015) · PLOS ONE · doi:10.1371/journal.pone.0128952 · Cited by 55
Metadata
- Authors
- Rieckmann, P., Albrecht, M., Kitze, B., Weber, T., Tumani, H., Broocks, A., Lüer, W., & Poser, S.
- Venue
- Neurology
- Published
- 1994-08
- Volume
- 44
- Issue
- 8
- Pages
- 1523-1523
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2007703142
- Cited by
- 225
- References
- 0
- FWCI
- 12.16
- Type
- journal article
- Language
- en
- Open access
- closed
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- Rieckmann, P., Albrecht, M., Kitze, B., Weber, T., Tumani, H., Broocks, A., Lüer, W., & Poser, S. (1994). Cytokine mRNA levels in mononuclear blood cells from patients with multiple sclerosis. Neurology. https://doi.org/10.1212/wnl.44.8.1523
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.