Plasma Biomarkers Discriminate Clinical Forms of Multiple Sclerosis
Open accessAbstract
Multiple sclerosis, the most common cause of neurological disability in young population after trauma, represents a significant public health burden. Current challenges associated with management of multiple sclerosis (MS) patients stem from the lack of biomarkers that might enable stratification of the different clinical forms of MS and thus prompt treatment for those patients with progressive MS, for whom there is currently no therapy available. In the present work we analyzed a set of thirty different plasma cytokines, chemokines and growth factors present in circulation of 129 MS patients with different clinical forms (relapsing remitting, secondary progressive and primary progressive MS) and 53 healthy controls, across two independent cohorts. The set of plasma analytes was quantified with Luminex xMAP technology and their predictive power regarding clinical outcome was evaluated both individually using ROC curves and in combination using logistic regression analysis. Our results from two independent cohorts of MS patients demonstrate that the divergent clinical and histology-based MS forms are associated with distinct profiles of circulating plasma protein biomarkers, with distinct signatures being composed of chemokines and growth/angiogenic factors. With this work, we propose that an evaluation of a set of 4 circulating biomarkers (HGF, Eotaxin/CCL11, EGF and MIP-1β/CCL4) in MS patients might serve as an effective tool in the diagnosis and more personalized therapeutic targeting of MS patients.
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OPCs have been suggested to express the primary CCL11 receptor CCR3, and elevated CCL11 levels are associated with MS disease duration and severity.
“Moreover, OPCs have been suggested to express the primary CCL11 receptor, CCR360 and elevated CCL11 levels are associated with MS disease duration and severity61,62.”
From Senescent-like microglia limit remyelination through the senescence associated secretory phenotype (2025) · cites this paper as [61]
The Results report that plasma CCL11 was higher in progressive than relapsing-remitting MS and correlated with EDSS, a measure of disability. The paper notes that progressive patients had longer disease duration, but our copy does not report a direct association between CCL11 levels and disease duration. The OPC/CCR3 statement is attached to a different citation, not this source. (LLM, conf=0.85)
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- Authors
- Tejera-Alhambra, M., Casrouge, A., de Andrés, C., Seyfferth, A., Ramos-Medina, R., Alonso, B., Vega, J., Fernández-Paredes, L., Albert, M. L., & Sánchez-Ramón, S.
- Affiliations
- Inserm (FR)
- Hospital General Universitario Gregorio Marañón (ES)
- Comunidad de Madrid (ES)
- Hospital Clínico San Carlos (ES)
- Venue
- PLOS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2015-06-03
- Volume
- 10
- Issue
- 6
- Pages
- e0128952
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC4454618
- OpenAlex
- W2193966886
- Cited by
- 55
- References
- 90
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 5 · 2023: 3 · 2022: 8 · 2021: 7 · 2020: 7 · 2019: 3 · 2018: 7 · 2017: 7 · 2016: 4
- FWCI
- 4.77
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- PLoS ONE (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- HAL (submittedVersion, cc-by)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Fundación Mapfre
- Fundación Salud 2000
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Health Sciences › Medicine › Neurology › Peripheral Neuropathies and Disorders
- Keywords
- multiple sclerosis, plasma biomarkers, relapsing-remitting multiple sclerosis, secondary progressive multiple sclerosis, primary progressive multiple sclerosis, cytokines, chemokines, growth factors, hepatocyte growth factor, epidermal growth factor, personalized treatment
- MeSH terms
- Adult, Diagnosis, Differential, Epidermal Growth Factor, Female, Humans, Middle Aged, Predictive Value of Tests, ROC Curve, Cohort Studies, Biomarkers, Case-Control Studies, Hepatocyte Growth Factor, Multiple Sclerosis, Chronic Progressive, Multiple Sclerosis, Relapsing-Remitting, Chemokine CCL4, Chemokine CCL11
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