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Degeneration of substantia nigra in chronic Parkinson's disease visualized by transcranial color-coded real-time sonography
Abstract
To detect morphologic abnormalities in Parkinson's disease (PD), we examined 30 patients with PD and 30 age- and sex-matched nonparkinsonian controls by transcranial color-coded real-time sonography (TCCS). In 12 severely affected PD patients, the echogenicity of the substantia nigra was distinctly increased. In the remaining 18 PD patients and in all controls, the substantia nigra was poorly visualized or nondetectable by TCCS. The degree of hyperechogenicity of the substantia nigra closely correlated with the severity and duration of PD (p < 0.001). The increased echogenicity of the substantia nigra notably results from nigral gliosis and reflects the stage of degeneration.
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Citations
Cited by
The diagnosis of Parkinson’s disease
Tolosa, E., Wenning, G., & Poewe, W. (2006) · The Lancet Neurology · doi:10.1016/s1474-4422(05)70285-4 · Cited by 902
Berg, D., Roggendorf, W., Schröder, U., Klein, R., Tatschner, T., Benz, P., Tucha, O., Preier, M., Lange, K. W., Reiners, K., et al. (2002) · Archives of Neurology · doi:10.1001/archneur.59.6.999 · Cited by 377
Self-citationTranscranial sonography in movement disorders
Berg, D., Godau, J., & Walter, U. (2008) · The Lancet Neurology · doi:10.1016/s1474-4422(08)70239-4 · Cited by 372
Brain iron pathways and their relevance to Parkinson's disease
Berg, D., Gerlach, M., Youdim, M. B. H., Double, K. L., Zecca, L., Riederer, P., & Becker, G. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00608.x · Cited by 362
Self-citationThe Relevance of Iron in the Pathogenesis of Parkinson's Disease
GÖTZ, M. E., DOUBLE, K., GERLACH, M., YOUDIM, M. B. H., & RIEDERERE, P. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1306.017 · Cited by 342
Metadata
- Authors
- Becker, G., Seufert, J., Bogdahn, U., Reichmann, H., & Reiners, K.
- Venue
- Neurology
- Published
- 1995-01
- Volume
- 45
- Issue
- 1
- Pages
- 182-184
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2041184080
- Cited by
- 397
- References
- 0
- FWCI
- 1.16
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Degeneration of substantia nigra in chronic Parkinson's disease visualized by transcranial color-coded real-time sonography. https://app.cochat.ai/papers/10.1212/wnl.45.1.182
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- Becker, G., Seufert, J., Bogdahn, U., Reichmann, H., & Reiners, K. (1995). Degeneration of substantia nigra in chronic Parkinson's disease visualized by transcranial color-coded real-time sonography. Neurology. https://doi.org/10.1212/wnl.45.1.182
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
