The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
The Relevance of Iron in the Pathogenesis of Parkinson's Disease
Abstract
A bstract: Investigations that revealed increased levels of iron in postmortem brains from patients with Parkinson's disease (PD) as compared to those from individuals not suffering from neurological disorders are reported. The chemical natures in which iron predominates in the brain and the relevance of neuromelanin for neuronal iron binding are discussed. Major findings have been that iron levels increase with the severity of neuropathological changes in PD, presumably due to increased transport through the blood‐brain barrier in late stages of parkinsonism. Glial iron is mainly stored as ferric iron in ferritin, while neuronal iron is predominantly bound to neuromelanin. Iron overload may induce progressive degeneration of nigrostriatal neurons by facilitating the formation of reactive biological intermediates, including reactive oxygen species, and the formation of cytotoxic protein aggregates. There are indications that iron‐mediated neuronal death in PD proceeds retrogradely. These results are also discussed with respect to their relevance for disease progression in relation to cytotoxic α‐synuclein protofibril formation.
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Mutation in the α-Synuclein Gene Identified in Families with Parkinson's Disease
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Brain iron pathways and their relevance to Parkinson's disease
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Self-citationTransferrin and Iron in Normal, Alzheimer's Disease, and Parkinson's Disease Brain Regions
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Cited by
Iron, brain ageing and neurodegenerative disorders
Zecca, L., Youdim, M. B. H., Riederer, P., Connor, J. R., & Crichton, R. R. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1537 · Cited by 1,801
Self-citationKell, D. B. (2009) · BMC Medical Genomics · doi:10.1186/1755-8794-2-2 · Cited by 554
Selective iron chelation in Friedreich ataxia: biologic and clinical implications
Boddaert, N., Le Quan Sang, K. H., Rötig, A., Leroy-Willig, A., Gallet, S., Brunelle, F., Sidi, D., Thalabard, J.-C., Munnich, A., & Cabantchik, Z. I. (2007) · Blood · doi:10.1182/blood-2006-12-065433 · Cited by 409
Iron Toxicity in Diseases of Aging: Alzheimer's Disease, Parkinson's Disease and Atherosclerosis
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Metadata
- Authors
- GÖTZ, M. E., DOUBLE, K., GERLACH, M., YOUDIM, M. B. H., & RIEDERERE, P.
- Venue
- Annals of the New York Academy of Sciences
- Publisher
- Wiley
- Published
- 2004-03
- Volume
- 1012
- Issue
- 1
- Pages
- 193-208
- ISSN
- 0077-8923 (ISSN-L)
- 1749-6632
- OpenAlex
- W1969609724
- Cited by
- 342
- References
- 15
- FWCI
- 12.24
- Type
- journal article
- Language
- en
- Open access
- closed
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- GÖTZ, M. E., DOUBLE, K., GERLACH, M., YOUDIM, M. B. H., & RIEDERERE, P. (2004). The Relevance of Iron in the Pathogenesis of Parkinson's Disease. Annals of the New York Academy of Sciences. https://doi.org/10.1196/annals.1306.017
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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