Cited by 829Dementia and Cognitive Impairment ResearchNeurological Disease Mechanisms and TreatmentsAlzheimer's disease research and treatments

The DOI matches its Crossref record.

Incidence and risk factors of vascular dementia and Alzheimer's disease in a defined elderly Japanese population: The Hisayama Study

Yoshitake, T., Kiyohara, Y., Kato, I., Ohmura, T., Iwamoto, H., Nakayama, K., Ohmori, S., Nomiyama, K., Kawano, H., Ueda, K., Sueishi, K., Tsuneyoshi, M., Fujishima, M.·1995·Neurology

DOI 10.1212/wnl.45.6.1161

Open this paper in CoChat — free account

Abstract

Article abstract—We followed 828 nondemented residents of Hisayama Town, Kyushu, Japan, aged 65 years or older (88.3% of the elderly population) for 7 years starting in 1985 in order to determine the type-specific incidence of dementia and its risk factors in the general Japanese population. Only two subjects were lost to the follow-up, during which period 103 subjects developed dementia. Morphologic examination of the brains of 89 subjects (86.4%) was made by autopsy or CT. We made the initial diagnosis of dementia based on the DSM-111-R criteria, with the diagnoses of vascular dementia (VD) being based on the NINDS-AIREN criteria and Alzheimer9s disease (AD) on the NINCDS-ADRDA criteria. The incidence of VD and AD increased with age for both sexes. The age-adjusted total incidence (per 1,000 person-years) of dementia was 19.3 for men and 20.9 for women. The corresponding rates for VD were 12.2 for men and 9.0 for women, and for AD, 5.1 for men and 10.9 for women. Among the VD subjects whose brain morphology we examined, the most frequent type of stroke was multiple lacunar infarcts (42%), but half these subjects lacked a stroke episode in their histories. Multivariate analysis showed that age, prior stroke episodes, systolic blood pressure, and alcohol consumption were significant independent risk factors for the occurrence of VD. In contrast, age and a low score on Hasegawa9s dementia scale were significant risk factors for AD, and physical activity was a significant preventive factor for AD. Our findings suggest that asymptomatic stroke is an important factor in the development of VD, with age, prior stroke episodes, systolic blood pressure, and alcohol consumption being independent risk factors for its occurrence. Age and a low scare on Hasegawa9s dementia scale are significant risk factors for AD, with moderate physical activity having a statistically significant preventive effect.

Integrity signals

Registry

Crossref · 10.1212/wnl.45.6.1161

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Sorted by citations

Items 501–600 of 826

The epidemiology of Alzheimer’s disease and vascular dementia in Japanese and African-American populations: the search for etiological clues
Shadlen, M., Larson, E. B., & Yukawa, M. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00115-9 · Cited by 23
The Lifelong Health Support 10: a Japanese prescription for a long and healthy life
Arafa, A., Kokubo, Y., Kashima, R., Teramoto, M., Sakai, Y., Nosaka, S., Nakao, Y. M., & Watanabe, E. (2022) · Environmental Health and Preventive Medicine · doi:10.1265/ehpm.22-00085 · Cited by 21
Metabolic and endocrinological causes of dementia
Flicker, L. A., & Ames, D. J. (2005) · International Psychogeriatrics · doi:10.1017/s1041610205001961 · Cited by 21
Small artery dementia in Japan: radiological differences between CADASIL, leukoaraiosis and Binswanger’s disease
Tomimoto, H., Ohtani, R., Wakita, H., Lin, J.-X., Ihara, M., Miki, Y., Oshima, F., Murata, T., Ishibashi, K., Suenaga, T., et al. (2006) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000090677 · Cited by 20
Global burden of young-onset dementia, from 1990 to 2021: an age-period-cohort analysis from the global burden of disease study 2021
He, Q., Wang, W., Zhang, Y., Yang, X., Tao, C., Ma, L., You, C., Ma, J., & Jiang, Y. (2025) · Translational Psychiatry · doi:10.1038/s41398-025-03275-w · Cited by 20
Lifetime cumulative incidence of dementia in a community-dwelling elderly population in Japan
Yoshida, D., Ohara, T., Hata, J., Shibata, M., Hirakawa, Y., Honda, T., Furuta, Y., Oishi, E., Sakata, S., Kanba, S., et al. (2020) · Neurology · doi:10.1212/wnl.0000000000009917 · Cited by 20
“Details about the follow-up survey on dementia have been described in our previous reports.(15,16) Follow-up screening surveys of cognitive function, including neuropsychological tests, the Hasegawa Dementia Scale (HDS),(17) the Hasegawa Dementia Scale–Revised (HDS-R),(18) or the Mini-Mental State Examination (MMSE),(…”
BackgroundMethod
Sociodemographic characteristics, clinical factors, and genetic polymorphisms associated with Alzheimer's disease
Bicalho, M. A. C., Pimenta, F. A. P., Bastos‐Rodrigues, L., Hansen, É. D. O., Neves, S. C., Melo, M., Rosa, D. V., de Souza, R. P., de Miranda, D. M., de Moraes, E. N., et al. (2012) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.3875 · Cited by 23
Impact of regional white matter lesions on cognitive function in subcortical vascular cognitive impairment
Ai, Q., Pu, Y., Sy, C. A., Liu, L., & Gao, P. (2014) · Neurological Research · doi:10.1179/1743132814y.0000000354 · Cited by 20
GLP-1 receptor regulates cell growth through regulating IDE expression level in Aβ1–42-treated PC12 cells
Li, H., Cao, L., Ren, Y., Jiang, Y., Xie, W., & Li, D. (2017) · Bioscience Reports · doi:10.1042/bsr20171284 · Cited by 20
The Relationships Between Components of Metabolic Syndrome and Mild Cognitive Impairment Subtypes: A Cross-Sectional Study of Japanese Older Adults
Bae, S., Shimada, H., Lee, S., Makizako, H., Lee, S., Harada, K., Doi, T., Tsutsumimoto, K., Hotta, R., Nakakubo, S., et al. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-161230 · Cited by 21
Neuroimaging of Vascular Dementia
Kanekar, S. G., & Poot, J. D. (2014) · Radiologic Clinics of North America · doi:10.1016/j.rcl.2013.11.004 · Cited by 19
C-Reactive Protein: Vascular Risk Marker in Elderly Patients with Mental Illness
Nilsson, K. H., Gustafson, L., & Hultberg, B. L. (2008) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000160957 · Cited by 19
Vascular Cognitive Impairment and Dementia
Martínez‐Lage, P., & Hachinski, V. (2001) · Springer eBooks · doi:10.1007/978-3-642-59519-6_73 · Cited by 18
Sex differences in mild vascular cognitive impairment: A multimodal transcranial magnetic stimulation study
Cantone, M., Fisicaro, F., Ferri, R., Bella, R., Pennisi, G., Lanza, G., & Pennisi, M. (2023) · PLoS ONE · doi:10.1371/journal.pone.0282751 · Cited by 18
Type 2 Diabetes Mellitus and Cognitive Performance in a Population-Based Sample of the Oldest Old: Impact of Comorbid Dementia
Hassing, L. B., Johansson, B. E. A., Pedersen, N. L., Nilsson, S. E., Berg, S., & McClearn, G. E. (2003) · Aging Neuropsychology and Cognition · doi:10.1076/anec.10.2.99.14458 · Cited by 18
“evidence that diabetes is a risk factor for dementia (Hassing et al., submitted; Leibson et al., 1997; Ott et al., 1999; Yoshitake et al., 1995) dementia would be expected to be over-represented among the elderly diabetics as compared to the nondiabetics, resulting in lower cognitive performance in the group of diabet…”
BackgroundInfluential
Can Clinical Data Predict Progression to Dementia in Amnestic Mild Cognitive Impairment?
Fellows, L. K., Bergman, H., Wolfson, C. M., & Chertkow, H. M. (2008) · Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques · doi:10.1017/s0317167100008891 · Cited by 18
Effect of alcohol and tobacco use on vascular dementia: a matched case control study
Takahashi, P. Y., Caldwell, & Targonski (2011) · Vascular Health and Risk Management · doi:10.2147/vhrm.s26194 · Cited by 16
Overview and Current Status of Alzheimer’s Disease in Bangladesh
Rahman, M. R., Tajmim, A., Ali, M., & Sharif, M. (2017) · Journal of Alzheimer s Disease Reports · doi:10.3233/adr-170012 · Cited by 21
The protected survivor model: Using resistant successful cognitive aging to identify protection in the very old
Silverman, J. M., & Schmeidler, J. (2017) · Medical Hypotheses · doi:10.1016/j.mehy.2017.10.022 · Cited by 17
Establishing a Scientific Consensus on the Cognitive Benefits of Physical Activity
Nazlieva, N., Mavilidi, M. F., Baars, M., & PAAS, F. G. W. C. (2019) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17010029 · Cited by 18
“For instance, a 7-year prospective study in Japan discovered that neither work nor leisure PA was protective against Alzheimer’s disease for Japanese participants (n = 828) [30].”
Background
Gender-Specific Differences in the Central Nervous System’s Response to Anesthesia
Mawhinney, L. J., Mabourakh, D., & Lewis, M. C. (2012) · Translational Stroke Research · doi:10.1007/s12975-012-0229-y · Cited by 17
Sociodemographic Factors Associated With Incidence of Dementia Among Senior Citizens of a Small Town in Japan
Arai, A., Katsumata, Y., Konno, K., & Tamashiro, H. (2004) · Care management journals · doi:10.1891/cmaj.2004.5.3.159 · Cited by 17
“The pattern of the age-specific dementia incidence rate in Minami Furano Town was similar to that found in other studies (Yoshitake et al., 1995; Rocca, Cha, Waring, & Kokmen, 1998; Ott, Breteler, van Harskamp, Stijnen, & Hofman, 1998) (Figure 2), even though the evaluation criteria for dementia…”
Result
Hypertension and Dementia
Fujishima, M., & Tsuchihashi, T. (1999) · Clinical and Experimental Hypertension · doi:10.3109/10641969909061021 · Cited by 18
Self-citation
Vascular dementia
Desmond, D. W. (2004) · Clinical Neuroscience Research · doi:10.1016/j.cnr.2004.04.009 · Cited by 17
Effect of exercise and curcumin on cardiomyocyte molecular mediators associated with oxidative stress and autophagy in aged male rats
Aziz, S. G., Pourheydar, B., Chodari, L., & Hamidifar, F. (2022) · Microvascular Research · doi:10.1016/j.mvr.2022.104380 · Cited by 16
Association between Blood Pressure, Blood Pressure Variability, and Post-Stroke Cognitive Impairment
Lee, K., Chang, A. Y., & Sung, P. (2021) · Biomedicines · doi:10.3390/biomedicines9070773 · Cited by 17
Blood Viscosity in Subcortical Vascular Mild Cognitive Impairment with versus without Cerebral Amyloid Burden
Noh, H. J., Seo, S. W., Jeong, Y., Park, J. E., Kim, G. H., Noh, Y., Cho, H., Kim, H. J., Yoon, C. W., Ye, B. S., et al. (2014) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2013.08.004 · Cited by 16
Neuronal dysfunction with aging and its amelioration
Susumu, A. N. D. O. (2012) · Proceedings of the Japan Academy Series B · doi:10.2183/pjab.88.266 · Cited by 15
Circulating biomarkers that predict incident dementia
Weinstein, G., & Seshadri, S. S. (2014) · Alzheimer s Research & Therapy · doi:10.1186/alzrt235 · Cited by 16
“On the other hand, late-life total cholesterol is inversely related to subsequent risk of dementia [27,28] or no association has been observed [29,30].”
Background
Setting priorities in Asian stroke research
Tan, K., Wong, K. S., & Venketasubramanian, N. (2006) · Cited by 16
Relationship Between Amyloid β Protein and Melatonin Metabolite in a Study of Electric Utility Workers
Noonan, C. W., Reif, J. S., Burch, J. B., Ichinose, T. Y., Yost, M. G., & Magnusson, K. R. (2002) · Journal of Occupational and Environmental Medicine · doi:10.1097/00043764-200208000-00012 · Cited by 16
A study of statin use in the prevention of cognitive impairment of vascular origin in the UK
Suribhatla, S., Dennis, M., & Potter, J. F. (2004) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2004.11.019 · Cited by 16
Impact of Neuroprotection on Incidence of Alzheimer's Disease
de la Fuente‐Fernández, R. (2006) · PLoS ONE · doi:10.1371/journal.pone.0000052 · Cited by 18
The World-Wide Impact of Dementia. Projections of Prevalance and Costs
Katzman, R., & Fox, P. J. (1999) · Springer eBooks · doi:10.1007/978-3-642-60076-0_1 · Cited by 16
Epidemiology of major age-related diseases in women compared to men
Giampaoli, S. (2000) · Aging Clinical and Experimental Research · doi:10.1007/bf03339896 · Cited by 16
Psychosocial Factors in Relation to Development of Dementia in Late-life: a Life Course Approach within the Kungsholmen Project
Karp, A. (2005) · Figshare · Cited by 16
MRI features of Binswanger's disease predict prognosis and associated pathology
Akiguchi, I., Budka, H., Shirakashi, Y., Wöehrer, A., Watanabe, T., Shiino, A., Yamamoto, Y., Kawamoto, Y., Krampla, W. W., Jungwirth, S., et al. (2014) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.123 · Cited by 15
Sex and gender differences in dementia
Salwierz, P., Davenport, C., Sumra, V., Iulita, M. F., Ferretti, M. T., & Tartaglia, M. C. (2022) · International review of neurobiology · doi:10.1016/bs.irn.2022.07.002 · Cited by 16
A review of the potential therapeutic role of statins in the treatment of Alzheimer’s disease: current research and opinion
Benito‐León, J., Sánchez‐Ferro, Á., Mitchell, A. J., & Bermejo-Pareja (2013) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s29105 · Cited by 15
Glomerular hyperfiltration is associated with dementia: A nationwide population-based study
Kang, M. W., Park, S., Lee, S., Lee, Y., Cho, S., Han, K., Cho, H., Kim, Y., Kim, Y. C., Han, S. S., et al. (2020) · PLoS ONE · doi:10.1371/journal.pone.0228361 · Cited by 17
Prevalence and incidence of possible vascular dementia among Mexican older adults: Analysis of the Mexican Health and Aging Study
Yeverino-Castro, S. G., Mejía-Arango, S., Mimenza-Alvarado, A. J., Cantú-Brito, C. G., Ávila‐Funes, J. A., & Aguilar-Navarro, S. G. (2021) · PLoS ONE · doi:10.1371/journal.pone.0253856 · Cited by 14
Does wine prevent dementia?
Pinder, R. M. (2009) · International Journal of Wine Research · doi:10.2147/ijwr.s4691 · Cited by 15
Engagement in leisure activities and benzodiazepine use in a French community‐dwelling elderly population
Bazin, F., Noïze, P., Dartigues, J., Ritchie, K. A., Tavernier, B., Moore, N. D., Pariente, A., & Fourrier‐Réglat, A. (2011) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.2773 · Cited by 13
Possible influence of selection bias on gender differences in the risk of Alzheimer's disease
Bonsignore, M. R., Barkow, K., & Heun, R. (2002) · Archives of Women s Mental Health · doi:10.1007/s00737-002-0144-4 · Cited by 14
Caracterização clínica da demência vascular: avaliação retrospectiva de uma amostra de pacientes ambulatoriais
Smid, J., Nitríni, R., Bahia, V. S., & Caramelli, P. (2001) · Arquivos de Neuro-Psiquiatria · doi:10.1590/s0004-282x2001000300015 · Cited by 14
Are Cognitive Function and Blood Pressure Related?
Viitanen, M. H., & Guo, Z. (1997) · Drugs & Aging · doi:10.2165/00002512-199711030-00001 · Cited by 14
Hypertension and cognitive decline
Stewart, R. (1999) · The British Journal of Psychiatry · doi:10.1192/bjp.174.4.286 · Cited by 14
“While elevated blood pressure is associated with an increased risk of future vascular dementia (Yoshitake et al, 1995), studies investigating dementia within the first few months following an ischaemic stroke have suggested that, if anydung, it is low rather than high blood pressure which is a risk…”
Background
The effect of lipid metabolism on age-associated cognitive decline: Lessons learned from model organisms and human
Wu, S., Liu, X., Yang, H., Ma, W., & Qin, Z. (2023) · IBRO Neuroscience Reports · doi:10.1016/j.ibneur.2023.08.2194 · Cited by 13
“Moreover, there were studies suggested that TG is irrelevant to cognitive impairment (Liu et al., 2020; Han and Kim, 2021; Yoshitake et al., 1995; Forti et al., 2010; Muller et al., 2007).”
Background
A dose–response meta-analysis of physical activity and the risk of alzheimer’s disease in prospective studies
Jiang, Y., Jin, Z., Wang, H., He, X., Fu, R., Yu, X., Fu, Q., Tian, J., Li, W., Zhu, X., et al. (2025) · Journal of Neurology · doi:10.1007/s00415-025-12960-1 · Cited by 13
Survival in Subcortical Vascular Dementia: Predictors and Comparison to Probable Alzheimer's Disease in a Tertiary Memory Clinic Population
Kim, J., Go, S. M., Seo, S. W., Kim, S. H., Chin, J., Moon, S. Y., Lim, H., Cheong, H., Choi, S. A., Lee, J. H., et al. (2015) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000434626 · Cited by 13
Arterial hypertension, cognitive disorders and dementia: a view of a cardiologist
Ostroumova, O. D., & Cherniaeva, M. S. (2018) · S S Korsakov Journal of Neurology and Psychiatry · doi:10.17116/jnevro2018118091117 · Cited by 16
Impact of glycemic status on longitudinal cognitive performance in men with and without HIV infection
Yang, J., Jacobson, L. P., Becker, J. T., Levine, A. J., Martin, E. M., Munro, C. A., Palella, F. J., Lake, J. E., Sacktor, N. C., & Brown, T. T. (2018) · AIDS · doi:10.1097/qad.0000000000001842 · Cited by 13
“impairment[70, 71] or dementia[58, 72] and T2DM increases the incidence of vascular [73-75] and Alzheimer dementia[75-77].”
An association of human T-cell lymphotropie virus type I infection with vascular dementia
Kira, J., HAMADA, T., Kawano, Y., Okayama, M., & Yamasaki, K. (2009) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.1997.tb00288.x · Cited by 13
Alzheimer’s: A Progressive Brain Disease: Causes, Symptoms, and Prevention
Amin, F., Shamsi, A., Asghar, M. N., Khaki, P. S. S., Khan, M. S., Tabrez, S. S. M., Zaidi, S. K., Khan, W., & Bano, B. (2019) · Springer eBooks · doi:10.1007/978-981-13-9636-6_2 · Cited by 12
Biological and Clinical Implications of Sex-Specific Differences in Alzheimer’s Disease
Santiago, J. A., & Potashkin, J. A. (2023) · Handbook of experimental pharmacology · doi:10.1007/164_2023_672 · Cited by 11
The Complex Role of Having Confidant on the Development of Alzheimer's Disease in a Community-Based Cohort of Older People in Brazil
Camozzato, A. L., Godinho, C., Varela, J. S., Köhler, C. A., Rinaldi, J., & Chaves, M. L. F. (2015) · Neuroepidemiology · doi:10.1159/000371521 · Cited by 12
Diabetes mellitus in patients with Alzheimer's disease: clinical description and correlation with the APOE genotype in a sample population from the province of Antioquia, Colombia.
Botero, L. E., Toro, A. E., Patiño, A. J., Salazar, G., Rodrı́guez, J. C., Suárez-Escudero, J. C., Alarcón, G. A., Corcimaru, A., Osorio, C., Jeong, J. S. Y., et al. (2012) · PubMed · doi:10.1590/s0120-41572012000300012 · Cited by 11
Prevalence of Alzheimer's disease with diabetes in the Japanese population
KIMURA, R., Tomiyasu, H., Takeuchi, T., Shimizu, M., Hayashi, Y., Okayama, N., Kamiya, Y., & Joh, T. (2008) · Psychogeriatrics · doi:10.1111/j.1479-8301.2008.00229.x · Cited by 13
Systematic analysis and prediction of the burden of Alzheimer’s disease and other dementias caused by hyperglycemia
He, D., Liu, M., Tang, Y., Tian, X., Zhou, L., Chen, Y., & Liu, X. (2025) · Frontiers in Public Health · doi:10.3389/fpubh.2024.1516267 · Cited by 11
Time‐dependent impact of type 2 diabetes mellitus on incident prodromal Alzheimer disease: A longitudinal study in 1395 participants
Luo, T., Tu, Y., Huang, S., Ma, Y., Wang, Q., Wang, Y., Wang, J., & Initiative, A. D. N. (2023) · European Journal of Neurology · doi:10.1111/ene.15868 · Cited by 13
Dissecting Sex‐Related Cognition between Alzheimer’s Disease and Diabetes: From Molecular Mechanisms to Potential Therapeutic Strategies
Ashraf, G. M., Ebada, M. A., Suhail, M., Ali, A., Uddin, M. S., Bilgrami, A. L., Perveen, A., Husain, A., Tarique, M., Hafeez, A., et al. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/4572471 · Cited by 11
The Neglected Factor in the Relationship between Executive Functioning and Obesity: The Role of Motor Control
Marra, M. L., Messina, A., Ilardi, C. R., Verde, G., Amato, R., Esposito, N., Troise, S., Orlando, A., Messina, G., Monda, V., et al. (2022) · Healthcare · doi:10.3390/healthcare10091775 · Cited by 11
Risk factors for vascular dementia: a hospital-based study in Taiwan.
Lin, J.-C., Hsu, W., Hsu, H.-P., Fung, H., & Chen, S.-T. (2007) · PubMed · Cited by 11
Relationships between Plasma β-Amyloid Peptide 1–42 and Atherosclerotic Risk Factors in Community-Based Older Populations
Fujiwara, Y., Takahashi, M., Tanaka, M., Hoshi, T., Someya, T., & Shinkai, S. (2003) · Gerontology · doi:10.1159/000073765 · Cited by 11
Urological surgery in patients aged 80 years and older: A 30‐year retrospective clinical study
Takao, T., Tsujimura, A., Kiuchi, H., Komori, K., Fujita, K., Miyagawa, Y., Takada, S., Nonomura, N., & Okuyama, Ä. (2008) · International Journal of Urology · doi:10.1111/j.1442-2042.2008.02110.x · Cited by 11
Relationships between Cerebrovascular Events, APOE Polymorphism and Alzheimer’s Disease in a Community Sample
Johnston, J. M., Nazar‐Stewart, V., Kelsey, S. F., Kamboh, M. I., & Ganguli, M. (2000) · Neuroepidemiology · doi:10.1159/000026271 · Cited by 11
Unraveling sex differences in Alzheimer's disease and related endophenotypes with brain proteomes
Mei, Z., Liu, J., Bennett, D. A., Seyfried, N., Wingo, A. P., & Wingo, T. S. (2025) · Alzheimer's & Dementia · doi:10.1002/alz.70206 · Cited by 11
The Neuropathologic Substrates of Vascular-Ischemic Dementia
Jellinger, K. A. (2005) · Humana Press eBooks · doi:10.1385/1-59259-824-2:023 · Cited by 10
Effects of Physical Activity on Cognitive Functioning in Middle Age: Evidence From the Whitehall II Prospective Cohort Study
Shephard, R. J. (2006) · Yearbook of Sports Medicine · doi:10.1016/s0162-0908(08)70441-0 · Cited by 10
New type of encephalomyelitis responsive to trimethoprim/sulfamethoxazole treatment in Japan
Sakiyama, Y., Kanda, N., Higuchi, Y., Yoshimura, M., Wakaguri, H., Takata, Y., Watanabe, O., Yuan, J., Tashiro, Y., Saigo, R., et al. (2015) · Neurology Neuroimmunology & Neuroinflammation · doi:10.1212/nxi.0000000000000143 · Cited by 11
The role of physical activity on the prevention of cognitive impairment
Corbi, G., Conti, V., Filippelli, A., Costanzo, A. D., & Ferrara, N. (2015) · Europe PMC (PubMed Central) · doi:10.14273/unisa-2002 · Cited by 10
Cerebral blood flow and metabolism in silent brain infarction and related cerebrovascular disorders
Yao, H., & Fujishima, M. (2001) · Annals of Medicine · doi:10.3109/07853890109002064 · Cited by 10
Self-citation
Low Blood Pressure and Risk of Dementia in the Kungsholmen Project
Qiu, C., Strauss, E. I. V., Fastbom, J., Winblad, B. G., & Fratiglioni, L. (2003) · Archives of Neurology · doi:10.1001/archneur.60.2.223 · Cited by 9
Vaskuläre Demenz und Hypertonie
Lüders, S., & Schrader, J. (2015) · DMW - Deutsche Medizinische Wochenschrift · doi:10.1055/s-0041-105598 · Cited by 9
Analysis of risk factors for mild cognitive impairment based on word list memory test results and questionnaire responses in healthy Japanese individuals registered in an online database
Ogawa, M., Sone, D., Maruo, K., Shimada, H., Suzuki, K., Watanabe, H., Matsuda, H., & Mizusawa, H. (2018) · PLoS ONE · doi:10.1371/journal.pone.0197466 · Cited by 9
Competing risk analysis of the association between dementia and major depressive disorder: a nationwide population-based study in Taiwan
Huang, C., Weng, S., Wang, J., & Hsieh, H. (2020) · Aging & Mental Health · doi:10.1080/13607863.2020.1720598 · Cited by 9
“Studies have reported a strong association between midlife hypertension and incident vascular dementia (Ninomiya et al., 2011; Prince et al., 2014; Ross et al., 1999; Sharp, Aarsland, Day, Sønnesyn, & Ballard, 2011; Ueda, Kawano, Hasuo, & Fujishima, 1992; Yoshitake et al., 1995).”
Background
Assessment of a Cognitive-Motor Training Program in Adults at Risk for Developing Dementia
Echlin, H. V., Gorbet, D. J., & Sergio, L. E. (2020) · Canadian Geriatrics Journal · doi:10.5770/cgj.23.394 · Cited by 10
Characteristics of aged ischemic stroke patients indicative of cardioembolism
Matsuzono, K., Mashiko, T., Ozawa, T., et al. (2020) · Journal of Thrombosis and Thrombolysis · doi:10.1007/s11239-020-02198-1 · Cited by 9
Growth Factors, AGEing, and the Diabetes Link in Alzheimer's Disease
Loy, C. T., & Twigg, S. M. (2009) · Journal of Alzheimer s Disease · doi:10.3233/jad-2009-0997 · Cited by 10
Homocysteine, Cystatin C and N-Terminal-Pro Brain Natriuretic Peptide
Nilsson, K. H., Gustafson, L., & Hultberg, B. L. (2007) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000111994 · Cited by 9
Comprehensive studies of cognitive impairment of the elderly with type 2 diabetes
Sakurai, T., & Yokono, K. (2006) · Geriatrics and gerontology international/Geriatrics & gerontology international · doi:10.1111/j.1447-0594.2006.00343.x · Cited by 9
Vascular Dementia: A Diagnostic Challenge
Gold, G. (2003) · International Psychogeriatrics · doi:10.1017/s1041610203009050 · Cited by 9
Motor intentional disorders in vascular mild cognitive impairment and vascular dementia of subcortical type
Yoon, D. S., Jung, K., Kim, G. H., et al. (2012) · Neurocase · doi:10.1080/13554794.2012.732085 · Cited by 8
Systematic review and meta-analysis of randomized controlled trials on the effects of exercise interventions on amyloid beta levels in humans
Pucci, I. M., Aguiar, A. F., Pucci, R. M., Casonatto, J., & Borghi, S. M. (2024) · Experimental Brain Research · doi:10.1007/s00221-024-06821-y · Cited by 12
“Over the past 28 years, studies have proposed exercise as a protective approach to preventing AD (Yoshitake et al. 1995; Ravaglia et al. 2008; Elwood et al. 2013; Iso-Markku et al. 2022).”
Development of a simplified Short-Term Memory recall Test (STMT) and its clinical evaluation
Kobayashi, N., Nakano, K., Tago, H., & Niwa, S. (2010) · Aging Clinical and Experimental Research · doi:10.1007/bf03324790 · Cited by 8
Gender difference in Psychogeriatric disorders
Takeda, M., Tanaka, T., & Kudo, T. (2011) · Geriatrics and gerontology international/Geriatrics & gerontology international · doi:10.1111/j.1447-0594.2011.00736.x · Cited by 8
Cytopathological alterations and therapeutic approaches in Binswanger's disease
Akiguchi, I., Tomimoto, H., Wakita, H., Yamamoto, Y., Suenaga, T., Ueno, M., & Budka, H. (1999) · Neuropathology · doi:10.1046/j.1440-1789.1999.00208.x · Cited by 8
Vascular Risk Factors for Alzheimer’s Disease
Breteler, M. M. B. (2000) · Springer eBooks · doi:10.1007/978-94-017-1007-7_3 · Cited by 8
Clinicoradiological Features and Long-term Cognitive and Functional Outcome in Patients with Deep Cerebral Venous Thrombosis
Patwardhan, A., Gupta, M., Philip, M., Rangarajan, A., Joshi, T., Alladi, S., Kulkarni, G. B., & Ramakrishnan, S. (2024) · Annals of Indian Academy of Neurology · doi:10.4103/aian.aian_792_23 · Cited by 7
Evolution of Dementia Related to the Use of Alcohol in the French Nationwide Discharge Summary Database Between 2007 and 2017
Rochoy, M., Gautier, S., Béné, J., Bordet, R., & Chazard, E. (2018) · American Journal of Alzheimer s Disease & Other Dementias® · doi:10.1177/1533317518822043 · Cited by 8
Physical activity and incident dementia in older Japanese adults: The Okayama study
Liu, Y., Mitsuhashi, T., Yamakawa, M., Sasai, M., Tsuda, T., Doi, H., & Hamada, J. (2019) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.5135 · Cited by 7
Voxel‐based specific regional analysis system for Alzheimer’s disease utility as a screening tool for unrecognized cognitive dysfunction of elderly patients in diabetes outpatient clinics: Multicenter retrospective exploratory study
Ueba, Y., Murakami, T., Yamamoto, T., Kuroe, A., Yamasaki, M., Kaneda, D., Otani, D., Kiyobayashi, S., Ikeda, K., Yabe, D., et al. (2021) · Journal of Diabetes Investigation · doi:10.1111/jdi.13622 · Cited by 6
Control of vascular risk factors
Gustafson, D., & Skoog, I. G. (2009) · Cambridge University Press eBooks · doi:10.1017/cbo9780511575976.019 · Cited by 7
Diabetes and the Nervous System
Vinik, A. I., CASELLINI, C. M., & Neumann, S. A. (2020) · Endocrinology · doi:10.1007/978-3-030-36694-0_10 · Cited by 9
Hypertension and dementia
Rigaud, A., Hanon, O., Seux, M., & Forette, F. (2001) · Current Hypertension Reports · doi:10.1007/s11906-001-0005-y · Cited by 7
DIABETES MELLITUS AND THE RISK OF DEMENTIA A Population-based Study
Xu, W. (2008) · Cited by 7
Cognitive Performance Among Older Persons in Japan and the United States
Saito, Y., Kim, J. K., Davarian, S., Hagedorn, A., & Crimmins, E. M. (2019) · Journal of the American Geriatrics Society · doi:10.1111/jgs.16163 · Cited by 6
Patients with the Subcortical Small Vessel Type of Dementia Have Disturbed Cardiometabolic Risk Profile
Axelsson, E., Wallin, A., & Svensson, J. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-191077 · Cited by 6
Pathobiology of Diabetic Encephalopathy in Animal Models
Sima, A. A. F. (2009) · Humana Press eBooks · doi:10.1007/978-1-60327-850-8_17 · Cited by 6
Hypertension and Dementia in the Elderly: The Leisure World Cohort Study
Paganini‐Hill, A. (2011) · International Journal of Hypertension · doi:10.1155/2012/205350 · Cited by 6
“Some found blood pressure levels were higher in individuals who developed dementia [12], Alzheimer’s disease [13], or vascular dementia [14] than in those who did not.”
Background

Authors: Yoshitake, T., Kiyohara, Y., Kato, I., Ohmura, T., Iwamoto, H., Nakayama, K., Ohmori, S., Nomiyama, K., Kawano, H., Ueda, K., Sueishi, K., Tsuneyoshi, M., & Fujishima, M.
Affiliations: Kyushu University (JP)
ORCID: Nakayama, K.
Kawano, H.
Ueda, K.
Venue: Neurology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 1995-06
Volume: 45
Issue: 6
Pages: 1161-1168
ISSN: 0028-3878 (ISSN-L)
1526-632X
DOI: 10.1212/wnl.45.6.1161
OpenAlex: W2147954981
Cited by: 829
References: 0
Citations by year: 2026: 10 · 2025: 16 · 2024: 14 · 2023: 11 · 2022: 22 · 2021: 18 · 2020: 24 · 2019: 20 · 2018: 16 · 2017: 31 · 2016: 27 · 2015: 29 · 2014: 27 · 2013: 28 · 2012: 35
FWCI: 13.01
Type: journal article
Language: en
Open access: closed
Locations: Neurology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Neurological Disorders and Stroke
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Keywords: vascular dementia, Alzheimer's disease, dementia incidence, risk factors, asymptomatic stroke, lacunar infarction, systolic blood pressure, alcohol consumption, physical activity, Hasegawa Dementia Scale
MeSH terms: Aged, Aged, 80 and over, Alzheimer Disease, Cerebrovascular Disorders, Female, Humans, Japan, Male, Risk Factors, Dementia, Vascular

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Incidence and risk factors of vascular dementia and Alzheimer's disease in a defined elderly Japanese population: The Hisayama Study

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cited by

Related

Metadata

Record

About these checks