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Cited by 218Epilepsy research and treatmentPharmacological Effects and Toxicity StudiesDiet and metabolism studies

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Progesterone therapy in women with complex partial and secondary generalized seizures

Herzog, Andrew G.·1995·Neurology
DOI 10.1212/wnl.45.9.1660
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Abstract

This open trial assessed the effects of adjunctive progesterone therapy on seizure frequency in 25 women with catamenial exacerbation of complex partial (CPS) and secondary generalized motor (SGMS) seizures. Progesterone was well tolerated by 23 of the 25 women and had readily reversible dose-related side effects of asthenia and emotional depression in two. Eighteen women (72%) experienced a decline in seizure frequency during a 3-month treatment period compared with the 3 months prior to therapy (p < 0.01). Average daily CPS frequency declined by 54% (p < 0.01), SGMS by 58% (p < 0.02).

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Research works printed but not linked: 16

  1. Smith SS. Estradiol administration increases neuronal responses to excitatory amino acid as a long-term effect. Brain Res 1989;503:354-357.
  2. 10.1212/WNL.37.1.1 · DOI
  3. Herzog AG. Reproductive endocrine considerations and hormonal therapy for women with epilepsy. Epilepsia 1991;32 (suppl 6):S27-S33. · DOI
  4. Laidlaw J. Catamenial epilepsy. Lancet 1956;271:1235-1237.
  5. Backstrom T. Epileptic seizures in women related to plasma estrogen and progesterone during the menstrual cycle. Acta Neurol Scand 1976;54:321-347.
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  8. Jones GS. The luteal phase defect. Fertil Steril 1976;27:351-356.
  9. 10.1212/WNL.36.1.1 · DOI
  10. 10.1111/j.1528-1157.1988.tb05807.x · DOI
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  12. Roscizewska D, Buntner B, Guz I, Zawisza L. Ovarian hormones, anticonvulsant drugs and seizures during the menstrual cycle in women with epilepsy. J Neurol Neurosurg Psychiatry 1986;49:47-51.
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  14. 10.1212/WNL.34.1.1 · DOI
  15. Dana Haeri J, Richens A. Effect of norethisterone on seizures associated with menstruation. Epilepsia 1983;24:377-381.
  16. Hall SM. Treatment of menstrual epilepsy with a progesterone-only oral contraceptive. Epilepsia 1977;18:235-236.

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Metadata

Authors
Herzog, A. G.
Affiliations
Beth Israel Deaconess Medical Center (US)
Corresponding author
Herzog, Andrew G.
ORCID
Herzog, Andrew G.
Venue
Neurology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
1995-09
Volume
45
Issue
9
Pages
1660-1662
ISSN
  • 0028-3878 (ISSN-L)
  • 1526-632X
DOI
10.1212/wnl.45.9.1660
OpenAlex
W2011191676
Cited by
218
References
0
Citations by year
2025: 3 · 2024: 2 · 2023: 4 · 2022: 2 · 2021: 4 · 2020: 7 · 2019: 1 · 2018: 4 · 2017: 3 · 2016: 3 · 2015: 3 · 2014: 6 · 2013: 15 · 2012: 9
FWCI
4.65
Type
journal article
Language
en
Open access
closed
Locations
  • Neurology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Clinical Neurology › Epilepsy research and treatment
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmacological Effects and Toxicity Studies
  • Health Sciences › Medicine › Physiology (medical) › Diet and metabolism studies
Keywords
progesterone therapy, adjunctive therapy, complex partial seizures, seizure frequency, women, menstrual cycle, adverse drug reactions
MeSH terms
Adolescent, Adult, Epilepsy, Generalized, Female, Humans, Progesterone, Epilepsy, Complex Partial

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