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Dose-response relationship of levodopa with mood and anxiety in fluctuating Parkinson's disease: A double-blind, placebo-controlled study
Abstract
We investigated the effect of levodopa on mood and anxiety in eight Parkinson's disease patients with motor fluctuations. Each patient received 0.0-, 0.5-, and 1.0-mg/kg/hr levodopa infusions in randomly assigned order under double-blind conditions on consecutive days. Mood elevation and anxiety reduction based on half-hourly patient rating and a corresponding increase in tapping speed occurred with active drug infusion but not placebo infusion. The effects were dose related. The higher-dose infusion rate produced more rapid onset, greater magnitude, and longer duration of response. We conclude that mood and anxiety fluctuations related to levodopa dosing are robust pharmacologic, and not placebo, effects.
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“The anxiety symptoms experienced by patients with PD are often responsive to dopaminergic medication [15].”
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Metadata
- Authors
- Maricle, R. A., Nutt, J. G., Valentine, R. J., & Carter, J. H.
- Affiliations
- Oregon Health & Science University (US)
- ORCID
- Nutt, John G.
- Venue
- Neurology
- Published
- 1995-09
- Volume
- 45
- Issue
- 9
- Pages
- 1757-1760
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2107507666
- Cited by
- 197
- References
- 5
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 2 · 2023: 3 · 2022: 3 · 2021: 3 · 2020: 4 · 2019: 3 · 2018: 5 · 2017: 16 · 2016: 10 · 2015: 11 · 2014: 7 · 2013: 11 · 2012: 6
- FWCI
- 0.61
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (R01NS021062)
- National Center for Research Resources (RR-00334, M01RR000334)
- NIH Clinical Center
- Topics
- Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Clinical Neurology › Deep Brain Stimulation and Movement Disorders
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- levodopa, Parkinson's disease, motor fluctuations, mood improvement, anxiety, levodopa infusion, placebo effect, tapping speed
- MeSH terms
- Affect, Aged, Anxiety, Dose-Response Relationship, Drug, Double-Blind Method, Female, Humans, Levodopa, Male, Middle Aged, Parkinson Disease
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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