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Cited by 197Parkinson's Disease Mechanisms and TreatmentsDeep Brain Stimulation and Movement DisordersNeurotransmitter Receptor Influence on Behavior

The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.

Dose-response relationship of levodopa with mood and anxiety in fluctuating Parkinson's disease: A double-blind, placebo-controlled study

Maricle, Robert A., Nutt, John G., Valentine, Rita J., Carter, Julie H.·1995·Neurology
DOI 10.1212/wnl.45.9.1757
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Abstract

We investigated the effect of levodopa on mood and anxiety in eight Parkinson's disease patients with motor fluctuations. Each patient received 0.0-, 0.5-, and 1.0-mg/kg/hr levodopa infusions in randomly assigned order under double-blind conditions on consecutive days. Mood elevation and anxiety reduction based on half-hourly patient rating and a corresponding increase in tapping speed occurred with active drug infusion but not placebo infusion. The effects were dose related. The higher-dose infusion rate produced more rapid onset, greater magnitude, and longer duration of response. We conclude that mood and anxiety fluctuations related to levodopa dosing are robust pharmacologic, and not placebo, effects.

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Crossref · 10.1212/wnl.45.9.1757

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Citations

Cites

Research works printed but not linked: 7

  1. Cummings JL. Depression and Parkinson's disease: a review. Am J Psychiatry 1992;149:443-454.
  2. Hantz P, Caradoc-Davies G, Caradoc-Davies T, Weatherall M, Dixon G. Depression in Parkinson's disease. Am J Psychiatry 1994;151:1010-1014.
  3. Henderson R, Kurlan R, Kersum JM, Como P. Preliminary examination of the comorbidity of anxiety and depression in Parkinson's disease. J Neuropsychiatry Clin Neurosci 1992;4:257-264.
  4. Menza MA, Sage J, Marshall E, Cody R, Duvoisin R. Mood changes and ``On-off'' phenomena in Parkinson's disease. Mov Disord 1990;5:148-151.
  5. Nissenbaum H, Quinn NP, Brown RG, Toone B, Gotham AM, Marsden CD. Mood swings associated with the ``on-off'' phenomenon in Parkinson's disease. Psychol Med 1987;17:899-904.
  6. Maricle RA, Nutt JG, Carter JH. Mood and anxiety fluctuation in Parkinson's disease associated with levodopa infusion. Mov Disord 1995;10:329-332.
  7. Nutt JG, Woodward WR, Carter JH, Gancher ST. Effects of long-term therapy on the pharmacodynamics of levodopa: relation to on-off phenomenon. Arch Neurol 1992;49:1123-1130.

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Metadata

Authors
Maricle, R. A., Nutt, J. G., Valentine, R. J., & Carter, J. H.
Affiliations
Oregon Health & Science University (US)
ORCID
Nutt, John G.
Venue
Neurology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
1995-09
Volume
45
Issue
9
Pages
1757-1760
ISSN
  • 0028-3878 (ISSN-L)
  • 1526-632X
DOI
10.1212/wnl.45.9.1757
OpenAlex
W2107507666
Cited by
197
References
5
Citations by year
2026: 2 · 2025: 1 · 2024: 2 · 2023: 3 · 2022: 3 · 2021: 3 · 2020: 4 · 2019: 3 · 2018: 5 · 2017: 16 · 2016: 10 · 2015: 11 · 2014: 7 · 2013: 11 · 2012: 6
FWCI
0.61
Type
journal article
Language
en
Open access
closed
Locations
  • Neurology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institute of Neurological Disorders and Stroke (R01NS021062)
  • National Center for Research Resources (RR-00334, M01RR000334)
  • NIH Clinical Center
Topics
  • Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
  • Health Sciences › Medicine › Clinical Neurology › Deep Brain Stimulation and Movement Disorders
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
levodopa, Parkinson's disease, motor fluctuations, mood improvement, anxiety, levodopa infusion, placebo effect, tapping speed
MeSH terms
Affect, Aged, Anxiety, Dose-Response Relationship, Drug, Double-Blind Method, Female, Humans, Levodopa, Male, Middle Aged, Parkinson Disease

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