ApoE epsilon 4 allele and cognitive decline in patients with Alzheimer's disease
Abstract
Many clinical and basic studies have confirmed an association between the apolipoprotein E (apoE) epsilon 4 allele and the development of Alzheimer's disease (AD). Corder et al. [1] reported that survival from onset was unrelated to epsilon 4 gene dose. In this issue, Kurz et al. [2] report that no association of the apoE epsilon 4 allele with cognitive decline was found in AD subjects. We examined the relationship between apoE alleles and the rate of cognitive decline in a longitudinal study of up to 3 years. Between February and October 1992, 105 subjects with probable AD diagnosed on the basis of NINCDS-ADRDA [3] criteria entered the study. All the subjects underwent a …
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There have been numerous conflicting reports regarding whether different apoE alleles influence the rate of cognitive decline following dementia onset.
“While the effect of the ε4 allele on the risk and age of onset for AD is generally consistent in most studies, there have been numerous conflicting reports regarding whether different apoE alleles influence the rate of cognitive decline following dementia onset (Asada et al., 1996; Craft et al., 1998; Frisoni et al., 1995; Growdon et al., 1996; Hoyt et al., 2005; Kurz et al., 1996).”
From The role of apolipoprotein E in Alzheimer's disease (2009) · cites this paper as Asada et al., 1996
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The role of apolipoprotein E in Alzheimer's disease
Kim, J., Basak, J. M., & Holtzman, D. M. (2009) · Neuron · doi:10.1016/j.neuron.2009.06.026 · Cited by 1,661 · see citing works
APOE ε4 allele predicts faster cognitive decline in mild Alzheimer disease
Cosentino, S., Scarmeas, N., Helzner, E., Glymour, M. M., Brandt, J., Albert, M., Blacker, D., & Stern, Y. (2008) · Neurology · doi:10.1212/01.wnl.0000304038.37421.cc · Cited by 214 · see citing works
ApoE deficiency leads to a progressive age-dependent blood-brain barrier leakage
Hafezi-Moghadam, A., Thomas, K. L., & Wagner, D. D. (2007) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00563.2005 · Cited by 149 · see citing works
- Authors
- Asada, T., Kariya, T., Yamagata, Z., Kinoshita, T., & Asaka, A.
- Affiliations
- National Center of Neurology and Psychiatry (JP)
- Venue
- Neurology
- Published
- 1996-08
- Volume
- 47
- Issue
- 2
- Pages
- 603-603
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2033518963
- Cited by
- 27
- References
- 0
- Citations by year
- 2021: 1 · 2020: 1 · 2019: 1 · 2014: 1 · 2013: 1 · 2012: 2
- FWCI
- 1.23
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Keywords
- APOE ε4, Alzheimer's disease, cognitive decline, gene dosage, genetic association, longitudinal study, NINCDS-ADRDA criteria
- MeSH terms
- Aged, Aged, 80 and over, Alleles, Alzheimer Disease, Apolipoproteins E, Humans, Middle Aged
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