ApoE deficiency leads to a progressive age-dependent blood-brain barrier leakage

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease.

Strittmatter, W. J., Saunders, A. M., Schmechel, D., Pericak-Vance, M., Enghild, J., Salvesen, G. S., & Roses, A. D. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.5.1977 · Cited by 4,268 · see citing works

FINE STRUCTURAL LOCALIZATION OF A BLOOD-BRAIN BARRIER TO EXOGENOUS PEROXIDASE

Reese, T. S., & Karnovsky, M. J. (1967) · The Journal of Cell Biology · doi:10.1083/jcb.34.1.207 · Cited by 2,629 · see citing works

Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells

Plump, A. S., Smith, J. D., Hayek, T., Aalto-Setälä, K., Walsh, A., Verstuyft, J. G., Rubin, E. M., & Breslow, J. L. (1992) · Cell · doi:10.1016/0092-8674(92)90362-g · Cited by 2,263 · see citing works

Spontaneous Hypercholesterolemia and Arterial Lesions in Mice Lacking Apolipoprotein E

Zhang, S. H., Reddick, R. L., Piedrahita, J. A., & Maeda, N. (1992) · Science · doi:10.1126/science.1411543 · Cited by 2,237 · see citing works

Astrocytes induce blood–brain barrier properties in endothelial cells

Janzer, R. C., & RAFF, M. C. (1987) · Nature · doi:10.1038/325253a0 · Cited by 1,613 · see citing works

A central role for inflammation in the pathogenesis of diabetic retinopathy

Joussen, A. M., Poulaki, V., Le, M. L., Koizumi, K., Esser, C., Janicki, H., Schraermeyer, U., Kociok, N., Fauser, S., Kirchhof, B., et al. (2004) · The FASEB Journal · doi:10.1096/fj.03-1476fje · Cited by 1,178 · see citing works

CEREBRAL BLOOD FLOW, BLOOD VOLUME AND OXYGEN UTILIZATION

Leenders, K. L., Perani, D., Lammertsma, A. A., Heather, J. D., Buckingham, P. D., Jones, T., Healy, M. J. R., GIBBS, J. M., WISE, R. J. S., Hatazawa, J., et al. (1990) · Brain · doi:10.1093/brain/113.1.27 · Cited by 1,094 · see citing works

Generation of mice carrying a mutant apolipoprotein E gene inactivated by gene targeting in embryonic stem cells.

Piedrahita, J. A., Zhang, S. H., Hagaman, J. R., Oliver, P. M., & Maeda, N. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.10.4471 · Cited by 944 · see citing works

Apolipoprotein E associated with astrocytic glia of the central nervous system and with nonmyelinating glia of the peripheral nervous system.

Boyles, J. K., Pitas, R. E., Wilson, E., Mahley, R. W., & Taylor, J. M. (1985) · Journal of Clinical Investigation · doi:10.1172/jci112130 · Cited by 829 · see citing works

Vascular risk factors for Alzheimer’s disease:

Breteler, M. M. B. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(99)00110-4 · Cited by 664 · see citing works

Apolipoprotein E mRNA is abundant in the brain and adrenals, as well as in the liver, and is present in other peripheral tissues of rats and marmosets.

Elshourbagy, N. A., Liao, W. S. ‐., Mahley, R. W., & Taylor, J. M. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.1.203 · Cited by 509 · see citing works

Platelet P-selectin facilitates atherosclerotic lesion development

Burger, P. C., & Wagner, D. D. (2003) · Blood · doi:10.1182/blood-2002-07-2209 · Cited by 409 · see citing works

M Protein, a Classical Bacterial Virulence Determinant, Forms Complexes with Fibrinogen that Induce Vascular Leakage

Herwald, H., Cramer, H., Mörgelin, M., Russell, W., Sollenberg, U. E., Norrby‐Teglund, A., Flodgaard, H. J., Lindbom, L., & Björck, L. (2004) · Cell · doi:10.1016/s0092-8674(04)00057-1 · Cited by 376 · see citing works

Heparin-binding protein (HBP/CAP37): A missing link in neutrophil-evoked alteration of vascular permeability

Gautam, N., Olofsson, A. M., Herwald, H., Iversen, L., Evy Lundgren-akerlund, B., Hedqvist, P., Arfors, K. ‐., Flodgaard, H. J., & Lindbom, L. (2001) · Nature Medicine · doi:10.1038/nm1001-1123 · Cited by 364 · see citing works

Effect of aging on the blood-brain barrier

Mooradian, A. D. (1988) · Neurobiology of Aging · doi:10.1016/s0197-4580(88)80013-7 · Cited by 296 · see citing works

Apolipoprotein E allele-dependent pathogenesis: a model for age-related retinal degeneration

Malek, G., Johnson, L. V., Mace, B. E., Saloupis, P., Schmechel, D. E., Rickman, D. W., Toth, C. A., Sullivan, P. M., & Rickman, C. B. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0503015102 · Cited by 284 · see citing works

Sensitive blood-retinal barrier breakdown quantitation using Evans blue.

Xu, Q., Qaum, T., & Adamis, A. P. (2001) · PubMed · Cited by 273 · see citing works

Regional Cerebral Oxygen Consumption, Blood Flow, and Blood Volume in Healthy Human Aging

Marchal, G., Rioux, P. P., Petit-Taboué, M.-C., Sette, G., Travère, J.-M., Poec, C. L., Courtheoux, P., Derlon, J.-M., & Baron, J. (1992) · Archives of Neurology · doi:10.1001/archneur.1992.00530340029014 · Cited by 271 · see citing works

Regional Cerebral Blood Volume and Hematocrit Measured in Normal Human Volunteers by Single-Photon Emission Computed Tomography

Sakai, F., 中沢, 圭., Tazaki, Y., Ishii, K., Hino, H., Igarashi, H., & Kanda, T. (1985) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1985.27 · Cited by 241 · see citing works

A gender difference in the association between APOE genotype and age-related cognitive decline

Mortensen, E. L., & Høgh, P. (2001) · Neurology · doi:10.1212/wnl.57.1.89 · Cited by 171 · see citing works

Tumors of the choroid plexus

Rickert, C. H., & Paulus, W. (2000) · Microscopy Research and Technique · doi:10.1002/1097-0029(20010101)52:1 · Cited by 160 · see citing works

Renin-dependent Cardiovascular Functions and Renin-independent Blood-Brain Barrier Functions Revealed by Renin-deficient Mice

Yanai, K., Saito, T., Kakinuma, Y., Kon, Y., Hirota, K., Taniguchi-Yanai, K., Nishijo, N., Shigematsu, Y., Horiguchi, H., Kasuya, Y., et al. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.1.5 · Cited by 152 · see citing works

ApoE Deficiency Compromises the Blood Brain Barrier Especially After Injury

Methia, N., André, P., Hafezi-Moghadam, A., Economopoulos, M., Thomas, K. L., & Wagner, D. D. (2001) · Molecular Medicine · doi:10.1007/bf03401973 · Cited by 150 · see citing works

A quantitative analysis of blood-brain barrier ultrastructure in the aging human.

Stewart, P. A., Magliocco, M., Hayakawa, K., Farrell, C. L., Del Maestro, R. F., Girvin, J., Kaufmann, J. C. E., Vinters, H. V., & Gilbert, J. (1987) · Microvascular Research · doi:10.1016/0026-2862(87)90022-7 · Cited by 148 · see citing works

Regional Brain Blood Flow, Blood Volume, and Haematocrit Values in the Adult Rat

Cremer, J. E., & Seville, M. P. (1983) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1983.35 · Cited by 145 · see citing works

Impaired blood–brain barrier function in angiotensinogen-deficient mice

Kakinuma, Y., Hama, H., Sugiyama, F., Yagami, K., Goto, K., Murakami, K., & Fukamizu, A. (1998) · Nature Medicine · doi:10.1038/2070 · Cited by 142 · see citing works

Impairment of the Blood–Nerve and Blood–Brain Barriers in Apolipoprotein E Knockout Mice

Fullerton, S. M., Shirman, G. A., Strittmatter, W. J., & Matthew, W. D. (2001) · Experimental Neurology · doi:10.1006/exnr.2001.7631 · Cited by 117 · see citing works

Passage of human amyloid β-protein 1–40 across the murine blood-brain barrier

Maness, L. M., Banks, W. A., Podlisny, M. B., Selkoe, D. J., & Kastin, A. J. (1994) · Life Sciences · doi:10.1016/0024-3205(94)00331-9 · Cited by 113 · see citing works

Hemodynamic changes during aging associated with cerebral blood flow and impaired cognitive function

Ajmani, R. S., Metter, E. J., Rajadas, J., Ingram, D. K., Spangler, E. L., Abugo, O. O., & Rifkind, J. M. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00118-4 · Cited by 104 · see citing works

Signaling via β2 Integrins Triggers Neutrophil-Dependent Alteration in Endothelial Barrier Function

Gautam, N., Herwald, H., Hedqvist, P., & Lindbom, L. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.191.11.1829 · Cited by 98 · see citing works

Apolipoprotein E, a Gene with Complex Biological Interactions in the Aging Brain

Roses, A. D. (1997) · Neurobiology of Disease · doi:10.1006/nbdi.1997.0161 · Cited by 86 · see citing works

Permeability of the Blood-Brain Barrier to Albumin and Insulin in the Young and Aged SAMP8 Mouse

Banks, W. A., Farr, S. A., & Morley, J. E. (2000) · The Journals of Gerontology Series A · doi:10.1093/gerona/55.12.b601 · Cited by 85 · see citing works

A damaged microcirculation contributes to neuronal cell death in Alzheimer’s disease☆

Grammas, P. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00102-0 · Cited by 81 · see citing works

Blood-Brain Barrier Permeability in Senescent Rats

Рапопорт, С. И., Ohno, K., & Pettigrew, K. D. (1979) · Journal of Gerontology · doi:10.1093/geronj/34.2.162 · Cited by 81 · see citing works

Apolipoprotein E Protects against Neuropathology Induced by a High-Fat Diet and Maintains the Integrity of the Blood-Brain Barrier during Aging

Mulder, M., Blokland, A., van den Berg, D.-J., Schulten, H., Bakker, A. H. F., Terwel, D., Honig, W., de Kloet, E. R., Havekes, L. M., Steinbusch, H. W. M., et al. (2001) · Laboratory Investigation · doi:10.1038/labinvest.3780307 · Cited by 74 · see citing works

The cerebromicrovasculature: A key player in the pathogenesis of Alzheimer's disease

Grammas, P., Yamada, M., & Zloković, B. V. (2002) · Journal of Alzheimer s Disease · doi:10.3233/jad-2002-4311 · Cited by 73 · see citing works

Vascular disorder in Alzheimer’s disease: role in pathogenesis of dementia and therapeutic targets

Zloković, B. V. (2002) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(02)00150-3 · Cited by 62 · see citing works

Age dependency of the regional cerebral blood volume (rCBV) measured with dynamic susceptibility contrast MR imaging (DSC)

Wenz, F., Rempp, K., Brix, G., Knopp, M. V., Gückel, F., Heß, T., & van Kaick, G. (1996) · Magnetic Resonance Imaging · doi:10.1016/0730-725x(95)02058-2 · Cited by 57 · see citing works

Intracellular modifications of human apolipoprotein E.

Zannis, V. I., vanderSpek, J. C., & Silverman, D. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)67033-4 · Cited by 57 · see citing works

Age-related changes in rat cerebral occludin and zonula occludens-1 (ZO-1)

Mooradian, A. D. (2003) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(02)00041-6 · Cited by 57 · see citing works

Mechanism of age related macular degeneration

Husain, D., Ambati, B. K., ADAMIS, A., & Miller, J. W. (2002) · Ophthalmology Clinics of North America · doi:10.1016/s0896-1549(01)00009-8 · Cited by 55 · see citing works

A QUANTITATIVE STUDY OF AGE‐RELATED CHANGES IN THE VASCULAR ARCHITECTURE OF THE RAT CEREBRAL CORTEX

Wilkinson, J., Hopewell, J. W., & Reinhold, H. S. (1981) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.1981.tb00245.x · Cited by 43 · see citing works

Mice lacking insulin or insulin-like growth factor 1 receptors in vascular endothelial cells maintain normal blood–brain barrier

Kondo, T., Hafezi‐Moghadam, A., Thomas, K. L., Wagner, D. D., & Kahn, C. R. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.03.043 · Cited by 40 · see citing works

Regional cerebral blood volume reduction in transgenic mutant APP (V717F, K670N/M671L) mice

Wu, E. X., Tang, H., Asai, T., & Yan, S. D. (2004) · Neuroscience Letters · doi:10.1016/j.neulet.2004.05.004 · Cited by 38 · see citing works

ApoE epsilon 4 allele and cognitive decline in patients with Alzheimer's disease

Asada, T., Kariya, T., Yamagata, Z., Kinoshita, T., & Asaka, A. (1996) · Neurology · doi:10.1212/wnl.47.2.603 · Cited by 27 · see citing works

Blood-nerve and blood-brain barrier permeabilities and nerve vascular space in Fischer-344 rats of different ages

Wadhwani, K. C., Koıstınaho, J., Balbo, A., & Rapoport, S. I. (1991) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(91)90091-d · Cited by 22 · see citing works

Asymmetrical changes in blood–brain barrier permeability during pentylenetetrazol-induced seizures and in acute hypertension

Öztaş, B. (1998) · Psychiatry Research Neuroimaging · doi:10.1016/s0925-4927(98)00014-6 · Cited by 13 · see citing works

Development, maintenance and disruption of the blood-brain barrier

Obermeier, B., Daneman, R., & Ransohoff, R. M. (2013) · Nature Medicine · doi:10.1038/nm.3407 · Cited by 2,452 · see citing works

Blood-Brain Barrier: From Physiology to Disease and Back

Sweeney, M. D., Zhao, Z., Montagne, A., Nelson, A. R., & Zlokovic, B. V. (2019) · Physiological Reviews · doi:10.1152/physrev.00050.2017 · Cited by 2,294 · see citing works

Nanoparticle-mediated brain drug delivery: Overcoming blood–brain barrier to treat neurodegenerative diseases

Saraiva, C., Praça, C., Ferreira, R., Santos, T., Ferreira, L., & Bernardino, L. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.05.044 · Cited by 1,609 · see citing works

Apolipoprotein E controls cerebrovascular integrity via cyclophilin A

Bell, R. D., Winkler, E. A., Singh, I., Sagare, A. P., Deane, R., Wu, Z., Holtzman, D. M., Betsholtz, C., Armulik, A., Sallstrom, J., et al. (2012) · Nature · doi:10.1038/nature11087 · Cited by 1,293 · see citing works

Blood-brain barrier dysfunction and recovery after ischemic stroke

Jiang, X., Andjelkovic, A. V., Zhu, L., Yang, T., Bennett, M. V. L., Chen, J., Keep, R. F., & Shi, Y. (2017) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2017.10.001 · Cited by 946 · see citing works

Alzheimer’s disease: A matter of blood–brain barrier dysfunction?

Montagne, A., Zhao, Z., & Zlokovic, B. V. (2017) · Journal of Experimental Medicine · doi:10.1084/jem.20171406 · Cited by 672 · see citing works

Function and therapeutic value of astrocytes in neurological diseases

Lee, H.-G., Wheeler, M. A., & Quintana, F. J. (2022) · Nature Reviews Drug Discovery · doi:10.1038/s41573-022-00390-x · Cited by 662 · see citing works

Age, APOE and sex: triad of risk of Alzheimer’s disease.

Riedel, B. C., Thompson, P. M., & Brinton, R. D. (2016) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2016.03.012 · Cited by 627 · see citing works

Glial influence on the blood brain barrier

Alvarez, J. I., Katayama, T., & Prat, A. (2013) · Glia · doi:10.1002/glia.22575 · Cited by 542 · see citing works

Cerebral Vascular Disease and Neurovascular Injury in Ischemic Stroke

Hu, X., Silva, T. M. D., Chen, J., & Faraci, F. M. (2017) · Circulation Research · doi:10.1161/circresaha.116.308427 · Cited by 444 · see citing works

Pathophysiologic relationship between Alzheimer's disease, cerebrovascular disease, and cardiovascular risk: A review and synthesis

Santos, C. Y., Snyder, P. J., Wu, W., Zhang, M., Echeverria, A., & Alber, J. (2017) · Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring · doi:10.1016/j.dadm.2017.01.005 · Cited by 431 · see citing works

Lung inflammation and genotoxicity following pulmonary exposure to nanoparticles in ApoE-/- mice

Jacobsen, N. R., Möller, P., Jensen, K. A., Vogel, U. B., Ladefoged, O., Loft, S. H., & Wallin, H. (2009) · Particle and Fibre Toxicology · doi:10.1186/1743-8977-6-2 · Cited by 351 · see citing works

The Multifaceted Profile of Activated Microglia

Lynch, M. A. (2009) · Molecular Neurobiology · doi:10.1007/s12035-009-8077-9 · Cited by 323 · see citing works

Mechanisms of Blood–Brain Barrier Dysfunction in Traumatic Brain Injury

Cash, A., & Theus, M. H. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21093344 · Cited by 324 · see citing works

Apolipoprotein E: From lipid transport to neurobiology

Hauser, P. S., Narayanaswami, V., & Ryan, R. O. (2011) · Progress in Lipid Research · doi:10.1016/j.plipres.2010.09.001 · Cited by 320 · see citing works

ApoE facilitates the microglial response to amyloid plaque pathology

Ulrich, J. D., Ulland, T. K., Mahan, T. E., Nyström, S., Nilsson, K. P., Song, W. M., Zhou, Y., Reinartz, M., Choi, S., Jiang, H., et al. (2018) · Journal of Experimental Medicine · doi:10.1084/jem.20171265 · Cited by 297 · see citing works

Healthy aging and the blood–brain barrier

Banks, W. A., Reed, M. J., Logsdon, A. F., Rhea, E. M., & Erickson, M. A. (2021) · Nature Aging · doi:10.1038/s43587-021-00043-5 · Cited by 293 · see citing works

Formation and integration of new neurons in the adult hippocampus

Denoth‐Lippuner, A., & Jessberger, S. (2021) · Nature reviews. Neuroscience · doi:10.1038/s41583-021-00433-z · Cited by 274 · see citing works

Apolipoprotein E Regulates the Integrity of Tight Junctions in an Isoform-dependent Manner in an in Vitro Blood-Brain Barrier Model

Nishitsuji, K., Hosono, T., Nakamura, T., Bu, G., & Michikawa, M. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.225532 · Cited by 275 · see citing works

Astrocytes and Aging

Palmer, A. L., & Ousman, S. S. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00337 · Cited by 246 · see citing works

Blood-brain barrier alterations in ageing and dementia

Popescu, B. O., Toescu, E. C., Popescu, L. M., Bajenaru, O. A., Muresanu, D. F., Schultzberg, M., & Bogdanović, N. (2009) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2009.02.321 · Cited by 235 · see citing works

The role of APOE in cerebrovascular dysfunction

Tai, L. M., Thomas, R., Marottoli, F. M., Koster, K. P., Kanekiyo, T., Morris, A. W. J., & Bu, G. (2016) · Acta Neuropathologica · doi:10.1007/s00401-016-1547-z · Cited by 231 · see citing works

The blood–brain barrier

Obermeier, B., Verma, A., & Ransohoff, R. M. (2016) · Handbook of clinical neurology · doi:10.1016/b978-0-444-63432-0.00003-7 · Cited by 210 · see citing works

Dual roles of astrocytes in plasticity and reconstruction after traumatic brain injury

Zhou, Y., Shao, A., Yao, Y., Tu, S., Deng, Y., & Zhang, J. (2020) · Cell Communication and Signaling · doi:10.1186/s12964-020-00549-2 · Cited by 206 · see citing works

Organ-specific protection mediated by cooperation between vascular and epithelial barriers

Spadoni, I., Fornasa, G., & Rescigno, M. (2017) · Nature reviews. Immunology · doi:10.1038/nri.2017.100 · Cited by 203 · see citing works

Lack of Widespread BBB Disruption in Alzheimer’s Disease Models: Focus on Therapeutic Antibodies

Bien-Ly, N., Boswell, C. A., Jeet, S., Beach, T. G., Hoyte, K., Luk, W., Shihadeh, V., Ulufatu, S., Foreman, O., Lu, Y., et al. (2015) · Neuron · doi:10.1016/j.neuron.2015.09.036 · Cited by 198 · see citing works

Targeting microglia for the treatment of Alzheimer’s Disease

Wes, P. D., Sayed, F. A., Bard, F., & Gan, L. (2016) · Glia · doi:10.1002/glia.22988 · Cited by 185 · see citing works

Inhaled ultrafine particulate matter affects CNS inflammatory processes and may act via MAP kinase signaling pathways

Kleinman, M. T., Araujo, J. A., Nel, A. E., Sioutas, C., Campbell, A., Cong, P., Li, H., & Bondy, S. C. (2008) · Toxicology Letters · doi:10.1016/j.toxlet.2008.03.001 · Cited by 178 · see citing works

Aberrant immune responses in a mouse with behavioral disorders

Heo, Y., Zhang, Y., Gao, D., Miller, V. M., & Lawrence, D. A. (2011) · PLoS ONE · doi:10.1371/journal.pone.0020912 · Cited by 168 · see citing works

Apolipoprotein E and cholesterol in aging and disease in the brain

de Chaves, E. P., Narayanaswami, V., Christoffersen, C., & Nielsen, L. B. (2008) · Future Lipidology · doi:10.2217/17460875.3.5.505 · Cited by 164 · see citing works

More than cholesterol transporters: lipoprotein receptors in CNS function and neurodegeneration

Lane-Donovan, C., Philips, G. T., & Herz, J. (2014) · Neuron · doi:10.1016/j.neuron.2014.08.005 · Cited by 158 · see citing works

Astrocyte alterations in neurodegenerative pathologies and their modeling in human induced pluripotent stem cell platforms

Oksanen, M., Lehtonen, Š., Jaronen, M., Goldsteins, G., Hämäläinen, R. H., & Koıstınaho, J. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03111-7 · Cited by 156 · see citing works

Increased Blood–Brain Barrier Permeability and Brain Edema After Focal Cerebral Ischemia Induced by Hyperlipidemia: Role of Lipid Peroxidation and Calpain-1/2, Matrix Metalloproteinase-2/9, and RhoA Overactivation

ElAli, A., Doeppner, T. R., Zechariah, A., & Hermann, D. M. (2011) · Stroke · doi:10.1161/strokeaha.111.615559 · Cited by 150 · see citing works

The relationship between iron dyshomeostasis and amyloidogenesis in Alzheimer's disease: Two sides of the same coin

Peters, D. G., Connor, J. R., & Meadowcroft, M. D. (2015) · Neurobiology of Disease · doi:10.1016/j.nbd.2015.08.007 · Cited by 145 · see citing works

Lack of hepatic apoE does not influence early Aβ deposition: observations from a new APOE knock-in model

Huynh, T.-P. V., Wang, C., Tran, A. C., Tabor, G. T., Mahan, T. E., Francis, C. M., Finn, M. B., Spellman, R., Manis, M., Tanzi, R. E., et al. (2019) · Molecular Neurodegeneration · doi:10.1186/s13024-019-0337-1 · Cited by 139 · see citing works

Apolipoprotein E4 impairs spontaneous blood brain barrier repair following traumatic brain injury

Main, B. S., Villapol, S., Sloley, S. S., Barton, D. J., Parsadanian, M., Iweka, C. A., Stefos, K. A., McCann, M. S., Washington, P. M., Rodriguez, O. C., et al. (2018) · Molecular Neurodegeneration · doi:10.1186/s13024-018-0249-5 · Cited by 136 · see citing works

Age‐associated changes in the blood‐brain barrier: comparative studies in human and mouse

Goodall, G., Wang, C., Simpson, J. E., Baker, D. J., Drew, D. R., Heath, P. R., Saffrey, M. J., Romero, I. A., & Wharton, S. B. (2017) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12408 · Cited by 128 · see citing works

Potential Bidirectional Relationship Between Periodontitis and Alzheimer’s Disease

Liccardo, D., Marzano, F., Carraturo, F., Guida, M., Femminella, G. D., Bencivenga, L., Agrimi, J., Addonizio, A., Melino, I., Valletta, A., et al. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00683 · Cited by 137 · see citing works

Genetic Restoration of Plasma ApoE Improves Cognition and Partially Restores Synaptic Defects in ApoE-Deficient Mice

Lane-Donovan, C., Wong, W. M., Durakoglugil, M. S., Wasser, C. R., Jiang, S., Xian, X., & Herz, J. (2016) · The Journal of Neuroscience · doi:10.1523/jneurosci.1054-16.2016 · Cited by 115 · see citing works

Promoting brain health through exercise and diet in older adults: a physiological perspective

Jackson, P. A., Pialoux, V., Corbett, D., Drogos, L. L., Erickson, K. I., Eskes, G. A., & Poulin, M. J. (2015) · The Journal of Physiology · doi:10.1113/jp271270 · Cited by 113 · see citing works

Exploring the “Multiple-Hit Hypothesis” of Neurodegenerative Disease: Bacterial Infection Comes Up to Bat

Patrick, K. L., Bell, S. L., Weindel, C. G., & Watson, R. O. (2019) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2019.00138 · Cited by 110 · see citing works

Positive correlation between elevated plasma cholesterol levels and cognitive impairments in LDL receptor knockout mice: relevance of cortico-cerebral mitochondrial dysfunction and oxidative stress

de Oliveira, J., Hort, M. A., Moreira, E. L. G., Glaser, V., Ribeiro‐do‐Valle, R. M., Prediger, R. D., Farina, M., Latini, A., & Bem, A. F. D. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.09.009 · Cited by 104 · see citing works

The role of the low-density lipoprotein receptor–related protein 1 (LRP-1) in regulating blood-brain barrier integrity

Zhao, Y., Li, Y., Zhao, J., Song, J., & Zhao, Y. (2016) · Reviews in the Neurosciences · doi:10.1515/revneuro-2015-0069 · Cited by 103 · see citing works

High-Density Lipoproteins and Cerebrovascular Integrity in Alzheimer’s Disease

Stukas, S. K., Robert, J., & Wellington, C. L. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.01.003 · Cited by 96 · see citing works

Pulmonary exposure to carbon black nanoparticles and vascular effects

Vesterdal, L. K., Folkmann, J. K., Jacobsen, N. R., Sheykhzade, M., Wallin, H., Loft, S. H., & Möller, P. (2010) · Particle and Fibre Toxicology · doi:10.1186/1743-8977-7-33 · Cited by 98 · see citing works

Mouse Models to Study the Effect of Cardiovascular Risk Factors on Brain Structure and Cognition

Bink, D. I., Ritz, K., Aronica, E., van der Weerd, L., & Daemen, M. J. A. P. (2013) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2013.140 · Cited by 95 · see citing works

Astrocytes in the regulation of cerebrovascular functions

Cohen‐Salmon, M., Slaoui, L., Mazaré, N., Gilbert, A., Oudart, M., Alvear‐Perez, R., Elorza‐Vidal, X., Chever, O., & Boulay, A. (2021) · Glia · doi:10.1002/glia.23924 · Cited by 93 · see citing works

Apolipoprotein E in Alzheimer’s disease: molecular insights and therapeutic opportunities

Belaidi, A. A., Bush, A. I., & Ayton, S. (2025) · Molecular Neurodegeneration · doi:10.1186/s13024-025-00843-y · Cited by 91 · see citing works

Elevated levels of soluble P-selectin in mice alter blood-brain barrier function, exacerbate stroke, and promote atherosclerosis

Kisucka, J., Chauhan, A. K., Zhao, B., Patten, I. S., Yesilaltay, A., Krieger, M., & Wagner, D. D. (2009) · Blood · doi:10.1182/blood-2008-10-186650 · Cited by 91 · see citing works

Acid-Base Disorders in Patients with Chronic Obstructive Pulmonary Disease: A Pathophysiological Review

Bruno, C. M., & Valenti, M. (2012) · BioMed Research International · doi:10.1155/2012/915150 · Cited by 91 · see citing works

Impact of aging and comorbidities on ischemic stroke outcomes in preclinical animal models: A translational perspective

Candelario‐Jalil, E., & Paul, S. (2020) · Experimental Neurology · doi:10.1016/j.expneurol.2020.113494 · Cited by 89 · see citing works

Interleukin-4 mediates the neuroprotective effects of rosiglitazone in the aged brain

Loane, D. J., Deighan, B. F., Clarke, R. M., Griffin, R. J., Lynch, A. M., & Lynch, M. A. (2007) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.09.001 · Cited by 87 · see citing works

Apolipoprotein E, Amyloid-β, and Blood-Brain Barrier Permeability in Alzheimer Disease

Donahue, J. E., & Johanson, C. E. (2008) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e31816a0dc8 · Cited by 86 · see citing works

The benefit of docosahexaenoic acid for the adult brain in aging and dementia

Salem, N., Vandal, M., & Calon, F. (2014) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2014.10.003 · Cited by 85 · see citing works

Antidepressant-like effects of rosiglitazone, a PPARγ agonist, in the rat forced swim and mouse tail suspension tests

Ahmed, A. A. E., Al‐Rasheed, N. M., & Al-Rasheed, N. M. (2009) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e328331b9bf · Cited by 82 · see citing works

ChronicPorphyromonas gingivalisinfection accelerates the occurrence of age-related granules in ApoE–/–mice brains

Singhrao, S. K., Chukkapalli, S. S., Poole, S., Velsko, I. M., Crean, S. J., & Kesavalu, L. N. (2017) · Journal of Oral Microbiology · doi:10.1080/20002297.2016.1270602 · Cited by 71 · see citing works

Antibodies as Mediators of Brain Pathology

Brimberg, L., Mader, S., Fujieda, Y., Arinuma, Y., Kowal, C., Volpe, B., & Diamond, B. (2015) · Trends in immunology · doi:10.1016/j.it.2015.09.008 · Cited by 64 · see citing works

ApoE Influences the Blood-Brain Barrier Through the NF-κB/MMP-9 Pathway After Traumatic Brain Injury

Teng, Z., Guo, Z., Zhong, J., Cheng, C., Huang, Z., Wu, Y., Tang, S., Luo, C., Peng, X., Wu, H., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-06932-3 · Cited by 68 · see citing works

Apolipoprotein E-Mimetic COG1410 Reduces Acute Vasogenic Edema following Traumatic Brain Injury

Cao, F., Jiang, Y., Wu, Y., Zhong, J., Liu, J., Qin, X., Chen, L., Vitek, M. P., Li, F., Xu, L., et al. (2015) · Journal of Neurotrauma · doi:10.1089/neu.2015.3887 · Cited by 66 · see citing works

Apolipoprotein E, an important player in longevity and age-related diseases

Ang, L. S., Cruz, R. P., Hendel, A., & Granville, D. J. (2008) · Experimental Gerontology · doi:10.1016/j.exger.2008.03.010 · Cited by 66 · see citing works

Animal Models of Metabolic Disorders in the Study of Neurodegenerative Diseases: An Overview

Bem, A. F. D., Krolow, R., Farias, H. R., de Rezende, V. L., Gelain, D. P., Moreira, J. C. F., Duarte, J. M. N., & de Oliveira, J. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.604150 · Cited by 64 · see citing works

Peripheral Versus Central Nervous System APOE in Alzheimer’s Disease: Interplay across the Blood-Brain Barrier

Chernick, D., Ortiz-Valle, S., Jeong, A., Qu, W., & Li, L. (2019) · Neuroscience Letters · doi:10.1016/j.neulet.2019.134306 · Cited by 54 · see citing works

Chronic hepatitis C virus infection and depression

Adinolfi, L. E., Nevola, R., Rinaldi, L., Romano, C., & Giordano, M. (2017) · Clinics in Liver Disease · doi:10.1016/j.cld.2017.03.007 · Cited by 59 · see citing works

Apolipoprotein E as a β-amyloid-independent factor in Alzheimer’s disease

Wolf, A. B., Valla, J., Bu, G., Kim, J., LaDu, M., Reiman, E. M., & Caselli, R. J. (2013) · Alzheimer's Research & Therapy · doi:10.1186/alzrt204 · Cited by 55 · see citing works

Immune-regulating effects of exercise on cigarette smoke-induced inflammation

Madani, A., Alack, K., Richter, M. J., & Krüger, K. (2018) · Journal of Inflammation Research · doi:10.2147/jir.s141149 · Cited by 56 · see citing works

Systematic Identification of Cell-Cell Communication Networks in the Developing Brain

Sheikh, B. N., Bondareva, O., Guhathakurta, S., Tsang, T. H., Sikora, K., Aizarani, N., Sagar, Holz, H., Grün, D., Hein, L., et al. (2019) · iScience · doi:10.1016/j.isci.2019.10.026 · Cited by 53 · see citing works

Cellular response of the blood-brain barrier to injury: Potential biomarkers and therapeutic targets for brain regeneration

Tenreiro, M. M. B., Ferreira, R., Bernardino, L. I., & Brito, M. A. (2016) · Neurobiology of Disease · doi:10.1016/j.nbd.2016.03.014 · Cited by 50 · see citing works

Oxidative stress impairs learning and memory in apoE knockout mice

Evola, M., Hall, A., Wall, T., Young, A. M., & Grammas, P. (2010) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2010.05.003 · Cited by 47 · see citing works

Hyperlipidemia-induced apoptosis of hippocampal neurons in apoE(-/-) mice may be associated with increased PCSK9 expression

Zhao, X.-S., Wu, Q., Peng, J., Pan, L.-H., Ren, Z., Liu, H.-T., Jiang, Z.-S., Wang, G.-X., Tang, Z.-H., & Liu, L.-S. (2017) · Molecular Medicine Reports · doi:10.3892/mmr.2016.6055 · Cited by 46 · see citing works

Apolipoprotein E mimetic peptide, CN ‐105, improves outcomes in ischemic stroke

Tu, T. M., Kolls, B. J., Soderblom, E. J., Cantillana, V., Ferrell, P. D., Moseley, M. A., Wang, H., Dawson, H. N., & Laskowitz, D. T. (2017) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.399 · Cited by 44 · see citing works

Paving the Way Toward Complex Blood-Brain Barrier Models Using Pluripotent Stem Cells

Lauschke, K., Frederiksen, L., & Hall, V. J. (2017) · Stem Cells and Development · doi:10.1089/scd.2017.0003 · Cited by 43 · see citing works

Production and extraction of astaxanthin fromPhaffia rhodozymaand its biological effect on alcohol-induced renal hypoxia inCarassius auratus

Alesci, A., Salvo, A., Lauriano, E. R., Gervasi, T., Palombieri, D., Bruno, M., Pergolizzi, S., & Cicero, N. (2014) · Natural Product Research · doi:10.1080/14786419.2014.979417 · Cited by 43 · see citing works

Immunoglobulin G Fc receptor deficiency prevents Alzheimer-like pathology and cognitive impairment in mice

Fernández‐Vizarra, P., López‐Franco, Ó., Mallavia, B., Higuera‐Matas, A., López-Parra, V., Ortiz-Muñoz, G., Ambrosio, E., Egido, J., Almeida, O. F. X., & Gómez‐Guerrero, C. (2012) · Brain · doi:10.1093/brain/aws195 · Cited by 42 · see citing works

ATP-Binding Cassette Transporters and Their Roles in Protecting the Brain

ElAli, A., & Hermann, D. M. (2011) · The Neuroscientist · doi:10.1177/1073858410391270 · Cited by 42 · see citing works

Targeting Apolipoprotein E for Alzheimer’s Disease: An Industry Perspective

Suidan, G. L., & Ramaswamy, G. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20092161 · Cited by 42 · see citing works

Oral Health as a Risk Factor for Alzheimer Disease

Pruntel, S. M., Munster, B. C. V., de Vries, J. J., Vissink, A., & Visser, A. (2023) · The Journal of Prevention of Alzheimer s Disease · doi:10.14283/jpad.2023.82 · Cited by 41 · see citing works

Recent Aspects of Periodontitis and Alzheimer’s Disease—A Narrative Review

Cichońska, D., Mazuś, M., & Kusiak, A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25052612 · Cited by 41 · see citing works

Genetic mouse models to study blood–brain barrier development and function

Sohet, F., & Daneman, R. (2013) · Fluids and Barriers of the CNS · doi:10.1186/2045-8118-10-3 · Cited by 40 · see citing works

Characterization of the neurogenic niche in the aging dentate gyrus using iterative immunofluorescence imaging

Cole, J. D., del Castillo, J. S., Gut, G., Gonzalez-Bohorquez, D., Pelkmans, L., & Jessberger, S. (2022) · eLife · doi:10.7554/elife.68000 · Cited by 41 · see citing works

Genome-wide analysis identifies novel loci influencing plasma apolipoprotein E concentration and Alzheimer’s disease risk

Aslam, M. M., Fan, K.-H., Lawrence, E., Bedison, M. A., Snitz, B. E., DeKosky, S. T., Lopez, O. L., Feingold, E., & Kamboh, M. I. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02170-4 · Cited by 39 · see citing works

ApoE-Deficient Promotes Blood–Brain Barrier Disruption in Experimental Autoimmune Encephalomyelitis via Alteration of MMP-9

Zheng, M., Wei, J., Tang, Y., Yang, C., Wei, Y., Yin, X., & Liu, Q. (2014) · Journal of Molecular Neuroscience · doi:10.1007/s12031-014-0291-x · Cited by 37 · see citing works

Apolipoprotein E as a novel therapeutic neuroprotection target after traumatic spinal cord injury

Cheng, X., Zheng, Y., Bu, P., Qi, X., Fan, C., Li, F., Kim, D., & Cao, Q. (2017) · Experimental Neurology · doi:10.1016/j.expneurol.2017.10.014 · Cited by 37 · see citing works

Apolipoprotein E, Carbon Dioxide Vasoreactivity, and Cognition in Older Adults: Effect of Hypertension

Hajjar, I., Sorond, F., & Lipsitz, L. A. (2015) · Journal of the American Geriatrics Society · doi:10.1111/jgs.13235 · Cited by 37 · see citing works

Identification of ApoE as an autocrine/paracrine factor that stimulates neural stem cell survival via MAPK/ERK signaling pathway

Gan, H. T., Tham, M., Hariharan, S., Ramasamy, S., Yu, Y. H., & Ahmed, S. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07227.x · Cited by 36 · see citing works

Cerebral Oxidative Stress and Microvasculature Defects in TNF-α Expressing Transgenic and Porphyromonas gingivalis -Infected ApoE –/– Mice

Rokad, F., Moseley, R., Hardy, R., Chukkapalli, S. S., Crean, S., Kesavalu, L. N., & Singhrao, S. K. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-170304 · Cited by 35 · see citing works

The blood brain barrier: Insights from development and ageing

Delaney, C. P., & Campbell, M. (2017) · Tissue Barriers · doi:10.1080/21688370.2017.1373897 · Cited by 35 · see citing works

Increase of arginase activity in old apolipoprotein-E deficient mice under Western diet associated with changes in neurovascular unit

Badaut, J., Copin, J., Fukuda, A. M., Gasche, Y. G., Schaller, K., & da Silva, R. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-132 · Cited by 35 · see citing works

Estrogen receptor-mediated resveratrol actions on blood-brain barrier of ovariectomized mice

Shin, J. A., Oh, S., Ahn, J., & Park, E. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.09.024 · Cited by 34 · see citing works

Association of Apolipoprotein E in Lipoprotein Subspecies With Risk of Dementia

Koch, M., DeKosky, S. T., Goodman, M., Sun, J., Furtado, J. D., Fitzpatrick, A. L., Mackey, R. H., Cai, T., Lopez, O. L., Kuller, L. H., et al. (2020) · JAMA Network Open · doi:10.1001/jamanetworkopen.2020.9250 · Cited by 34 · see citing works

From Fundamentals to Innovation in Alzheimer’s Disease: Molecular Findings and Revolutionary Therapies

Sighencea, M. G., Popescu, R. Ș., & Trifu, S. C. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252212311 · Cited by 32 · see citing works

Endothelial TDP-43 depletion disrupts core blood–brain barrier pathways in neurodegeneration

Omar, O. M., Kimble, A. L., Ashok, C., Tyburski, J. D., Pandey, S., Wu, Q., Reese, B., Jellison, E. R., Hao, B., Li, Y., et al. (2025) · Nature Neuroscience · doi:10.1038/s41593-025-01914-5 · Cited by 35 · see citing works

Opposing Roles of apolipoprotein E in aging and neurodegeneration

Hudry, E., Klickstein, J., Cannavo, C., Jackson, R., Muzikansky, A., Gandhi, S., Urick, D., Sargent, T., Wrobleski, L., Roe, A. D., et al. (2019) · Life Science Alliance · doi:10.26508/lsa.201900325 · Cited by 30 · see citing works

ABC Transporters in Neurological Disorders: An Important Gateway for Botanical Compounds Mediated Neuro-Therapeutics

Jha, N. K., Kar, R., & Niranjan, R. (2019) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026619666190412121811 · Cited by 29 · see citing works

Harnessing BDNF Signaling to Promote Resilience in Aging

Faraji, J., & Metz, G. A. S. (2024) · Aging and Disease · doi:10.14336/ad.2024.0961 · Cited by 28 · see citing works

Proteomics of mouse brain endothelium uncovers dysregulation of vesicular transport pathways during aging

Völgyi, K., González-Gallego, J., Müller, S. A., Beaufort, N., Malik, R., Schifferer, M., Todorov, M. I., Crusius, D., Robinson, S., Schmidt, A., et al. (2024) · Nature Aging · doi:10.1038/s43587-024-00598-z · Cited by 24 · see citing works

Blood–brain barrier disruption in atrial fibrillation: a potential contributor to the increased risk of dementia and worsening of stroke outcomes?

Aryal, R., & Patabendige, A. (2021) · Open Biology · doi:10.1098/rsob.200396 · Cited by 24 · see citing works

Transglutaminase 2 limits the extravasation and the resultant myocardial fibrosis associated with factor XIII-A deficiency

Griffin, K. J., Newell, L. M., Simpson, K. R., Beckers, C., Drinkhill, M. J., Standeven, K. F., Cheah, L. T., Iismaa, S. E., Grant, P. J., Jackson, C. L., et al. (2019) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2019.12.013 · Cited by 23 · see citing works

Progress and prospects: Immunobiology of gene therapy for neurodegenerative disease: prospects and risks

McMenamin, M. M., & Wood, M. J. A. (2010) · Gene Therapy · doi:10.1038/gt.2010.2 · Cited by 23 · see citing works

Hypercholesterolemia and neurodegeneration. Comparison of hippocampal phenotypes in LDLr knockout and APPswe/PS1dE9 mice

Ettcheto, M., Petrov, D., Pedrós, I., de Lemos, L., Pallàs, M., Alegret, M., Laguna, J. C., Folch, J., & Camins, A. (2015) · Experimental Gerontology · doi:10.1016/j.exger.2015.03.010 · Cited by 22 · see citing works

Associations between atherosclerosis and neurological diseases, beyond ischemia-induced cerebral damage

Colín‐Castelán, D., & Zaina, S. (2019) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-019-09486-z · Cited by 19 · see citing works

Apolipoprotein E Protects against Neuropathology Induced by a High-Fat Diet and Maintains the Integrity of the Blood-Brain Barrier during Aging

Mulder, M., Blokland, A., van den Berg, D.-J., Schulten, H., Bakker, A. H. F., Terwel, D., Honig, W., de Kloet, E. R., Havekes, L. M., Steinbusch, H. W. M., et al. (2001) · Laboratory Investigation · doi:10.1038/labinvest.3780307 · Cited by 74 · see citing works

ApoE Deficiency Compromises the Blood Brain Barrier Especially After Injury

Methia, N., André, P., Hafezi-Moghadam, A., Economopoulos, M., Thomas, K. L., & Wagner, D. D. (2001) · Molecular Medicine · doi:10.1007/bf03401973 · Cited by 150 · see citing works

Detrimental Effects of ApoE ε4 on Blood–Brain Barrier Integrity and Their Potential Implications on the Pathogenesis of Alzheimer’s Disease

Kirchner, K., Garvert, L., Kühn, A. L., Bonk, S., Grabe, H. J., & der Auwera, S. V. (2023) · Cells · doi:10.3390/cells12212512 · Cited by 39 · see citing works

Accelerated pericyte degeneration and blood–brain barrier breakdown in apolipoprotein E4 carriers with Alzheimer’s disease

Halliday, M. R., Rege, S. V., Ma, Q., Zhao, Z., Miller, C. A., Winkler, E. A., & Zlokovic, B. V. (2016) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2015.44 · Cited by 649 · see citing works

Apolipoprotein E, Amyloid-β, and Blood-Brain Barrier Permeability in Alzheimer Disease

Donahue, J. E., & Johanson, C. E. (2008) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e31816a0dc8 · Cited by 86 · see citing works