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Intraepidermal nerve fiber density in patients with painful sensory neuropathy
Abstract
Despite prominent symptoms of neuropathic pain, patients with small-fiber sensory neuropathies have few objective abnormalities on clinical examination and routine electrodiagnostic studies. We quantified intraepidermal nerve fiber (IENF) density in sections of skin obtained by punch skin biopsy, and found it to be significantly reduced in patients with painful sensory neuropathies compared with age-matched control subjects. In addition, IENF density correlated with clinical estimates of neuropathy severity, as judged by the extent of clinically identifiable sensory abnormalities. IENF density at the calf was lower than that obtained from skin at more proximal sites, indicating the length dependency of small-fiber loss in these neuropathies.
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Cited by
England, J. D., Gronseth, G. S., Franklin, G., Miller, R. G., Asbury, A. K., Carter, G. T., Cohen, J. A., Fisher, M. A., Howard, J. F., Kinsella, L. J., et al. (2005) · Neurology · doi:10.1212/01.wnl.0000149522.32823.ea · Cited by 742
The spectrum of neuropathy in diabetes and impaired glucose tolerance
Sumner, C. J., Sheth, S., Griffin, J. W., Cornblath, D. R., & Polydefkis, M. (2003) · Neurology · doi:10.1212/wnl.60.1.108 · Cited by 708
Self-citationEpidermal Nerve Fiber Density: Normative Reference Range and Diagnostic Efficiency
McArthur, J. C., Stocks, E. A., Hauer, P., Cornblath, D. R., & Griffin, J. W. (1998) · Archives of Neurology · doi:10.1001/archneur.55.12.1513 · Cited by 560
Self-citationSmall‐fiber sensory neuropathies: Clinical course and neuropathology of idiopathic cases
Holland, N. R., Crawford, T. O., Hauer, P., Cornblath, D. R., Griffin, J. W., & McArthur, J. C. (1998) · Annals of Neurology · doi:10.1002/ana.410440111 · Cited by 340
Self-citationWhole‐body mapping of spatial acuity for pain and touch
Mancini, F., Bauleo, A., Cole, J., Lui, F., Porro, C. A., Haggard, P., & Iannetti, G. D. (2014) · Annals of Neurology · doi:10.1002/ana.24179 · Cited by 330
Metadata
- Authors
- Holland, N. R., Stocks, A., Hauer, P., Cornblath, D. R., Griffin, J. W., & McArthur, J. C.
- Venue
- Neurology
- Published
- 1997-03
- Volume
- 48
- Issue
- 3
- Pages
- 708-711
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2156264261
- Cited by
- 300
- References
- 0
- FWCI
- 5.74
- Type
- journal article
- Language
- en
- Open access
- closed
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- Holland, N. R., Stocks, A., Hauer, P., Cornblath, D. R., Griffin, J. W., & McArthur, J. C. (1997). Intraepidermal nerve fiber density in patients with painful sensory neuropathy. Neurology. https://doi.org/10.1212/wnl.48.3.708
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