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Prognostic indicators of survival in ALS
Abstract
We analyzed data from the 245-patient placebo group of the ALS CNTF Treatment Study Group study, a large, prospective, multicenter study of recombinant human ciliary neurotrophic factor to determine prognostic factors for length of survival in ALS. Variables examined included baseline demographic characteristics, indices of disease severity, pulmonary function, and clinical laboratory tests. Shorter survival was associated with greater age, lower percent-predicted forced vital capacity (FVC%), and lower serum chloride at study entry. A shorter interval from symptom onset to diagnosis of ALS and greater weight loss in the 2 months before study entry also predicted shortened survival times. The rate of muscle strength loss before study entry did not predict risk of mortality. Serum chloride, reflecting the degree of respiratory acidosis, was identified for the first time as being correlated with prognosis in ALS. The relationship between a patient's FVC% and the probability of survival is described.
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Cited by
Cedarbaum, J. M., Stambler, N., Malta, E., Fuller, C., Hilt, D., Thurmond, B., & Nakanishi, A. (1999) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(99)00210-5 · Cited by 3,307
Self-citationKiernan, M. C., Vucic, S., Cheah, B. C., Turner, M. R., Eisen, A., Hardiman, O., Burrell, J. R., & Zoing, M. C. (2011) · The Lancet · doi:10.1016/s0140-6736(10)61156-7 · Cited by 2,603
Prognostic factors in ALS: A critical review
Chiò, A., Logroscino, G., Hardiman, O., Swingler, R., Mitchell, D., Beghi, E., Traynor, B. G., & On Behalf of the Eurals Consortium (2009) · Amyotrophic Lateral Sclerosis · doi:10.3109/17482960802566824 · Cited by 1,172
Efficacy of minocycline in patients with amyotrophic lateral sclerosis: a phase III randomised trial
Gordon, P. H., Moore, D. H., Miller, R. G., Florence, J. M., Verheijde, J. L., Doorish, C., Hilton, J. F., Spitalny, G. M., MacArthur, R. B., Mitsumoto, H., et al. (2007) · The Lancet Neurology · doi:10.1016/s1474-4422(07)70270-3 · Cited by 649
Prognosis in amyotrophic lateral sclerosis: A population-based study
del Aguila, M. A., Longstreth, W. T., McGuire, V., Koepsell, T. D., & van Belle, G. (2003) · Neurology · doi:10.1212/01.wnl.0000049472.47709.3b · Cited by 469
Effects of gender in amyotrophic lateral sclerosis
McCombe, P. A., & Henderson, R. D. (2010) · Gender Medicine · doi:10.1016/j.genm.2010.11.010 · Cited by 379
ALSFRS-R score and its ratio: A useful predictor for ALS-progression
Kollewe, K., Mauss, U., Krampfl, K., Petri, S., Dengler, R., & Mohammadi, B. (2008) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2008.07.016 · Cited by 253
The gut microbiome: a key player in the complexity of amyotrophic lateral sclerosis (ALS)
Boddy, S. L., Giovannelli, I., Sassani, M., Cooper-Knock, J., Snyder, M. P., Segal, E., Elinav, E., Barker, L. A., Shaw, P. J., & McDermott, C. J. (2021) · BMC Medicine · doi:10.1186/s12916-020-01885-3 · Cited by 127
Quantifying the Eating Abnormalities in Frontotemporal Dementia
Ahmed, R. M., Irish, M., Kam, J., van Keizerswaard, J., Bartley, L., Samaras, K., Hodges, J. R., & Piguet, O. (2014) · JAMA Neurology · doi:10.1001/jamaneurol.2014.1931 · Cited by 120
Metadata
- Authors
- Stambler, N., Charatan, M., Cedarbaum, J. M., & ALS CNTF Treatment Study Group*
- Venue
- Neurology
- Published
- 1998-01
- Volume
- 50
- Issue
- 1
- Pages
- 66-72
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2130462384
- Cited by
- 254
- References
- 0
- FWCI
- 7.33
- Type
- journal article
- Language
- en
- Open access
- closed
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