The DOI matches its Crossref record.
A placebo-controlled trial of insulin-like growth factor-I in amyotrophic lateral sclerosis
Abstract
To test the safety and efficacy of recombinant human insulin-like growth factor-I (rhIGF-I) in ALS, 183 patients from eight European centers were randomized to receive double-blind placebo (n = 59) or rhIGF-I 0.1 mg/kg/day (n = 124) subcutaneously for 9 months. At study completion, the primary efficacy outcome measure (change in disease progression as assessed by the Appel ALS rating scale) showed no significant difference between treatment groups. RhIGF-I appeared to be safe and well-tolerated.
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Citations
Cited by
Apoptosis in neurodegenerative disorders
Mattson, M. P. (2000) · Nature Reviews Molecular Cell Biology · doi:10.1038/35040009 · Cited by 1,605
Prognostic factors in ALS: A critical review
Chiò, A., Logroscino, G., Hardiman, O., Swingler, R., Mitchell, D., Beghi, E., Traynor, B. G., & On Behalf of the Eurals Consortium (2009) · Amyotrophic Lateral Sclerosis · doi:10.3109/17482960802566824 · Cited by 1,172
Turner, M. R., Cagnin, A., Turkheimer, F. E., Miller, C. C. J., Shaw, C. E., Brooks, D. J., Leigh, P. N., & Banati, R. B. (2004) · Neurobiology of Disease · doi:10.1016/j.nbd.2003.12.012 · Cited by 737
Self-citationCurrent hypotheses for the underlying biology of amyotrophic lateral sclerosis
Rothstein, J. D. (2009) · Annals of Neurology · doi:10.1002/ana.21543 · Cited by 703
ALS clinical trials review: 20 years of failure. Are we any closer to registering a new treatment?
Petrov, D., Mansfield, C., Moussy, A., & Hermine, O. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00068 · Cited by 451
Metadata
- Authors
- Borasio, G. D., Robberecht, W., Leigh, P. N., Emile, J., Guiloff, R. J., Jerusalem, F., Silani, V., Vos, P. E., Wokke, J. H. J., Dobbins, T., & European ALS/IGF-I Study Group*
- Venue
- Neurology
- Published
- 1998-08
- Volume
- 51
- Issue
- 2
- Pages
- 583-586
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2090227048
- Cited by
- 340
- References
- 0
- FWCI
- 9.86
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: A placebo-controlled trial of insulin-like growth factor-I in amyotrophic lateral sclerosis. https://app.cochat.ai/papers/10.1212/wnl.51.2.583
- The paper
- Borasio, G. D., Robberecht, W., Leigh, P. N., Emile, J., Guiloff, R. J., Jerusalem, F., Silani, V., Vos, P. E., Wokke, J. H. J., Dobbins, T., & European ALS/IGF-I Study Group*. (1998). A placebo-controlled trial of insulin-like growth factor-I in amyotrophic lateral sclerosis. Neurology. https://doi.org/10.1212/wnl.51.2.583
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
