Apoptosis in neurodegenerative disorders

Mitochondria and Apoptosis

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The versatility and universality of calcium signalling

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Motor Neuron Degeneration in Mice that Express a Human Cu,Zn Superoxide Dismutase Mutation

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Pathobiology of ischaemic stroke: an integrated view

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Cell death during development of the nervous system

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Ischemic Cell Death in Brain Neurons

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Excitotoxic cell death

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THE MITOCHONDRIAL DEATH/LIFE REGULATOR IN APOPTOSIS AND NECROSIS

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Glutamate-induced neuronal death: a succession of necrosis or apoptosis depending on mitochondrial function

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An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria

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Aging, energy, and oxidative stress in neurodegenerative diseases

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Apoptosis and delayed degeneration after spinal cord injury in rats and monkeys

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Overexpression of BCL-2 in transgenic mice protects neurons from naturally occurring cell death and experimental ischemia

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Apoptosis is induced by beta-amyloid in cultured central nervous system neurons.

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Functional recovery in parkinsonian monkeys treated with GDNF

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Apoptotic DNA Fragmentation

Nagata, S. (2000) · Experimental Cell Research · doi:10.1006/excr.2000.4834 · Cited by 906 · see citing works

Mitochondrial manganese superoxide dismutase prevents neural apoptosis and reduces ischemic brain injury: suppression of peroxynitrite production, lipid peroxidation, and mitochondrial dysfunction

Keller, J. N., Kindy, M. S., Holtsberg, F. W., St. Clair, D. K., Yen, H.-C., Germeyer, A., Steiner, S. M., Bruce-Keller, A. J., Hutchins, J. B., & Mattson, M. P. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-02-00687.1998 · Cited by 863 · see citing works

Reduced fertility and postischaemic brain injury in mice deficient in cytosolic phospholipase A2

Bonventre, J. V., Huang, Z., Taheri, M. R., O’Leary, E., Li, E., Moskowitz, M. A., & Sapirstein, A. (1997) · Nature · doi:10.1038/37635 · Cited by 846 · see citing works

Inhibition of interleukin 1β converting enzyme family proteases reduces ischemic and excitotoxic neuronal damage

Hara, H., Friedlander, R. M., Gagliardini, V., Ayata, C., Fink, K., Huang, Z., Shimizu‐Sasamata, M., Yuan, J., & Moskowitz, M. A. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.5.2007 · Cited by 835 · see citing works

Functional Role of Caspase-1 and Caspase-3 in an ALS Transgenic Mouse Model

Li, M., Ona, V. O., Guégan, C., Chen, M., Jackson-Lewis, V. R., Andrews, L. J., Olszewski, A. J., Stieg, P. E., Lee, J.-P., Przedborski, S., et al. (2000) · Science · doi:10.1126/science.288.5464.335 · Cited by 717 · see citing works

Understanding cell death in parkinson's disease

Jenner, P., & Olanow, C. W. (1998) · Annals of Neurology · doi:10.1002/ana.410440712 · Cited by 686 · see citing works

Inhibition of caspase-1 slows disease progression in a mouse model of Huntington's disease

Ona, V. O., Li, M., Vonsattel, J. P., Andrews, L. J., Khan, S. Q., Chung, W. M., Frey, A. S., Menon, A., Li, X., Stieg, P. E., et al. (1999) · Nature · doi:10.1038/20446 · Cited by 640 · see citing works

Calcium promotes cell survival through CaM-K kinase activation of the protein-kinase-B pathway

Yano, S., Tokumitsu, H., & Soderling, T. R. (1998) · Nature · doi:10.1038/25147 · Cited by 617 · see citing works

Immunohistochemical evidence for apoptosis in Alzheimer's disease.

Su, J., Anderson, A., Cummings, B. J., & Cotman, C. (1994) · NeuroReport · doi:10.1097/00001756-199412000-00031 · Cited by 607 · see citing works

Activation of CPP32-Like Caspases Contributes to Neuronal Apoptosis and Neurological Dysfunction after Traumatic Brain Injury

Yakovlev, A. G., Knoblach, S. M., Fan, L., Fox, G. B., Goodnight, R., & Faden, A. I. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-19-07415.1997 · Cited by 575 · see citing works

Increased apoptosis of Huntington disease lymphoblasts associated with repeat length-dependent mitochondrial depolarization

Sawa, A., Wiegand, G. W., Cooper, J. K., Margolis, R. L., Sharp, A. H., Lawler, J. F., Greenamyre, J. T., Snyder, S. H., & Ross, C. A. (1999) · Nature Medicine · doi:10.1038/13518 · Cited by 552 · see citing works

Alzheimer's disease

Cummings, J. L., Vinters, H. V., Cole, G. M., & Khachaturian, Z. S. (1998) · Neurology · doi:10.1212/wnl.51.1_suppl_1.s2 · Cited by 515 · see citing works

Calcium signaling in the ER: its role in neuronal plasticity and neurodegenerative disorders

Mattson, M. P., LaFerla, F. M., Chan, S. L., Leissring, M. A., Shepel, P. N., & Geiger, J. D. (2000) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)01548-4 · Cited by 499 · see citing works

Alzheimer’s Presenilin Mutation Sensitizes Neural Cells to Apoptosis Induced by Trophic Factor Withdrawal and Amyloid β-Peptide: Involvement of Calcium and Oxyradicals

Guo, Q., Sopher, B. L., Furukawa, K., Pham, D. G., Robinson, N., Martin, G. M., & Mattson, M. P. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-11-04212.1997 · Cited by 487 · see citing works

Bcl-2: Prolonging Life in a Transgenic Mouse Model of Familial Amyotrophic Lateral Sclerosis

Kostić, V., Jackson-Lewis, V. R., de Bilbao, F., Dubois‐Dauphin, M., & Przedborski, S. (1997) · Science · doi:10.1126/science.277.5325.559 · Cited by 482 · see citing works

Interfering with Apoptosis: Ca 2+ -Binding Protein ALG-2 and Alzheimer's Disease Gene ALG-3

Vito, P., Lacaná, E., & D'adamio, L. (1996) · Science · doi:10.1126/science.271.5248.521 · Cited by 468 · see citing works

Mitochondrial Susceptibility to Oxidative Stress Exacerbates Cerebral Infarction That Follows Permanent Focal Cerebral Ischemia in Mutant Mice with Manganese Superoxide Dismutase Deficiency

Murakami, K., Kondo, T., 川瀬, 誠., Li, Y., Sato, S., Chen, S. F., & Chan, P. H. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-01-00205.1998 · Cited by 467 · see citing works

Apoptosis and the Nervous System

Sastry, P. S., & Rao, K. S. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0740001.x · Cited by 458 · see citing works

Activation of the caspase-3 apoptotic cascade in traumatic spinal cord injury

Springer, J. E., Azbill, R. D., & Knapp, P. E. (1999) · Nature Medicine · doi:10.1038/11387 · Cited by 453 · see citing works

A controlled trial of recombinant methionyl human BDNF in ALS

The BDNF Study Group (Phase III) (1999) · Neurology · doi:10.1212/wnl.52.7.1427 · Cited by 453 · see citing works

Apoptosis after traumatic human spinal cord injury

Emery, É., Aldana, P. R., Bunge, M. B., Puckett, W., Srinivasan, A. N., Keane, R. W., Bethea, J. R., & Levi, A. D. (1998) · Journal of neurosurgery · doi:10.3171/jns.1998.89.6.0911 · Cited by 442 · see citing works

Widespread Elimination of Naturally Occurring Neuronal Death inBax-Deficient Mice

White, F. A., Keller-Peck, C. R., Knudson, C. M., Korsmeyer, S. J., & Snider, W. D. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-04-01428.1998 · Cited by 436 · see citing works

Caspase-8 Is Required for Cell Death Induced by Expanded Polyglutamine Repeats

Sánchez, I., Xu, C., Juo, P., Kakizaka, A., Blenis, J., & Yuan, J. (1999) · Neuron · doi:10.1016/s0896-6273(00)80716-3 · Cited by 412 · see citing works

Wild-Type Huntingtin Protects from Apoptosis Upstream of Caspase-3

Rigamonti, D., Bauer, J. H., De‐Fraja, C., Conti, L., Sipione, S., Sciorati, C., Clementi, E., Hackam, A. S., Hayden, M. R., Li, Y., et al. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-10-03705.2000 · Cited by 406 · see citing works

A second cytotoxic proteolytic peptide derived from amyloid β-protein precursor

Lu, D. C.-T., Rabizadeh, S., Chandra, S. S., Shayya, R. F., Ellerby, L., Ye, X., Salvesen, G. S., Koo, E. H., & Bredesen, D. E. (2000) · Nature Medicine · doi:10.1038/74656 · Cited by 395 · see citing works

The Presenilins in Alzheimer's Disease--Proteolysis Holds the Key

Haass, C., & Strooper, B. D. (1999) · Science · doi:10.1126/science.286.5441.916 · Cited by 388 · see citing works

Aggregates from mutant and wild‐type α‐synuclein proteins and NAC peptide induce apoptotic cell death in human neuroblastoma cells by formation of β‐sheet and amyloid‐like filaments

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Inhibiting Caspase Cleavage of Huntingtin Reduces Toxicity and Aggregate Formation in Neuronal and Nonneuronal Cells

Wellington, C. L., Singaraja, R. R., Ellerby, L., Savill, J. M., Roy, S., Leavitt, B. R., Cattaneo, E. F., Hackam, A. S., Sharp, A. H., Thornberry, N. A., et al. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m001475200 · Cited by 358 · see citing works

Modification of ion homeostasis by lipid peroxidation: roles in neuronal degeneration and adaptive plasticity

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A placebo-controlled trial of insulin-like growth factor-I in amyotrophic lateral sclerosis

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Activation of K+ channels and suppression of neuronal activity by secreted β-amyloid-precursor protein

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Environment Influences Functional Outcome of Cerebral Infarction in Rats

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Sustained Sensory/Motor and Cognitive Deficits With Neuronal Apoptosis Following Controlled Cortical Impact Brain Injury in the Mouse

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Mutant Huntingtin Expression in Clonal Striatal Cells: Dissociation of Inclusion Formation and Neuronal Survival by Caspase Inhibition

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Reduced Ischemic Brain Injury in Interleukin-1β Converting Enzyme—Deficient Mice

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Dietary lipids and antioxidants in Parkinson's disease: A population‐based, case‐control study

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Increases in Bcl‐2 and cleavage of caspase‐1 and caspase‐3 in human brain after head injury

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The Actin-Severing Protein Gelsolin Modulates Calcium Channel and NMDA Receptor Activities and Vulnerability to Excitotoxicity in Hippocampal Neurons

Furukawa, K., Fu, W., Li, Y., Witke, W., Kwiatkowski, D. J., & Mattson, M. P. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-21-08178.1997 · Cited by 269 · see citing works

ALS-Linked Cu/Zn–SOD Mutation Increases Vulnerability of Motor Neurons to Excitotoxicity by a Mechanism Involving Increased Oxidative Stress and Perturbed Calcium Homeostasis

Kruman, I. I., Pedersen, W. A., Springer, J. E., & Mattson, M. P. (1999) · Experimental Neurology · doi:10.1006/exnr.1999.7190 · Cited by 268 · see citing works

Vitamin E and Alzheimer disease: the basis for additional clinical trials

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Par-4 is a mediator of neuronal degeneration associated with the pathogenesis of Alzheimer disease

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Studies of the molecular mechanisms in the regulation of telomerase activity

Liu, J. (1999) · The FASEB Journal · doi:10.1096/fasebj.13.15.2091 · Cited by 253 · see citing works

Anti-apoptotic Role of Telomerase in Pheochromocytoma Cells

Fu, W., Begley, J. G., Killen, M. W., & Mattson, M. P. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.11.7264 · Cited by 248 · see citing works

Ciliary neurotrophic factor prevents degeneration of adult rat substantia nigra dopaminergic neurons in vivo.

Hagg, T., & Varon, S. S. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.13.6315 · Cited by 229 · see citing works

Apoptosis and carcinogenesis.

Wyllie, A. (1997) · PubMed · Cited by 224 · see citing works

Oxidative Stress and Motor Neurone Disease

Cookson, M., & Shaw, P. J. (1999) · Brain Pathology · doi:10.1111/j.1750-3639.1999.tb00217.x · Cited by 223 · see citing works

Regulation of CBP-Mediated Transcription by Neuronal Calcium Signaling

Hu, S., Chrivia, J. C., & Ghosh, A. (1999) · Neuron · doi:10.1016/s0896-6273(00)80738-2 · Cited by 222 · see citing works

Blockade of the Mitochondrial Permeability Transition Pore Diminishes Infarct Size in the Rat after Transient Middle Cerebral Artery Occlusion

Matsumoto, S., Friberg, H., Ferrand-Drake, M., & Wieloch, T. W. (1999) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-199907000-00002 · Cited by 215 · see citing works

Lack of the p50 Subunit of Nuclear Factor-κB Increases the Vulnerability of Hippocampal Neurons to Excitotoxic Injury

Yu, Z., Zhou, D., Bruce‐Keller, A. J., Kindy, M. S., & Mattson, M. P. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-20-08856.1999 · Cited by 213 · see citing works

Pivotal Role for Acidic Sphingomyelinase in Cerebral Ischemia-Induced Ceramide and Cytokine Production, and Neuronal Apoptosis

Yu, Z. F., Nikolova‐Karakashian, M., Zhou, D., Cheng, G., Schuchman, E. H., & Mattson, M. P. (2000) · Journal of Molecular Neuroscience · doi:10.1385/jmn:15:2:85 · Cited by 208 · see citing works

GLIAL CELLS IN NEUROTOXICITY DEVELOPMENT

Aschner, M., Allen, J. W., Kimelberg, H. K., LoPachin, R. M., & Streit, W. J. (1999) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.39.1.151 · Cited by 189 · see citing works

The Catalytic Subunit of Telomerase Is Expressed in Developing Brain Neurons and Serves a Cell Survival-Promoting Function

Fu, W., Killen, M. W., Culmsee, C., Dhar, S., Pandita, T. K., & Mattson, M. P. (2000) · Journal of Molecular Neuroscience · doi:10.1385/jmn:14:1-2:003 · Cited by 184 · see citing works

Proteolytic Processing of the Alzheimer's Disease Amyloid Precursor Protein within Its Cytoplasmic Domain by Caspase-like Proteases

Weidemann, A., Paliga, K., Dürrwang, U., Reinhard, F. B. M., Schuckert, O., Evin, G. M., & Masters, C. L. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.9.5823 · Cited by 173 · see citing works

β-Amyloid Induces Local Neurite Degeneration in Cultured Hippocampal Neurons: Evidence for Neuritic Apoptosis

Ivins, K. J., Bui, E. T. N., & Cotman, C. W. (1998) · Neurobiology of Disease · doi:10.1006/nbdi.1998.0228 · Cited by 164 · see citing works

Trinucleotide repeat length and clinical progression in Huntington's disease

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Caspase Dependent DNA Fragmentation Might Be Associated with Excitotoxicity in Alzheimer Disease

Masliah, E., Mallory, M. E., Alford, M. F., Tanaka, S., & Hansen, L. A. (1998) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199811000-00007 · Cited by 151 · see citing works

Cytokine-Induced Nuclear Factor Kappa B Activation Promotes the Survival of Developing Neurons

Middleton, G., Hamanoue, M., Enokido, Y., Wyatt, S. L., Pennica, D., Jaffray, E., Hay, R. T., & Davies, A. M. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.148.2.325 · Cited by 149 · see citing works

Improvement of cognitive deficits and decreased cholinergic neuronal cell loss and apoptotic cell death following neurotrophin infusion after experimental traumatic brain injury

Sinson, G. P., PERRI, B. R., Trojanowski, J. Q., Flamm, E. S., & McIntosh, T. K. (1997) · Journal of neurosurgery · doi:10.3171/jns.1997.86.3.0511 · Cited by 144 · see citing works

The Amyloid Precursor Protein-binding Protein APP-BP1 Drives the Cell Cycle through the S-M Checkpoint and Causes Apoptosis in Neurons

Chen, Y., McPhie, D. L., Hirschberg, J., & Neve, R. L. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.12.8929 · Cited by 137 · see citing works

Caspase-Mediated Degradation of AMPA Receptor Subunits: A Mechanism for Preventing Excitotoxic Necrosis and Ensuring Apoptosis

Glazner, G. W., Chan, S. L., Lu, C., & Mattson, M. P. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-10-03641.2000 · Cited by 134 · see citing works

Transgenic models of Huntington's disease.

Sathasivam, K., Hobbs, C., Mangiarini, L., Mahal, A., Turmaine, M., Doherty, P., Davies, S., & Bates, G. (1999) · Human Molecular Genetics · doi:10.1098/rstb.1999.0447 · Cited by 133 · see citing works

Expression of Fas and Fas Ligand After Experimental Traumatic Brain Injury in the Rat

Beer, R., Franz, G., Schöpf, M., Reindl, M., Zelger, B. W. H., Schmutzhard, E., Poewe, W. H., & Kampfl, A. (2000) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200004000-00004 · Cited by 129 · see citing works

Neurotrophic factors [activity-dependent neurotrophic factor (ADNF) and basic fibroblast growth factor (bFGF)] interrupt excitotoxic neurodegenerative cascades promoted by a PS1 mutation

Guo, Q., Sebastian, L., Sopher, B. L., Miller, M. W., Glazner, G. W., Ware, C. B., Martin, G. M., & Mattson, M. P. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.7.4125 · Cited by 124 · see citing works

Cyclosporin Ameliorates Traumatic Brain-Injury-Induced Alterations of Hippocampal Synaptic Plasticity

Albensi, B. C., Sullivan, P. G., Thompson, M. B., Scheff, S. W., & Mattson, M. P. (2000) · Experimental Neurology · doi:10.1006/exnr.1999.7338 · Cited by 118 · see citing works

Growth factors prevent changes in Bcl-2 and Bax expression and neuronal apoptosis induced by nitric oxide

Tamatani, M., Ogawa, S., Núñez, G., & Tohyama, M. (1998) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4400439 · Cited by 118 · see citing works

Mechanisms for neuronal degeneration in amyotrophic lateral sclerosis and in models of motor neuron death (Review).

Martin, L. J., Price, A. C., Kaiser, A., et al. (2000) · International Journal of Molecular Medicine · doi:10.3892/ijmm.5.1.3 · Cited by 106 · see citing works

Active killing of neurons during development and following stress: a role for p75NTR and Fas?

Raoul, C., Pettmann, B., & Henderson, C. E. (2000) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(99)00055-0 · Cited by 106 · see citing works

Reduction of post-traumatic brain injury and free radical production by inhibition of the caspase-1 cascade

Fink, K., Andrews, L. J., Butler, W. E., Ona, V. O., Li, M., Bogdanov, M. B., Endres, M., Khan, S. Q., Namura, S., Stieg, P. E., et al. (1999) · Neuroscience · doi:10.1016/s0306-4522(99)00345-0 · Cited by 105 · see citing works

Apoptosis following spinal cord injury in rats and preventative effect of N-methyl-d-aspartate receptor antagonist

Wada, S., Yone, K., Ishidou, Y., Nagamine, T., Nakahara, S., Niiyama, T., & Sakou, T. (1999) · Journal of Neurosurgery Spine · doi:10.3171/spi.1999.91.1.0098 · Cited by 103 · see citing works

The tumor-suppressor gene, p53, is induced in injured brain regions following experimental traumatic brain injury

Napieralski, J. A., Raghupathi, R., & McIntosh, T. K. (1999) · Molecular Brain Research · doi:10.1016/s0169-328x(99)00155-2 · Cited by 103 · see citing works

Potential Usefulness of Basic Fibroblast Growth Factor as a Treatment for Stroke

Ay, H., Ay, İ., Koroshetz, W., & Finklestein, S. P. (1999) · Cerebrovascular Diseases · doi:10.1159/000015941 · Cited by 92 · see citing works

Intraneuronal Aggregate Formation and Cell Death after Viral Expression of Expanded Polyglutamine Tracts in the Adult Rat Brain

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Transgenic mice expressing a dominant negative mutant interleukin-1β converting enzyme show resistance to MPTP neurotoxicity

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