A pilot study of dehydroepiandrosterone sulfate in myotonic dystrophy.
Abstract
We studied the effect of i.v. administration of a dehydroepiandrosterone sulfate (DHEAS) preparation (200 mg/day for 8 weeks) in 11 patients with myotonic dystrophy (MyD). After DHEAS, activities of daily living improved, muscle strength increased, and myotonia decreased. Conduction block and premature beats also improved in the four patients with cardiac involvement. This pilot study may provide a rationale for a controlled study of DHEAS in MyD.
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Scores of activity of daily living were improved by DHEA in patients with myotonic dystrophy, whereas no change was observed in healthy elderly men.
“scores of activity of daily living were improved by DHEA in patients with myotonic dystrophy (329), whereas no change was observed in healthy elderly men (330).”
From Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone (2003) · cites this paper as [329]
Cites
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Labrie, F., Luu-The, V., Labrie, C., Bélanger, A., Simard, J., Lin, S.-X., & Pelletier, G. (2003) · Endocrine Reviews · doi:10.1210/er.2001-0031 · Cited by 544 · see citing works
A High Serum Cortisol/DHEA-S Ratio Is a Risk Factor for Sarcopenia in Elderly Diabetic Patients
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- Authors
- Sugino, M., Ohsawa, N., Ito, T., Ishida, S., Yamasaki, H., Kimura, F., & Shinoda, K.
- Affiliations
- Osaka Medical and Pharmaceutical University (JP)
- From the First Department of Internal Medicine, Osaka Medical College, Osaka, Japan.
- ORCID
- Venue
- Neurology
- Published
- 1998-08
- Volume
- 51
- Issue
- 2
- Pages
- 586-589
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2012190089
- Cited by
- 49
- References
- 8
- Citations by year
- 2025: 1 · 2023: 1 · 2019: 1 · 2016: 1 · 2015: 1 · 2013: 1 · 2012: 2
- FWCI
- 1.32
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Genetic Neurodegenerative Diseases
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Health Sciences › Medicine › Neurology › Amyotrophic Lateral Sclerosis Research
- Keywords
- dehydroepiandrosterone sulfate, myotonic dystrophy, intravenous administration, myotonia, muscle strength, activities of daily living, cardiac conduction block, extrasystoles, cardiac involvement
- MeSH terms
- Activities of Daily Living, Adult, Female, Humans, Male, Middle Aged, Myotonic Dystrophy, Pilot Projects, Dehydroepiandrosterone Sulfate
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