The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Interferon beta in the treatment of multiple sclerosis: Mechanisms of action
Abstract
Interferon beta (IFN-beta) has been shown in several clinical trials to have efficacy in MS. Its mechanism of action, however, remains unclear. In this review, several biological activities of IFN-beta are highlighted, including its inhibitory effects on proliferation of leukocytes and antigen presentation. Furthermore, IFN-beta may modulate the profile of cytokine production toward that of the anti-inflammatory phenotype, and this appears to occur in the systemic circulation and within the CNS. Finally, IFN-beta can reduce T-cell migration by inhibiting the activity of T-cell matrix metalloproteinases. These activities are likely to act in concert to account for the mechanism of IFN-beta in MS.
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Cites
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Intramuscular interferon beta‐1a for disease progression in relapsing multiple sclerosis
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Regulatory T Cell Clones Induced by Oral Tolerance: Suppression of Autoimmune Encephalomyelitis
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Chemokines and the Arrest of Lymphocytes Rolling Under Flow Conditions
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Epithelial cells as sensors for microbial infection.
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TNF is a potent anti-inflammatory cytokine in autoimmune-mediated demyelination
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Matrix metalloproteinases in immunity
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Cited by
Biclustering algorithms for biological data analysis: a survey
Madeira, S. C., & Oliveira, A. L. (2004) · IEEE/ACM Transactions on Computational Biology and Bioinformatics · doi:10.1109/tcbb.2004.2 · Cited by 2,049
Disruption of central nervous system barriers in multiple sclerosis
Alvarez, J. I., Cayrol, R., & Prat, A. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2010.06.017 · Cited by 334
Lack of Neuronal IFN-β-IFNAR Causes Lewy Body- and Parkinson’s Disease-like Dementia
Ejlerskov, P., Hultberg, J. G., Wang, J., Carlsson, R., Ambjørn, M., Kuss, M., Liu, Y., Porcu, G., Kolkova, K., Friis Rundsten, C., et al. (2015) · Cell · doi:10.1016/j.cell.2015.08.069 · Cited by 211
Immunomodulatory activity of interferon‐beta
Kasper, L. H., & Reder, A. T. (2014) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.84 · Cited by 159
Interferon-β1bin multiple sclerosis
Buttmann, M., & Rieckmann, P. (2007) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.7.3.227 · Cited by 43
Metadata
- Authors
- Wee Yong, V., Chabot, S., Stuve, O., & Williams, G.
- Venue
- Neurology
- Published
- 1998-09
- Volume
- 51
- Issue
- 3
- Pages
- 682-689
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2069947868
- Cited by
- 344
- References
- 37
- FWCI
- 12.20
- Type
- journal article
- Language
- en
- Open access
- closed
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- Wee Yong, V., Chabot, S., Stuve, O., & Williams, G. (1998). Interferon beta in the treatment of multiple sclerosis: Mechanisms of action. Neurology. https://doi.org/10.1212/wnl.51.3.682
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
