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The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.

Pathologic heterogeneity in clinically diagnosed corticobasal degeneration

Boeve, B.F., Maraganore, D.M., Parisi, J.E., Ahlskog, J.E., Graff-Radford, N., Caselli, R.J., Dickson, D.W., Kokmen, E., Petersen, R.C.·1999·Neurology
DOI 10.1212/wnl.53.4.795
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Abstract

Background Early reports suggested that corticobasal degeneration (CBD) is a distinct clinicopathologic entity. Because patients have had a fairly consistent constellation of clinical and laboratory findings, many have proposed that the pathologic diagnosis can be surmised with confidence during life. Objective To analyze the pathologic findings in a large series of cases with clinically diagnosed CBD. Methods Using the medical research linkage system of the Mayo Clinic for the period January 1990 to December 1997, we identified cases diagnosed during life with CBD who subsequently underwent autopsy. All patients had progressive asymmetric rigidity and apraxia (except one with rigidity but no apraxia) with other findings, suggesting additional cortical and basal ganglionic dysfunction. All cases underwent standardized neuropathologic examination with the distribution and severity of the pathologic changes determined for each case and the pathologic diagnoses based on currently accepted criteria. Results Thirteen cases were identified. The pathologic diagnoses were CBD in seven, AD in two, and one each for progressive supranuclear palsy, Pick's disease, nonspecific degenerative changes, and Creutzfeldt-Jakob disease. Two cases had negligible basal ganglia and nigral degeneration despite previously having obvious extrapyramidal signs. However, all patients had focal or asymmetric cortical atrophy with coexisting neuronal loss and gliosis with or without status spongiosis, which…

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Cites

Research works printed but not linked: 8

  1. 10.1212/WNL.39.1.140 · DOI
  2. Rosenfield D, Bogatka C, Viswanath N, Lang A, Jankovic J. Speech apraxia in cortico-basal ganglionic degeneration. Ann Neurol 1991;30:296–297.
  3. Lang A Riley D Bergeron C. Cortical-basal ganglionic degeneration. In: Calne D ed. Neurodegenerative diseases. Philadelphia:WB Saunders 1994:877–894.
  4. Watts R Mirra S Richardson E. Corticobasal ganglionic degeneration. In: Marsden C Fahn S eds. Movement disorders 3. Oxford:Butterworth-Heinemann 1994:282–299.
  5. Cambier J, Masson M, Dairou R, Henin D. Etude anatomo-clinique d’une forme parietale de maladie de Pick. Rev Neurol (Paris) 1981;137:33–38.
  6. Cannard K, Galvez-Jimenez N, Watts R. Creutzfeldt-Jakob disease presenting and evolving as rapidly progressive corticobasal degeneration. Neurology 1998;50 (suppl 4):A95. Abstract.
  7. Heilman K Gonzales-Rothi L. Apraxia. In: Heilman K Valenstein E eds. Clinical neuropsychology. New York:Oxford University Press 1985:131–150.
  8. Goldhammer L. The apraxic and parietal hand and their definite localizing value tonic, motor, and visuokinetic phenomena in parietal lobe syndromes. Neurology 1989;39 (suppl 1):225. Abstract.

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Authors
Boeve, B. F., Maraganore, D. M., Parisi, J. E., Ahlskog, J. E., Graff-Radford, N., Caselli, R. J., Dickson, D. W., Kokmen, E., & Petersen, R. C.
Affiliations
  • Mayo Clinic (US)
  • From the Departments of Neurology (Drs. BoeveMaraganore, Ahlskog, Kokmen, and Petersen), Laboratory Medicine and Pathology (Dr. Parisi), Mayo Clinic, Rochester, MN; Department of Neurology (Dr. Graff-Radford) and the Neuropathology Laboratory (Dr. Dickson), Mayo Clinic, Jacksonville, FL; and Department of Neurology (Dr. Caselli), Mayo Clinic, Scottsdale, AZ.
ORCID
Venue
Neurology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
1999-09
Volume
53
Issue
4
Pages
795-795
ISSN
  • 0028-3878 (ISSN-L)
  • 1526-632X
DOI
10.1212/wnl.53.4.795
OpenAlex
W1986748953
Cited by
417
References
41
Citations by year
2026: 7 · 2025: 8 · 2024: 12 · 2023: 8 · 2022: 11 · 2021: 14 · 2020: 22 · 2019: 10 · 2018: 10 · 2017: 21 · 2016: 15 · 2015: 19 · 2014: 21 · 2013: 21 · 2012: 13
FWCI
6.33
Type
journal article
Language
en
Open access
closed
Locations
  • Neurology (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute on Aging (AG-08031, P30AG008031)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
Keywords
corticobasal degeneration, clinicopathological correlation, cortical atrophy, basal ganglia degeneration, nigral degeneration, extrapyramidal signs, apraxia, progressive supranuclear palsy, Pick's disease, Creutzfeldt-Jakob disease, gliosis, neuropathologic diagnosis
MeSH terms
Aged, Basal Ganglia Diseases, Brain, Female, Humans, Male, Middle Aged, Prospective Studies, Neurodegenerative Diseases

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