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Cited by 238Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsAnxiety, Depression, Psychometrics, Treatment, Cognitive Processes

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

The occurrence of depressive symptoms in the preclinical phase of AD: A population-based study

Berger, A- K., Fratiglioni, L., Forsell, Y., Winblad, B., Bäckman, L.·1999·Neurology
DOI 10.1212/wnl.53.9.1998
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Abstract

Objective To examine preclinical depressive symptoms 3 years before the diagnosis of AD. Methods The authors compared incident AD patients and nondemented individuals in terms of baseline mood- and motivation-related symptoms of depression, and assessed whether depressive symptoms in preclinical AD are related to self-perceived memory problems. Participants came from a population-based longitudinal study on aging and dementia in Stockholm, Sweden. The sample consisted of 222 persons older than 74 years who were followed for a 3-year interval. Thirty-four individuals had developed AD at follow-up, whereas 188 remained nondemented. Dementia diagnosis was made according to the criteria of the Diagnostic and Statistical Manual of Mental Disorders, 3rd edition, revised. Depressive symptoms were assessed by the Comprehensive Psychopathological Rating Scale. Results The incident AD patients had more depressive symptoms than the nondemented persons at baseline. There was a dominance of motivation-related symptoms of depression (e.g., lack of interest, loss of energy, concentration difficulties) in preclinical AD. This association remained when adjusting for subjective memory complaints. Conclusions Depressive symptoms are elevated preclinically in AD, and this elevation is not merely a by-product of self-perceived cognitive difficulties. Thus, depressive symptoms may be part of the preclinical phase in AD.

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Crossref · 10.1212/wnl.53.9.1998

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  • Depression as a risk factor for dementia and depression as a prodromal symptom remain controversial, the causal relation between depression and dementia is difficult to clarify, and previous literature findings are inconsistent.

    “In the pathogenesis of dementia, both ideas that mention depression as a risk factor for dementia and depression as a prodromal symptom remain controversial. It is difficult to clarify the causal relation between depression and dementia, and findings in the previous literature are inconsistent on these issues [10, 38, 39].”

    From Risk analysis of use of different classes of antidepressants on subsequent dementia: A nationwide cohort study in Taiwan (2017) · cites this paper as [38]

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Metadata

Authors
Berger, A. K., Fratiglioni, L., Forsell, Y., Winblad, B., & Bäckman, L.
Affiliations
  • Uppsala University (SE)
  • From the Stockholm Gerontology Research Center and Department of Clinical NeuroscienceOccupational Therapy, and Elderly Care Research (A-K. Berger and Drs. Fratiglioni, Forsell, Winblad, and Bäckman), Division of Geriatric Medicine, Karolinska Institute, Stockholm; and the Department of Psychology (Dr. Bäckman), Uppsala University, Sweden.
ORCID
Venue
Neurology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
1999-12
Volume
53
Issue
9
Pages
1998-1998
ISSN
  • 0028-3878 (ISSN-L)
  • 1526-632X
DOI
10.1212/wnl.53.9.1998
OpenAlex
W2049155848
Cited by
238
References
1
Citations by year
2026: 4 · 2025: 1 · 2024: 1 · 2023: 3 · 2022: 3 · 2021: 7 · 2020: 4 · 2019: 5 · 2018: 8 · 2017: 8 · 2016: 12 · 2015: 6 · 2014: 6 · 2013: 8 · 2012: 14
FWCI
4.20
Type
journal article
Language
en
Open access
closed
Locations
  • Neurology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Keywords
Alzheimer's disease, preclinical Alzheimer's disease, depressive symptoms, depression, mood symptoms, subjective memory complaints, incident dementia, older adults, dementia risk
MeSH terms
Aged, Aged, 80 and over, Alzheimer Disease, Amnesia, Depression, Female, Humans, Longitudinal Studies, Male, Mental Status Schedule, Motivation, Self Concept, Sick Role

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