The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Effect of l -carnitine treatment for valproate-induced hepatotoxicity
Abstract
The authors analyzed the association of L-carnitine treatment with hepatic survival in 92 patients with severe, symptomatic, valproate-induced hepatotoxicity. Forty-eight percent of the 42 patients treated with L-carnitine survived, but only 10% of the 50 patients treated solely with aggressive supportive care survived (p < 0.001). Early intervention with IV rather than enteral L-carnitine was associated with the greatest hepatic survival. Specifically, all 10 patients who were diagnosed in <5 days and treated with IV L-carnitine survived. Most patients had features of chronic illness and most children appeared to be malnourished.
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Cites
Lee, W. M. (2003) · New England Journal of Medicine · doi:10.1056/nejmra021844 · Cited by 1,594
Cited by
EASL Clinical Practice Guidelines: Drug-induced liver injury
Andrade, R. J., Aithal, G. P., Björnsson, E. S., Kaplowitz, N., Kullak-Ublick, G. A., Larrey, D., & Karlsen, T. H. (2019) · Journal of Hepatology · doi:10.1016/j.jhep.2019.02.014 · Cited by 1,276
Idiosyncratic drug hepatotoxicity
Kaplowitz, N. (2005) · Nature Reviews Drug Discovery · doi:10.1038/nrd1750 · Cited by 1,054
Andrade, R. J., Chalasani, N., Björnsson, E. S., Suzuki, A., Kullak-Ublick, G. A., Watkins, P. B., Devarbhavi, H., Merz, M., Lucena, M. I., Kaplowitz, N., et al. (2019) · Nature Reviews Disease Primers · doi:10.1038/s41572-019-0105-0 · Cited by 924
Navarro, V. J., & Senior, J. R. (2006) · New England Journal of Medicine · doi:10.1056/nejmra052270 · Cited by 811
Flanagan, J. L., Simmons, P. A., Vehige, J., Willcox, M. D., & Garrett, Q. (2010) · Nutrition & Metabolism · doi:10.1186/1743-7075-7-30 · Cited by 611
Metadata
- Authors
- Bohan, T. P., Helton, E., McDonald, I., König, S., Gazitt, S., Sugimoto, T., Scheffner, D., Cusmano, L., Li, S., & Koch, G.
- Venue
- Neurology
- Published
- 2001-05-22
- Volume
- 56
- Issue
- 10
- Pages
- 1405-1409
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2035206369
- Cited by
- 184
- References
- 1
- FWCI
- 6.41
- Type
- journal article
- Language
- en
- Open access
- closed
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- The paper
- Bohan, T. P., Helton, E., McDonald, I., König, S., Gazitt, S., Sugimoto, T., Scheffner, D., Cusmano, L., Li, S., & Koch, G. (2001). Effect of l -carnitine treatment for valproate-induced hepatotoxicity. Neurology. https://doi.org/10.1212/wnl.56.10.1405
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
