The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Controlled trial of N-acetylcysteine for patients with probable Alzheimer’s disease
Abstract
The antioxidant N-acetylcysteine (NAC) or placebo was administered in a double-blind fashion to patients who met National Institute of Neurological and Communicative Disorders and Stroke-Alzheimer's Disease and Related Disorders Association criteria for probable AD. Testing for efficacy occurred after 3 and 6 months of treatment. Comparison of interval change favored NAC treatment on nearly every outcome measure, although significant differences were obtained only for a subset of cognitive tasks.
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“NAC augmentation of standard treatment in Alzheimer’s disease was associated with improvements in verbal abilities and executive control cognitive tasks compared with controls [157].”
From Cognitive remission: a novel objective for the treatment of major depression? (2016) · cites this paper as [157]
Citations
Cites
McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., & Stadlan, E. M. (1984) · Neurology · doi:10.1212/wnl.34.7.939 · Cited by 27,915
Assessment of Older People: Self-Maintaining and Instrumental Activities of Daily Living
Lawton, M. P., & Brody, E. M. (1969) · The Gerontologist · doi:10.1093/geront/9.3_part_1.179 · Cited by 18,540
Katz, S. (1983) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1983.tb03391.x · Cited by 2,734
A Controlled Trial of Selegiline, Alpha-Tocopherol, or Both as Treatment for Alzheimer's Disease
Sano, M., Ernesto, C., Thomas, R. G., Klauber, M. R., Schafer, K., Grundman, M., Woodbury, P., Growdon, J., Cotman, C. W., Pfeiffer, E., et al. (1997) · New England Journal of Medicine · doi:10.1056/nejm199704243361704 · Cited by 2,380
Excess brain protein oxidation and enzyme dysfunction in normal aging and in Alzheimer disease.
Smith, C. D., Carney, J. M., Starke-Reed, P. E., Oliver, C. N., Stadtman, E. R., Floyd, R. A., & Markesbery, W. R. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.23.10540 · Cited by 1,296
Oxidative damage to mitochondrial DNA is increased in Alzheimer’s disease
Mecocci, P., MacGarvey, U., & Beal, M. F. (1994) · Annals of Neurology · doi:10.1002/ana.410360510 · Cited by 1,037
Lyras, L., Cairns, N. J., Jenner, A., Jenner, P., & Halliwell, B. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.68052061.x · Cited by 531
Autopsy Samples of Alzheimer's Cortex Show Increased Peroxidation In Vitro
Subbarao, K. V., Richardson, J. S., & Ang, L. C. (1990) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1990.tb08858.x · Cited by 463
The Role of Oxidative Stress in Alzheimer Disease
Markesbery, W. R. (1999) · Archives of Neurology · doi:10.1001/archneur.56.12.1449 · Cited by 312
de Vries, N., & Flora, S. D. (1993) · Journal of Cellular Biochemistry · doi:10.1002/jcb.240531040 · Cited by 273
Cited by
Sorted by citations
The role of oxidative stress in neurodegenerative diseases
Kim, G. H., Kim, J. E., Rhie, S. J., & Yoon, S. (2015) · Experimental Neurobiology · doi:10.5607/en.2015.24.4.325 · Cited by 1,355
The chemistry and biological activities of N-acetylcysteine
Samuni, Y., Goldstein, S., Dean, O. M., & Berk, M. (2013) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2013.04.016 · Cited by 876
Rushworth, G. F., & Megson, I. L. (2013) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2013.09.006 · Cited by 724
N-Acetylcysteine—a safe antidote for cysteine/glutathione deficiency
Atkuri, K. R., Mantovani, J. J., Herzenberg, L. A., & Herzenberg, L. A. (2007) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2007.04.005 · Cited by 721
Bioinorganic Chemistry of Alzheimer’s Disease
Kepp, K. P. (2012) · Chemical Reviews · doi:10.1021/cr300009x · Cited by 683
Metadata
- Authors
- Adair, J. C., Knoefel, J. E., & Morgan, N.
- Affiliations
- University of New Mexico (US)
- Venue
- Neurology
- Published
- 2001-10-23
- Volume
- 57
- Issue
- 8
- Pages
- 1515-1517
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2084485820
- Cited by
- 240
- References
- 10
- Citations by year
- 2026: 9 · 2025: 7 · 2024: 10 · 2023: 11 · 2022: 12 · 2021: 11 · 2020: 15 · 2019: 12 · 2018: 11 · 2017: 13 · 2016: 17 · 2015: 13 · 2014: 11 · 2013: 15 · 2012: 10
- FWCI
- 3.19
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroprotection in Cerebral Ischemia
- Keywords
- N-acetylcysteine, Alzheimer's disease, antioxidants, cognitive function, NIA-AA criteria, treatment efficacy
- MeSH terms
- Acetylcysteine, Alzheimer Disease, Double-Blind Method, Female, Humans, Male, Free Radical Scavengers, Treatment Outcome
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