The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Cycad neurotoxins, consumption of flying foxes, and ALS-PDC disease in Guam
Abstract
The Chamorro people of Guam have been afflicted with a complex of neurodegenerative diseases (now known as ALS-PDC) with similarities to ALS, AD, and PD at a far higher rate than other populations throughout the world. Chamorro consumption of flying foxes may have generated sufficiently high cumulative doses of plant neurotoxins to result in ALS-PDC neuropathologies, since the flying foxes forage on neurotoxic cycad seeds.
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Citations
Cites
Guam Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Linked to a Plant Excitant Neurotoxin
Spencer, P. S., Nunn, P. B., Hugon, J., Ludolph, A. C., Ross, S. M., Roy, D. N., & Robertson, R. C. (1987) · Science · doi:10.1126/science.3603037 · Cited by 897
Old world fruit bats: an action plan for their conservation
Mickleburgh, S. P., Hutson, A. M., & Racey, P. A. (1992) · IUCN eBooks · doi:10.2305/iucn.ch.1992.ssc-ap.6.en · Cited by 367
Flying Primates? Megabats Have the Advanced Pathway from Eye to Midbrain
Pettigrew, J. D. (1986) · Science · doi:10.1126/science.3945827 · Cited by 265
Caparros-Lefebvre, D., & Elbaz, A. (1999) · The Lancet · doi:10.1016/s0140-6736(98)10166-6 · Cited by 255
Flying Foxes as Strong Interactors in South Pacific Island Ecosystems: A Conservation Hypothesis
COX, P. A., ELMQVIST, T., PIERSON, E. D., & RAINEY, W. E. (1991) · Conservation Biology · doi:10.1111/j.1523-1739.1991.tb00351.x · Cited by 211
Self-citationKurland, L. K., & Mulder, D. W. (1954) · Neurology · doi:10.1212/wnl.4.5.355 · Cited by 201
Duncan, M. W., Steele, J. C., Kopin, I. J., & Markey, S. P. (1990) · Neurology · doi:10.1212/wnl.40.5.767 · Cited by 192
Gajdusek, D. C., & Salazar, A. M. (1982) · Neurology · doi:10.1212/wnl.32.2.107 · Cited by 192
Kelly, B. C., & Gobas, F. A. P. C. (2001) · Environmental Science & Technology · doi:10.1021/es0011966 · Cited by 176
NEUROFIBRILLARY DEGENERATION ON GUAM
Anderson, F. H., Richardson, E. P., Okazaki, H., & Brody, J. A. (1979) · Brain · doi:10.1093/brain/102.1.65 · Cited by 105
Cited by
Kiernan, M. C., Vucic, S., Cheah, B. C., Turner, M. R., Eisen, A., Hardiman, O., Burrell, J. R., & Zoing, M. C. (2011) · The Lancet · doi:10.1016/s0140-6736(10)61156-7 · Cited by 2,603
Harke, M. J., Steffen, M. M., Gobler, C. J., Otten, T. G., Wilhelm, S. W., Wood, S. A., & Paerl, H. W. (2016) · Harmful Algae · doi:10.1016/j.hal.2015.12.007 · Cited by 1,084
Role of complement in neurodegeneration and neuroinflammation
BONIFATI, D., & KISHORE, U. (2007) · Molecular Immunology · doi:10.1016/j.molimm.2006.03.007 · Cited by 313
Mitra, J., Guerrero, E. N., Hegde, P. M., Liachko, N. F., Wang, H., Vasquez, V., Gao, J., Pandey, A., Taylor, J. P., Kraemer, B. C., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1818415116 · Cited by 305
A prospective longitudinal study on the microbiota composition in amyotrophic lateral sclerosis
Di Gioia, D., Bozzi Cionci, N., Baffoni, L., Amoruso, A., Pane, M., Mogna, L., Gaggìa, F., Lucenti, M. A., Bersano, E., Cantello, R., et al. (2020) · BMC Medicine · doi:10.1186/s12916-020-01607-9 · Cited by 151
Metadata
- Authors
- Cox, P. A., & Sacks, O. W.
- Venue
- Neurology
- Published
- 2002-03-26
- Volume
- 58
- Issue
- 6
- Pages
- 956-959
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2066393684
- Cited by
- 329
- References
- 18
- FWCI
- 11.30
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Cycad neurotoxins, consumption of flying foxes, and ALS-PDC disease in Guam. https://app.cochat.ai/papers/10.1212/wnl.58.6.956
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- Cox, P. A., & Sacks, O. W. (2002). Cycad neurotoxins, consumption of flying foxes, and ALS-PDC disease in Guam. Neurology. https://doi.org/10.1212/wnl.58.6.956
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
