A prospective longitudinal study on the microbiota composition in amyotrophic lateral sclerosis
Open accessAbstract
Background: A connection between amyotrophic lateral sclerosis (ALS) and altered gut microbiota composition has previously been reported in animal models. This work is the first prospective longitudinal study addressing the microbiota composition in ALS patients and the impact of a probiotic supplementation on the gut microbiota and disease progression. Methods: Fifty patients and 50 matched controls were enrolled. The microbial profile of stool samples from patients and controls was analyzed via PCR-Denaturing Gradient Gel Electrophoresis, and the main microbial groups quantified via qPCR. The whole microbiota was then analyzed via next generation sequencing after amplification of the V3–V4 region of 16S rDNA. Patients were then randomized to receive probiotic treatment or placebo and followed up for 6 months with ALSFRS-R, BMI, and FVC%. Results: The results demonstrate that the gut microbiota of ALS patients is characterized by some differences with respect to controls, regardless of the disability degree. Moreover, the gut microbiota composition changes during the course of the disease as demonstrated by the significant decrease in the number of observed operational taxonomic unit during the follow-up. Interestingly, an unbalance between potentially protective microbial groups, such as Bacteroidetes, and other with potential neurotoxic or pro-inflammatory activity, such as Cyanobacteria, has been shown. The 6-month probiotic treatment influenced the gut microbial composition; however, it did not bring the biodiversity of intestinal microbiota of patients closer to that of control subjects and no influence on the progression of the disease measured by ALSFRS-R was demonstrated. Conclusions: Our study poses the bases for larger clinical studies to characterize the microbiota changes as a novel ALS biomarker and to test new microbial strategy to ameliorate the health status of the gut. Trial registration: CE 107/14, approved by the Ethics Committee of the “Maggiore della Carità” University Hospital, Italy.
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In a prospective longitudinal study of patients with ALS, intestinal flora was restored by probiotic supplementation compared to normal controls.
“Similarly, in a prospective longitudinal study of patients with ALS, Di Gioia et al. (102) found that intestinal flora was restored by probiotic supplementation compared to normal controls.”
From Modulation of the gut–brain axis via the gut microbiota: a new era in treatment of amyotrophic lateral sclerosis (2023) · cites this paper as [102]
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Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases
Loh, J. S., Mak, W. Q., Tan, L. K. S., Ng, C. X., Chan, H. H., Yeow, S. H., Foo, J. B., Ong, Y. S., How, C. W., & Khaw, K. Y. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01743-1 · Cited by 1,193 · see citing works
Kanmani, S., & Koo, B. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21207551 · Cited by 381 · see citing works
Chidambaram, S. B., Essa, M. M., Rathipriya, A. G., Bishir, M., Ray, B., Mahalakshmi, A. M., Tousif, A. H., Sakharkar, M. K., Kashyap, R. S., Friedland, R. P., et al. (2022) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.107988 · Cited by 204 · see citing works
Ashique, S., Mohanto, S., Ahmed, M. G., Mishra, N., Garg, A., Chellappan, D. K., Omara, T., Iqbal, S., & Kahwa, I. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e34092 · Cited by 201 · see citing works
RetractedThe gut microbiome: a key player in the complexity of amyotrophic lateral sclerosis (ALS)
Boddy, S. L., Giovannelli, I., Sassani, M., Cooper-Knock, J., Snyder, M. P., Segal, E., Elinav, E., Barker, L. A., Shaw, P. J., & McDermott, C. J. (2021) · BMC Medicine · doi:10.1186/s12916-020-01885-3 · Cited by 127 · see citing works
Béland, L.-C., Markovinovic, A., Jakovac, H., De Marchi, F., Bilic, E., Mazzini, L., Kriz, J., & Munitic, I. (2020) · Brain Communications · doi:10.1093/braincomms/fcaa124 · Cited by 125 · see citing works
Self-citationBicknell, B. T., Liebert, A. D., Borody, T. J., Herkes, G., McLachlan, C. S., & Kiat, H. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24119577 · Cited by 129 · see citing works
Ning, J., Huang, S., Chen, S.-D., Zhang, Y.-R., Huang, Y., & Yu, J. (2022) · Journal of Alzheimer s Disease · doi:10.3233/jad-215411 · Cited by 114 · see citing works
The Role of Microbiome in Brain Development and Neurodegenerative Diseases
Nandwana, V., Nandwana, N. K., Das, Y., Saito, M., Panda, T., Das, S., Almaguel, F. A., Hosmane, N. S., & Das, B. C. (2022) · Molecules · doi:10.3390/molecules27113402 · Cited by 113 · see citing works
Role of Gut Microbiota in Neurological Disorders and Its Therapeutic Significance
Tiwari, P., Dwivedi, R., Bansal, M., Tripathi, M., & Dada, R. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12041650 · Cited by 106 · see citing works
The amyotrophic lateral sclerosis exposome: recent advances and future directions
Goutman, S. A., Savelieff, M. G., Jang, D., Hur, J., & Feldman, E. L. (2023) · Nature Reviews Neurology · doi:10.1038/s41582-023-00867-2 · Cited by 102 · see citing works
The microbiota–microglia axis in central nervous system disorders
Mossad, O., & Erny, D. (2020) · Brain Pathology · doi:10.1111/bpa.12908 · Cited by 98 · see citing works
Vladimirovna, G. M., Dvoretskaya, Y. D., Burakova, I. Y., Syromyatnikov, M., Попов, Е. С., Kokina, A. V., Mikhaylov, E., & Popov, V. N. (2022) · Microorganisms · doi:10.3390/microorganisms10051020 · Cited by 88 · see citing works
Moțățăianu, A., Şerban, G. M., & Andone, S. R. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242015094 · Cited by 90 · see citing works
Bile acids and neurological disease
Hurley, M. J., Bates, R., Macnaughtan, J., & Schapira, A. H. V. (2022) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2022.108311 · Cited by 82 · see citing works
Hu, C., & Rzymski, P. (2022) · Life · doi:10.3390/life12040476 · Cited by 73 · see citing works
Role of the Exposome in Neurodegenerative Disease: Recent Insights and Future Directions
Sakowski, S. A., Koubek, E. J., Chen, K. S., Goutman, S. A., & Feldman, E. L. (2024) · Annals of Neurology · doi:10.1002/ana.26897 · Cited by 73 · see citing works
Masrori, P., Beckers, J., Gossye, H., & Damme, P. V. (2022) · Molecular Neurodegeneration · doi:10.1186/s13024-022-00525-z · Cited by 72 · see citing works
The Promise of Niacin in Neurology
Wuerch, E. C., Urgoiti, G. B. R., & Yong, V. W. (2023) · Neurotherapeutics · doi:10.1007/s13311-023-01376-2 · Cited by 68 · see citing works
The Gut Microbiota-Immunity Axis in ALS: A Role in Deciphering Disease Heterogeneity?
Niccolai, E., Pilato, V. D., Nannini, G., Baldi, S., Russo, E., Zucchi, E., Martinelli, I., Menicatti, M., Bartolucci, G., Mandrioli, J., et al. (2021) · Biomedicines · doi:10.3390/biomedicines9070753 · Cited by 66 · see citing works
D’Amico, E., Grosso, G., Nieves, J. W., Zanghì, A., Factor-Litvak, P. R., & Mitsumoto, H. (2021) · Nutrients · doi:10.3390/nu13072273 · Cited by 64 · see citing works
What Are the Key Gut Microbiota Involved in Neurological Diseases? A Systematic Review
Bonnechère, B., Amin, N., & van Duijn, C. M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232213665 · Cited by 64 · see citing works
Aberrant enteric neuromuscular system and dysbiosis in amyotrophic lateral sclerosis
Zhang, Y., Ogbu, D., Garrett, S., Xia, Y., & Sun, J. (2021) · Gut Microbes · doi:10.1080/19490976.2021.1996848 · Cited by 61 · see citing works
From Dysbiosis to Neurodegenerative Diseases through Different Communication Pathways: An Overview
Intili, G., Paladino, L., Rappa, F., Alberti, G., Plicato, A., Calabrò, F., Fucarino, A., Cappello, F., Bucchieri, F., Tomasello, G., et al. (2023) · Biology · doi:10.3390/biology12020195 · Cited by 61 · see citing works
The Gut–Organ Axis within the Human Body: Gut Dysbiosis and the Role of Prebiotics
Saxami, G., Kerezoudi, E. N., Eliopoulos, C., Arapoglou, D., & Kyriacou, A. (2023) · Life · doi:10.3390/life13102023 · Cited by 60 · see citing works
The Gut Microbiome–Brain Crosstalk in Neurodegenerative Diseases
Ghezzi, L., Cantoni, C., Rotondo, E., & Galimberti, D. (2022) · Biomedicines · doi:10.3390/biomedicines10071486 · Cited by 58 · see citing works
Gentile, F., Doneddu, P. E., Riva, N., Nobile‐Orazio, E., & Quattrini, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21207471 · Cited by 57 · see citing works
Destination Amyotrophic Lateral Sclerosis
Keon, M., Musrie, B., Dinger, M. E., Brennan, S. E., Santos, J., & Saksena, N. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2021.596006 · Cited by 56 · see citing works
A Gut Feeling in Amyotrophic Lateral Sclerosis: Microbiome of Mice and Men
Martin, S., Battistini, C., & Sun, J. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.839526 · Cited by 54 · see citing works
Interplay between immunity and amyotrophic lateral sclerosis: Clinical impact
Marchi, F. D., Munitić, I., Amedei, A., Berry, J. D., Feldman, E. L., Aronica, E., Nardo, G., Weehaeghe, D. V., Niccolai, E., Prtenjača, N., et al. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.06.027 · Cited by 52 · see citing works
Self-citationThe panoramic view of amyotrophic lateral sclerosis: A fatal intricate neurological disorder
Dhasmana, S., Dhasmana, A., Narula, A. S., Jaggi, M., Yallapu, M. M., & Chauhan, S. C. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.120156 · Cited by 52 · see citing works
Fakhri, S., Yarmohammadi, A., Yarmohammadi, M., Farzaei, M. H., & Echeverría, J. (2021) · Marine Drugs · doi:10.3390/md19030165 · Cited by 51 · see citing works
Romero‐Ramírez, L., & Mey, J. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25179279 · Cited by 49 · see citing works
Overlapping Neuroimmune Mechanisms and Therapeutic Targets in Neurodegenerative Disorders
Marchi, F. D., Munitić, I., Vidatic, L., Papić, E., Rački, V., Nimac, J., Jurak, I., Novotni, G., Rogelj, B., Vuletić, V., et al. (2023) · Biomedicines · doi:10.3390/biomedicines11102793 · Cited by 46 · see citing works
Self-citationThe Brain–Gut–Bone Axis in Neurodegenerative Diseases: Insights, Challenges, and Future Prospects
Li, R., Miao, Z., Liu, Y., Chen, X., Wang, H., Su, J., & Chen, J. (2024) · Advanced Science · doi:10.1002/advs.202307971 · Cited by 48 · see citing works
Gut microbiome and amyotrophic lateral sclerosis: a systematic review of current evidence
Sun, J., Huang, T., Debelius, J. W., & Fang, F. (2021) · Journal of Internal Medicine · doi:10.1111/joim.13336 · Cited by 43 · see citing works
Lu, G., Wen, Q., Cui, B., Li, Q., & Zhang, F. (2022) · Journal of Biomedical Research · doi:10.7555/jbr.36.20220088 · Cited by 43 · see citing works
Gut microbiome correlates with plasma lipids in amyotrophic lateral sclerosis
Guo, K., Figueroa‐Romero, C., Noureldein, M. H., Murdock, B. J., Savelieff, M. G., Hur, J., Goutman, S. A., & Feldman, E. L. (2023) · Brain · doi:10.1093/brain/awad306 · Cited by 42 · see citing works
Yan, J., Chen, H., Zhang, Y., Peng, L., Wang, Z.-K., Lan, X., Yu, S., & Yang, Y. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2353396 · Cited by 40 · see citing works
Butyrate as a potential therapeutic agent for neurodegenerative disorders
Chakraborty, P., Gamage, H. K. A. H., & Laird, A. S. (2024) · Neurochemistry International · doi:10.1016/j.neuint.2024.105745 · Cited by 41 · see citing works
Choe, U. (2025) · Journal of Functional Foods · doi:10.1016/j.jff.2025.106870 · Cited by 45 · see citing works
Hong, D., Zhang, C., Wu, W., Lu, X., & Zhang, L. (2023) · Frontiers in Neurology · doi:10.3389/fneur.2023.1133546 · Cited by 38 · see citing works
Chen, S., Cai, X., Lao, L., Wang, Y., Su, H., & Sun, H. (2024) · Aging and Disease · doi:10.14336/ad.2023.0524 · Cited by 38 · see citing works
Chen, S., Zhang, P., Duan, H., Wang, J., Qiu, Y., Cui, Z., Yin, Y., Wan, D., & Xie, L. (2023) · The Innovation · doi:10.1016/j.xinn.2023.100479 · Cited by 39 · see citing works
Gut microbiota immune cross-talk in amyotrophic lateral sclerosis
Kaul, M., Mukherjee, D., Weiner, H. L., & Cox, L. M. (2024) · Neurotherapeutics · doi:10.1016/j.neurot.2024.e00469 · Cited by 35 · see citing works
Chen, F., Zhang, H., Du, E., Fan, Q., Zhao, N., Jin, F., Zhang, W., Guo, W., Huang, S., & Wei, J. (2021) · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology · doi:10.1186/s40104-021-00611-0 · Cited by 34 · see citing works
Uceda, S., Echeverry‐Alzate, V., Reiriz, M., Miguel, E. M., Pérez-Curiel, A., Gómez-Senent, S., & Beltrán-Velasco, A. I. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241713294 · Cited by 35 · see citing works
Chui, Z. S. W., Chan, L. M. L., Zhang, E. W. H., Liang, S., Choi, E. P. H., Lok, K. Y. W., Tun, H. M., & Kwok, J. Y. Y. (2024) · Scientific Reports · doi:10.1038/s41598-024-59250-w · Cited by 33 · see citing works
The Association between Dysbiosis and Neurological Conditions Often Manifesting with Chronic Pain
Garvey, M. (2023) · Biomedicines · doi:10.3390/biomedicines11030748 · Cited by 30 · see citing works
Fontdevila, L., Povedano, M., Domínguez, R., Boada, J., Serrano, J. C. E., Pamplona, R., Ayala, V., & Portero‐Otín, M. (2024) · Scientific Reports · doi:10.1038/s41598-024-75083-z · Cited by 29 · see citing works
Boeri, L., Perottoni, S., Izzo, L., Giordano, C., & Albani, D. (2021) · Advanced Healthcare Materials · doi:10.1002/adhm.202002043 · Cited by 28 · see citing works
Diet-microbiome-gut-brain nexus in acute and chronic brain injury
Krakovski, M., Arora, N., Jain, S., Glover, J., Dombrowski, K. E., Hernandez, B., Yadav, H., & Sarma, A. K. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.1002266 · Cited by 27 · see citing works
Gut-Modulating Agents and Amyotrophic Lateral Sclerosis: Current Evidence and Future Perspectives
Eddin, A. N., Alfuwais, M., Eddin, R. N., AlKattan, K. M., & Yaqinuddin, A. (2024) · Nutrients · doi:10.3390/nu16050590 · Cited by 26 · see citing works
Gut microbiota links with cognitive impairment in amyotrophic lateral sclerosis: A multi-omics study
Gong, Z., Ba, L., Tang, J., Yang, Y., Li, Z., Liu, M., Yang, C., Ding, F., & Zhang, M. (2022) · Journal of Biomedical Research · doi:10.7555/jbr.36.20220198 · Cited by 25 · see citing works
Cuffaro, F., Lamminpää, I., Niccolai, E., & Amedei, A. (2024) · Nutrients · doi:10.3390/nu17010102 · Cited by 25 · see citing works
Xin, Z., Xin, C., Huo, J., Liu, Q., Dong, H., Li, R., & Liu, Y. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-03988-x · Cited by 25 · see citing works
Gut-Brain Axis Deregulation and Its Possible Contribution to Neurodegenerative Disorders
Villavicencio-Tejo, F., Olesen, M. A., Navarro, L., Calisto, N., Iribarren, C., GARCÍA, K. P., Corsini, G., & Quintanilla, R. A. (2023) · Neurotoxicity Research · doi:10.1007/s12640-023-00681-0 · Cited by 23 · see citing works
Dysautonomia in Amyotrophic Lateral Sclerosis
Oprisan, A. L., & Popescu, B. O. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241914927 · Cited by 24 · see citing works
Gut Symptoms, Gut Dysbiosis and Gut-Derived Toxins in ALS
Lee, A., Henderson, R. D., Aylward, J., & McCombe, P. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25031871 · Cited by 23 · see citing works
Target Metabolites to Slow Down Progression of Amyotrophic Lateral Sclerosis in Mice
Ogbu, D., Zhang, Y., Claud, K., Xia, Y., & Sun, J. (2022) · Metabolites · doi:10.3390/metabo12121253 · Cited by 20 · see citing works
Yang, J., Jie, L., Gu, T., Sun, Q., Xu, W., & Peng, Y. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25020841 · Cited by 20 · see citing works
Astrocytes in Amyotrophic Lateral Sclerosis
Vaz, S. H., Pinto, S., Sebastião, A. M., & Brites, D. M. T. O. (2021) · Exon Publications eBooks · doi:10.36255/exonpublications.amyotrophiclateralsclerosis.astrocytes.2021 · Cited by 20 · see citing works
Luo, S., Pan, M., Fu, G., Meng, X., Zhao, Z., Yu, H., Yue, G.-X., & Lei, T. (2025) · Pharmacological Research · doi:10.1016/j.phrs.2025.107974 · Cited by 19 · see citing works
Marchi, F. D., Vignaroli, F., Mazzini, L., Comi, C., & Tondo, G. (2023) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527322666230608110201 · Cited by 19 · see citing works
Self-citationGautam, P., Yadav, R., Vishwakarma, R. K., Shekhar, S., Pathak, A., & Singh, C. (2025) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.5c00254 · Cited by 18 · see citing works
More than just a number: the gut microbiota and brain function across the extremes of life
Nuzum, N. D., Deady, C., Kittel‐Schneider, S., Cryan, J. F., O’Mahony, S. M., & Clarke, G. A. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2418988 · Cited by 20 · see citing works
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Niccolai, E., Gloria, L. D., Trolese, M. C., Fabbrizio, P., Baldi, S., Nannini, G., Margotta, C., Nastasi, C., Ramazzotti, M., Bartolucci, G., et al. (2024) · Acta Neuropathologica Communications · doi:10.1186/s40478-024-01877-x · Cited by 15 · see citing works
Ayala, V., Fontdevila, L., Rico-Rios, S., Povedano, M., Andrés‐Benito, P., Torres, P., Serrano, J. C. E., Pamplona, R., & Portero‐Otín, M. (2025) · Sclerosis · doi:10.3390/sclerosis3010008 · Cited by 15 · see citing works
The Current Potential Pathogenesis of Amyotrophic Lateral Sclerosis
Jiang, S., & Xu, R. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04269-3 · Cited by 15 · see citing works
Tang, W., Wang, Q., Sun, M., Liu, C., Huang, Y., Zhou, M., Zhang, X., Meng, Z., & Zhang, J. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.122952 · Cited by 14 · see citing works
Lessons to Learn from the Gut Microbiota: A Focus on Amyotrophic Lateral Sclerosis
Calvo, A. C., Valledor-Martín, I., Moreno‐Martínez, L., Toivonen, J. M., & Osta, R. (2022) · Genes · doi:10.3390/genes13050865 · Cited by 14 · see citing works
Mutant and curli-producing E. coli enhance the disease phenotype in a hSOD1-G93A mouse model of ALS
Kurlawala, Z., McMillan, J. D., Singhal, R. A., Morehouse, J. R., Burke, D. A., Sears, S. M., Duregon, E., Beverly, L. J., Siskind, L. J., & Friedland, R. P. (2023) · Scientific Reports · doi:10.1038/s41598-023-32594-5 · Cited by 12 · see citing works
Neurodegenerative Disorders and the Gut-Microbiome-Brain Axis: A Literature Review
Dandamudi, B. J., Dimaano, K. A. M., Shah, N., AlQassab, O., Al-Sulaitti, Z., Nelakuditi, B., & Mohammed, L. (2024) · Cureus · doi:10.7759/cureus.72427 · Cited by 12 · see citing works
Banerjee, A., Pradhan, L. K., Sahoo, P. K., Jena, K. K., Chauhan, N. R., Chauhan, S., & Das, S. K. (2021) · Archives of Microbiology · doi:10.1007/s00203-021-02276-9 · Cited by 13 · see citing works
Ray, D., Bose, P., Mukherjee, S., Roy, S., & Kaity, S. (2025) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2025.125776 · Cited by 11 · see citing works
Marchi, F. D., Collo, A., Scognamiglio, A., Cavaletto, M., Cionci, N. B., Biroli, G., Gioia, D. D., Riso, S., & Mazzini, L. (2021) · Nutrition · doi:10.1016/j.nut.2021.111525 · Cited by 11 · see citing works
Self-citationAlterations in nasal microbiota of patients with amyotrophic lateral sclerosis
Liu, K., Guo, Q., Ding, Y., Luo, L., Huang, J., & Zhang, Q. (2023) · Chinese Medical Journal · doi:10.1097/cm9.0000000000002701 · Cited by 12 · see citing works
Auclair‐Ouellet, N., Kassem, O., Bronner, S., Oula, M.-L., & Binda, S. (2025) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1699884 · Cited by 11 · see citing works
Loher, P., Londin, E. R., Ilieva, H. S., Pasinelli, P., & Rigoutsos, I. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-04747-2 · Cited by 10 · see citing works
Mazzini, L., Marchi, F. D., Niccolai, E., Mandrioli, J., & Amedei, A. (2021) · Exon Publications eBooks · doi:10.36255/exonpublications.amyotrophiclateralsclerosis.microbiota.2021 · Cited by 10 · see citing works
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Functional Nutrients to Ameliorate Neurogenic Muscle Atrophy
Moresi, V., Renzini, A., Cavioli, G., Seelaender, M. C. L., Coletti, D., Gigli, G., & Cedola, A. (2022) · Metabolites · doi:10.3390/metabo12111149 · Cited by 9 · see citing works
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Microbiota Dysbiosis in Amyotrophic Lateral Sclerosis: A Systematic Review of Human Studies
Gautam, P., Vishwakarma, R. K., Nath, M., Nath, G., & Pathak, A. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-05481-5 · Cited by 8 · see citing works
Zhu, H., He, H., Yang, M., Zhu, H., Hagiwara, A., Shu, L., Xu, J., Miao, Y., Han, X., & Wang, C. (2025) · iScience · doi:10.1016/j.isci.2025.114044 · Cited by 8 · see citing works
Dai, Y., Qian, Y., Qu, Y., Guan, W., Xie, J., Wang, D., Butler, C. A., Dashper, S. G., Carroll, I. M., Divaris, K., et al. (2025) · Briefings in Bioinformatics · doi:10.1093/bib/bbaf374 · Cited by 12 · see citing works
The Potential Role of m6A in the Regulation of TBI-Induced BGA Dysfunction
Huang, P., Liu, M., Zhang, J., Zhong, X., & Zhong, C. (2022) · Antioxidants · doi:10.3390/antiox11081521 · Cited by 7 · see citing works
A multivariate method to correct for batch effects in microbiome dataPreprint
Wang, Y., & Cao, K. L. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.10.27.358283 · Cited by 7 · see citing works
Phage-Microbiota Crosstalk: Implications for Central Nervous System Disorders
Salari, V., Parrella, E., Mengoni, F., Cintra, L., Bertini, G., & Fabene, P. F. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26136183 · Cited by 6 · see citing works
Pathophysiological Correlation between Cigarette Smoking and Amyotrophic Lateral Sclerosis
Menounos, S., Hansbro, P. M., Diwan, A. D., & Das, A. (2021) · NeuroSci · doi:10.3390/neurosci2020008 · Cited by 6 · see citing works
Chen, Y., Wang, D., Liao, Y., Zuo, G., & Lu, X. (2024) · Discover Medicine · doi:10.1007/s44337-024-00135-2 · Cited by 5 · see citing works
Targeting gut-brain-immune axis in amyotrophic lateral sclerosis
Mudda, N., Zhang, L., & Sampelli, P. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1637976 · Cited by 5 · see citing works
Garg, G., Trisal, A., & Singh, A. K. (2025) · Neuroscience · doi:10.1016/j.neuroscience.2025.03.020 · Cited by 6 · see citing works
Aragonés, Á. M., Martínez‐Manzanares, E., & Tapia-Paniagua, S. T. (2022) · Revista Española de Medicina Legal · doi:10.1016/j.remle.2022.02.002 · Cited by 5 · see citing works
Ogbu, D., Zhang, Y., Claud, K., Xia, Y., & Sun, J. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.01.15.476456 · Cited by 5 · see citing works
Dai, Y., Qian, Y., Qu, Y., Guan, W., Xie, J., Wang, D., Butler, C. A., Dashper, S. G., Carroll, I. M., Divaris, K., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.10.18.619118 · Cited by 5 · see citing works
Microbiota–gut–brain axis and bile acids–driven neuromodulation
Dong, T., Zhang, T., Wang, H., Zhang, J., Abdullah, R., Sun, B., & Peng, G. (2025) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-25-00927 · Cited by 4 · see citing works
The Gut-Brain Axis (GBA): Implications for Brain Longevity
Gautam, P., Vishwakarma, R. K., & Pathak, A. (2025) · Nutritional neurosciences · doi:10.1007/978-981-95-2790-8_9 · Cited by 4 · see citing works
Microbiome and metabolites impact enteric and central nervous systems in ALS
Walton, E. I., & Sun, J. (2026) · Gut Microbes · doi:10.1080/19490976.2026.2692737 · Cited by 4 · see citing works
- Authors
- Di Gioia, D., Bozzi Cionci, N., Baffoni, L., Amoruso, A., Pane, M., Mogna, L., Gaggìa, F., Lucenti, M. A., Bersano, E., Cantello, R., De Marchi, F., & Mazzini, L.
- Affiliations
- University of Bologna (IT)
- Università degli Studi del Piemonte Orientale “Amedeo Avogadro” (IT)
- Corresponding author
- Mazzini, Letizia
- ORCID
- Venue
- BMC Medicine
- Published
- 2020-06-17
- Volume
- 18
- Issue
- 1
- Pages
- 153-153
- ISSN
- 1741-7015 (ISSN-L)
- PMC
- PMC7298784
- OpenAlex
- W3035761210
- Cited by
- 151
- References
- 88
- Citations by year
- 2026: 16 · 2025: 24 · 2024: 34 · 2023: 27 · 2022: 24 · 2021: 21 · 2020: 5
- FWCI
- 6.24
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- BMC Medicine (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Probiotical S.p.A. (--)
- Università degli Studi del Piemonte Orientale (AGING Project for Department of Excellence at the Department of Translational Medicine (DIMET), Università del Piemonte Orientale, Novara, Italy)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Neurology › Amyotrophic Lateral Sclerosis Research
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Keywords
- amyotrophic lateral sclerosis, gut microbiota, probiotic supplementation, disease progression, Bacteroidetes, cyanobacteria, microbial diversity, ALS biomarkers, 16S rRNA gene sequencing, stool microbiome
- MeSH terms
- Gastrointestinal Microbiome, Adolescent, Adult, Aged, Amyotrophic Lateral Sclerosis, Animals, Female, Humans, Longitudinal Studies, Male, Middle Aged, Prospective Studies, Young Adult
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