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Cited by 5Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsMedical Imaging Techniques and Applications

The DOI matches its Crossref record.

Diagnostic Accuracy of Amyloid and FDG PET in Pathologically-Confirmed Dementia (S8.005)

Rabinovici, Gil, Lehmann, Manja, Rosen, Howard, Ghosh, Pia, Cohn-Sheehy, Brendan, Trojanowski, John, Mendez, Mario, Vinters, Harry, Dickson, Dennis, Gorno-Tempini, Marilu, Boxer, Adam, Kramer, Joel, Miller, Bruce, Grinberg, Lea, Seeley, William, Jagust, William·2014·Neurology
DOI 10.1212/wnl.82.10_supplement.s8.005
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Abstract

OBJECTIVE: To assess the diagnostic accuracy of amyloid and FDG PET compared to pathology in a consecutive series of patients evaluated at an academic dementia clinic. BACKGROUND: Pathological validation studies of amyloid imaging have been conducted largely in end-of-life subjects that may not represent clinical practice. Few studies have compared amyloid PET with other diagnostic modalities. DESIGN/METHODS: 37 patients (mean age 66.5±8.8, MMSE 21.1±6.8) underwent PIB (all) and FDG (N=34) PET. Clinical diagnoses included Alzheimer’s disease (AD, N=10), frontotemporal dementia (FTD, N=24), mild cognitive impairment (N=2) and prion disease (N=1). PET scans were visually interpreted by two raters blinded to clinical diagnosis (PIB: positive or negative; FDG: AD or FTD). Pathologic diagnoses (2.9±1.8 years after PET; 36 autopsies and one biopsy) were based on standard research criteria. RESULTS: Pathologic diagnoses included: high-likelihood AD (N=9), FTD (N=24) and prion disease (N=1). Three patients met criteria for both high-likelihood AD and FTD - these cases were considered AD in evaluating PET performance. PIB reads had a sensitivity of 100% (both raters) and specificity of 88%-92% for AD. Mixed AD/FTD cases were all PIB+. Three of four PIB+ patients (by at least one rater) who did not meet high-likelihood AD criteria had frequent neuritic plaques (CERAD) and one had sparse neuritic but frequent diffuse plaques. FDG reads had a sensitivity of 83%-92% and specificity of 77%…

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  • Because of its high negative predictive value, absence of amyloid binding reliably points towards a non-Alzheimer's disease cause of dementia, such as bvFTD.

    “Regarding amyloid imaging, because of its high negative predictive value, absence of amyloid binding reliably points towards a non-Alzheimer's disease cause of dementia, such as bvFTD (Rabinovici et al. , 2014).”

    From Recommendations to distinguish behavioural variant frontotemporal dementia from psychiatric disorders (2020) · cites this paper as Rabinovici et al. , 2014

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Authors
Rabinovici, G., Lehmann, M., Rosen, H., Ghosh, P., Cohn-Sheehy, B., Trojanowski, J., Mendez, M., Vinters, H., Dickson, D., Gorno-Tempini, M., Boxer, A., Kramer, J., Miller, B., Grinberg, L., Seeley, W., & Jagust, W.
Affiliations
  • Lawrence Berkeley National Laboratory (US)
  • University of California, San Francisco (US)
  • Helen Wills Neuroscience Institute UC Berkeley Berkeley CA United States
  • University of Pennsylvania (US)
  • VA Greater Los Angeles Healthcare System (US)
  • Los Angeles CA United States
  • Mayo Clinic (US)
  • UCSF Memory & Aging Center, Dept. of Neurology San Francisco CA United States
ORCID
Venue
Neurology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2014-04-08
Volume
82
Issue
10_supplement
ISSN
  • 0028-3878 (ISSN-L)
  • 1526-632X
DOI
10.1212/wnl.82.10_supplement.s8.005
OpenAlex
W1881862985
Cited by
5
References
0
Citations by year
2025: 2 · 2020: 1 · 2017: 1 · 2015: 1
FWCI
0.51
Type
journal article
Language
en
Open access
closed
Locations
Neurology (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Medical Imaging Techniques and Applications
Keywords
FDG-PET, Alzheimer's disease, frontotemporal dementia, prion disease, mild cognitive impairment, Pib, diagnostic accuracy, neuritic plaques, positive predictive value, negative predictive value, sensitivity and specificity, autopsy neuropathology, CERAD

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