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Cited by 291

The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.

The Impact of Postoperative Pain on the Development of Postoperative Delirium

Lynch, Eileen P., Lazor, Marissa A, Gellis, Janice E., Orav, John, Goldman, Lee, Marcantonio, Edward R.·1998·Anesthesia & Analgesia

Abstract

We performed a prospective observational study to examine the role of postoperative pain and its treatment on the development of postoperative delirium.Pain was measured in direct patient interviews using a visual analog scale (VAS) and was assessed for pain at rest, pain with movement, and maximal pain over the previous 24 h. Postoperative delirium was diagnosed during these interviews by using the confusion assessment method (CAM) and/or by using data from the medical record and the hospital's nursing intensity index. The method of postoperative analgesia, type of opioid, and cumulative opioid dose were also recorded. After controlling for known preoperative risk factors for delirium (age, alcohol abuse, cognitive function, physical function, serum chemistries, and type of surgery), higher pain scores at rest was associated with an increased risk of delirium over the first 3 postoperative days (adjusted risk ratio 1.20, P = 0.04). Pain with movement and maximal pain were not associated with delirium. Method of postoperative analgesia, type of opioid, and cumulative opioid dose were not associated with an increased risk of delirium. We conclude that more effective control of postoperative pain reduces the incidence of postoperative delirium. Implications: We performed daily interviews in a large population of patients undergoing noncardiac surgery to measure their level of pain and development of delirium. We found an association between higher pain levels at rest and the development of delirium. Our results suggest that better control of postoperative pain may reduce this serious complication. (Anesth Analg 1998;86:781-5)

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Crossref · 10.1213/00000539-199804000-00019

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Metadata

Authors
Lynch, E. P., Lazor, M. A., Gellis, J. E., Orav, J., Goldman, L., & Marcantonio, E. R.
Venue
Anesthesia & Analgesia
Published
1998-04
Volume
86
Issue
4
Pages
781-785
ISSN
0003-2999 (ISSN-L)
OpenAlex
W4245362645
Cited by
291
References
16
FWCI
5.69
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: The Impact of Postoperative Pain on the Development of Postoperative Delirium. https://app.cochat.ai/papers/10.1213/00000539-199804000-00019
The paper
Lynch, E. P., Lazor, M. A., Gellis, J. E., Orav, J., Goldman, L., & Marcantonio, E. R. (1998). The Impact of Postoperative Pain on the Development of Postoperative Delirium. Anesthesia & Analgesia. https://doi.org/10.1213/00000539-199804000-00019

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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.