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Cox’s regression model for counting processes: A large sample study
Open accessAbstract
The Cox regression model for censored survival data specifies that covariates have a proportional effect on the hazard function of the life-time distribution of an individual. In this paper we discuss how this model can be extended to a model where covariate processes have a proportional effect on the intensity process of a multivariate counting process. This permits a statistical regression analysis of the intensity of a recurrent event allowing for complicated censoring patterns and time dependent covariates. Furthermore, this formulation gives rise to proofs with very simple structure using martingale techniques for the asymptotic properties of the estimators from such a model. Finally an example of a statistical analysis is included.
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“An additional pre-specified analysis, the Andersen-Gill model using a Cox proportional-hazard with the counting-process formulation, was performed to model the total events (50,51).”
From Effects of Icosapent Ethyl on Total Ischemic Events (2019) · cites this paper as [50]
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Subramaniam, A. V., Weston, S. A., Killian, J. M., Schulte, P. J., Roger, V. L., Redfield, M. M., Blecker, S., & Dunlay, S. M. (2022) · Circulation Heart Failure · doi:10.1161/circheartfailure.121.009218 · Cited by 55
Diel, I., Body, J., Stopeck, A., Vadhan‐Raj, S., Spencer, A. G., Steger, G. G., von Moos, R., Goldwasser, F., Feng, A., & Braun, A. (2015) · European Journal of Cancer · doi:10.1016/j.ejca.2015.04.017 · Cited by 56
Dabrowska, D. M. (1997) · The Annals of Statistics · doi:10.1214/aos/1031594730 · Cited by 55
Strasak, A. M., Lang, S., Kneib, T., Brant, L. J., Klenk, J., Hilbe, W., Oberaigner, W., Ruttmann, E., Kaltenbach, L., Concin, H., et al. (2008) · Annals of Epidemiology · doi:10.1016/j.annepidem.2008.08.009 · Cited by 56
Survival Analysis with Error-Prone Time-Varying Covariates: A Risk Set Calibration Approach
Liao, X., Zucker, D. M., Li, Y., & Spiegelman, D. L. (2010) · Biometrics · doi:10.1111/j.1541-0420.2010.01423.x · Cited by 55
“The asymptotic distribution theory proven in Web Appendix B follows arguments in Andersen and Gill (1982) and Lin and Wei (1989); the reader is referred to Web Appendix B for further details.”
BackgroundHDL Cholesterol, Apolipoproteins, and Cardiovascular Risk in Hemodialysis Patients
Silbernagel, G., Genser, B., Drechsler, C., Scharnagl, H., Grammer, T. B., Stojaković, T., Krane, V., Ritz, E., Wanner, C., & März, W. (2014) · Journal of the American Society of Nephrology · doi:10.1681/asn.2013080816 · Cited by 58
Prosperi, M., Cozzi‐Lepri, A., Castagna, A., Mussini, C., Murri, R., Giacometti, A., Torti, C., Costantini, A., Narciso, P., Ghinelli, F., et al. (2010) · Clinical Infectious Diseases · doi:10.1086/651688 · Cited by 55
“as the date of enrollment [19] were fitted to identify indepen-”
MethodSemiparametric regression for the weighted composite endpoint of recurrent and terminal events
Mao, L., & Lin, D. Y. (2015) · Biostatistics · doi:10.1093/biostatistics/kxv050 · Cited by 55
Dramatic Declines in Higher Education Appropriations: State Conditions for Budget Punctuations
Li, A. Y. (2016) · Research in Higher Education · doi:10.1007/s11162-016-9432-0 · Cited by 55
Shi, L., Liu, P. F., Wang, Y., Zanobetti, A., Kosheleva, A., Koutrakis, P., & Schwartz, J. D. (2016) · Scientific Reports · doi:10.1038/srep30161 · Cited by 54
Metadata
- Authors
- Andersen, P. K., & Gill, R. D.
- ORCID
- Gill, R. D.
- Venue
- The Annals of Statistics
- Publisher
- Institute of Mathematical Statistics
- Published
- 1982-12-01
- Volume
- 10
- Issue
- 4
- Pages
- 1100-1120
- ISSN
- 0090-5364 (ISSN-L)
- 2168-8966
- OpenAlex
- W1986705681
- Cited by
- 4,419
- References
- 26
- Citations by year
- 2026: 174 · 2025: 189 · 2024: 217 · 2023: 180 · 2022: 207 · 2021: 244 · 2020: 228 · 2019: 197 · 2018: 219 · 2017: 162 · 2016: 181 · 2015: 181 · 2014: 189 · 2013: 163 · 2012: 148
- FWCI
- 20.56
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Annals of Statistics (publishedVersion)
- Project Euclid (Cornell University) (submittedVersion)
- Topics
- Physical Sciences › Mathematics › Statistics and Probability › Statistical Methods and Inference
- Physical Sciences › Mathematics › Statistics and Probability › Probability and Statistical Research
- Physical Sciences › Mathematics › Statistics and Probability › Statistical Distribution Estimation and Applications
- Keywords
- Cox regression model, counting processes, recurrent events, intensity process, censoring, time-varying covariates, martingale method, asymptotic properties, estimators
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