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Confounding and Collapsibility in Causal Inference
Open accessAbstract
Consideration of confounding is fundamental to the design and analysis of studies of causal effects. Yet, apart from confounding in experimental designs, the topic is given little or no discussion in most statistics texts. We here provide an overview of confounding and related concepts based on a counterfactual model for causation. Special attention is given to definitions of confounding, problems in control of confounding, the relation of confounding to exchangeability and collapsibility, and the importance of distinguishing confounding from noncollapsibility.
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“Both models account for potential biases and confounding factors [20, 21].”
From Health and Socio-Economic Impacts of Climate-Related Displacement in Bangladesh’s Chars: Causal Evidence From a Household Survey (2026) · cites this paper as [20]
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“The causal interpretation of the estimated treatment effects relies on the standard identification assumptions used in the program-evaluation literature [16, 20, 21].”
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“First, because of noncollapsibility, the marginal relationship between the outcome and instruments after integrating out the confounder and the exposure does not follow a logistic regression model (Greenland et al., 1999).”
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“This summary is then said to be collapsible” according to Greenland, Pearl, and Robins (1999) which is consistent with the definition in Huitfeldt et al. (2019).”
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Expérimentation, inférence statistique et analyse causale
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“However, since the odds ratio is a non-collapsible measure, we chose not to use this measure [38].”
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“Omitting prognostic variables is not an option for non-collapsible effect measures such as odds ratios (Greenland et al. 1999; Huitfeldt et al. 2019; Tang et al. 2013).”
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Mitigating Confounding Bias for Recommendation via Counterfactual Inference
He, M., Hu, X., Li, C., Chen, X., & Wang, J. (2023) · Lecture notes in computer science · doi:10.1007/978-3-031-26387-3_32 · Cited by 4
“In this work, we treat the exposure data as the evidence of confounders exists in the data (refer [9, 26] for details and proof which we omit for brevity).”
MethodA unified analysis of regression adjustment in randomized experiments
Reluga, K., Ye, T., & Zhao, Q. (2024) · Electronic Journal of Statistics · doi:10.1214/24-ejs2233 · Cited by 4
“…carry over to a wider class of generalized linear model, even if the link function we use is collapsible (a link function is collapsible if including independent regressors does not change the population regression coefficients, see Greenland et al., 1999; Daniel et al., 2021, for more detials).”
BackgroundMatthews, J. N. S., & Badi, N. H. (2015) · Statistics in Medicine · doi:10.1002/sim.6508 · Cited by 4
Bagged one‐to‐one matching for efficient and robust treatment effect estimation
Samuels, L. R., & Greevy, R. A. (2018) · Statistics in Medicine · doi:10.1002/sim.7926 · Cited by 4
Xi, D., & Bretz, F. (2021) · Biometrical Journal · doi:10.1002/bimj.202100060 · Cited by 4
“Note that the collapsibility definition used by Pearl (2009) and Greenland et al. (1999) chooses the prevalence of X as weights, so that their definition is stronger than (1) and the logic-respecting definition in Liu et al. (2021). The subgroup mixable estimation (SME) principle used by Liu et al. (2021) was original…”
MethodInfluentialRubin, D. B. (2006) · Handbook of statistics · doi:10.1016/s0169-7161(06)26024-3 · Cited by 5
Relationship of causal effects in a causal chain and related inference
Geng, Z. (2004) · Science in China Series A Mathematics · doi:10.1360/02ys0374 · Cited by 4
“According to the counterfactual model and the causal diagram, confounding bias may be eliminated by controlling confounders that are not affected by treatment or exposure, called the back door criterion in the causal diagram [3] and standardization in the counterfactual model [5, 6 ] .F urther”
BackgroundSensitivity Analysis in Non-Inferiority Trials with Residual Inconstancy After Covariate Adjustment
Zhang, Z., Nie, L., Soon, G. G., & Zhang, B. (2014) · Journal of the Royal Statistical Society Series C (Applied Statistics) · doi:10.1111/rssc.12050 · Cited by 4
“It will be of interest to extend the proposed approach to those effect measures with appropriate adjustment for possible non-collapsibility (Gail et al., 1984; Greenland et al., 1999).”
BackgroundModèles structuraux et inférence causale
Juhel, J. (2015) · Presses universitaires de Rennes eBooks · doi:10.4000/books.pur.61649 · Cited by 4
Rothman, K. J., & Greenland, S. (2005) · Springer eBooks · doi:10.1007/978-3-540-26577-1_2 · Cited by 4
Self-citationRothman, K. J., & Greenland, S. (2013) · Springer eBooks · doi:10.1007/978-0-387-09834-0_44 · Cited by 4
Self-citationParametric Potential-Outcome Survival Models for Causal Inference
Gong, Z. (2008) · UC Research Repository (University of Canterbury) · doi:10.26021/1683 · Cited by 4
“The observational study counterpart to noncompliance in randomised studies is the problem of confounding by unobserved covariates, and because the observed study data are uninformative about unobserved covariates, causal inference in the observational study setting can be highly sensitive to prior assumptions about th…”
BackgroundBehavioral Feedback: Do Individual Choices Influence Scientific Results?
Oster, E. F. (2018) · National Bureau of Economic Research · doi:10.3386/w25225 · Cited by 4
“This issue is well-known (e.g. Greenland et al, 1999; Vandenbroucke et al, 2007).”
BackgroundEffect Modification and Collapsibility in Evaluations of Public Health Interventions
Luque-Fernández, M. Á., Redondo‐Sánchez, D., & Schomaker, M. (2019) · American Journal of Public Health · doi:10.2105/ajph.2018.304916 · Cited by 4
Hernán, M. Á. (2019) · Wiley StatsRef: Statistics Reference Online · doi:10.1002/9781118445112.stat03729.pub2 · Cited by 4
Current intelligence bulletin 69: NIOSH practices in occupational risk assessment.
Daniels, R., Gilbert, S., Kuppusamy, S., Kuempel, E., Park, R., Pandalai, S. P., Smith, R. J., Wheeler, M., Whittaker, C., & Schulte, P. (2020) · doi:10.26616/nioshpub2020106 · Cited by 5
“Although Appendix B provides some discussion on specific types of biases that may be encountered, for additional information risk assessors may consult several highly cited articles [Arrighi and Hertz-Picciotto 1994; Delgado-Rodríguez and Llorca 2004; Greenland et al. 1999; Grimes and Schulz 2002; Sackett 1979] and ep…”
BackgroundMatched design for marginal causal effect on restricted mean survival time in observational studies
Lin, Z., Ni, A., & Lü, B. (2023) · Journal of Causal Inference · doi:10.1515/jci-2022-0035 · Cited by 3
“However, the hazard ratio is generally not an appropriate marginal causal effect measure due to its noncollapsibility property [Greenland et al., 1999, Martinussen and Vansteelandt, 2013, Sjölander et al., 2016]. Other effect measures need to be considered to warrant valid marginal causal interpretation for survival d…”
BackgroundInfluentialHade, E. M. (2012) · OhioLink ETD Center (Ohio Library and Information Network) · Cited by 3
Amplification of Bias Due to Exposure Measurement Error
Richardson, D. B., Keil, A. P., & Cole, S. R. (2021) · American Journal of Epidemiology · doi:10.1093/aje/kwab228 · Cited by 3
Hill’s Criterion ‘Experiment’: The Counterfactual Approach in Non-Radiation and Radiation Sciences
Koterov, A. N., Ushenkova, L. N., & Biryukov, A. P. (2021) · Biology Bulletin · doi:10.1134/s1062359021120062 · Cited by 3
“In review publications on the topic and in other documents, it is noted [15, 17, 18, 59, 62, 63] that, for the first time, a counterfactual approach for determining the cause (for various definitions of the cause, see [2]) was proposed by the philosopher D.”
BackgroundRedefining effect modification
Doi, S. A. R., Abdulmajeed, J., & Xu, C. (2022) · Journal of Evidence-Based Medicine · doi:10.1111/jebm.12495 · Cited by 3
Simple Ways to Interpret Effects in Modeling Binary Data
Agresti, A., Tarantola, C., & Varriale, R. (2023) · Statistics for social and behavioral sciences · doi:10.1007/978-3-031-31186-4_5 · Cited by 3
Årnes, A. P., Fjeld, M. K., Stigum, H., Nielsen, C. S., Stubhaug, A., Johansen, A., Hopstock, L. A., Morseth, B., Wilsgaard, T., & Steingrímsdóttir, Ó. A. (2024) · Pain · doi:10.1097/j.pain.0000000000003209 · Cited by 3
Pearce, N. E., & Greenland, S. (2024) · Springer eBooks · doi:10.1007/978-1-4614-6625-3_10-1 · Cited by 3
Self-citationSensitivity Analysis and Bias Analysis
Greenland, S. (2024) · Springer eBooks · doi:10.1007/978-1-4614-6625-3_60-1 · Cited by 3
Self-citation
Metadata
- Authors
- Greenland, S., Pearl, J., & Robins, J. M.
- Venue
- Statistical Science
- Publisher
- Institute of Mathematical Statistics
- Published
- 1999-02-01
- Volume
- 14
- Issue
- 1
- Pages
- 29-46
- ISSN
- 0883-4237 (ISSN-L)
- 2168-8745
- OpenAlex
- W1996016456
- Cited by
- 933
- References
- 108
- Citations by year
- 2026: 43 · 2025: 47 · 2024: 61 · 2023: 53 · 2022: 65 · 2021: 75 · 2020: 48 · 2019: 40 · 2018: 40 · 2017: 36 · 2016: 35 · 2015: 44 · 2014: 52 · 2013: 47 · 2012: 47
- FWCI
- 13.67
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Statistical Science (publishedVersion)
- Project Euclid (Cornell University) (submittedVersion)
- Topics
- Physical Sciences › Mathematics › Statistics and Probability › Advanced Causal Inference Techniques
- Physical Sciences › Mathematics › Statistics and Probability › Statistical Methods in Epidemiology
- Social Sciences › Arts and Humanities › History and Philosophy of Science › Philosophy of Biology and Scientific Explanation
- Keywords
- confounding, collapsibility, counterfactual modeling, causal inference, exchangeability, causal effects, observational studies
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