Transmission of glioblastoma multiforme following bilateral lung transplantation from an affected donor: Case study and review of the literature
Open accessAbstract
Donor-acquired solid organ malignancy is a rare complication of organ transplantation. We report a case of a patient who received bilateral lung transplants for pulmonary fibrosis from a donor with known glioblastoma multiforme (GBM). The lungs, heart, liver, and kidneys were harvested after a lethal intracranial bleed and accepted for transplantation by four centers. An enlarged hilar lymph node sampled at the time of transplant was found to contain GBM. Four months later, the patient developed diffuse interstitial pulmonary infiltrates with mediastinal lymphadenopathy. Lung biopsy confirmed metastatic GBM. The patient died 2 weeks after the diagnosis was established. The patient receiving the donor liver also developed GBM. We present a case study, review of the literature, and suggested interventions to minimize the risk of transmission.
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In a reported case, glioblastoma lung metastases were observed only when lungs from an affected donor were transplanted into an immunosuppressed patient.
“Glioblastoma metastases to the lung were only observed when the lungs of a deceased donor were transplanted into an immunosuppressed patient”
From Metabolic reprogramming and cancer progression (2020) · cites this paper as [101]
That case suggests that glioblastoma can remain dormant indefinitely in immunocompetent hosts.
“suggesting an indefinite period of dormancy in immunocompetent hosts (101).”
From Metabolic reprogramming and cancer progression (2020) · cites this paper as [101]
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Metabolic reprogramming and cancer progression
Faubert, B., Solmonson, A., & DeBerardinis, R. J. (2020) · Science · doi:10.1126/science.aaw5473 · Cited by 2,740 · see citing works
- Authors
- Armanios, M. Y., Grossman, S. A., Yang, S. C., White, B., Perry, A., Burger, P. C., & Orens, J. B.
- Affiliations
- Johns Hopkins University (US)
- Washington University in St. Louis (US)
- University of Maryland, Baltimore (US)
- Corresponding author
- Armanios, Mary Y.
- Venue
- Neuro-Oncology
- Publisher
- Oxford University Press (OUP)
- Published
- 2004-07-01
- Volume
- 6
- Issue
- 3
- Pages
- 259-263
- ISSN
- 1522-8517 (ISSN-L)
- 1523-5866
- PMC
- PMC1871995
- OpenAlex
- W2103036539
- Cited by
- 80
- References
- 21
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 1 · 2023: 2 · 2022: 7 · 2021: 3 · 2020: 4 · 2019: 3 · 2018: 1 · 2017: 4 · 2016: 1 · 2015: 7 · 2014: 9 · 2013: 5 · 2012: 4
- FWCI
- 1.71
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Neuro-Oncology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Organ Donation and Transplantation
- Health Sciences › Medicine › Surgery › Transplantation: Methods and Outcomes
- Health Sciences › Medicine › Genetics › Glioma Diagnosis and Treatment
- Keywords
- glioblastoma, lung transplantation, bilateral lung transplantation, pulmonary fibrosis, hilar lymph node metastasis, mediastinal lymphadenopathy, post-transplant malignancy
- MeSH terms
- Adult, Glioblastoma, Humans, Male, Tissue Donors, Lung Transplantation
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