The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
The Hes gene family: repressors and oscillators that orchestrate embryogenesis
Abstract
Embryogenesis involves orchestrated processes of cell proliferation and differentiation. The mammalian Hes basic helix-loop-helix repressor genes play central roles in these processes by maintaining progenitor cells in an undifferentiated state and by regulating binary cell fate decisions. Hes genes also display an oscillatory expression pattern and control the timing of biological events, such as somite segmentation. Many aspects of Hes expression are regulated by Notch signaling, which mediates cell-cell communication. This primer describes these pleiotropic roles of Hes genes in some developmental processes and aims to clarify the basic mechanism of how gene networks operate in vertebrate embryogenesis.
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Citations
Cites
The cell biology of neurogenesis
Götz, M., & Huttner, W. B. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1739 · Cited by 2,130
Oscillations in NF-κB Signaling Control the Dynamics of Gene Expression
Nelson, D. E., Ihekwaba, A. E. C., Elliott, M., Johnson, J. R., Gibney, C. A., Foreman, B. E., Nelson, G., See, V., Horton, C. A., Spiller, D. G., et al. (2004) · Science · doi:10.1126/science.1099962 · Cited by 1,186
The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors
Kawaguchi, Y., Cooper, B., Gannon, M., Ray, M., MacDonald, R. J., & Wright, C. V. E. (2002) · Nature Genetics · doi:10.1038/ng959 · Cited by 1,007 · cited 1×
“4A) (Krapp et al., 1998; Gradwohl et al., 2000; Kawaguchi et al., 2002).”
Takke, C., Dornseifer, P., Weizsäcker, E. V., & Campos-Ortega, J. A. (1999) · Development · doi:10.1242/dev.126.9.1811 · Cited by 192
Cited by
Imayoshi, I., Sakamoto, M., Yamaguchi, M., Mori, K., & Kageyama, R. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.4987-09.2010 · Cited by 716
Self-citationDurand, A., Donahue, B., Peignon, G., Letourneur, F., Cagnard, N., Slomianny, C., Perret, C., Shroyer, N. F., & Romagnolo, B. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1201652109 · Cited by 323
Maladaptive regeneration - the reawakening of developmental pathways in NASH and fibrosis
Zhu, C., Tabas, I., Schwabe, R. F., & Pajvani, U. B. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-020-00365-6 · Cited by 112
Sagner, A., Gaber, Z. B., Delile, J., Kong, J. H., Rousso, D. L., Pearson, C. A., Weicksel, S. E., Melchionda, M., Mousavy Gharavy, S. N., Briscoe, J., et al. (2018) · PLoS Biology · doi:10.1371/journal.pbio.2003127 · Cited by 96
Mammalian Transcription Factor Networks: Recent Advances in Interrogating Biological Complexity
Wilkinson, A. C., Nakauchi, H., & Göttgens, B. (2017) · Cell Systems · doi:10.1016/j.cels.2017.07.004 · Cited by 76
Metadata
- Authors
- Kageyama, R., Ohtsuka, T., & Kobayashi, T.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2007-04-01
- Volume
- 134
- Issue
- 7
- Pages
- 1243-1251
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2098272219
- Cited by
- 644
- References
- 4
- FWCI
- 13.41
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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