her4 , a zebrafish homologue of the Drosophila neurogenic gene E(spl) , is a target of NOTCH signalling
Abstract
her4 encodes a zebrafish bHLH protein of the HAIRY-E(SPL) family. The gene is transcribed in a complex pattern in the developing nervous system and in the hypoblast. During early neurogenesis, her4 expression domains include the regions of the neural plate from which primary neurons arise, suggesting that the gene is involved in directing their development. Indeed, misexpression of specific her4 variants leads to a reduction in the number of primary neurons formed. The amino-terminal region of HER4, including the basic domain, and the region between the putative helix IV and the carboxy-terminal tetrapeptide WRPW are essential for this effect, since HER4 variants lacking either of these regions are non-functional. However, the carboxy-terminal WRPW itself is dispensable. We have examined the interrelationships between deltaD, deltaA, notch1, her4 and neurogenin1 by means of RNA injections. her4 is involved in a regulatory feedback loop which modulates the activity of the proneural gene neurogenin, and as a consequence, of deltaA and deltaD. Activation of notch1 leads to strong activation of her4, to suppression of neurogenin transcription and, ultimately, to a reduction in the number of primary neurons. These results suggest that her4 acts as a target of notch-mediated signals that regulate primary neurogenesis.
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her4 is a Notch target, so her4 promoter activity can report Notch signaling.
“The her4 gene is a downstream target of Notch; thus her4 promoter activity can serve as a probe for Notch signaling”
From HB-EGF is Necessary and Sufficient for Müller Glia Dedifferentiation and Retina Regeneration (2012) · cites this paper as Takke et al., 1999
Cites
Stages of embryonic development of the zebrafish
Kimmel, C. B., Ballard, W. W., Kimmel, S. R., Ullmann, B., & Schilling, T. F. (1995) · Developmental Dynamics · doi:10.1002/aja.1002030302 · Cited by 12,037 · see citing works
Murre, C., Page-McCaw, P., Vaessin, H., Caudy, M. A., Jan, L. Y., Jan, Y. N., Cabrera, C. V., Buskin, J. N., Hauschka, S. D., Lassar, A. B., et al. (1989) · Cell · doi:10.1016/0092-8674(89)90434-0 · Cited by 1,815 · see citing works
Expression of achaete-scute homolog 3 in Xenopus embryos converts ectodermal cells to a neural fate.Preprint
Turner, D. L., & Weintraub, H. (1994) · Genes & Development · doi:10.1101/gad.8.12.1434 · Cited by 1,023 · see citing works
Palmeirim, I., Henrique, D., Ish‐Horowicz, D., & Pourquié, O. (1997) · Cell · doi:10.1016/s0092-8674(00)80451-1 · Cited by 951 · see citing works
Identification of neurogenin, a vertebrate neuronal determination gene.
Ma, Q.-F., Kintner, C., & Anderson, D. J. (1996) · Cell · doi:10.1016/s0092-8674(00)81321-5 · Cited by 874 · see citing works
The choice of cell fate in the epidermis of Drosophila
Heitzler, P., & Simpson, P. (1991) · Cell · doi:10.1016/0092-8674(91)90263-x · Cited by 750 · see citing works
Chitnis, A. B., Henrique, D., Lewis, J. H., Ish‐Horowicz, D., & Kintner, C. R. (1995) · Nature · doi:10.1038/375761a0 · Cited by 675 · see citing works
Identification of separate slow and fast muscle precursor cells in vivo, prior to somite formation
Devoto, S. H., Melançon, E., Eisen, J. S., & Westerfield, M. (1996) · Development · doi:10.1242/dev.122.11.3371 · Cited by 667 · see citing works
Sasai, Y., Kageyama, R., Tagawa, Y., Shigemoto, R., & Nakanishi, S. (1992) · Genes & Development · doi:10.1101/gad.6.12b.2620 · Cited by 665 · see citing works
Bailey, A. M., & Posakony, J. W. (1995) · Genes & Development · doi:10.1101/gad.9.21.2609 · Cited by 592 · see citing works
LIN-12/Notch signaling: lessons from worms and fliesPreprint
Greenwald, I. (1998) · Genes & Development · doi:10.1101/gad.12.12.1751 · Cited by 541 · see citing works
On the phenotype and development of mutants of early neurogenesis inDrosophila melanogaster
Lehmann, R., Jim�nez, F., Dietrich, U., & Campos-Ortega, J. A. (1983) · Development Genes and Evolution · doi:10.1007/bf00848482 · Cited by 494 · see citing works
Self-citationIntrinsic activity of the lin-12 and Notch intracellular domains in vivo
Struhl, G., Fitzgerald, K. J., & Greenwald, I. (1993) · Cell · doi:10.1016/0092-8674(93)90424-o · Cited by 466 · see citing works
Henrique, D., Hirsinger, E., Adam, J., Roux, I., Pourquié, O., Ish‐Horowicz, D., & Lewis, J. H. (1997) · Current Biology · doi:10.1016/s0960-9822(06)00293-4 · Cited by 431 · see citing works
Lecourtois, M., & Schweisguth, F. (1995) · Genes & Development · doi:10.1101/gad.9.21.2598 · Cited by 430 · see citing works
Lieber, T., Kidd, S., Alcamo, E., Corbin, V., & Young, M. W. (1993) · Genes & Development · doi:10.1101/gad.7.10.1949 · Cited by 421 · see citing works
Rebay, I., Fehon, R. G., & Artavanis‐Tsakonas, S. (1993) · Cell · doi:10.1016/0092-8674(93)90423-n · Cited by 413 · see citing works
Expression of an extracellular deletion of Xotch diverts cell fate in Xenopus embryos
Coffman, C. R., Skoglund, P., Harris, W. A., & Kintner, C. R. (1993) · Cell · doi:10.1016/0092-8674(93)90247-n · Cited by 369 · see citing works
Fisher, A. L., Ohsako, S., & Caudy, M. A. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.6.2670 · Cited by 353 · see citing works
Heitzler, P., Bourouis, M., Ruel, L., Carteret, C., & Simpson, P. (1996) · Development · doi:10.1242/dev.122.1.161 · Cited by 334 · see citing works
Zebrafish elav/HuC homologue as a very early neuronal marker
Kim, C., Ueshima, E., Muraoka, O., Tanaka, H., Yeo, S., Huh, T., & Miki, N. (1996) · Neuroscience Letters · doi:10.1016/0304-3940(96)13021-4 · Cited by 317 · see citing works
Akazawa, C., Sasai, Y., Nakanishi, S., & Kageyama, R. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)36694-3 · Cited by 299 · see citing works
Hinz, U., Giebel, B., & Campos‐Ortega, J. A. (1994) · Cell · doi:10.1016/0092-8674(94)90174-0 · Cited by 299 · see citing works
Self-citationWettstein, D. A., Turner, D. L., & Kintner, C. R. (1997) · Development · doi:10.1242/dev.124.3.693 · Cited by 287 · see citing works
Multiple delta genes and lateral inhibition in zebrafish primary neurogenesis
Haddon, C., Smithers, L. E., Schneider‐Maunoury, S., Coche, T. G., Henrique, D., & Lewis, J. H. (1998) · Development · doi:10.1242/dev.125.3.359 · Cited by 266 · see citing works
Klämbt, C., Knust, E., Tietze, K., & Campos‐Ortega, J. A. (1989) · The EMBO Journal · doi:10.1002/j.1460-2075.1989.tb03365.x · Cited by 264 · see citing works
Self-citationKorzh, V. P., Edlund, H., & Thor, S. (1993) · Development · doi:10.1242/dev.118.2.417 · Cited by 250 · see citing works
The activity of Neurogenin1 is controlled by local cues in the zebrafish embryo
Blader, P., Fischer, N., Gradwohl, G., Guillemot, F., & Strähle, U. (1997) · Development · doi:10.1242/dev.124.22.4557 · Cited by 243 · see citing works
Rushlow, C., Hogan, A., Pinchin, S. M., Howe, K. M., Lardelli, M. T., & Ish‐Horowicz, D. (1989) · The EMBO Journal · doi:10.1002/j.1460-2075.1989.tb08461.x · Cited by 240 · see citing works
Bier, E., Vaessin, H., Younger, S. H., Jan, L. Y., & Jan, Y. N. (1992) · Genes & Development · doi:10.1101/gad.6.11.2137 · Cited by 239 · see citing works
Inoue, A., Takahashi, M., Hatta, K., Hotta, Y., & Okamoto, H. (1994) · Developmental Dynamics · doi:10.1002/aja.1001990102 · Cited by 232 · see citing works
Dawson, S. R., Turner, D. L., Weintraub, H. M., & Parkhurst, S. M. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.12.6923 · Cited by 221 · see citing works
Knust, E., Schrons, H., Grawe, F., & Campos‐Ortega, J. A. (1992) · Genetics · doi:10.1093/genetics/132.2.505 · Cited by 216 · see citing works
Self-citationChitnis, A. B., & Kintner, C. R. (1996) · Development · doi:10.1242/dev.122.7.2295 · Cited by 178 · see citing works
Delidakis, C., & Artavanis‐Tsakonas, S. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.18.8731 · Cited by 174 · see citing works
Müller, M., Weizsäcker, E. V., & Campos‐Ortega, J. A. (1996) · Development · doi:10.1242/dev.122.7.2071 · Cited by 163 · see citing works
Self-citationKunisch, M., Haenlin, M., & Campos‐Ortega, J. A. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.21.10139 · Cited by 159 · see citing works
Self-citationFunctional interactions of neurogenic genes of Drosophila melanogaster.
de la Concha, A., Dietrich, U., Weigel, D., & Campos‐Ortega, J. A. (1988) · Genetics · doi:10.1093/genetics/118.3.499 · Cited by 158 · see citing works
Self-citationRegulation of neuronal specification in the zebrafish spinal cord by Delta function
Appel, B., & Eisen, J. S. (1998) · Development · doi:10.1242/dev.125.3.371 · Cited by 156 · see citing works
Bierkamp, C., & Campos‐Ortega, J. A. (1993) · Mechanisms of Development · doi:10.1016/0925-4773(93)90027-u · Cited by 148 · see citing works
Self-citationThree novel Notch genes in zebrafish: implications for vertebrate Notch gene evolution and function
Westin, J., & Lardelli, M. (1997) · Development Genes and Evolution · doi:10.1007/s004270050091 · Cited by 134 · see citing works
Dornseifer, P., Takke, C., & Campos‐Ortega, J. A. (1997) · Mechanisms of Development · doi:10.1016/s0925-4773(97)00037-3 · Cited by 134 · see citing works
Self-citationNakao, K., & Campos‐Ortega, J. A. (1996) · Neuron · doi:10.1016/s0896-6273(00)80046-x · Cited by 130 · see citing works
Self-citationSingson, A. W., Leviten, M. W., Bang, A. G., Hua, X. H., & Posakony, J. W. (1994) · Genes & Development · doi:10.1101/gad.8.17.2058 · Cited by 120 · see citing works
Molecular analysis of the neurogenic locus Enhancer of split of Drosophila melanogaster
Knust, E., Tietze, K., & Campos‐Ortega, J. A. (1987) · The EMBO Journal · doi:10.1002/j.1460-2075.1987.tb02757.x · Cited by 119 · see citing works
Self-citationTietze, K., Oellers, N., & Knust, E. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.13.6152 · Cited by 113 · see citing works
Oellers, N., Dehio, M., & Knust, E. (1994) · Molecular and General Genetics MGG · doi:10.1007/bf00583897 · Cited by 111 · see citing works
Cell autonomy of expression of neurogenic genes of Drosophila melanogaster.
Technau, G. M., & Campos‐Ortega, J. A. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.13.4500 · Cited by 107 · see citing works
Self-citationEvolutionarily Conserved Sequences of Striated Muscle Myosin Heavy Chain Isoforms
Miller, J. B., Teal, S., & Stockdale, F. E. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)51604-5 · Cited by 83 · see citing works
Kramatschek, B., & Campos‐Ortega, J. A. (1994) · Development · doi:10.1242/dev.120.4.815 · Cited by 80 · see citing works
Self-citationFunctional dissection of the Drosophila Enhancer of split protein, a suppressor of neurogenesis
Giebel, B., & Campos‐Ortega, J. A. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.12.6250 · Cited by 76 · see citing works
Self-citationWainwright, S. M., & Ish‐Horowicz, D. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.6.2475 · Cited by 75 · see citing works
Notch-related genes in animal development
Lardelli, M., Williams, R. T. P., & Lendahl, U. (1995) · The International Journal of Developmental Biology · doi:10.1387/ijdb.8645561 · Cited by 57 · see citing works
Inhibition of cell fate in Drosophila by Enhancer of split genes
Tata, F., & Hartley, D. A. (1995) · Mechanisms of Development · doi:10.1016/0925-4773(95)00377-0 · Cited by 53 · see citing works
Genomic regions regulating early embryonic expression of the Drosophila neurogenic gene Delta
Haenlin, M., Kunisch, M., Kramatschek, B., & Campos‐Ortega, J. A. (1994) · Mechanisms of Development · doi:10.1016/0925-4773(94)90099-x · Cited by 46 · see citing works
Self-citationMüller, M., Weizsäcker, E. V., & Campos‐Ortega, J. A. (1996) · Development Genes and Evolution · doi:10.1007/s004270050041 · Cited by 42 · see citing works
Self-citationA zebrafish Id homologue and its pattern of expression during embryogenesis
Sawai, S., & Campos‐Ortega, J. A. (1997) · Mechanisms of Development · doi:10.1016/s0925-4773(97)00071-3 · Cited by 28 · see citing works
Self-citationWülbeck, C., Fromental-Ramain, C., & Campos‐Ortega, J. A. (1994) · Mechanisms of Development · doi:10.1016/0925-4773(94)90077-9 · Cited by 24 · see citing works
Self-citationWülbeck, C., & Campos‐Ortega, J. A. (1997) · Development Genes and Evolution · doi:10.1007/s004270050103 · Cited by 23 · see citing works
Self-citationMüller, G. B., Streicher, J., & Müller, R. J. (1996) · Development Genes and Evolution · doi:10.1007/s004270050062 · Cited by 22 · see citing works
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HES and HERP families: Multiple effectors of the notch signaling pathway
Iso, T., Kedes, L., & Hamamori, Y. (2003) · Journal of Cellular Physiology · doi:10.1002/jcp.10208 · Cited by 1,240 · see citing works
Lawson, N. D., Scheer, N., Pham, V. N., Kim, C., Chitnis, A. B., Campos‐Ortega, J. A., & Weinstein, B. M. (2001) · Development · doi:10.1242/dev.128.19.3675 · Cited by 915 · see citing works
Self-citationItoh, M., Kim, C., Palardy, G. R., Oda, T., Jiang, Y., Maust, D. T., Yeo, S., Lorick, K. L., Wright, G. J., Ariza‐McNaughton, L., et al. (2003) · Developmental Cell · doi:10.1016/s1534-5807(02)00409-4 · Cited by 779 · see citing works
The Hes gene family: repressors and oscillators that orchestrate embryogenesis
Kageyama, R., Ohtsuka, T., & Kobayashi, T. (2007) · Development · doi:10.1242/dev.000786 · Cited by 683 · see citing works
Geling, A., Steiner, H., Willem, M., Bally‐Cuif, L., & Haass, C. (2002) · The EMBO Reports · doi:10.1093/embo-reports/kvf124 · Cited by 497 · see citing works
Regeneration of the adult zebrafish brain from neurogenic radial glia-type progenitors
Kroehne, V., Freudenreich, D., Hans, S., Kaslin, J., & Brand, M. (2011) · Development · doi:10.1242/dev.072587 · Cited by 448 · see citing works
Davis, R. L., & Turner, D. L. (2001) · Oncogene · doi:10.1038/sj.onc.1205094 · Cited by 387 · see citing works
Neurogenesis in zebrafish – from embryo to adult
Viales, R. R., Strähle, U., & Scholpp, S. (2013) · Neural Development · doi:10.1186/1749-8104-8-3 · Cited by 374 · see citing works
Adult neurogenesis and brain regeneration in zebrafish
Kızıl, Ç., Kaslin, J., Kroehne, V., & Brand, M. (2011) · Developmental Neurobiology · doi:10.1002/dneu.20918 · Cited by 346 · see citing works
Regulation of Neurogenesis by Interkinetic Nuclear Migration through an Apical-Basal Notch Gradient
Bene, F. D., Wehman, A. M., Link, B. A., & Baier, H. (2008) · Cell · doi:10.1016/j.cell.2008.07.017 · Cited by 339 · see citing works
Robb, L. G., Hartley, L., Begley, C. G., Brodnicki, T. C., Copeland, N. G., Gilbert, D. J., Jenkins, N. A., & Elefanty, A. G. (2000) · Developmental Dynamics · doi:10.1002/1097-0177(2000)9999:9999 · Cited by 78 · see citing works
Nakagawa, O., Nakagawa, M., Richardson, J. A., Olson, E. N., & Srivastava, D. (1999) · Developmental Biology · doi:10.1006/dbio.1999.9454 · Cited by 282 · see citing works
HB-EGF is Necessary and Sufficient for Müller Glia Dedifferentiation and Retina Regeneration
Wan, J., Ramachandran, R., & Goldman, D. (2012) · Developmental Cell · doi:10.1016/j.devcel.2011.11.020 · Cited by 262 · see citing works
Chapouton, P., Skupien, P., Hesl, B., Coolen, M., Moore, J. C., Madelaine, R., Kremmer, E., Faus-Kessler, T., Blader, P., Lawson, N. D., et al. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.6170-09.2010 · Cited by 259 · see citing works
Notch signaling regulates cardiomyocyte proliferation during zebrafish heart regeneration
Zhao, L., Borikova, A. L., Ben-Yair, R., Guner‐Ataman, B., MacRae, C. A., Lee, R. T., Burns, C. G., & Burns, C. E. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1311705111 · Cited by 255 · see citing works
An instructive function for Notch in promoting gliogenesis in the zebrafish retina
Scheer, N., Groth, A., Hans, S., & Campos‐Ortega, J. A. (2001) · Development · doi:10.1242/dev.128.7.1099 · Cited by 245 · see citing works
Self-citationHERP, a Novel Heterodimer Partner of HES/E(spl) in Notch Signaling
Iso, T., Sartorelli, V., Poizat, C. I., Iezzi, S., Wu, H., Chung, G., Kedes, L., & Hamamori, Y. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.17.6080-6089.2001 · Cited by 217 · see citing works
HERP, a New Primary Target of Notch Regulated by Ligand Binding
Iso, T., Sartorelli, V., Chung, G., Shichinohe, T., Kedes, L., & Hamamori, Y. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.17.6071-6079.2001 · Cited by 191 · see citing works
Nrarp is a novel intracellular component of the Notch signaling pathwayPreprint
Lamar, E., Deblandre, G. A., Wettstein, D. A., Gawantka, V., Pollet, N., Niehrs, C., & Kintner, C. R. (2001) · Genes & Development · doi:10.1101/gad.908101 · Cited by 188 · see citing works
Cornell, R. A., & Eisen, J. S. (2002) · Development · doi:10.1242/dev.129.11.2639 · Cited by 185 · see citing works
Özbudak, E. M., & Lewis, J. H. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.0040015 · Cited by 167 · see citing works
Multiple roles for Gata5 in zebrafish endoderm formation
Reiter, J. F., Kikuchi, Y., & Stainier, D. Y. R. (2001) · Development · doi:10.1242/dev.128.1.125 · Cited by 172 · see citing works
Henry, C. A., Urban, M. K., Dill, K. K., Merlie, J. P., Page, M. F., Kimmel, C. B., & Amacher, S. L. (2002) · Development · doi:10.1242/dev.129.15.3693 · Cited by 164 · see citing works
Pasini, A., Amiel, A., Rothbächer, U., Roure, A., Lemaire, P., & Darras, S. (2006) · PLoS Biology · doi:10.1371/journal.pbio.0040225 · Cited by 152 · see citing works
Yeo, S., Kim, M., Kim, H.-S., Huh, T., & Chitnis, A. B. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2006.10.020 · Cited by 154 · see citing works
Takke, C., & Campos‐Ortega, J. A. (1999) · Development · doi:10.1242/dev.126.13.3005 · Cited by 153 · see citing works
Self-citationHes6 acts in a positive feedback loop with the neurogenins to promote neuronal differentiation
Koyano‐Nakagawa, N., Kim, J., Anderson, D. J., & Kintner, C. R. (2000) · Development · doi:10.1242/dev.127.19.4203 · Cited by 149 · see citing works
Itoh, M., & Chitnis, A. B. (2001) · Mechanisms of Development · doi:10.1016/s0925-4773(01)00308-2 · Cited by 143 · see citing works
Cheng, Y., Amoyel, M., Qiu, X., Jiang, Y., Xu, Q., & Wilkinson, D. G. (2004) · Developmental Cell · doi:10.1016/s1534-5807(04)00097-8 · Cited by 141 · see citing works
Kokubo, H., Lun, Y., & Johnson, R. L. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.0880 · Cited by 139 · see citing works
Alunni, A., Krecsmarik, M., Bosco, A., Galant, S., Pan, L., Moens, C. B., & Bally‐Cuif, L. (2013) · Development · doi:10.1242/dev.095018 · Cited by 135 · see citing works
Jagged2a-Notch Signaling Mediates Cell Fate Choice in the Zebrafish Pronephric Duct
Ma, M., & Jiang, Y. (2007) · PLoS Genetics · doi:10.1371/journal.pgen.0030018 · Cited by 134 · see citing works
Wu, Y.-Y., Liu, Y., Levine, E., & Rao, M. S. (2003) · Developmental Dynamics · doi:10.1002/dvdy.10278 · Cited by 138 · see citing works
Ishitani, T., Hirao, T., Suzuki, M., Isoda, M., Ishitani, S., Harigaya, K., Kitagawa, M., Matsumoto, K., & Itoh, M. (2010) · Nature Cell Biology · doi:10.1038/ncb2028 · Cited by 131 · see citing works
Notch signalling regulates left-right asymmetry through ciliary length control
Lopes, S. S., Lourenço, R., Pacheco, L. G. C. A., Moreno, N., Kreiling, J. A., & Saúde, L. (2010) · Development · doi:10.1242/dev.054452 · Cited by 126 · see citing works
The genetics and embryology of zebrafish metamerism
Holley, S. A. (2007) · Developmental Dynamics · doi:10.1002/dvdy.21162 · Cited by 123 · see citing works
Bernardos, R. L., Lentz, S. I., Wolfe, M. S., & Raymond, P. A. (2004) · Developmental Biology · doi:10.1016/j.ydbio.2004.11.018 · Cited by 117 · see citing works
Notch activity in the nervous system: to switch or not switch?
Cau, E., & Blader, P. (2009) · Neural Development · doi:10.1186/1749-8104-4-36 · Cited by 109 · see citing works
Cunliffe, V. T. (2004) · Development · doi:10.1242/dev.01166 · Cited by 111 · see citing works
Kim, H., Shin, J., Kim, S., Poling, J., Park, H., & Appel, B. (2008) · Developmental Dynamics · doi:10.1002/dvdy.21620 · Cited by 99 · see citing works
Basal body proteins regulate Notch signaling via endosomal trafficking
Leitch, C. C., Lodh, S., Prieto-Echagüe, V., Badano, J. L., & Zaghloul, N. A. (2014) · Journal of Cell Science · doi:10.1242/jcs.130344 · Cited by 98 · see citing works
Ciliopathy proteins regulate paracrine signaling by modulating proteasomal degradation of mediators
Liu, Y. P., Tsai, I.-C., Morleo, M., Oh, E. C. T., Leitch, C. C., Massa, F., Lee, B., Parker, D. S., Finley, D. J., Zaghloul, N. A., et al. (2014) · Journal of Clinical Investigation · doi:10.1172/jci71898 · Cited by 94 · see citing works
Diotel, N., Lübke, L., Strähle, U., & Rastegar, S. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.568930 · Cited by 93 · see citing works
Than‐Trong, E., Ortica, S., Mella, S., Nepal, C., Alunni, A., & Bally‐Cuif, L. (2018) · Development · doi:10.1242/dev.161034 · Cited by 88 · see citing works
Ohata, S., Aoki, R., Kinoshita, S., Yamaguchi, M., Tsuruoka-Kinoshita, S., Tanaka, H., Wada, H., Watabe, S., Tsuboi, T., Masai, I., et al. (2011) · Neuron · doi:10.1016/j.neuron.2010.12.026 · Cited by 92 · see citing works
Aday, A. W., Zhu, L. J., Lakshmanan, A., Wang, J., & Lawson, N. D. (2011) · Developmental Biology · doi:10.1016/j.ydbio.2011.03.007 · Cited by 90 · see citing works
Yamamoto, M., Morita, R., Mizoguchi, T., Matsuo, H., Isoda, M., Ishitani, T., Chitnis, A. B., Matsumoto, K., Crump, J. G., Hozumi, K., et al. (2010) · Development · doi:10.1242/dev.051011 · Cited by 90 · see citing works
Nrarp functions to modulate neural-crest-cell differentiation by regulating LEF1 protein stability
Ishitani, T., Matsumoto, K., Chitnis, A. B., & Itoh, M. (2005) · Nature Cell Biology · doi:10.1038/ncb1311 · Cited by 89 · see citing works
Geling, A., Itoh, M., Tallafuß, A., Chapouton, P., Tannhäuser, B., Kuwada, J. Y., Chitnis, A. B., & Bally‐Cuif, L. (2003) · Development · doi:10.1242/dev.00375 · Cited by 87 · see citing works
Shin, J., Poling, J., Park, H., & Appel, B. (2007) · Development · doi:10.1242/dev.001602 · Cited by 87 · see citing works
Sequence and embryonic expression of deltaC in the zebrafish
Smithers, L. E., Haddon, C., Jiang, Y., & Lewis, J. H. (2000) · Mechanisms of Development · doi:10.1016/s0925-4773(99)00231-2 · Cited by 86 · see citing works
Holland, L. Z., Schubert, M., Holland, N. D., & Neuman, T. (2000) · Developmental Biology · doi:10.1006/dbio.2000.9810 · Cited by 86 · see citing works
her5expression reveals a pool of neural stem cells in the adult zebrafish midbrain
Chapouton, P., Adolf, B., Leucht, C., Tannhäuser, B., Ryu, S., Driever, W., & Bally‐Cuif, L. (2006) · Development · doi:10.1242/dev.02573 · Cited by 84 · see citing works
Matsuda, M., & Chitnis, A. B. (2010) · Development · doi:10.1242/dev.052761 · Cited by 81 · see citing works
Bae, Y., Shimizu, T., & Hibi, M. (2005) · Development · doi:10.1242/dev.01710 · Cited by 79 · see citing works
Scheer, N., Riedl, I., Warren, J. T., Kuwada, J. Y., & Campos‐Ortega, J. A. (2002) · Mechanisms of Development · doi:10.1016/s0925-4773(01)00621-9 · Cited by 75 · see citing works
Self-citationChapouton, P., Webb, K. J., Stigloher, C., Alunni, A., Adolf, B., Hesl, B., Topp, S., Kremmer, E., & Bally‐Cuif, L. (2011) · The Journal of Comparative Neurology · doi:10.1002/cne.22599 · Cited by 73 · see citing works
Koyano‐Nakagawa, N., Wettstein, D. A., & Kintner, C. R. (1999) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.1999.0783 · Cited by 73 · see citing works
Genome-wide loss-of-function analysis of deubiquitylating enzymes for zebrafish development
Tse, W. K. F., Eisenhaber, B., Ho, S. H., Ng, Q., Eisenhaber, F., & Jiang, Y. (2009) · BMC Genomics · doi:10.1186/1471-2164-10-637 · Cited by 72 · see citing works
Geling, A., Plessy, C., Rastegar, S., Strähle, U., & Bally‐Cuif, L. (2004) · Development · doi:10.1242/dev.01093 · Cited by 71 · see citing works
Mutations in FAM50A suggest that Armfield XLID syndrome is a spliceosomopathy
Lee, Y., Khan, K., Uhas, K. A., Srikanth, S., Thompson, N., Pardo, M., Yu, L., Norris, J. W., Peng, Y., Gripp, K. W., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-17452-6 · Cited by 71 · see citing works
Kaur, S. J., Gupta, S., Chaudhary, M., Khursheed, M. A., Mitra, S., Kurup, A. J., & Ramachandran, R. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.04.002 · Cited by 66 · see citing works
Kawamura, A., Koshida, S., & Takada, S. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.01754-07 · Cited by 67 · see citing works
Thatcher, E. J., Flynt, A. S., Li, N., Patton, J. R., & Patton, J. G. (2007) · Developmental Dynamics · doi:10.1002/dvdy.21211 · Cited by 66 · see citing works
Chen, W., & Corliss, D. C. (2004) · Developmental Biology · doi:10.1016/j.ydbio.2003.11.010 · Cited by 65 · see citing works
her3, a zebrafish member of thehairy-E(spl)family, is repressed by Notch signalling
Hans, S., Scheer, N., Riedl, I., Weizsäcker, E. V., Blader, P., & Campos‐Ortega, J. A. (2004) · Development · doi:10.1242/dev.01167 · Cited by 64 · see citing works
Self-citationInteraction with Notch determines endocytosis of specific Delta ligands in zebrafish neural tissue
Matsuda, M., & Chitnis, A. B. (2008) · Development · doi:10.1242/dev.027938 · Cited by 59 · see citing works
Lamar, E., Kintner, C. R., & Goulding, M. (2001) · Development · doi:10.1242/dev.128.8.1335 · Cited by 59 · see citing works
Her9 represses neurogenic fate downstream of Tbx1 and retinoic acid signaling in the inner ear
Radosevic, M., Robert‐Moreno, A., Coolen, M., Bally‐Cuif, L., & Alsina, B. (2011) · Development · doi:10.1242/dev.056093 · Cited by 56 · see citing works
Lunatic fringe promotes the lateral inhibition of neurogenesis
Nikolaou, N., Watanabe‐Asaka, T., Gerety, S. S., Distel, M., Köster, R. W., & Wilkinson, D. G. (2009) · Development · doi:10.1242/dev.034736 · Cited by 57 · see citing works
Katz, S., Cussigh, D., Urbán, N., Blomfield, I. M., Guillemot, F., Bally‐Cuif, L., & Coolen, M. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.09.088 · Cited by 53 · see citing works
Leve, C., Gajewski, M., Rohr, K. B., & Tautz, D. (2001) · Development Genes and Evolution · doi:10.1007/s00427-001-0181-4 · Cited by 55 · see citing works
Delta-Notch signaling induces hypochord development in zebrafish
Latimer, A. J., Dong, X., Markov, Y., & Appel, B. (2002) · Development · doi:10.1242/dev.129.11.2555 · Cited by 53 · see citing works
Zhang, C., Li, Q., Lim, C.-H., Qiu, X., & Jiang, Y. (2007) · Developmental Biology · doi:10.1016/j.ydbio.2007.01.034 · Cited by 52 · see citing works
Nornes, S., Newman, M., Verdile, G., Wells, S., Stoick-Cooper, C. L., Tucker, B., Frederich-Sleptsova, I., Martins, R. N., & Lardelli, M. T. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm317 · Cited by 51 · see citing works
Patterning and cell fate in the inner ear: a case for N otch in the chicken embryo
Neves, J., Abelló, G., Petrovic, J., & Giráldez, F. (2012) · Development Growth & Differentiation · doi:10.1111/dgd.12016 · Cited by 50 · see citing works
Notch signaling regulates midline cell specification and proliferation in zebrafish
Latimer, A. J., & Appel, B. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2006.05.039 · Cited by 50 · see citing works
Galant, S., Furlan, G., Coolen, M., Dirian, L., Foucher, I., & Bally‐Cuif, L. (2016) · Developmental Biology · doi:10.1016/j.ydbio.2016.09.022 · Cited by 50 · see citing works
Shankaran, S. S., Sieger, D., Schröter, C. J., Czepe, C., Pauly, M.-C., Laplante, M. A., Becker, T. S., Oates, A. C., & Gajewski, M. (2007) · Developmental Biology · doi:10.1016/j.ydbio.2007.01.004 · Cited by 50 · see citing works
Characterization of expanded intermediate cell mass in zebrafish chordin morphant embryos
Leung, A. Y. H., Mendenhall, E. M., Kwan, T. T. F., Liang, R., Eckfeldt, C. E., Chen, E. Y., Hammerschmidt, M., Grindley, S., Ekker, S. C., & Verfaillie, C. M. (2004) · Developmental Biology · doi:10.1016/j.ydbio.2004.09.032 · Cited by 50 · see citing works
Holland, L. Z., Abi‐Rached, L., Tamme, R., Holland, N. D., Inoko, H., Shiina, T., Burgtorf, C., & Lardelli, M. T. (2001) · Developmental Biology · doi:10.1006/dbio.2001.0160 · Cited by 49 · see citing works
Notch signaling can regulate endoderm formation in zebrafish
Kikuchi, Y., Verkade, H. M., Reiter, J. F., Kim, C., Chitnis, A. B., Kuroiwa, A., & Stainier, D. Y. R. (2004) · Developmental Dynamics · doi:10.1002/dvdy.10483 · Cited by 49 · see citing works
Mecp2 regulates neural cell differentiation by suppressing the Id1 to Her2 axis in zebrafish
Gao, H. F., Bu, Y., Wu, Q., Wang, X., Chang, N., Lei, L., Chen, S., Liu, D. N., Zhu, X., Hu, K., et al. (2015) · Journal of Cell Science · doi:10.1242/jcs.167874 · Cited by 48 · see citing works
Perineurial Glia Require Notch Signaling during Motor Nerve Development but Not Regeneration
Binari, L. A., Lewis, G. M., & Kucenas, S. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.4893-12.2013 · Cited by 48 · see citing works
Identification of neural progenitor pools by E(Spl) factors in the embryonic and adult brain
Stigloher, C., Chapouton, P., Adolf, B., & Bally‐Cuif, L. (2007) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2007.10.032 · Cited by 48 · see citing works
Pasini, A., Jiang, Y., & Wilkinson, D. G. (2004) · Development · doi:10.1242/dev.01031 · Cited by 46 · see citing works
Notch Signaling Can Inhibit Xath5 Function in the Neural Plate and Developing Retina
Schneider, M. L., Turner, D. L., & Vetter, M. L. (2001) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.2001.1040 · Cited by 45 · see citing works
Bally-Cuif, L., Goutel, C., Wassef, M., Wurst, W., & Rosa, F. (2000) · Genes & Development · doi:10.1101/gad.14.13.1664 · Cited by 45 · see citing works
Specification and positioning of the anterior neuroectoderm in deuterostome embryos
Range, R. (2014) · genesis · doi:10.1002/dvg.22759 · Cited by 43 · see citing works
her11 is involved in the somitogenesis clock in zebrafish
Sieger, D., Tautz, D., & Gajewski, M. (2004) · Development Genes and Evolution · doi:10.1007/s00427-004-0427-z · Cited by 43 · see citing works
Antagonizing Activity of Chick Grg4 against Tectum-Organizing Activity
Sugiyama, S., Funahashi, J., & Nakamura, H. (2000) · Developmental Biology · doi:10.1006/dbio.2000.9643 · Cited by 41 · see citing works
Ohata, S., Kinoshita, S., Aoki, R., Tanaka, H., Wada, H., Tsuruoka-Kinoshita, S., Tsuboi, T., Watabe, S., & Okamoto, H. (2009) · Development · doi:10.1242/dev.033290 · Cited by 40 · see citing works
notch3 is essential for oligodendrocyte development and vascular integrity in zebrafish
Zaucker, A., Mercurio, S., Sternheim, N., Talbot, W. S., & Marlow, F. L. (2013) · Disease Models & Mechanisms · doi:10.1242/dmm.012005 · Cited by 40 · see citing works
Ke, Z., Kondrichin, I., Gong, Z., & Korzh, V. (2008) · Molecular and cellular neurosciences · doi:10.1016/j.mcn.2007.10.013 · Cited by 40 · see citing works
Salta, E., Lau, P., Frigerio, C. S., Coolen, M., Bally‐Cuif, L., & Strooper, B. D. (2014) · Developmental Cell · doi:10.1016/j.devcel.2014.07.006 · Cited by 38 · see citing works
Celotto, L., Rost, F., Machate, A., Bläsche, J., Dahl, A., Weber, A., Hans, S., & Brand, M. (2023) · eLife · doi:10.7554/elife.86507 · Cited by 36 · see citing works
Taelman, V. F., Campenhout, C. V., Sölter, M., Pieler, T., & Bellefroid, E. (2006) · Development · doi:10.1242/dev.02458 · Cited by 37 · see citing works
her9 promotes floor plate development in zebrafish
Latimer, A. J., Shin, J., & Appel, B. (2005) · Developmental Dynamics · doi:10.1002/dvdy.20264 · Cited by 37 · see citing works
Hsieh, F.-Y., Ma, T., Shih, H., Lin, S., Huang, C.-W., Wang, H.-Y., & Cheng, Y. (2013) · Developmental Biology · doi:10.1016/j.ydbio.2013.01.007 · Cited by 36 · see citing works
Gajewski, M., Elmasri, H., Girschick, M., Sieger, D., & Winkler, C. (2006) · Development Genes and Evolution · doi:10.1007/s00427-006-0059-6 · Cited by 36 · see citing works
- Authors
- Takke, C., Dornseifer, P., Weizsäcker, E. V., & Campos-Ortega, J. A.
- Affiliations
- University of Cologne (DE)
- Universität zu Köln Institut für Entwicklungsbiologie , , 50923 Köln, Germany
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1999-05-01
- Volume
- 126
- Issue
- 9
- Pages
- 1811-1821
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2106017246
- Cited by
- 192
- References
- 61
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 10 · 2023: 10 · 2022: 2 · 2021: 1 · 2020: 7 · 2019: 8 · 2018: 2 · 2017: 2 · 2016: 6 · 2015: 5 · 2014: 8 · 2013: 10 · 2012: 3
- FWCI
- 3.79
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Development (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Zebrafish Biomedical Research Applications
- Keywords
- ErbB4, Notch signaling, primary neurogenesis, bHLH transcription factors, neurogenin1, proneural genes, δD, Notch1, hypoblast, neural plate, zebrafish, transcriptional feedback loop, ectopic expression
- MeSH terms
- Animals, DNA-Binding Proteins, Drosophila, Embryo, Nonmammalian, Embryonic Induction, Feedback, Membrane Proteins, Nerve Tissue Proteins, Nervous System, Neurons, Repressor Proteins, Transcription Factors, Transcription, Genetic, Zebrafish, Signal Transduction, Trans-Activators, Protein Structure, Secondary, Helix-Loop-Helix Motifs, Homeodomain Proteins, Gene Expression Regulation, Developmental, Insect Proteins, Drosophila Proteins, Xenopus Proteins, Zebrafish Proteins, Basic Helix-Loop-Helix Proteins, Receptors, Notch, LIM-Homeodomain Proteins
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