The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Drosophila Regulatory factor X is necessary for ciliated sensory neuron differentiation
Open accessAbstract
Ciliated neurons play an important role in sensory perception in many animals. Modified cilia at dendrite endings serve as sites of sensory signal capture and transduction. We describe Drosophila mutations that affect the transcription factor RFX and genetic rescue experiments that demonstrate its central role in sensory cilium differentiation. Rfxmutant flies show defects in chemosensory and mechanosensory behaviors but have normal phototaxis, consistent with Rfx expression in ciliated sensory neurons and neuronal precursors but not in photoreceptors. The mutant behavioral phenotypes are correlated with abnormal function and structure of neuronal cilia, as shown by the loss of sensory transduction and by defects in ciliary morphology and ultrastructure. These results identify Rfx as an essential regulator of ciliated sensory neuron differentiation inDrosophila.
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Cited by
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Creyghton, M. P., Cheng, A. W., Welstead, G. G., Kooistra, T., Carey, B. W., Steine, E. J., Hanna, J., Lodato, M. A., Frampton, G. M., Sharp, P. A., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1016071107 · Cited by 4,302
Genes and molecular pathways underpinning ciliopathies
Reiter, J. F., & Leroux, M. R. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.60 · Cited by 1,588
Basto, R., Lau, J., Vinogradova, T., Gardiol, A., Woods, C. G., Khodjakov, A., & Raff, J. W. (2006) · Cell · doi:10.1016/j.cell.2006.05.025 · Cited by 686
Venken, K. J. T., Schulze, K. L., Haelterman, N. A., Pan, H., He, Y., Evans-Holm, M., Carlson, J. W., Levis, R. W., Spradling, A. C., Hoskins, R. A., et al. (2011) · Nature Methods · doi:10.1038/nmeth.1662 · Cited by 675
Foxj1 transcription factors are master regulators of the motile ciliogenic program
Yu, X., Ng, C. P., Habacher, H., & Roy, S. (2008) · Nature Genetics · doi:10.1038/ng.263 · Cited by 495
Metadata
- Authors
- Dubruille, R., Laurençon, A., Vandaele, C., Shishido, E., Coulon-Bublex, M., Swoboda, P., Couble, P., Kernan, M., & Durand, B.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2002-12-01
- Volume
- 129
- Issue
- 23
- Pages
- 5487-5498
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W1985719373
- Cited by
- 158
- References
- 3
- FWCI
- 3.34
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Dubruille, R., Laurençon, A., Vandaele, C., Shishido, E., Coulon-Bublex, M., Swoboda, P., Couble, P., Kernan, M., & Durand, B. (2002). Drosophila Regulatory factor X is necessary for ciliated sensory neuron differentiation. Development. https://doi.org/10.1242/dev.00148
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