The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Oocyte-derived BMP15 and FGFs cooperate to promote glycolysis in cumulus cells
Abstract
Mammalian oocytes are deficient in their ability to carry out glycolysis. Therefore, the products of glycolysis that are necessary for oocyte development are provided to oocytes by companion cumulus cells. Mouse oocytes secrete paracrine factors that promote glycolysis in cumulus cells. The objective of this study was to identify paracrine factors secreted by oocytes that promote glycolysis and expression of mRNA encoding the glycolytic enzymes PFKP and LDHA. Candidates included growth differentiation factor 9 (GDF9),bone morphogenetic protein 15 (BMP15) and fibroblast growth factors (FGFs). Bmp15-/- and Gdf9+/-Bmp15-/- (double mutant, DM) cumulus cells exhibited reduced levels of both glycolysis and Pfkp and Ldha mRNA,and mutant oocytes were deficient in promoting glycolysis and expression of Pfkp and Ldha mRNA in cumulus cells of wild-type (WT) mice. Alone, neither recombinant BMP15, GDF9 nor FGF8 promoted glycolysis and expression of Pfkp and Ldha mRNA in WT cumulus cells. Co-treatment with BMP15 and FGF8 promoted glycolysis and increased expression of Pfkp and Ldha mRNA in WT cumulus cells to the same levels as WT oocytes; however, the combinations of BMP15/GDF9 or GDF9/FGF8 did not. Furthermore, SU5402, an FGF receptor-dependent protein kinase inhibitor,inhibited Pfkp and Ldha expression in cumulus cells promoted by paracrine oocyte factors. Therefore, oocyte-derived BMP15 and FGFs cooperate to promote glycolysis in cumulus cells.
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Cites
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method
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Receptor Specificity of the Fibroblast Growth Factor Family
Ornitz, D. M., Xu, J., Colvin, J. S., McEwen, D. G., MacArthur, C. A., Coulier, F., Gao, G., & Goldfarb, M. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.25.15292 · Cited by 1,871
Receptor Specificity of the Fibroblast Growth Factor Family
Zhang, X., Ibrahimi, O. A., Olsen, S. K., Umemori, H., Mohammadi, M., & Ornitz, D. M. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m601252200 · Cited by 1,164
Cited by
Oocyte environment: follicular fluid and cumulus cells are critical for oocyte health
Dumesic, D. A., Meldrum, D. R., Katz-Jaffe, M. G., Krisher, R. L., & Schoolcraft, W. B. (2015) · Fertility and Sterility · doi:10.1016/j.fertnstert.2014.11.015 · Cited by 640
Richani, D., Dunning, K. R., Thompson, J. G., & Gilchrist, R. B. (2021) · Human Reproduction Update · doi:10.1093/humupd/dmaa043 · Cited by 346
Influence of follicular fluid and cumulus cells on oocyte quality: clinical implications
Da Broi, M. G., Giorgi, V. S. I., Wang, F., Keefe, D. L., Albertini, D., & Navarro, P. A. (2018) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-018-1143-3 · Cited by 312
Regulation of folliculogenesis and the determination of ovulation rate in ruminants
Scaramuzzi, R. J., Baird, D. T., Campbell, B. K., Driancourt, M.-A., Dupont, J., Fortune, J. E., Gilchrist, R. B., Martin, G. B., McNatty, K. P., McNeilly, A. S., et al. (2011) · Reproduction, Fertility and Development · doi:10.1071/rd09161 · Cited by 310
Kidder, G. M., & Vanderhyden, B. C. (2010) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y10-009 · Cited by 305
Metadata
- Authors
- Sugiura, K., Su, Y.-Q., Diaz, F. J., Pangas, S. A., Sharma, S., Wigglesworth, K., O'Brien, M. J., Matzuk, M. M., Shimasaki, S., & Eppig, J. J.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2007-07-15
- Volume
- 134
- Issue
- 14
- Pages
- 2593-2603
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2122459288
- Cited by
- 325
- References
- 3
- FWCI
- 18.25
- Type
- journal article
- Language
- en
- Open access
- closed
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- Sugiura, K., Su, Y.-Q., Diaz, F. J., Pangas, S. A., Sharma, S., Wigglesworth, K., O'Brien, M. J., Matzuk, M. M., Shimasaki, S., & Eppig, J. J. (2007). Oocyte-derived BMP15 and FGFs cooperate to promote glycolysis in cumulus cells. Development. https://doi.org/10.1242/dev.006882
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