The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
Conditional inactivation of Tgfbr2 in cranial neural crest causes cleft palate and calvaria defects
Abstract
Cleft palate and skull malformations represent some of the most frequent congenital birth defects in the human population. Previous studies have shown that TGFβ signaling regulates the fate of the medial edge epithelium during palatal fusion and postnatal cranial suture closure during skull development. It is not understood, however, what the functional significance of TGFβ signaling is in regulating the fate of cranial neural crest (CNC)cells during craniofacial development. We show that mice with Tgfbr2conditional gene ablation in the CNC have complete cleft secondary palate,calvaria agenesis, and other skull defects with complete phenotype penetrance. Significantly, disruption of the TGFβ signaling does not adversely affect CNC migration. Cleft palate in Tgfbr2 mutant mice results from a cell proliferation defect within the CNC-derived palatal mesenchyme. The midline epithelium of the mutant palatal shelf remains functionally competent to mediate palatal fusion once the palatal shelves are placed in close contact in vitro. Our data suggests that TGFβ IIR plays a crucial, cell-autonomous role in regulating the fate of CNC cells during palatogenesis. During skull development, disruption of TGFβ signaling in the CNC severely impairs cell proliferation in the dura mater, consequently resulting in calvaria agenesis. We provide in vivo evidence that TGFβ signaling within the CNC-derived dura mater provides essential inductive instruction for both the CNC- and mesoderm-derived calvarial bone development. This study demonstrates that TGFβ IIR plays an essential role in the development of the CNC and provides a model for the study of abnormal CNC development.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Generalized lacZ expression with the ROSA26 Cre reporter strain
Soriano, P. (1999) · Nature Genetics · doi:10.1038/5007 · Cited by 4,859
The Transforming Growth Factor-beta Family
Massague, J. (1990) · Annual Review of Cell Biology · doi:10.1146/annurev.cb.06.110190.003121 · Cited by 3,015
Fate of the mammalian cranial neural crest during tooth and mandibular morphogenesis
Chai, Y., Jiang, X., Ito, Y., Bringas, P., Han, J., Rowitch, D. H., Soriano, P., McMahon, A. P., & Sucov, H. M. (2000) · Development · doi:10.1242/dev.127.8.1671 · Cited by 1,465
Self-citationSanford, L. P., Ormsby, I., Groot, A. C. G.-D., Sariola, H., Friedman, R., Boivin, G. P., Cardell, E. L., & Doetschman, T. (1997) · Development · doi:10.1242/dev.124.13.2659 · Cited by 1,447
Danielian, P. S., Muccino, D., Rowitch, D. H., Michael, S. K., & McMahon, A. P. (1998) · Current Biology · doi:10.1016/s0960-9822(07)00562-3 · Cited by 1,293
Patterning the Vertebrate Neuraxis
Lumsden, A., & Krumlauf, R. (1996) · Science · doi:10.1126/science.274.5290.1109 · Cited by 1,146
Kaartinen, V., Voncken, J. W., Shuler, C., Warburton, D., Bu, D., Heisterkamp, N., & Groffen, J. (1995) · Nature Genetics · doi:10.1038/ng1295-415 · Cited by 1,031
Self-citationTransforming growth factor–β3 is required for secondary palate fusion
Proetzel, G., Pawlowski, S. A., Wiles, M. V., Yin, M., Boivin, G. P., Howles, P. N., Ding, J., Ferguson, M. W. J., & Doetschman, T. (1995) · Nature Genetics · doi:10.1038/ng1295-409 · Cited by 908
The role of the neural crest in patterning of avian cranial skeletal, connective, and muscle tissues
Noden, D. M. (1983) · Developmental Biology · doi:10.1016/0012-1606(83)90318-4 · Cited by 870
Tissue origins and interactions in the mammalian skull vault.
Jiang, X., Iseki, S., Maxson, R. E., Sucov, H. M., & Morriss-Kay, G. M. (2002) · Developmental Biology · doi:10.1006/dbio.2001.0487 · Cited by 782
Cited by
Mossey, P. A., Little, J., Munger, R. G., Dixon, M. J., & Shaw, W. C. (2009) · The Lancet · doi:10.1016/s0140-6736(09)60695-4 · Cited by 1,764
Retinoic acid from the meninges regulates cortical neuron generation.
Siegenthaler, J. A., Ashique, A. M., Zarbalis, K., Patterson, K. P., Hecht, J. H., Kane, M. A., Folias, A. E., Choe, Y., May, S. R., Kume, T., et al. (2009) · Cell · doi:10.1016/j.cell.2009.10.004 · Cited by 402
Lewis, A. E., Vasudevan, H. N., O’Neill, A. K., Soriano, P., & Bush, J. O. (2013) · Developmental Biology · doi:10.1016/j.ydbio.2013.04.026 · Cited by 289
Two developmental modules establish 3D beak-shape variation in Darwin's finches
Mallarino, R., Grant, P. R., Grant, B. R., Herrel, A., Kuo, W. P., & Abzhanov, A. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1011480108 · Cited by 216
Periderm: life-cycle and function during orofacial and epidermal development
Hammond, N. L., Dixon, J., & Dixon, M. J. (2019) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2017.08.021 · Cited by 80
Metadata
- Authors
- Ito, Y., Yeo, J. Y., Chytil, A., Han, J., Bringas, P., Nakajima, A., Shuler, C. F., Moses, H. L., & Chai, Y.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2003-11-01
- Volume
- 130
- Issue
- 21
- Pages
- 5269-5280
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2001584235
- Cited by
- 349
- References
- 45
- FWCI
- 8.04
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
