The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Mutation of weak atrium/atrial myosin heavy chain disrupts atrial function and influences ventricular morphogenesis in zebrafish
Abstract
The embryonic vertebrate heart is composed of two major chambers, a ventricle and an atrium, each of which has a characteristic size, shape and functional capacity that contributes to efficient circulation. Chamber-specific gene expression programs are likely to regulate key aspects of chamber formation. Here, we demonstrate that epigenetic factors also have a significant influence on chamber morphogenesis. Specifically, we show that an atrium-specific contractility defect has a profound impact on ventricular development. We find that the zebrafish locus weak atrium encodes an atrium-specific myosin heavy chain that is required for atrial myofibrillar organization and contraction. Despite their atrial defects, weak atrium mutants can maintain circulation through ventricular contraction. However, the weak atrium mutant ventricle becomes unusually compact,exhibiting a thickened myocardial wall, a narrow lumen and changes in myocardial gene expression. As weak atrium/atrial myosin heavy chainis expressed only in the atrium, the ventricular phenotypes in weak atrium mutants represent a secondary response to atrial dysfunction. Thus, not only is cardiac form essential for cardiac function, but there also exists a reciprocal relationship in which function can influence form. These findings are relevant to our understanding of congenital defects in cardiac chamber morphogenesis.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The incidence of congenital heart disease.
Hoffman, J. I. E., & Kaplan, S. (2002) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(02)01886-7 · Cited by 6,099
Effective targeted gene ‘knockdown’ in zebrafish
Nasevicius, A., & Ekker, S. C. (2000) · Nature Genetics · doi:10.1038/79951 · Cited by 2,483
Morpholino Antisense Oligomers: Design, Preparation, and Properties
SUMMERTON, J., & WELLER, D. (1997) · Antisense and Nucleic Acid Drug Development · doi:10.1089/oli.1.1997.7.187 · Cited by 1,116
Bruneau, B. G., Nemer, G., Schmitt, J. P., Charron, F., Robitaille, L., Caron, S., Conner, D. A., Gessler, M., Nemer, M., Seidman, C. E., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00493-7 · Cited by 1,061
The Genetic Basis for Cardiomyopathy
Seidman, J. G., & Seidman, C. (2001) · Cell · doi:10.1016/s0092-8674(01)00242-2 · Cited by 1,046
Intracardiac fluid forces are an essential epigenetic factor for embryonic cardiogenesis
Hove, J. R., Köster, R. W., Forouhar, A. S., Acevedo-Bolton, G., Fraser, S. E., & Gharib, M. (2003) · Nature · doi:10.1038/nature01282 · Cited by 997
Immunochemical analysis of myosin heavy chain during avian myogenesis in vivo and in vitro.
Bader, D., Masaki, T., & Fischman, D. A. (1982) · The Journal of cell biology · doi:10.1083/jcb.95.3.763 · Cited by 919
Hentze, M. W., & Kulozik, A. E. (1999) · Cell · doi:10.1016/s0092-8674(00)80542-5 · Cited by 809
Srivastava, D., Thomas, T., Lin, Q., Kirby, M. L., Brown, D., & Olson, E. N. (1997) · Nature Genetics · doi:10.1038/ng0697-154 · Cited by 726
Cardiac troponin T is essential in sarcomere assembly and cardiac contractility
Sehnert, A. J., Huq, A., Weinstein, B. M., Walker, C., Fishman, M., & Stainier, D. Y. R. (2002) · Nature Genetics · doi:10.1038/ng875 · Cited by 635
Self-citation
Cited by
Zebrafish as a model to study cardiac development and human cardiac disease
Bakkers, J. (2011) · Cardiovascular Research · doi:10.1093/cvr/cvr098 · Cited by 654
Bioelectric signaling and the control of cardiac cell identity in response to mechanical forces
Fukui, H., Chow, R. W.-Y., Xie, J., Foo, Y. Y., Yap, C. H., Minc, N., Mochizuki, N., & Vermot, J. (2021) · Science · doi:10.1126/science.abc6229 · Cited by 103
The Impact of Mechanical Forces in Heart Morphogenesis
Granados-Riveron, J. T., & Brook, J. D. (2012) · Circulation: Cardiovascular Genetics · doi:10.1161/circgenetics.111.961086 · Cited by 90
Nonmuscle α-Actinin-4 Couples Sarcomere Function to Cardiac Remodeling
Hayes, J. B., Choudhary, D., Ritter, D., Neininger-Castro, A. C., Willet, A. H., Caplan, L. R., Wang, Y., Liu, X., Taneja, N., Sanchez, Z. C., et al. (2026) · Circulation Research · doi:10.1161/circresaha.125.326412 · Cited by 5
Metadata
- Authors
- Berdougo, E., Coleman, H., Lee, D. H., Stainier, D. Y. R., & Yelon, D.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2003-12-15
- Volume
- 130
- Issue
- 24
- Pages
- 6121-6129
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2096132763
- Cited by
- 261
- References
- 39
- FWCI
- 3.11
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
