The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Disrupted gonadogenesis and male-to-female sex reversal in Pod1 knockout mice
Abstract
Congenital defects in genital and/or gonadal development occur in 1 in 1000 humans, but the molecular basis for these defects in most cases remains undefined. We show that the basic helix-loop-helix transcription factor Pod1(capsulin/epicardin/Tcf21) is essential for normal development of the testes and ovaries, and hence for sexual differentiation. The gonads of Pod1knockout (KO) mice were markedly hypoplastic, and the urogenital tracts of both XX and XY mice remained indistinguishable throughout embryogenesis. Within Pod1 KO gonads, the number of cells expressing the cholesterol side-chain cleavage enzyme (Scc) was increased markedly. Biochemical and genetic approaches demonstrated that Pod1 transcriptionally represses steroidogenic factor 1 (Sf1/Nr5a1/Ad4BP), an orphan nuclear receptor that regulates the expression of multiple genes (including Scc) that mediate sexual differentiation. Our results establish that Pod1 is essential for gonadal development, and place it in a transcriptional network that orchestrates cell fate decisions in gonadal progenitors.
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Cites
Pericyte Loss and Microaneurysm Formation in PDGF-B-Deficient Mice
Lindahl, P., Johansson, B. R., Levéen, P., & Betsholtz, C. (1997) · Science · doi:10.1126/science.277.5323.242 · Cited by 2,226
Steroidogenic factor 1: a key determinant of endocrine development and function
Parker, K. L., & Schimmer, B. P. (1997) · Endocrine Reviews · doi:10.1210/edrv.18.3.0301 · Cited by 764
Self-citationAchermann, J. C., Ozisik, G., Ito, M., Orun, U. A., Harmanci, K., Gurakan, B., & Jameson, J. L. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.4.8376 · Cited by 305
Crawford, P. A., Sadovsky, Y., & Milbrandt, J. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.7.3997 · Cited by 134
Cited by
Sex Determination and Gonadal Development in Mammals
Wilhelm, D., Palmer, S., & Koopman, P. (2007) · Physiological Reviews · doi:10.1152/physrev.00009.2006 · Cited by 686
Acharya, A., Baek, S. T., Huang, G., Eskiocak, B., Goetsch, S., Sung, C. Y., Banfi, S., Sauer, M. F., Olsen, G. S., Duffield, J. S., et al. (2012) · Development · doi:10.1242/dev.079970 · Cited by 498
Large-scale GWAS reveals insights into the genetic architecture of same-sex sexual behavior
Ganna, A., Verweij, K. J. H., Nivard, M. G., Maier, R., Wedow, R., Busch, A. S., Abdellaoui, A., Guo, S., Sathirapongsasuti, J. F., 23andMe Research Team, et al. (2019) · Science · doi:10.1126/science.aat7693 · Cited by 406
Arab, K., Park, Y. J., Lindroth, A. M., Schäfer, A., Oakes, C., Weichenhan, D., Lukanova, A., Lundin, E., Risch, A., Meister, M., et al. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.06.031 · Cited by 290
Adrenocortical zonation, renewal, and remodeling
Pihlajoki, M., Dörner, J., Cochran, R. S., Heikinheimo, M., & Wilson, D. B. (2015) · Frontiers in Endocrinology · doi:10.3389/fendo.2015.00027 · Cited by 114
Metadata
- Authors
- Cui, S., Ross, A., Stallings, N., Parker, K. L., Capel, B., & Quaggin, S. E.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2004-08-15
- Volume
- 131
- Issue
- 16
- Pages
- 4095-4105
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2060004978
- Cited by
- 183
- References
- 4
- FWCI
- 4.71
- Type
- journal article
- Language
- en
- Open access
- closed
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