Initiation of Wnt signaling: control of Wnt coreceptor Lrp6 phosphorylation/activation via frizzled, dishevelled and axin functions

Zeng, Xin, Huang, He, Tamai, Keiko, Zhang, Xinjun, Harada, Yuko, Yokota, Chika, Almeida, Karla, Wang, Jianbo +5 more·2008·Development

Cited by (492)

Items 201–300 of 492

  1. Functional dissection of phosphorylation of Disheveled in Drosophila
    Wang A. Yanfeng, Hebist Berhane, Marion Mola, Jaskirat Singh, Andreas Jenny, Marek Mlodzik · 2011 · Developmental Biology
  2. Wnt pathway activity confers chemoresistance to cancer stem-like cells in a neuroblastoma cell line
    Sharada D. Vangipuram, Steven A. Buck, William D. Lyman · 2012 · Tumor Biology
  3. Wnt Signaling: Role in Regulation of Haematopoiesis
    Ram Babu Undi, Usha Gutti, Itishri Sahu, Shilpa Sarvothaman, Satya Ratan Pasupuleti, Ravinder Kandi, Ravi Kumar Gutti · 2015 · Indian Journal of Hematology and Blood Transfusion
  4. Wnt signalling induces accumulation of phosphorylated β-catenin in two distinct cytosolic complexes
    Jan P. Gerlach, Benjamin Lucas Emmink, Hisashi Nojima, Onno Kranenburg, Madelon M. Maurice · 2014 · Open Biology
  5. A lithium-containing nanoporous coating on entangled titanium scaffold can enhance osseointegration through Wnt/β-catenin pathway
    Wei Xin Liu, Desheng Chen, Guofeng Jiang, Qiuyan Li, Qiaojie Wang, Mengqi Cheng, Guo He, Xianlong Zhang · 2017 · Nanomedicine Nanotechnology Biology and Medicine
  6. Osteogenesis and Bone Regeneration
    Haisheng Yang · 2019 · IntechOpen eBooks
  7. Frat oncoproteins act at the crossroad of canonical and noncanonical Wnt-signaling pathways
    Renée van Amerongen, Martijn C. Nawijn, Jan-Paul Lambooij, Natalie Proost, Jos Jonkers, Anton J. M. Berns · 2009 · Oncogene
  8. Molecular dissection of Wnt3a-Frizzled8 interaction reveals essential and modulatory determinants of Wnt signaling activity
    Sumit Kumar, Mihaela Žigman, Trushar R. Patel, Benjamin Trageser, Julia Christina Gross, Karolin Rahm, Michael Boutros, Dietmar Gradl, Herbert Steinbeißer, Thomas W. Holstein et al. · 2014 · BMC Biology
  9. Autoinhibition of Dishevelled protein regulated by its extreme C terminus plays a distinct role in Wnt/β-catenin and Wnt/planar cell polarity (PCP) signaling pathways
    Jing Qi, Ho‐Jin Lee, Audrey Saquet, Xiao-Ning Cheng, Ming Shao, Jie Zheng, De‐Li Shi · 2017 · Journal of Biological Chemistry
  10. Wnt/β-catenin signaling pathway safeguards epigenetic stability and homeostasis of mouse embryonic stem cells
    Ilda Theka, Francesco Sottile, Marco Cammisa, Sarah Bonnin, Marta Sánchez-Delgado, Umberto Di Vicino, Maria Victoria Neguembor, Karthik Arumugam, Francesco Aulicino, David Monk et al. · 2019 · Scientific Reports
  11. Apigenin, A Plant Flavone Playing Noble Roles in Cancer Prevention Via Modulation of Key Cell Signaling Networks
    Deepti Singh, Mohammad Afsar Khan, Hifzur Rahman Siddique · 2019 · Recent Patents on Anti-Cancer Drug Discovery
  12. Structure-Based Design of 1,4-Dibenzoylpiperazines as β-Catenin/B-Cell Lymphoma 9 Protein–Protein Interaction Inhibitors
    John A. Wisniewski, Jinya Yin, Kevin B. Teuscher, Min Zhang, Haitao Ji · 2016 · ACS Medicinal Chemistry Letters
  13. Modulation of the β-Catenin Signaling Pathway by the Dishevelled-Associated Protein Hipk1
    Sarah H. Louie, Xiao Yong Yang, William H. Conrad, Jeanot Muster, Stéphane Angers, Randall T. Moon, Benjamin N. R. Cheyette · 2009 · PLoS ONE
  14. Glycogen synthase kinase-3β (GSK-3β) and its dysregulation in glioblastoma multiforme
    Ryan J. Atkins, Stanley S. Stylli, Rodney Brian Luwor, Andrew Henry Kaye, Christopher M. Hovens · 2013 · Journal of Clinical Neuroscience
  15. Cardiac neural crest and outflow tract defects in Lrp6 mutant mice
    Lanying Song, Yunhong Li, Kai Wang, Chengji J. Zhou · 2009 · Developmental Dynamics
  16. Signaling Pathways Involved in Antidepressant-Induced Cell Proliferation and Synaptic Plasticity
    Fuencisla Pilar-Cuéllar, Rebeca Vidal, Álvaro Díaz, Elena Castro, Severiano Dos-Anjos, Verónica Inés Vargas, Beatriz Romero, Elsa M. Valdizán · 2014 · Current Pharmaceutical Design
  17. Peptide-based mediated disruption of N-cadherin-LRP5/6 interaction promotes Wnt signaling and bone formation
    Eric Haÿ, Thibault Buczkowski, Caroline Marty, Sophie Da Nascimento, Pascal Sonnet, Pierre J. Marie · 2012 · Journal of Bone and Mineral Research
  18. GRP78 activates the Wnt/HOXB9 pathway to promote invasion and metastasis of hepatocellular carcinoma by chaperoning LRP6
    Haixia Xiong, Han Xiao, Chenglin Luo, Leifeng Chen, Xiuxia Liu, Zhigang Hu, Shubing Zou, Jiafu Guan, Dongxiao Yang, Kai Wang · 2019 · Experimental Cell Research
  19. Raddeanin A inhibits growth and induces apoptosis in human colorectal cancer through downregulating the Wnt/β-catenin and NF-κB signaling pathway
    Yu Wang, Xiaowen Bao, Ang Zhao, Jie Zhang, Mingya Zhang, Qi Zhang, Bo Ma · 2018 · Life Sciences
  20. Regulation of developmental intercellular signalling by intracellular trafficking
    Ben‐Zion Shilo, Eyal D. Schejter · 2011 · The EMBO Journal
  21. Pigment Epithelium-Derived Factor 34-mer Peptide Prevents Liver Fibrosis and Hepatic Stellate Cell Activation through Down-Regulation of the PDGF Receptor
    Tung‐Han Tsai, Shou‐Chuan Shih, Tsung‐Chuan Ho, Hsin‐I Ma, Mingying Liu, Show‐Li Chen, Yeou‐Ping Tsao · 2014 · PLoS ONE
  22. GSK-3� and Vitamin D Receptor are Involved in �-Catenin and Snail Signaling in High Glucose-Induced Epithelial-Mesenchymal Transition of Mouse Podocytes
    Jia Guo, Nannan Xia, Lili Yang, Sijie Zhou, Qian Zhang, Yingjin Qiao, Zhangsuo Liu · 2014 · Cellular Physiology and Biochemistry
  23. Vertebrate Axial Patterning: From Egg to Asymmetry
    Douglas W. Houston · 2016 · Advances in experimental medicine and biology
  24. Akt inhibition-dependent downregulation of the Wnt/β-Catenin Signaling pathway contributes to antimony-induced neurotoxicity
    Weiwei Shi, Yanfen Tang, Ye Zhi, Z. Li, Shali Yu, Junkang Jiang, Jinfeng Zhu, Jinlong Li, Feng Wang, Liling Su et al. · 2020 · The Science of The Total Environment
  25. Destruction complex dynamics: Wnt/β-catenin signaling alters Axin-GSK3β interactions inin vivo
    Daniel B. Lybrand, Misha Naiman, Jessie May Laumann, Mitzi Boardman, Samuel Petshow, Kevin Hansen, Gregory David Scott, Marcel Wehrli · 2019 · Development
  26. Functional Characterization of a Small-Molecule Inhibitor of the DKK1-LRP6 Interaction
    Sara Iozzi, Rosaria Remelli, Barbara Lelli, Daniela Diamanti, Silvia Pileri, Luisa Bracci, Renza Roncarati, Andrea Caricasole, Simonetta Bernocco · 2012 · ISRN Molecular Biology
  27. Loss-of-function point mutations and two-furin domain derivatives provide insights about R-spondin2 structure and function
    Shengjian Li, Ten‐Yang Yen, Yoshimi Endo, Małgorzata Klauzińska, Bolormaa Baljinnyam, Bruce A. Macher, Robert Callahan, Jeffrey S. Rubin · 2009 · Cellular Signalling
  28. Role of Wnt/β-catenin pathway in cancer drug resistance: Insights into molecular aspects of major solid tumors
    Charudatt Samant, Ramesh R. Kale, Karkala Sreedhara Ranganath Pai, Krishnadas Nandakumar, Mandar Bhonde · 2024 · Biochemical and Biophysical Research Communications
  29. Sialidase NEU 3 contributes neoplastic potential on colon cancer cells as a key modulator of gangliosides by regulating W nt signaling
    Kohta Takahashi, Masahiro Hosono, Ikuro Sato, Keiko Hata, Tadashi Wada, Kazunori Yamaguchi, Kazuo Nitta, Hiroshi Shima, Taeko Miyagi · 2015 · International Journal of Cancer
  30. Fine-Tuning of the RIG-I-Like Receptor/Interferon Regulatory Factor 3-Dependent Antiviral Innate Immune Response by the Glycogen Synthase Kinase 3/β-Catenin Pathway
    Kashif Aziz Khan, Florence Dô, Alexandre Marineau, Priscilla Doyon, Jean-François Clément, James Robert Woodgett, Bradley W. Doble, Marc J. Servant · 2015 · Molecular and Cellular Biology
  31. LRPs in WNT Signalling
    Gary R. Davidson · 2021 · Handbook of experimental pharmacology
  32. Superresolution microscopy localizes endogenous Dvl2 to Wnt signaling-responsive biomolecular condensates
    Antonia Schubert, Oksana Voloshanenko, Franziska Ragaller, Philipp Gmach, Dominique Kranz, Christian Scheeder, Thilo Miersch, Matthias Schulz, Lorenz H. P. Trümper, Claudia Rebecca Binder et al. · 2022 · Proceedings of the National Academy of Sciences
  33. Canonical Wnt signaling enhances pro-inflammatory response to titanium by macrophages
    Derek Avery, Lais Morandini, Luke S. Sheakley, Arth H. Shah, Loc Bui, Jefferson O. Abaricia, René Olivares‐Navarrete · 2022 · Biomaterials
  34. Non-canonical Wnt signaling pathways in hematopoiesis
    Kathleen M. Kokolus, Michael J. Nemeth · 2009 · Immunologic Research
  35. Beta-Catenin Versus the Other Armadillo Catenins
    Rachel K. Miller, Ji Yeon Hong, William A. Muñoz, Pierre D. McCrea · 2013 · Progress in molecular biology and translational science
  36. Protease-activated Receptor-1 (PAR1) Acts via a Novel Gα13-Dishevelled Axis to Stabilize β-Catenin Levels
    Hagit Turm, Myriam Maoz, Vered Katz, Yongjun Yin, Stefan Offermanns, Rachel Bar‐Shavit · 2010 · Journal of Biological Chemistry
  37. Βeta-catenin N-terminal domain: An enigmatic region prone to cancer causing mutations
    Mohd Saleem Dar, Paramjit Singh, Riyaz Ahmad Mir, Mohd Jamal Dar · 2017 · Mutation Research/Reviews in Mutation Research
  38. TFE3 is a diagnostic marker for solid pseudopapillary neoplasms of the pancreas
    Yina Jiang, Juan Xie, Bo Wang, Yudong Mu, Peijun Liu · 2018 · Human Pathology
  39. Role of WNT 10A in failure of tooth development in humans and zebrafish
    Qiuping Yuan, Min Zhao, Bhavna Tandon, Lorena Maili, Xiaoming Liu, Anqi Zhang, Evan H. Baugh, Tam Tran, Renato Menezes Silva, Jacqueline T. Hecht et al. · 2017 · Molecular Genetics & Genomic Medicine
  40. Toggling a Conformational Switch in Wnt/β-catenin Signaling: Regulation of Axin Phosphorylation
    Ofelia Tacchelly-Benites, Zheng-Han Wang, Eungi Yang, Ethan Lee, Yashi Ahmed · 2013 · Bioessays
  41. Axin phosphorylation in both Wnt-off and Wnt-on states requires the tumor suppressor APC
    Ofelia Tacchelly‐Benites, Zhenghan Wang, Eungi Yang, Hassina Benchabane, Ai Tian, Michael P. Randall, Yashi F. Ahmed · 2018 · PLoS Genetics
  42. Current applications of adipose-derived mesenchymal stem cells in bone repair and regeneration: A review of cell experiments, animal models, and clinical trials
    Zhengyue Zhang, Xiao Yang, Xiankun Cao, An Qin, Jie Zhao · 2022 · Frontiers in Bioengineering and Biotechnology
  43. Interactions between Casein Kinase Iε (CKIε) and Two Substrates from Disparate Signaling Pathways Reveal Mechanisms for Substrate-Kinase Specificity
    Caroline L. Dahlberg, Elizabeth Z. Nguyen, David R. Goodlett, David Kimelman · 2009 · PLoS ONE
  44. The transcriptional coactivator WBP2 primes triple-negative breast cancer cells for responses to Wnt signaling via the JNK/Jun kinase pathway
    Zilin Li, Shen Kiat Lim, Liang Xu, Yoon Pin Lim · 2018 · Journal of Biological Chemistry
  45. A conserved role for arrow in posterior axis patterning across Arthropoda
    Emily V.W. Setton, Prashant P. Sharma · 2021 · Developmental Biology
  46. Nucleation of the destruction complex on the centrosome accelerates degradation of β-catenin and regulates Wnt signal transmission
    Ryan S. Lach, Chongxu Qiu, Erfan Zeyaei Kajbaf, Naomi J. Baxter, Dasol Han, Alex Wang, Hannah Lock, Orlando Chirikian, Beth L. Pruitt, Maxwell Z. Wilson · 2022 · Proceedings of the National Academy of Sciences
  47. Potential cross-talk between (pro)renin receptors and Wnt/frizzled receptors in cardiovascular and renal disorders
    Pitchai Balakumar, Gowraganahalli Jagadeesh · 2011 · Hypertension Research
  48. Receptor heterodimerization as a novel mechanism for regulation of Wnt/β-catenin signaling
    Kyungwon Lee, Younghwa Shin, Rui Cheng, Kyoungmin Park, Yang Hu, Jeffrey McBride, Xuemin He, Yusuke Takahashi, Jian‐xing Ma · 2014 · Journal of Cell Science
  49. The canonical way to make a heart: β-catenin and plakoglobin in heart development and remodeling
    Oksana O. Piven, Cecilia Lanny Winata · 2017 · Experimental Biology and Medicine
  50. Signaling pathways as linear transmitters
    Harry Nunns, Lea A. Goentoro · 2018 · eLife
  51. A silyl andrographolide analogue suppresses Wnt/β-catenin signaling pathway in colon cancer
    Somrudee Reabroi, Arthit Chairoungdua, Rungnapha Saeeng, Teerapich Kasemsuk, Witchuda Saengsawang, Weiming Zhu, Pawinee Piyachaturawat · 2018 · Biomedicine & Pharmacotherapy
  52. miR-155 Is Downregulated in Familial Adenomatous Polyposis and Modulates WNT Signaling by Targeting AXIN1 and TCF4
    Anna Prossomariti, Giulia Piazzi, Leonarda D’Angelo, Sara Miccoli, Daniela Turchetti, Chiara Alquati, Claudio Montagna, Franco Bazzoli, Luigi Ricciardiello · 2018 · Molecular Cancer Research
  53. Roles of individual human Dishevelled paralogs in the Wnt signalling pathways
    Petra Paclíková, Tomasz Witold Radaszkiewicz, David Potěšil, Jakub Harnoš, Zbyněk Zdráhal, Vı́tězslav Bryja · 2021 · Cellular Signalling
  54. Impaired neurogenesis and neural progenitor fate choice in a human stem cell model of SETBP1 disorder
    Lucia Fernandez Cardo, Daniel Cabezas de la Fuente, Meng Li · 2023 · Molecular Autism
  55. WNT10B Enhances Proliferation through β-Catenin and RAC1 GTPase in Human Corneal Endothelial Cells
    Jeong Goo Lee, Martin Heur · 2015 · Journal of Biological Chemistry
  56. Roles of GSK-3 and β-Catenin in Antiviral Innate Immune Sensing of Nucleic Acids
    Alexandre Marineau, Kashif Aziz Khan, Marc J. Servant · 2020 · Cells
  57. Stably overexpressed human Frizzled-2 signals through the β-catenin pathway and does not activate Ca2+-mobilization in Human Embryonic Kidney 293 cells
    Folkert Verkaar, J VANROSMALEN, Jos F.M. Smits, W. Matthijs Blankesteijn, G ZAMAN · 2008 · Cellular Signalling
  58. Characterization and function of a β-catenin homolog from Litopenaeus vannamei in WSSV infection
    Jiazhen Sun, Lingwei Ruan, Cong‐Zhao Zhou, Hong Shi, Xun Xu · 2017 · Developmental & Comparative Immunology
  59. Ubiquitin Ligases Involved in the Regulation of Wnt, TGF-β, and Notch Signaling Pathways and Their Roles in Mouse Development and Homeostasis
    Nikol Dibus, Tomáš Liďák, Lukáš C̆ermák · 2019 · Genes
  60. Deciphering the Role of WNT Signaling in Metabolic Syndrome–Linked Alzheimer’s Disease
    Abuzer Ali, Amena Ali, Wasim Ahmad, Niyaz Ahmad, Sana Irfan Khan, Sheikh Md Nuruddin, Ibraheem Husain · 2019 · Molecular Neurobiology
  61. Rad6B acts downstream of Wnt signaling to stabilize β-catenin: Implications for a novel Wnt/β-catenin target
    Brigitte Gérard, Larry R. Tait, Pratima Nangia‐Makker, Malathy P.V. Shekhar · 2011 · Journal of Molecular Signaling
  62. Bone Development and Remodeling
    Christa Maes, Henry M. Kronenberg · 2015 · Elsevier eBooks
  63. MicroRNAs in osteoblast differentiation and fracture healing: From pathogenesis to therapeutic implication
    Jilong Yao, Ruiwen Xin, Chao Zhao, Chun-Fu Yu · 2024 · Injury
  64. Structural and Functional Insights into Dishevelled-Mediated Wnt Signaling
    Lei Wang, Rui Zhu, Zehua Wen, Hua‐Jun Fan, Teresa Norwood-Jackson, Danielle Jathan, Ho‐Jin Lee · 2024 · Cells
  65. CDK14 Contributes to Reactive Gliosis via Interaction with Cyclin Y in Rat Model of Spinal Cord Injury
    Chengwei Duan, Yonghua Liu, Lu Lu, Rixin Cai, Huaqing Xue, Xingxing Mao, Chen Chen, Rong Qian, Dongmei Zhang, Aiguo Shen · 2015 · Journal of Molecular Neuroscience
  66. Targeting the Wnt pathway in cancer
    K. Goss, M. Kahn · 2011 · Springer eBooks
  67. Dual functions of DP1 promote biphasic Wnt‐on and Wnt‐off states during anteroposterior neural patterning
    Wantae Kim, Hyunjoon Kim, Vladimir L. Katanaev, Seung Joon Lee, Tohru Ishitani, Boksik Cha, Jin‐Kwan Han, Eek‐hoon Jho · 2012 · The EMBO Journal
  68. The role of the Ser/Thr cluster in the phosphorylation of PPPSP motifs in Wnt coreceptors
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  69. Computational Modeling of the Interplay between Cadherin-Mediated Cell Adhesion and Wnt Signaling Pathway
    Chen, Jiawen, Xie, Zhong-Ru, Wu, Yinghao · 2014 · PLoS ONE
  70. Nanoquinacrine caused apoptosis in oral cancer stem cells by disrupting the interaction between GLI1 and β catenin through activation of GSK3β
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  71. Alterations of Wnt/β-catenin signaling pathway in hepatocellular carcinomas associated with hepatitis C virus
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  72. The First Propeller Domain of LRP6 Regulates Sensitivity to DKK1
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  73. Resveratrol ameliorates high-phosphate-induced VSMCs to osteoblast-like cells transdifferentiation and arterial medial calcification in CKD through regulating Wnt/β-catenin signaling
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  75. Natural Functions of PLIN2 Mediating Wnt/LiCl Signaling and Glycogen Synthase Kinase 3 (GSK3)/GSK3 Substrate-Related Effects Are Modulated by Lipid
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  76. Dual Roles for Membrane Association of Drosophila Axin in Wnt Signaling
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  77. Low-density lipoprotein receptor-related protein 6 is a novel coreceptor of protease-activated receptor-2 in the dynamics of cancer-associated β-catenin stabilization
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  78. The phosphatase Pgam5 antagonizes Wnt/β-Catenin signaling in embryonic anterior-posterior axis patterning
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  79. Low-Density Lipoprotein Receptor-Related Protein 6 (LRP6) rs10845498 Polymorphism Is Associated with a Decreased Risk of Non-Small Cell Lung Cancer
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  80. Aberrantly activated Wnt/β‐catenin pathway co‐receptors LRP5 and LRP6 regulate osteoblast differentiation in the developing coronal sutures of an Apert syndrome ( Fgfr2S252W /+) mouse model
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  81. Competitive blocking of LRP4–sclerostin binding interface strongly promotes bone anabolic functions
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  83. β-Catenin is markedly induced in a murine model of an arteriovenous fistula: the effect of metalloproteinase inhibition
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  84. MARK2/Par1b Insufficiency Attenuates DVL Gene Transcription via Histone Deacetylation in Lumbosacral Spina Bifida
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  85. WIF1 can effectively co-regulate pro-apoptotic activity through the combination with DKK1
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  86. Wnt signalling: What The X@# is WTX?
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  89. Cas9 Mediated Correction of β-catenin Mutation and Restoring the Expression of Protein Phosphorylation in Colon Cancer HCT-116 Cells Decrease Cell Proliferation in vitro and Hamper Tumor Growth in Mice in vivo
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  90. Influence of PI‐3K/Akt pathway on Wnt signalling in regulating myeloid progenitor cell proliferation. Evidence for a role of autocrine/paracrine Wnt regulation
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  91. Wingless-type family member 3A triggers neuronal polarization via cross-activation of the insulin-like growth factor-1 receptor pathway
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  92. Isoxazole 9 (ISX9), a small molecule targeting Axin, activates Wnt/β‐catenin signalling and promotes hair regrowth
    Sapna Sayed, Jiaxing Song, Ling Wang, Tobias Achu Muluh, Boxin Liu, Zhixian Lin, Yun Tang, Zijie Su, Huan Li, Vivian Weiwen Xue et al. · 2023 · British Journal of Pharmacology
  93. Glycogen synthase kinase 3 beta in somites plays a role during the angiogenesis of zebrafish embryos
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  94. Phosphorylation of PPP(S/T)P motif of the free LRP6 intracellular domain is not required to activate the Wnt/β‐catenin pathway and attenuate GSK3β activity
    Brandon R. Beagle, Kaihong Mi, Gail V.W. Johnson · 2009 · Journal of Cellular Biochemistry
  95. Differential Role of Axin RGS Domain Function in Wnt Signaling during Anteroposterior Patterning and Maternal Axis Formation
    Patricia N. Schneider, Diane C. Slusarski, Douglas W. Houston · 2012 · PLoS ONE
  96. Dishevelled C‐terminus: prolyl and histidinyl motifs
    Hurng‐Yi Wang, C C Malbon · 2011 · Acta Physiologica
  97. S100A4 negatively regulates β-catenin by inducing the Egr-1-PTEN-Akt-GSK3β degradation pathway
    Wonseok Yang, KeeSoo Nam, Ji‐hyun Ju, Kyung‐min Lee, Sunhwa Oh, Incheol Shin · 2014 · Cellular Signalling
  98. Xenopus axin‐related protein: A link between its centrosomal localization and function in the Wnt/β‐catenin pathway
    Evguenia M. Alexandrova, Sergei Y. Sokol · 2009 · Developmental Dynamics
  99. Delicate Analysis of Post-Translational Modifications on Dishevelled 3
    Chaochao Wu, Wei Wei, Chen Li, Qingrun Li, Quanhu Sheng, Rong Zeng · 2012 · Journal of Proteome Research
  100. Effect of Klotho protein during porcine oocyte maturation via Wnt signaling
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