The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Embryonic signaling centers expressing BMP, WNT and FGF proteins interact to pattern the cerebral cortex
Abstract
Recent findings implicate embryonic signaling centers in patterning the mammalian cerebral cortex. We used mouse in utero electroporation and mutant analysis to test whether cortical signaling sources interact to regulate one another. We identified interactions between the cortical hem, rich in Wingless-Int (WNT) proteins and bone morphogenetic proteins (BMPs), and an anterior telencephalic source of fibroblast growth factors (FGFs). Expanding the FGF8 domain suppressed Wnt2b, Wnt3a and Wnt5a expression in the hem. Next to the hem, the hippocampus was shrunken, consistent with its dependence for growth on a hem-derived WNT signal. Maintenance of hem WNT signaling and hippocampal development thus require a constraint on the FGF8 source, which is likely to be supplied by BMP activity. When endogenous BMP signaling is inhibited by noggin, robust Fgf8 expression appears ectopically in the cortical primordium. Abnormal signaling centers were further investigated in mice lacking the transcription factor EMX2, in which FGF8 activity is increased, WNT expression reduced, and the hippocampus defective. Suggesting that these defects are causally related, sequestering FGF8 in Emx2 homozygous mutants substantially recovered WNT expression in the hem and partially rescued hippocampal development. Because noggin can induce Fgf8 expression, we examined noggin and BMP signaling in the Emx2 mutant. As the telencephalic vesicle closed, Nog expression was expanded and BMP activity reduced,potentially leading to FGF8 upregulation. Our findings point to a cross-regulation of BMP, FGF, and WNT signaling in the early telencephalon,integrated by EMX2, and required for normal cortical development.
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Cites
Specification of Cerebral Cortical Areas
Rakic, P. (1988) · Science · doi:10.1126/science.3291116 · Cited by 3,127 · cited 2×
“5639”
BackgroundRevised nomenclature for avian telencephalon and some related brainstem nuclei
Reiner, A., Perkel, D. J., Bruce, L. L., Butler, A. B., Csillag, A., Kuenzel, W., Medina, L., Paxinos, G., Shimizu, T., Striedter, G., et al. (2004) · Journal of Comparative Neurology · doi:10.1002/cne.20118 · Cited by 1,148
One hundred years of positional information.
Wolpert, L. (1996) · Trends in Genetics · doi:10.1016/s0168-9525(96)80019-9 · Cited by 265
Cited by
Patterning and plasticity of the cerebral cortex
Sur, M., & Rubenstein, J. L. R. (2005) · Science · doi:10.1126/science.1112070 · Cited by 677
Cell-cycle control and cortical development
Dehay, C., & Kennedy, H. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2097 · Cited by 655
The cerebrospinal fluid provides a proliferative niche for neural progenitor cells
Lehtinen, M. K., Zappaterra, M. W., Chen, X., Yang, Y. J., Hill, A. D., Lun, M., Maynard, T., Gonzalez, D., Kim, S., Ye, P., et al. (2011) · Neuron · doi:10.1016/j.neuron.2011.01.023 · Cited by 648
Map Plasticity in Somatosensory Cortex
Feldman, D. E., & Brecht, M. (2005) · Science · doi:10.1126/science.1115807 · Cited by 587
Regulation of the GABA cell phenotype in hippocampus of schizophrenics and bipolars
Benes, F. M., Lim, B., Matzilevich, D., Walsh, J. P., Subburaju, S., & Minns, M. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0703806104 · Cited by 483
Lhx2 Selector Activity Specifies Cortical Identity and Suppresses Hippocampal Organizer Fate
Mangale, V. S., Hirokawa, K. E., Satyaki, P. R. V., Gokulchandran, N., Chikbire, S., Subramanian, L., Shetty, A. S., Martynoga, B., Paul, J., Mai, M. V., et al. (2008) · Science · doi:10.1126/science.1151695 · Cited by 316
Decision by division: making cortical maps
Rakic, P., Ayoub, A. E., Breunig, J. J., & Dominguez, M. H. (2009) · Trends in Neurosciences · doi:10.1016/j.tins.2009.01.007 · Cited by 287
Tornero, D., Wattananit, S., Grønning Madsen, M., Koch, P., Wood, J., Tatarishvili, J., Mine, Y., Ge, R., Monni, E., Devaraju, K., et al. (2013) · Brain · doi:10.1093/brain/awt278 · Cited by 241
Miyoshi, G., Young, A., Petros, T., Karayannis, T., McKenzie Chang, M., Lavado, A., Iwano, T., Nakajima, M., Taniguchi, H., Huang, Z. J., et al. (2015) · The Journal of Neuroscience · doi:10.1523/jneurosci.1164-15.2015 · Cited by 135
Peukert, D., Weber, S., Lumsden, A., & Scholpp, S. (2011) · PLoS Biology · doi:10.1371/journal.pbio.1001218 · Cited by 118
The cerebral cortex malformation in thanatophoric dysplasia: neuropathology and pathogenesis
Hevner, R. F. (2005) · Acta Neuropathologica · doi:10.1007/s00401-005-1059-8 · Cited by 106
Patterning the Dorsal Telencephalon: A Role for Sonic Hedgehog?
Rash, B. G., & Grove, E. A. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.3204-07.2007 · Cited by 103
Self-citationGene networks controlling early cerebral cortex arealization
Mallamaci, A., & Stoykova, A. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.04634.x · Cited by 95
The origins of the circumventricular organs
Kiecker, C. (2018) · Journal of Anatomy · doi:10.1111/joa.12771 · Cited by 92
Paronett, E. M., Meechan, D. W., Karpinski, B. A., LaMantia, A.-S., & Maynard, T. M. (2015) · Cerebral Cortex · doi:10.1093/cercor/bhu285 · Cited by 54
Metadata
- Authors
- Shimogori, T., Banuchi, V., Ng, H. Y., Strauss, J. B., & Grove, E. A.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2004-11-15
- Volume
- 131
- Issue
- 22
- Pages
- 5639-5647
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2112809461
- Cited by
- 301
- References
- 3
- FWCI
- 5.00
- Type
- journal article
- Language
- en
- Open access
- closed
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