Lhx2 Selector Activity Specifies Cortical Identity and Suppresses Hippocampal Organizer Fate

Generalized lacZ expression with the ROSA26 Cre reporter strain

Soriano, P. (1999) · Nature Genetics · doi:10.1038/5007 · Cited by 5,237 · see citing works

The cell biology of neurogenesis

Götz, M., & Huttner, W. B. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1739 · Cited by 2,130 · see citing works

Manipulating the Mouse Embryo: A Laboratory Manual

Behringer, R. R., Gertsenstein, M., Nagy, K. V., & Nagy, A. (2002) · Cited by 2,046 · see citing works

Efficient Recombination in Diverse Tissues by a Tamoxifen-Inducible Form of Cre: A Tool for Temporally Regulated Gene Activation/Inactivation in the Mouse

Hayashi, S., & McMahon, A. P. (2002) · Developmental Biology · doi:10.1006/dbio.2002.0597 · Cited by 1,347 · see citing works

The cell cycle of the pseudostratified ventricular epithelium of the embryonic murine cerebral wall

Takahashi, T., Nowakowski, R. S., & Caviness, V. S. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-09-06046.1995 · Cited by 673 · see citing works

A local Wnt-3a signal is required for development of the mammalian hippocampus

Lee, S. M. K., Tole, S., Grove, E. A., & McMahon, A. P. (2000) · Development · doi:10.1242/dev.127.3.457 · Cited by 636 · see citing works

Genetic Control of Wing Disc Development in Drosophila

Garcı́a-Bellido, A. (1975) · Novartis Foundation symposium · doi:10.1002/9780470720110.ch8 · Cited by 578 · see citing works

Morphogens, Compartments, and Pattern: Lessons from Drosophila?

Lawrence, P. A., & Struhl, G. (1996) · Cell · doi:10.1016/s0092-8674(00)81297-0 · Cited by 556 · see citing works

Six3 repression of Wnt signaling in the anterior neuroectoderm is essential for vertebrate forebrain developmentPreprint

Lagutin, O. V., Zhu, C. C., Kobayashi, D., Topczewski, J., Shimamura, K., Puelles, L., Russell, H. R. C., McKinnon, P. J., Solnica‐Krezel, L., & Oliver, G. C. (2003) · Genes & Development · doi:10.1101/gad.1059403 · Cited by 528 · see citing works

Lhx2, a LIM homeobox gene, is required for eye, forebrain, and definitive erythrocyte development

Porter, F. D., Drago, J., Xu, Y., Cheema, S. S., Wassif, C. A., Huang, S.-P., Lee, E., Grinberg, A., Massalas, J. S., Bodine, D. M., et al. (1997) · Development · doi:10.1242/dev.124.15.2935 · Cited by 491 · see citing works

Compartments and their boundaries in vertebrate brain development

Kiecker, C. M., & Lumsden, A. (2005) · Nature reviews. Neuroscience · doi:10.1038/nrn1702 · Cited by 408 · see citing works

Hippocampus development and generation of dentate gyrus granule cells is regulated by LEF1

Galcerán, J., Miyashita-Lin, E. M., Devaney, E. J., Rubenstein, J. L. R., & Grosschedl, R. (2000) · Development · doi:10.1242/dev.127.3.469 · Cited by 399 · see citing works

The chemokine SDF1 regulates migration of dentate granule cells

Bagri, A., Gurney, T. A., He, X., Zou, Y.-R., Littman, D. R., Tessier‐Lavigne, M., & Pleasure, S. J. (2002) · Development · doi:10.1242/dev.129.18.4249 · Cited by 387 · see citing works

Interaction between dorsal and ventral cells in the imaginal disc directs wing development in Drosophila

Díaz‐Benjumea, F. J. (1993) · Cell · doi:10.1016/0092-8674(93)90494-b · Cited by 361 · see citing works

Embryonic signaling centers expressing BMP, WNT and FGF proteins interact to pattern the cerebral cortex

Shimogori, T., Banuchi, V., Ng, H., Strauss, J. B., & Grove, E. (2004) · Development · doi:10.1242/dev.01428 · Cited by 317 · see citing works

Pax6Modulates the Dorsoventral Patterning of the Mammalian Telencephalon

Stoykova, A., Treichel, D., Hallonet, M. E. R., & Gruß, P. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-21-08042.2000 · Cited by 314 · see citing works

Analysis of Fgf8 gene function in vertebrate development.Preprint

Lewandoski, M. B., Meyers, E. N., & Martin, G. R. (1997) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.1997.062.01.021 · Cited by 300 · see citing works

Patterning of the Dorsal Telencephalon and Cerebral Cortex by a Roof Plate-Lhx2 Pathway

Monuki, E. S., Porter, F. D., & Walsh, C. A. (2001) · Neuron · doi:10.1016/s0896-6273(01)00504-9 · Cited by 294 · see citing works

Pax6-dependent regulation of adhesive patterning, R-cadherin expression and boundary formation in developing forebrain

Stoykova, A., Götz, M., Gruss, P., & Price, J. (1997) · Development · doi:10.1242/dev.124.19.3765 · Cited by 284 · see citing works

Massive loss of Cajal-Retzius cells does not disrupt neocortical layer order

Yoshida, M., Assimacopoulos, S., Jones, K. R., & Grove, E. A. (2006) · Development · doi:10.1242/dev.02209 · Cited by 275 · see citing works

A Noninvasive Genetic/Pharmacologic Strategy for Visualizing Cell Morphology and Clonal Relationships in the Mouse

Badea, T. C., Wang, Y., & Nathans, J. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-06-02314.2003 · Cited by 256 · see citing works

BMP Signaling Is Required Locally to Pattern the Dorsal Telencephalic Midline

Hébert, J. M., Mishina, Y. M., & McConnell, S. K. (2002) · Neuron · doi:10.1016/s0896-6273(02)00900-5 · Cited by 256 · see citing works

Intrinsic programs of patterned cell lineages in isolated vertebrate CNS ventricular zone cells

Qian, X., Goderie, S. K., Shen, Q., Stern, J. H., & Temple, S. (1998) · Development · doi:10.1242/dev.125.16.3143 · Cited by 245 · see citing works

Organization of radial glial cells during the development of the rat dentate gyrus

Rickmann, M., Amaral, D. G., & Cowan, W. M. (1987) · The Journal of Comparative Neurology · doi:10.1002/cne.902640403 · Cited by 243 · see citing works

Regulation of human neural precursor cells by laminin and integrins

Flanagan, L. A., Rebaza, L. M., Derzic, S., Schwartz, P. H., & Monuki, E. S. (2006) · Journal of Neuroscience Research · doi:10.1002/jnr.20778 · Cited by 243 · see citing works

Boundaries in Development: Formation and Function

Irvine, K. D., & Rauskolb, C. (2001) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.17.1.189 · Cited by 220 · see citing works

Role of β-catenin in the developing cortical and hippocampal neuroepithelium

Machoň, O., van den Bout, C. J., Backman, M., Kemler, R., & Krauss, S. J. K. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00519-0 · Cited by 212 · see citing works

A dynamic gradient of Wnt signaling controls initiation of neurogenesis in the mammalian cortex and cellular specification in the hippocampus

Machoň, O., Backman, M., Machoňová, O., Kozmík, Z., Vacı́k, T., Andersen, L., & Krauss, S. J. K. (2007) · Developmental Biology · doi:10.1016/j.ydbio.2007.08.038 · Cited by 208 · see citing works

Wnt Signaling Mutants Have Decreased Dentate Granule Cell Production and Radial Glial Scaffolding Abnormalities

Zhou, C. J., Zhao, C., & Pleasure, S. J. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.4071-03.2004 · Cited by 196 · see citing works

Identification of aPax6-Dependent Epidermal Growth Factor Family Signaling Source at the Lateral Edge of the Embryonic Cerebral Cortex

Assimacopoulos, S., Grove, E. A., & Ragsdale, C. W. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-16-06399.2003 · Cited by 186 · see citing works

LIM-homeodomain gene Lhx2 regulates the formation of the cortical hem

Bulchand, S., Grove, E. A., Porter, F. D., & Tole, S. (2001) · Mechanisms of Development · doi:10.1016/s0925-4773(00)00515-3 · Cited by 181 · see citing works

The role of apterous in the control of dorsoventral compartmentalization and PS integrin gene expression in the developing wing of Drosophila

Blair, S. S., Brower, D. L., Thomas, J. B., & Zavortink, M. (1994) · Development · doi:10.1242/dev.120.7.1805 · Cited by 181 · see citing works

Morphogenesis of the Dentate Gyrus: What We Are Learning from Mouse Mutants

Li, G., & Pleasure, S. J. (2005) · Developmental Neuroscience · doi:10.1159/000085980 · Cited by 156 · see citing works

Foxg1Confines Cajal-Retzius Neuronogenesis and Hippocampal Morphogenesis to the Dorsomedial Pallium

Muzio, L., & Mallamaci, A. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.4804-04.2005 · Cited by 155 · see citing works

Direct and indirect roles of CNS dorsal midline cells in choroid plexus epithelia formation

Currle, D. S., Cheng, X., Hsu, C.-M., & Monuki, E. S. (2005) · Development · doi:10.1242/dev.01915 · Cited by 123 · see citing works

Early specification and autonomous development of cortical fields in the mouse hippocampus

Tole, S., Christian, C., & Grove, E. A. (1997) · Development · doi:10.1242/dev.124.24.4959 · Cited by 114 · see citing works

Ventralized dorsal telencephalic progenitors in Pax6 mutant mice generate GABA interneurons of a lateral ganglionic eminence fate

Kroll, T. T., & O’Leary, D. D. M. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0500819102 · Cited by 111 · see citing works

Lhx2 mediates the activity of Six3 in zebrafish forebrain growth

Ando, H., Kobayashi, M., Tsubokawa, T., Uyemura, K., Furuta, T., & Okamoto, H. (2005) · Developmental Biology · doi:10.1016/j.ydbio.2005.09.023 · Cited by 108 · see citing works

Central Roles of the Roof Plate in Telencephalic Development and Holoprosencephaly

Cheng, X., Hsu, C.-M., Currle, D. S., Hu, J. S., Barkovich, A. J., & Monuki, E. S. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.0714-06.2006 · Cited by 101 · see citing works

Selective Adhesion of Cells from Different Telencephalic Regions

Götz, M., Wizenmann, A., Reinhardt, S., Lumsden, A., & Price, J. (1996) · Neuron · doi:10.1016/s0896-6273(00)80074-4 · Cited by 90 · see citing works

Conservation of the expression and function of apterous orthologs in Drosophila and mammals

Rincón-Limas, D. E., Lu, C.-H., Canal, I., Calleja, M., Rodrı́guez-Esteban, C., Izpisúa‐Belmonte, J. C., & Botas, J. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.5.2165 · Cited by 84 · see citing works

Emx1 and Emx2 cooperate in initial phase of archipallium development

Shinozaki, K., Yoshida, M., Nakamura, M., Aizawa, S., & Suda, Y. (2004) · Mechanisms of Development · doi:10.1016/j.mod.2004.03.013 · Cited by 75 · see citing works

Chondroitin sulfate proteoglycan expression pattern in hippocampal development: Potential regulation of axon tract formation

Wilson, M. T., & Snow, D. M. (2000) · The Journal of Comparative Neurology · doi:10.1002/1096-9861(20000828)424:3 · Cited by 72 · see citing works

Detailed Field Pattern Is Intrinsic to the Embryonic Mouse Hippocampus Early in Neurogenesis

Tole, S., & Grove, E. A. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-05-01580.2001 · Cited by 63 · see citing works

A transgenic marker mouse line labels Cajal–Retzius cells from the cortical hem and thalamocortical axons

Zhao, C., Guan, W., & Pleasure, S. J. (2006) · Brain Research · doi:10.1016/j.brainres.2006.01.042 · Cited by 56 · see citing works

Emx1-Specific Expression of Foreign Genes Using “Knock-in” Approach

Jin, X.-L., Guo, H., Mao, C., Atkins, N., Wang, H., Avasthi, P. P., Tu, Y.-T., & Li, Y. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.2532 · Cited by 44 · see citing works

Abnormal Development of Mouse Embryoid Bodies Lacking p27 Kip1 Cell Cycle Regulator

Bryja, V., Čajánek, L., Pachernı́k, J., Hall, A. C., Horváth, V., Dvořák, P., & Hampl, A. (2005) · Stem Cells · doi:10.1634/stemcells.2004-0174 · Cited by 22 · see citing works

Self-Organized Formation of Polarized Cortical Tissues from ESCs and Its Active Manipulation by Extrinsic Signals

Eiraku, M., Watanabe, K., Matsuo-Takasaki, M., Kawada, M., Yonemura, S., Matsumura, M., Wataya, T., Nishiyama, A., Muguruma, K., & Sasai, Y. (2008) · Cell Stem Cell · doi:10.1016/j.stem.2008.09.002 · Cited by 1,522 · see citing works

Comprehensive functional genomic resource and integrative model for the human brain

Wang, D., Liu, S., Warrell, J., Won, H., Shi, X., Navarro, F. C. P., Clarke, D., Gu, M., Emani, P., Yang, Y. T., et al. (2018) · Science · doi:10.1126/science.aat8464 · Cited by 965 · see citing works

Area Patterning of the Mammalian Cortex

O’Leary, D. D. M., Chou, S., & Sahara, S. (2007) · Neuron · doi:10.1016/j.neuron.2007.10.010 · Cited by 574 · see citing works

Generation of functional hippocampal neurons from self-organizing human embryonic stem cell-derived dorsomedial telencephalic tissue

Sakaguchi, H., Kadoshima, T., Soen, M., Narii, N., Ishida, Y., Ohgushi, M., Takahashi, J., Eiraku, M., & Sasai, Y. (2015) · Nature Communications · doi:10.1038/ncomms9896 · Cited by 542 · see citing works

Modeling human cortical development in vitro using induced pluripotent stem cells

Mariani, J., Simonini, M. V., Palejev, D., Tomasini, L., Coppola, G., Szekely, A. M., Horvath, T. L., & Vaccarino, F. M. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1202944109 · Cited by 526 · see citing works

Neurogenesis in the embryonic and adult brain: same regulators, different roles

Urbán, N., & Guillemot, F. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00396 · Cited by 493 · see citing works

The genetics of early telencephalon patterning: some assembly required

Hébert, J. M., & Fishell, G. (2008) · Nature reviews. Neuroscience · doi:10.1038/nrn2463 · Cited by 377 · see citing works

Opposing roles of hepatic stellate cell subpopulations in hepatocarcinogenesis

Filliol, A., Saito, Y., Nair, A., Dapito, D. H., Yu, L.-X., Ravichandra, A., Bhattacharjee, S., Affo, S., Fujiwara, N., Su, H., et al. (2022) · Nature · doi:10.1038/s41586-022-05289-6 · Cited by 349 · see citing works

Lhx2/Ldb1-mediated trans interactions regulate olfactory receptor choice

Monahan, K., Horta, A., & Lomvardas, S. (2019) · Nature · doi:10.1038/s41586-018-0845-0 · Cited by 245 · see citing works

Regulatory logic of neuronal diversity: Terminal selector genes and selector motifs

Hobert, O. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0806070105 · Cited by 280 · see citing works

miR-124a is required for hippocampal axogenesis and retinal cone survival through Lhx2 suppression

Sanuki, R., Onishi, A., Koike, C., Muramatsu, R., Watanabe, S., Muranishi, Y., Irie, S., Uneo, S., Koyasu, T., Matsui, R., et al. (2011) · Nature Neuroscience · doi:10.1038/nn.2897 · Cited by 276 · see citing works

A Single-Cell RNA Sequencing Study Reveals Cellular and Molecular Dynamics of the Hippocampal Neurogenic Niche

Artegiani, B., Lyubimova, A., Muraro, M., van Es, J. H., van Oudenaarden, A., & Clevers, H. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.11.050 · Cited by 259 · see citing works

Long noncoding RNA genes: conservation of sequence and brain expression among diverse amniotes

Chodroff, R. A., Goodstadt, L., Sirey, T., Oliver, P. L., Davies, K. E., Green, E. D., Molnár, Z., & Ponting, C. P. (2010) · Genome biology · doi:10.1186/gb-2010-11-7-r72 · Cited by 252 · see citing works

Chromatin accessibility dynamics in a model of human forebrain development

Trevino, A. E., Sinnott-Armstrong, N., Andersen, J., Yoon, S.-J., Huber, N., Pritchard, J. K., Chang, H. Y., Greenleaf, W. J., & Pașca, S. P. (2020) · Science · doi:10.1126/science.aay1645 · Cited by 251 · see citing works

Decoding the development of the human hippocampus

Zhong, S., Ding, W., Sun, L., Lu, Y., Dong, H., Fan, X., Liu, Z., Chen, R., Zhang, S., Ma, Q., et al. (2020) · Nature · doi:10.1038/s41586-019-1917-5 · Cited by 236 · see citing works

Genetic regulation of arealization of the neocortex

O’Leary, D. D. M., & Sahara, S. (2008) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2008.05.011 · Cited by 219 · see citing works

Hedgehog Pathway Activation and Epithelial-to-Mesenchymal Transitions During Myofibroblastic Transformation of Rat Hepatic Cells in Culture and Cirrhosis

Choi, S. S., Omenetti, A., Witek, R. P., Moylan, C. A., Syn, W.-K., Jung, Y., Yang, L., Sudan, D. L., Sicklick, J. K., Michelotti, G. A., et al. (2009) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00292.2009 · Cited by 219 · see citing works

Rewiring of human neurodevelopmental gene regulatory programs by human accelerated regions

Girskis, K. M., Stergachis, A. B., DeGennaro, E. M., Doan, R. N., Qian, X., Johnson, M. B., Wang, P. P., Sejourne, G. M., Nagy, M. A., Pollina, E. A., et al. (2021) · Neuron · doi:10.1016/j.neuron.2021.08.005 · Cited by 193 · see citing works

Evolution of the hippocampus in reptiles and birds

Striedter, G. (2016) · The Journal of comparative neurology · doi:10.1002/cne.23803 · Cited by 161 · see citing works

Discrete domains of gene expression in germinal layers distinguish the development of gyrencephaly

Romero, C. D. J., Bruder, C. E. G., Tomasello, U., Sanz‐Anquela, J. M., & Borrell, V. (2015) · The EMBO Journal · doi:10.15252/embj.201591176 · Cited by 173 · see citing works

The Ventral Hippocampus Is the Embryonic Origin for Adult Neural Stem Cells in the Dentate Gyrus

Li, G., Fang, L., Fernández, G., & Pleasure, S. J. (2013) · Neuron · doi:10.1016/j.neuron.2013.03.019 · Cited by 171 · see citing works

Annual Research Review: Development of the cerebral cortex: implications for neurodevelopmental disorders

Rubenstein, J. L. R. (2010) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2010.02307.x · Cited by 170 · see citing works

Wnt Signaling and Forebrain DevelopmentPreprint

Harrison-Uy, S. J., & Pleasure, S. J. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a008094 · Cited by 163 · see citing works

Wnt Signaling in Vertebrate Neural Development and Function

Mulligan, K. A., & Cheyette, B. N. R. (2012) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-012-9404-x · Cited by 165 · see citing works

Lmx1a regulates fates and location of cells originating from the cerebellar rhombic lip and telencephalic cortical hem

Chizhikov, V. V., Lindgren, A., Mishima, Y., Roberts, R. W., Aldinger, K. A., Miesegaes, G. R., Currle, D. S., Monuki, E. S., & Millen, K. J. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0910786107 · Cited by 160 · see citing works

Transcripts involved in calcium signaling and telencephalic neuronal fate are altered in induced pluripotent stem cells from bipolar disorder patients

Chen, H. M., DeLong, C. J., Bame, M., Rajapakse, I., Herron, T. J., McInnis, M. G., & O’Shea, K. S. (2014) · Translational Psychiatry · doi:10.1038/tp.2014.12 · Cited by 153 · see citing works

Genetic dissection of the glutamatergic neuron system in cerebral cortex

Matho, K. S., Huilgol, D., Galbavy, W., He, M., Kim, G., An, X., Lu, J., Wu, P., Di Bella, D. J., Shetty, A. S., et al. (2021) · Nature · doi:10.1038/s41586-021-03955-9 · Cited by 155 · see citing works

Prox1 postmitotically defines dentate gyrus cells by specifying granule cell identity over CA3 pyramidal cell fate in the hippocampus

Iwano, T., Masuda, A., Kiyonari, H., Enomoto, H., & Matsuzaki, F. (2012) · Development · doi:10.1242/dev.080002 · Cited by 155 · see citing works

Molecular underpinnings of prefrontal cortex development in rodents provide insights into the etiology of neurodevelopmental disorders

Schubert, D., Martens, G. J. M., & Kolk, S. M. (2014) · Molecular Psychiatry · doi:10.1038/mp.2014.147 · Cited by 149 · see citing works

NFIA Controls Telencephalic Progenitor Cell Differentiation through Repression of the Notch Effector Hes1

Piper, M., Barry, G., Hawkins, J., Mason, S., Lindwall, C., Little, E. B., Sarkar, A., Smith, A. G., Moldrich, R. X., Boyle, G. M., et al. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.6167-09.2010 · Cited by 147 · see citing works

A Crucial Role for Primary Cilia in Cortical Morphogenesis

Willaredt, M. A., Hasenpusch‐Theil, K., Gardner, H., Kitanović, I., Hirschfeld‐Warneken, V. C., Gojak, C., Gorgas, K., Bradford, C. L., Spatz, J. P., Wölfl, S., et al. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.2084-08.2008 · Cited by 144 · see citing works

Cooperative interactions enable singular olfactory receptor expression in mouse olfactory neurons

Monahan, K., Schieren, I., Cheung, J., Mumbey-Wafula, A., Monuki, E. S., & Lomvardas, S. (2017) · eLife · doi:10.7554/elife.28620 · Cited by 144 · see citing works

Genes and signaling events that establish regional patterning of the mammalian forebrain

Hoch, R. V., Rubenstein, J. L. R., & Pleasure, S. (2009) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2009.02.005 · Cited by 147 · see citing works

Lhx2 specifies regional fate in Emx1 lineage of telencephalic progenitors generating cerebral cortex

Chou, S., Pérez‐García, C. G., Kroll, T. T., & O’Leary, D. D. M. (2009) · Nature Neuroscience · doi:10.1038/nn.2427 · Cited by 125 · see citing works

Lhx2 and Lhx9 Determine Neuronal Differentiation and Compartition in the Caudal Forebrain by Regulating Wnt Signaling

Peukert, D., Weber, S., Lumsden, A., & Scholpp, S. (2011) · PLoS Biology · doi:10.1371/journal.pbio.1001218 · Cited by 118 · see citing works

How development sculpts hippocampal circuits and function

Cossart, R., & Khazipov, R. (2021) · Physiological Reviews · doi:10.1152/physrev.00044.2020 · Cited by 119 · see citing works

Lhx2links the intrinsic and extrinsic factors that control optic cup formation

Yun, S., Saijoh, Y., Hirokawa, K. E., Kopinke, D., Murtaugh, L. C., Monuki, E. S., & Levine, E. M. (2009) · Development · doi:10.1242/dev.041202 · Cited by 111 · see citing works

FGF8 acts as a classic diffusible morphogen to pattern the neocortex

Toyoda, R., Assimacopoulos, S., Wilcoxon, J., Taylor, A., Feldman, P., Suzuki‐Hirano, A., Shimogori, T., & Grove, E. A. (2010) · Development · doi:10.1242/dev.055392 · Cited by 110 · see citing works

Fibroblast growth factor signaling in development of the cerebral cortex

Iwata, T., & Hevner, R. F. (2009) · Development Growth & Differentiation · doi:10.1111/j.1440-169x.2009.01104.x · Cited by 108 · see citing works

Pharyngeal mesoderm regulatory network controls cardiac and head muscle morphogenesis

Harel, I., Maezawa, Y., Avraham, R., Rinon, A., Ma, H., Cross, J. W., Leviatan, N., Hegesh, J. T., Roy, A., Jacob‐Hirsch, J., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1208690109 · Cited by 110 · see citing works

Spatial Regionalization and Heterochrony in the Formation of Adult Pallial Neural Stem Cells

Dirian, L., Galant, S., Coolen, M., Chen, W., Bedu, S., Houart, C., Bally-Cuif, L., & Foucher, I. (2014) · Developmental Cell · doi:10.1016/j.devcel.2014.05.012 · Cited by 109 · see citing works

Tumor suppressor Nf2 limits expansion of the neural progenitor pool by inhibiting Yap/Taz transcriptional coactivators

Lavado, A., He, Y. Y., Paré, J., Neale, G. A. M., Olson, E. N., Giovannini, M., & Cao, X. (2013) · Development · doi:10.1242/dev.096537 · Cited by 108 · see citing works

Cell fate decisions, transcription factors and signaling during early retinal development

Diacou, R., Nandigrami, P., Fiser, A., Liu, W., Ashery‐Padan, R., & Cvekl, A. (2022) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2022.101093 · Cited by 103 · see citing works

Restoring eye size in Astyanax mexicanus blind cavefish embryos through modulation of the Shh and Fgf8 forebrain organising centres

Pottin, K., Hinaux, H., & Rétaux, S. (2011) · Development · doi:10.1242/dev.054106 · Cited by 107 · see citing works

Hippocampal development – Old and new findings

Khalaf‐Nazzal, R., & Francis, F. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.05.061 · Cited by 103 · see citing works

MACF1 regulates the migration of pyramidal neurons via microtubule dynamics and GSK-3 signaling

Ka, M., Jung, E., Mueller, U. W., & Kim, W.-Y. (2014) · Developmental Biology · doi:10.1016/j.ydbio.2014.09.009 · Cited by 104 · see citing works

Lhx2 Is an Essential Factor for Retinal Gliogenesis and Notch Signaling

de Melo, J., Zibetti, C., Clark, B. S., Hwang, W., Miranda‐Angulo, A. L., Qian, J. X., & Blackshaw, S. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.3145-15.2016 · Cited by 100 · see citing works

How to make a hippocampal dentate gyrus granule neuron

Yu, D. X., Marchetto, M. C., & Gage, F. H. (2014) · Development · doi:10.1242/dev.096776 · Cited by 103 · see citing works

Variable expressivity of ciliopathy neurological phenotypes that encompass Meckel–Gruber syndrome and Joubert syndrome is caused by complex de-regulated ciliogenesis, Shh and Wnt signalling defects

Abdelhamed, Z. A., Wheway, G., Szymańska, K., Natarajan, S., Toomes, C., Inglehearn, C. F., & Johnson, C. A. (2013) · Human Molecular Genetics · doi:10.1093/hmg/dds546 · Cited by 99 · see citing works

Architectural Niche Organization by LHX2 Is Linked to Hair Follicle Stem Cell Function

Folgueras, A. R., Guo, X., Pasolli, H. A., Stokes, N., Polak, L., Zheng, D., & Fuchs, E. V. (2013) · Cell stem cell · doi:10.1016/j.stem.2013.06.018 · Cited by 102 · see citing works

Transcriptional Regulation of Enhancers Active in Protodomains of the Developing Cerebral Cortex

Pattabiraman, K., Golonzhka, O., Lindtner, S., Nord, A. S., Taher, L., Hoch, R. V., Silberberg, S. N., Zhang, D., Chen, B., Zeng, H., et al. (2014) · Neuron · doi:10.1016/j.neuron.2014.04.014 · Cited by 99 · see citing works

Transcription factor Lhx2 is necessary and sufficient to suppress astrogliogenesis and promote neurogenesis in the developing hippocampus

Subramanian, L., Sarkar, A., Shetty, A. S., Muralidharan, B., Padmanabhan, H. K., Piper, M., Monuki, E. S., Bach, I., Gronostajski, R. M., Richards, L. J., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1101109108 · Cited by 100 · see citing works

Tissue specific DNA methylation of CpG islands in normal human adult somatic tissues distinguishes neural from non-neural tissues

Ghosh, S., Yates, A. J., Frühwald, M. C., Miecznikowski, J. C., Plass, C., & Smiraglia, D. J. (2010) · Epigenetics · doi:10.4161/epi.5.6.12228 · Cited by 98 · see citing works

The cortical hem regulates the size and patterning of neocortex

Caronia, G., Yoshida, M., Gulden, F. O., Assimacopoulos, S., & Grove, E. A. (2014) · Development · doi:10.1242/dev.106914 · Cited by 96 · see citing works

The Rfx4 Transcription Factor Modulates Shh Signaling by Regional Control of Ciliogenesis

Ashique, A. M., Choe, Y., Karlén, M., May, S., Phamluong, K., Solloway, M. J., Ericson, J., & Peterson, A. S. (2009) · Science Signaling · doi:10.1126/scisignal.2000602 · Cited by 96 · see citing works

Neurodevelopmental Perspectives on Wnt Signaling in Psychiatry

Mulligan, K. A., & Cheyette, B. N. R. (2016) · Complex Psychiatry · doi:10.1159/000453266 · Cited by 95 · see citing works

Foxg1 Coordinates the Switch from Nonradially to Radially Migrating Glutamatergic Subtypes in the Neocortex through Spatiotemporal Repression

Kumamoto, T., Toma, K., Gunadi, G., McKenna, W. L., Kasukawa, T., Katzman, S. J., Chen, B., & Hanashima, C. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.02.023 · Cited by 95 · see citing works

Specific Glial Populations Regulate Hippocampal Morphogenesis

Barry, G., Piper, M., Lindwall, C., Moldrich, R. X., Mason, S., Little, E. B., Sarkar, A., Tole, S., Gronostajski, R. M., & Richards, L. J. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.4000-08.2008 · Cited by 95 · see citing works

Evolutionary conservation and conversion of Foxg1 function in brain development

Kumamoto, T., & Hanashima, C. (2017) · Development Growth & Differentiation · doi:10.1111/dgd.12367 · Cited by 90 · see citing works

BMP4 Sufficiency to Induce Choroid Plexus Epithelial Fate from Embryonic Stem Cell-Derived Neuroepithelial Progenitors

Watanabe, M., Kang, Y., Davies, L. M., Meghpara, S., Lau, K., Chung, C., Kathiriya, J. J., Hadjantonakis, A., & Monuki, E. S. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.3227-12.2012 · Cited by 93 · see citing works

Neural Stem Cell of the Hippocampus

Rolando, C., & Taylor, V. (2014) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/b978-0-12-416022-4.00007-x · Cited by 91 · see citing works

The LIM and POU homeobox genes ttx-3 and unc-86 act as terminal selectors in distinct cholinergic and serotonergic neuron types

Zhang, F., Bhattacharya, A., Nelson, J. C., Abe, N., Gordon, P., Lloret-Fernández, C., Maicas, M., Flames, N., Mann, R. S., Colón‐Ramos, D. A., et al. (2013) · Development · doi:10.1242/dev.099721 · Cited by 92 · see citing works

LHX2 Is Necessary for the Maintenance of Optic Identity and for the Progression of Optic Morphogenesis

Roy, A., de Melo, J., Chaturvedi, D., Thein, T., Cabrera‐Socorro, A., Houart, C., Meyer, G., Blackshaw, S., & Tole, S. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.4216-12.2013 · Cited by 88 · see citing works

Lhx2 Balances Progenitor Maintenance with Neurogenic Output and Promotes Competence State Progression in the Developing Retina

Gordon, P. J., Yun, S., Clark, A. M., Monuki, E. S., Murtaugh, L. C., & Levine, E. M. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.1494-13.2013 · Cited by 82 · see citing works

LHX2 regulates the neural differentiation of human embryonic stem cells via transcriptional modulation of PAX6 and CER1

Hou, P.-S., Chuang, C.-Y., Kao, C.-F., Chou, S., Stone, L., Ho, H., Chien, C. L., & Kuo, H. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt567 · Cited by 81 · see citing works

Distinct Lineage-Dependent Structural and Functional Organization of the Hippocampus

Xu, H.-T., Han, Z., Gao, P., He, S., Li, Z., Shi, W., Kodish, O., Shao, W., Brown, K. N., Huang, K., et al. (2014) · Cell · doi:10.1016/j.cell.2014.03.067 · Cited by 80 · see citing works

Evolution of the mammalian dentate gyrus

Hevner, R. F. (2015) · The Journal of Comparative Neurology · doi:10.1002/cne.23851 · Cited by 80 · see citing works

Lhx2 Regulates the Development of the Forebrain Hem System

Roy, A., González‐Gómez, M., Pierani, A., Meyer, G., & Tole, S. (2013) · Cerebral Cortex · doi:10.1093/cercor/bhs421 · Cited by 77 · see citing works

Three-dimensional liquid metal-based neuro-interfaces for human hippocampal organoids

Wu, Y. Q., Cheng, J., Qi, J., Hang, C., Dong, R., Low, B. C., Yu, H., & Jiang, X. (2024) · Nature Communications · doi:10.1038/s41467-024-48452-5 · Cited by 78 · see citing works

LHX2 Interacts with the NuRD Complex and Regulates Cortical Neuron Subtype Determinants<i>Fezf2</i>and<i>Sox11</i>

Muralidharan, B., Khatri, Z., Maheshwari, U., Gupta, R., Roy, B., Pradhan, S. J., Karmodiya, K., Padmanabhan, H., Shetty, A. S., Balaji, C., et al. (2017) · The Journal of Neuroscience · doi:10.1523/jneurosci.2836-16.2016 · Cited by 65 · see citing works

Lhx2, an evolutionarily conserved, multifunctional regulator of forebrain development

Chou, S.-J., & Tole, S. (2019) · Brain Research · doi:10.1016/j.brainres.2018.02.046 · Cited by 74 · see citing works

Signals from the edges: The cortical hem and antihem in telencephalic development

Subramanian, L., Remedios, R., Shetty, A. S., & Tole, S. (2009) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2009.04.001 · Cited by 74 · see citing works

The LIM Homeodomain Factor Lhx2 Is Required for Hypothalamic Tanycyte Specification and Differentiation

Salvatierra, J., Lee, D. A., Zibetti, C., Duran‐Moreno, M., Yoo, S., Newman, E. A., Wang, H., Bedont, J. L., de Melo, J., Miranda‐Angulo, A. L., et al. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.1711-14.2014 · Cited by 71 · see citing works

TheLhx2Transcription Factor Controls Thalamocortical Axonal Guidance by Specific Regulation of Robo1 and Robo2 Receptors

Marcos-Mondéjar, P., Peregrín, S., Li, J. Y. H., Carlsson, L., Tole, S., & López‐Bendito, G. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.5851-11.2012 · Cited by 71 · see citing works

Lmo4 Establishes Rostral Motor Cortex Projection Neuron Subtype Diversity

Cederquist, G., Azim, E., Shnider, S. J., Padmanabhan, H. K., & Macklis, J. D. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.5140-12.2013 · Cited by 71 · see citing works

The Mammalian DM Domain Transcription Factor Dmrta2 Is Required for Early Embryonic Development of the Cerebral Cortex

Konno, D., Iwashita, M., Satoh, Y., Momiyama, A., Abe, T., Kiyonari, H., & Matsuzaki, F. (2012) · PLoS ONE · doi:10.1371/journal.pone.0046577 · Cited by 68 · see citing works

Zbtb20-Induced CA1 Pyramidal Neuron Development and Area Enlargement in the Cerebral Midline Cortex of Mice

Nielsen, J. V., Blom, J. B., Noraberg, J., & Jensen, N. A. (2009) · Cerebral Cortex · doi:10.1093/cercor/bhp261 · Cited by 67 · see citing works

Microtubule-Actin Crosslinking Factor 1 Is Required for Dendritic Arborization and Axon Outgrowth in the Developing Brain

Ka, M., & Kim, W.-Y. (2015) · Molecular Neurobiology · doi:10.1007/s12035-015-9508-4 · Cited by 67 · see citing works

The Doublesex Homolog Dmrt5 is Required for the Development of the Caudomedial Cerebral Cortex in Mammals

Saulnier, A., Keruzoré, M., Clercq, S. D., Bar, I., Moers, V., Magnani, D., Walcher, T., Filippis, C., Kricha, S., Parlier, D., et al. (2012) · Cerebral Cortex · doi:10.1093/cercor/bhs234 · Cited by 66 · see citing works

Pbx Regulates Patterning of the Cerebral Cortex in Progenitors and Postmitotic Neurons

Golonzhka, O., Nord, A. S., Tang, P. L.-F., Lindtner, S., Ypsilanti, A. R., Ferretti, E., Visel, A., Selleri, L., & Rubenstein, J. L. R. (2015) · Neuron · doi:10.1016/j.neuron.2015.10.045 · Cited by 66 · see citing works

Switching modes in corticogenesis: mechanisms of neuronal subtype transitions and integration in the cerebral cortex

Toma, K., & Hanashima, C. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00274 · Cited by 65 · see citing works

Transcriptional and epigenetic mechanisms of early cortical development: An examination of how Pax6 coordinates cortical development

Ypsilanti, A. R., & Rubenstein, J. L. R. (2015) · The Journal of Comparative Neurology · doi:10.1002/cne.23866 · Cited by 62 · see citing works

Distinctive population of <i>Gfap</i>‐expressing neural progenitors arising around the dentate notch migrate and form the granule cell layer in the developing hippocampus

Seki, T., Sato, T., Toda, K., Osumi, N., Imura, T., & Shioda, S. (2014) · Journal of Comparative Neurology · doi:10.1002/cne.23460 · Cited by 60 · see citing works

Timing Specific Requirement of microRNA Function is Essential for Embryonic and Postnatal Hippocampal Development

Li, Q., Bian, S., Hong, J., Kawase‐Koga, Y., Zhu, E., Zheng, Y., Yang, L., & Sun, T. (2011) · PLoS ONE · doi:10.1371/journal.pone.0026000 · Cited by 63 · see citing works

Bone Morphogenetic Protein Signaling in the Developing Telencephalon Controls Formation of the Hippocampal Dentate Gyrus and Modifies Fear-Related Behavior

Caronia, G., Wilcoxon, J., Feldman, P., & Grove, E. A. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.0550-10.2010 · Cited by 63 · see citing works

Lhx2 regulates the timing of β-catenin-dependent cortical neurogenesis

Hsu, L. C.-L., Nam, S., Cui, Y., Chang, C.-P., Wang, C.-F., Kuo, H., Touboul, J. D., & Chou, S. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1507145112 · Cited by 63 · see citing works

Constitutive activation of canonical Wnt signaling disrupts choroid plexus epithelial fate

Parichha, A., Suresh, V., Chatterjee, M., Kshirsagar, A., Ben‐Reuven, L., Olender, T., Taketo, M. M., Radošević, V., Bobić‐Rasonja, M., Trnski, S., et al. (2022) · Nature Communications · doi:10.1038/s41467-021-27602-z · Cited by 62 · see citing works

Cyclic Expression of Lhx2 Regulates Hair Formation

Törnqvist, G., Sandberg, A., Hägglund, A., & Carlsson, L. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1000904 · Cited by 60 · see citing works

LIM‐homeobox gene 2 promotes tumor growth and metastasis by inducing autocrine and paracrine PDGF‐B signaling

Kuzmanov, A., Hopfer, U., Marti, P., Meyer‐Schaller, N., Yilmaz, M., & Christofori, G. (2013) · Molecular Oncology · doi:10.1016/j.molonc.2013.12.009 · Cited by 61 · see citing works

Zbtb20 Defines a Hippocampal Neuronal Identity Through Direct Repression of Genes That Control Projection Neuron Development in the Isocortex

Nielsen, J. V., Thomassen, M., Møllgård, K., Noraberg, J., & Jensen, N. A. (2013) · Cerebral Cortex · doi:10.1093/cercor/bhs400 · Cited by 58 · see citing works

Role for Lhx2 in corticogenesis through regulation of progenitor differentiation

Chou, S., & O’Leary, D. D. M. (2013) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2013.02.006 · Cited by 60 · see citing works

Adult Neural Stem Cells: Born to Last

Morales, A. V., & Mira, H. (2019) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2019.00096 · Cited by 59 · see citing works

Epigenomic profiling of retinal progenitors reveals LHX2 is required for developmental regulation of open chromatin

Zibetti, C., Liu, S., Wan, J., Qian, J. X., & Blackshaw, S. (2019) · Communications Biology · doi:10.1038/s42003-019-0375-9 · Cited by 59 · see citing works

Lhx2 regulates a cortex-specific mechanism for barrel formation

Shetty, A. S., Godbole, G., Maheshwari, U., Padmanabhan, H. K., Chaudhary, R., Muralidharan, B., Hou, P.-S., Monuki, E. S., Kuo, H., Rema, V., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1311158110 · Cited by 59 · see citing works

Development and Organization of the Evolutionarily Conserved Three-Layered Olfactory Cortex

Klingler, E. (2017) · eNeuro · doi:10.1523/eneuro.0193-16.2016 · Cited by 58 · see citing works

ATP-Dependent Chromatin Remodeling During Cortical Neurogenesis

Sokpor, G., Castro-Hernández, R., Rosenbusch, J., Staiger, J. F., & Tuoc, T. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00226 · Cited by 60 · see citing works

Neurog2 Simultaneously Activates and Represses Alternative Gene Expression Programs in the Developing Neocortex

Kovach, C. P., Dixit, R., Li, S., Mattar, P. A., Wilkinson, G., Elsen, G. E., Kurrasch, D. M., Hevner, R. F., & Schuurmans, C. J. (2012) · Cerebral Cortex · doi:10.1093/cercor/bhs176 · Cited by 55 · see citing works

Tamoxifen administration in pregnant mice can be deleterious to both mother and embryo

Ved, N., Curran, A., Ashcroft, F. M., & Sparrow, D. B. (2019) · Laboratory Animals · doi:10.1177/0023677219856918 · Cited by 58 · see citing works

In vitro generation of HSC-like cells from murine ESCs/iPSCs by enforced expression of LIM-homeobox transcription factor Lhx2

Kitajima, K., Minehata, K., Sakimura, K., Nakano, T., & Hara, T. (2011) · Blood · doi:10.1182/blood-2010-07-298596 · Cited by 54 · see citing works

Differential Expression of LIM-Homeodomain Factors in Cajal-Retzius Cells of Primates, Rodents, and Birds

Abellán, A., Menuet, A., Dehay, C., Medina, L. M., & Rétaux, S. (2009) · Cerebral Cortex · doi:10.1093/cercor/bhp242 · Cited by 53 · see citing works

Instructions for the hippocampus

Flight, M. H. (2008) · Nature reviews. Neuroscience · doi:10.1038/nrn2341 · Cited by 1 · see citing works

Supporting Online Material for Lhx2 Selector Activity Specifies Cortical Identity and Suppresses Hippocampal Organizer Fate

Mangale, V. S., Hirokawa, K. E., Satyaki, P. R. V., Subramanian, L., Shetty, A. S., Martynoga, B., Paul, J., Li, Y., Flanagan, L. A., Tole, S., et al. (2008)

Organizing Brain Development

Hines, P. J. (2008) · Science Signaling · doi:10.1126/stke.13ec27

Gene behind your thoughts

Das, B. (2008) · Nature India · doi:10.1038/nindia.2008.128

Lhx2 specifies regional fate in Emx1 lineage of telencephalic progenitors generating cerebral cortex

Chou, S., Pérez‐García, C. G., Kroll, T. T., & O’Leary, D. D. M. (2009) · Nature Neuroscience · doi:10.1038/nn.2427 · Cited by 125 · see citing works