The DOI matches its Crossref record.
Chx10 repression of Mitf is required for the maintenance of mammalian neuroretinal identity
Open accessAbstract
During vertebrate eye development, the cells of the optic vesicle (OV)become either neuroretinal progenitors expressing the transcription factor Chx10, or retinal pigment epithelium (RPE) progenitors expressing the transcription factor Mitf. Chx10 mutations lead to microphthalmia and impaired neuroretinal proliferation. Mitf mutants have a dorsal RPE-to-neuroretinal phenotypic transformation, indicating that Mitfis a determinant of RPE identity. We report here that Mitf is expressed ectopically in the Chx10or-J/or-J neuroretina(NR), demonstrating that Chx10 normally represses the neuroretinal expression of Mitf. The ectopic expression of Mitf in the Chx10or-J/or-J NR deflects it towards an RPE-like identity; this phenotype results not from a failure of neuroretinal specification, but from a partial loss of neuroretinal maintenance. Using Chx10 and Mitf transgenic and mutant mice, we have identified an antagonistic interaction between Chx10 and Mitf in regulating retinal cell identity. FGF (fibroblast growth factor) exposure in a developing OV has also been shown to repress Mitf expression. We demonstrate that the repression of Mitfby FGF is Chx10 dependent, indicating that FGF, Chx10 and Mitf are components of a pathway that determines and maintains the identity of the NR.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Generation of three-dimensional retinal tissue with functional photoreceptors from human iPSCs
Zhong, X., Gutierrez, C., Xue, T., Hampton, C., Vergara, M. N., Cao, L.-H., Peters, A., Park, T. S., Zambidis, E. T., Meyer, J. S., et al. (2014) · Nature Communications · doi:10.1038/ncomms5047 · Cited by 970
Modeling early retinal development with human embryonic and induced pluripotent stem cells
Meyer, J. S., Shearer, R. L., Capowski, E. E., Wright, L. S., Wallace, K. A., McMillan, E. L., Zhang, S.-C., & Gamm, D. M. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0905245106 · Cited by 601
Meyer, J. S., Howden, S. E., Wallace, K. A., Verhoeven, A. D., Wright, L. S., Capowski, E. E., Pinilla, I., Martin, J. M., Tian, S., Stewart, R., et al. (2011) · Stem Cells · doi:10.1002/stem.674 · Cited by 469
Bharti, K., Nguyen, M. T., Skuntz, S., Bertuzzi, S., & Arnheiter, H. (2006) · Pigment Cell Research · doi:10.1111/j.1600-0749.2006.00318.x · Cited by 237
Self-citationIdentification and Characterization of MicroRNAs Expressed in the Mouse Eye
Karali, M., Peluso, I., Marigo, V., & Banfi, S. (2007) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.06-0866 · Cited by 196
Bharti, K., Gasper, M., Ou, J., Brucato, M., Clore-Gronenborn, K., Pickel, J., & Arnheiter, H. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002757 · Cited by 158
Self-citationAchberger, K., Haderspeck, J. C., Kleger, A., & Liebau, S. (2019) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2018.05.005 · Cited by 75
Lane, B. M., & Lister, J. A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0049357 · Cited by 40
Kang, J., Gong, J., Yang, C., Lin, X., Yan, L., Gong, Y., & Xu, H. (2023) · Stem Cell Reviews and Reports · doi:10.1007/s12015-023-10553-x · Cited by 5
Metadata
- Authors
- Horsford, D. J., Nguyen, M.-T. T., Sellar, G. C., Kothary, R., Arnheiter, H., & McInnes, R. R.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2005-01-01
- Volume
- 132
- Issue
- 1
- Pages
- 177-187
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2143210568
- Cited by
- 217
- References
- 0
- FWCI
- 3.28
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
