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Two contrasting roles for Notch activity in chick inner ear development:specification of prosensory patches and lateral inhibition of hair-cell differentiation
Abstract
Lateral inhibition mediated by Notch is thought to generate the mosaic of hair cells and supporting cells in the inner ear, but the effects of the activated Notch protein itself have never been directly tested. We have explored the role of Notch signalling by transiently overexpressing activated Notch (NICD) in the chick otocyst. We saw two contrasting consequences, depending on the time and site of gene misexpression: (1)inhibition of hair-cell differentiation within a sensory patch; and (2)induction of ectopic sensory patches. We infer that Notch signalling has at least two functions during inner ear development. Initially, Notch activity can drive cells to adopt a prosensory character, defining future sensory patches. Subsequently, Notch signalling within each such patch mediates lateral inhibition, restricting the proportion of cells that differentiate as hair cells so as to generate the fine-grained mixture of hair cells and supporting cells.
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Citations
Cited by
Smaller inner ear sensory epithelia in Neurog1 null mice are related to earlier hair cell cycle exit
Matei, V., Pauley, S., Kaing, S., Rowitch, D., Beisel, K. W., Morris, K., Feng, F., Jones, K., Lee, J., & Fritzsch, B. (2005) · Developmental Dynamics · doi:10.1002/dvdy.20551 · Cited by 435
Notch ligands with contrasting functions: Jagged1 and Delta1 in the mouse inner ear
Brooker, R., Hozumi, K., & Lewis, J. (2006) · Development · doi:10.1242/dev.02284 · Cited by 330
Self-citationThe Notch Ligand JAG1 Is Required for Sensory Progenitor Development in the Mammalian Inner Ear
Kiernan, A. E., Xu, J., & Gridley, T. (2006) · PLoS Genetics · doi:10.1371/journal.pgen.0020004 · Cited by 290
Notch Promotes Neural Lineage Entry by Pluripotent Embryonic Stem Cells
Lowell, S., Benchoua, A., Heavey, B., & Smith, A. G. (2006) · PLoS Biology · doi:10.1371/journal.pbio.0040121 · Cited by 260
Doetzlhofer, A., Basch, M. L., Ohyama, T., Gessler, M., Groves, A. K., & Segil, N. (2009) · Developmental Cell · doi:10.1016/j.devcel.2008.11.008 · Cited by 254
Metadata
- Authors
- Daudet, N., & Lewis, J.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2005-02-01
- Volume
- 132
- Issue
- 3
- Pages
- 541-551
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2018682447
- Cited by
- 231
- References
- 0
- FWCI
- 7.04
- Type
- journal article
- Language
- en
- Open access
- closed
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- Daudet, N., & Lewis, J. (2005). Two contrasting roles for Notch activity in chick inner ear development:specification of prosensory patches and lateral inhibition of hair-cell differentiation. Development. https://doi.org/10.1242/dev.01589
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