The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Cilia-driven fluid flow in the zebrafish pronephros, brain and Kupffer's vesicle is required for normal organogenesis
Abstract
Cilia, as motile and sensory organelles, have been implicated in normal development, as well as diseases including cystic kidney disease,hydrocephalus and situs inversus. In kidney epithelia, cilia are proposed to be non-motile sensory organelles, while in the mouse node, two cilia populations, motile and non-motile have been proposed to regulate situs. We show that cilia in the zebrafish larval kidney, the spinal cord and Kupffer's vesicle are motile, suggesting that fluid flow is a common feature of each of these organs. Disruption of cilia structure or motility resulted in pronephric cyst formation, hydrocephalus and left-right asymmetry defects. The data show that loss of fluid flow leads to fluid accumulation, which can account for organ distension pathologies in the kidney and brain. In Kupffer's vesicle,loss of flow is associated with loss of left-right patterning, indicating that the `nodal flow' mechanism of generating situs is conserved in non-mammalian vertebrates.
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Cites
Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells
Nauli, S. M., Alenghat, F. J., Luo, Y., Williams, E., Vassilev, P., Li, X., Elia, A. E. H., Lu, W., Brown, E. M., Quinn, S. J., et al. (2003) · Nature Genetics · doi:10.1038/ng1076 · Cited by 2,057
Pazour, G. J., Dickert, B. L., Vucica, Y., Seeley, E. S., Rosenbaum, J. L., Witman, G. B., & Cole, D. G. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.151.3.709 · Cited by 1,147
Yoder, B. K., Hou, X., & Guay-Woodford, L. M. (2002) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000029587.47950.25 · Cited by 935
Self-citationPazour, G. J., San Agustin, J. T., Follit, J. A., Rosenbaum, J. L., & Witman, G. B. (2002) · Current Biology · doi:10.1016/s0960-9822(02)00877-1 · Cited by 531
Morphogenesis of the murine node and notochordal plate
Sulik, K., Dehart, D. B., Inagaki, T., Carson, J. L., Vrablic, T., Gesteland, K., & Schoenwolf, G. C. (1994) · Developmental Dynamics · doi:10.1002/aja.1002010309 · Cited by 338
Cited by
The Ciliopathies: An Emerging Class of Human Genetic Disorders
Badano, J. L., Mitsuma, N., Beales, P. L., & Katsanis, N. (2006) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.7.080505.115610 · Cited by 1,144
The Vertebrate Primary Cilium in Development, Homeostasis, and Disease
Gerdes, J. M., Davis, E. E., & Katsanis, N. (2009) · Cell · doi:10.1016/j.cell.2009.03.023 · Cited by 706
Foxj1 transcription factors are master regulators of the motile ciliogenic program
Yu, X., Ng, C. P., Habacher, H., & Roy, S. (2008) · Nature Genetics · doi:10.1038/ng.263 · Cited by 495
Nephronophthisis-Associated Ciliopathies
Hildebrandt, F., & Zhou, W. (2007) · Journal of the American Society of Nephrology · doi:10.1681/asn.2006121344 · Cited by 406
Park, T. J., Haigo, S. L., & Wallingford, J. B. (2006) · Nature Genetics · doi:10.1038/ng1753 · Cited by 389
Metadata
- Authors
- Kramer-Zucker, A. G., Olale, F., Haycraft, C. J., Yoder, B. K., Schier, A. F., & Drummond, I. A.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2005-04-15
- Volume
- 132
- Issue
- 8
- Pages
- 1907-1921
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2058525645
- Cited by
- 669
- References
- 5
- FWCI
- 21.01
- Type
- journal article
- Language
- en
- Open access
- closed
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