Developmental regulation of the Hox genes during axial morphogenesis in the mouse
Abstract
The Hox genes confer positional information to the axial and paraxial tissues as they emerge gradually from the posterior aspect of the vertebrate embryo. Hox genes are sequentially activated in time and space, in a way that reflects their organisation into clusters in the genome. Although this co-linearity of expression of the Hox genes has been conserved during evolution, it is a phenomenon that is still not understood at the molecular level. This review aims to bring together recent findings that have advanced our understanding of the regulation of the Hox genes during mouse embryonic development. In particular, we highlight the integration of these transducers of anteroposterior positional information into the genetic network that drives tissue generation and patterning during axial elongation.
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Hox gene expression in the developing central nervous system is considered a canonical descriptor of AP axis position.
“Hox gene expression in the developing central nervous system is considered a canonical descriptor of AP axis position46.”
From The emergent landscape of the mouse gut endoderm at single-cell resolution (2019) · cites this paper as [46]
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- Authors
- Deschamps, J., & van Nes, J.
- Affiliations
- Hubrecht Institute for Developmental Biology and Stem Cell Research (NL)
- Hubrecht Laboratory, Netherlands Institute for Developmental Biology,Uppsalalaan 8, 3584 CT Utrecht, The Netherlands
- Corresponding author
- Deschamps, Jacqueline
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2005-07-01
- Volume
- 132
- Issue
- 13
- Pages
- 2931-2942
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2119666376
- Cited by
- 375
- References
- 1
- Citations by year
- 2026: 5 · 2025: 16 · 2024: 8 · 2023: 10 · 2022: 13 · 2021: 22 · 2020: 17 · 2019: 23 · 2018: 19 · 2017: 18 · 2016: 23 · 2015: 16 · 2014: 18 · 2013: 13 · 2012: 25
- FWCI
- 1.75
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Development (publishedVersion)
- PubMed (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- HighWire Press Open Archive (submittedVersion)
- Pure Amsterdam UMC (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Hedgehog Signaling Pathway Studies
- Keywords
- Hox genes, anterior-posterior patterning, positional information, Hox gene regulation, mouse embryo development, axial elongation, gene regulatory networks
- MeSH terms
- Animals, Genes, Homeobox, Gene Expression Regulation, Developmental, Body Patterning, Mice
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