Pancreatic epithelial plasticity mediated by acinar cell transdifferentiation and generation of nestin-positive intermediates
Means, Anna L., Meszoely, Ingrid M., Suzuki, Kazufumi, Miyamoto, Yoshiharu, Rustgi, Anil K., Coffey, Robert J., Wright, Christopher V. E., Stoffers, Doris A. +1 more·2005·Development
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- The BRG1/SOX9 axis is critical for acinar cell–derived pancreatic tumorigenesisMotoyuki Tsuda, Akihisa Fukuda, Nilotpal Roy, Yukiko Hiramatsu, Laura Leonhardt, Nobuyuki Kakiuchi, Kaja Hoyer, Satoshi Ogawa, Norihiro Goto, Kozo Ikuta et al. · 2018 · Journal of Clinical Investigation
- Pancreatic beta-cells: From generation to regenerationPatrick Collombat, Xiaobo Xu, Harry Heimberg, Ahmed Mansouri · 2010 · Seminars in Cell and Developmental Biology
- EPHA2-dependent outcompetition of KRASG12D mutant cells by wild-type neighbors in the adult pancreasWilliam Hill, Ανδρέας Ζαραγκούλιας, Beatriz Salvador-Barberó, Geraint J. Parfitt, Markella Alatsatianos, Ana Padilha, Sean R. Porazinski, Thomas E. Woolley, Jennifer P. Morton, Owen James Sansom et al. · 2021 · Current Biology
- Multifaceted role for p53 in pancreatic cancer suppressionMello, Stephano S., Flowers, Brittany M., Mazur, Pawel K., Lee, James J., Müller, Fabian, Denny, Sarah K., Ferreira, Sofia, Hanson, Kathryn, Kim, Seung K., Greenleaf, William J. et al. · 2023 · Proceedings of the National Academy of Sciences
- The epigenetic regulators Bmi1 and Ring1B are differentially regulated in pancreatitis and pancreatic ductal adenocarcinomaCarles Martínez‐Romero, Ilse Rooman, Anouchka Skoudy, Carmen E. Guerra, Xavier Molero, Ana María González-Castro, Mar Iglesias, Tania Lobato, Almudena Bosch, Mariano Barbacid et al. · 2009 · The Journal of Pathology
- Role of bone marrow-derived cells in experimental chronic pancreatitisFrédéric Marrache, Swaroop Pendyala, Govind Bhagat, Kelly S. Betz, Zhigang Song, Timothy Cragin Wang · 2008 · Gut
- Pancreatic Cancer and Its Microenvironment—Recent Advances and Current ControversiesKinga B. Stopa, Agnieszka A. Kusiak, Mateusz D. Szopa, Paweł E. Ferdek, Monika A. Jakubowska · 2020 · International Journal of Molecular Sciences
- Beta-catenin is selectively required for the expansion and regeneration of mature pancreatic acinar cellsKeefe, Matthew, Wang, Hui, De La O, Jean-Paul, Khan, Ameena, Firpo, Matthew A., Murtaugh, L. Charles · 2012 · Disease Models & Mechanisms
- Cell Replacement Strategies Aimed at Reconstitution of the β-Cell Compartment in Type 1 DiabetesG. Orlando, P. Gianello, M. Salvatori, R. Stratta, S. Soker, C. Ricordi, J. Domínguez-Bendala · 2014 · Diabetes
- Ex Vivo Expansion and Differentiation of Human and Mouse Fetal Pancreatic Progenitors Are Modulated by Epidermal Growth FactorPaola Bonfanti, Estelle Nobécourt, Masaya Oshima, Olivier Albagli, Veerle Laurysens, Geert M. Stangé, Mozhdeh Sojoodi, Yves Heremans, Harry Heimberg, Raphaël Scharfmann · 2015 · Stem Cells and Development
- Human epididymis protein 4 is up-regulated in gastric and pancreatic adenocarcinomasRyan L. O'Neal, Ki Taek Nam, Bonnie LaFleur, Brittney Barlow, Koji Nozaki, Hyuk‐Joon Lee, Woo Ho Kim, Han‐Kwang Yang, Chanjuan Shi, Anirban Maitra et al. · 2012 · Human Pathology
- Adult human pancreatic acinar cells dedifferentiate into an embryonic progenitor-like state in 3D suspension cultureJonathan Baldan, Isabelle Houbracken, Ilse Rooman, Luc Bouwens · 2019 · Scientific Reports
- SETDB1 Inhibits p53-Mediated Apoptosis and is Required for Formation of Pancreatic Ductal Adenocarcinomas in Mice.S. Ogawa, A. Fukuda, Y. Matsumoto, Yuta Hanyu, M. Sono, Yuichi Fukunaga, Tomonori Masuda, O. Araki, M. Nagao, Takaaki Yoshikawa et al. · 2020 · Gastroenterology
- Control of Apoptosis in Treatment and Biology of Pancreatic CancerShrey Modi, Devika Kir, Sulagna Banerjee, Ashok Kumar Saluja · 2015 · Journal of Cellular Biochemistry
- Development of a functional salivary gland tissue chip with potential for high-content drug screeningYuanhui Song, Hitoshi Uchida, Azmeer Sharipol, Lindsay R. Piraino, Jared A. Mereness, Matthew H. Ingalls, Jonathan A. Rebhahn, Shawn D. Newlands, Lisa A. DeLouise, Catherine E. Ovitt et al. · 2021 · Communications Biology
- Molecular and Cellular Basis of Regeneration and Tissue RepairDaniel Eberhard, D. Tosh · 2007 · Cellular and Molecular Life Sciences
- Acinar Cystadenoma of the PancreasTze Sheng Khor, Kamran Badizadegan, Cristina Rosa Ferrone, Carlos F. Fernandez-del Castillo, Gaurav S. Desai, Adam J. Saenz, Long P. Le, Gregory Yves Lauwers, Vikram Deshpande · 2012 · The American Journal of Surgical Pathology
- Phenylalanine regulates initiation of digestive enzyme mRNA translation in pancreatic acinar cells and tissue segments in dairy calvesLong J Guo, Huibin Tian, Jing Shen, Chen Zheng, Shimin Liu, Yangchun Cao, Chuanjiang Cai, Junhu Yao · 2017 · Bioscience Reports
- Activation of the intrinsic fibroinflammatory program in adult pancreatic acinar cells triggered by Hippo signaling disruptionJun Liu, Ming Gao, MICHAEL J. NIPPER, Janice Deng, Francis E. Sharkey, Randy L. Johnson, Howard C. Crawford, Yidong Chen, Pei Wang · 2019 · PLoS Biology
- Heparin-binding epidermal growth factor-like growth factor eliminates constraints on activated Kras to promote rapid onset of pancreatic neoplasiaK C Ray, M. Elizabeth Moss, Jeffrey L. Franklin, Connie Weaver, James N. Higginbotham, Yan Song, Frank L. Revetta, Stacy A. Blaine, LaReash Bridges, Katherine E. Guess et al. · 2013 · Oncogene
- The inflammatory milieu within the pancreatic cancer microenvironment correlates with clinicopathologic parameters, chemoresistance and survivalDaniel Delitto, Brian S. Black, Heather L. Sorenson, Andrea E. Knowlton, Ryan Michael Thomas, George A. Sarosi, Lyle L. Moldawer, K.E. Behrns, Chen Liu, Thomas J. George et al. · 2015 · BMC Cancer
- NFATc4 Regulates Sox9 Gene Expression in Acinar Cell Plasticity and Pancreatic Cancer InitiationElisabeth Heßmann, Jin‐San Zhang, NM Chen, Marie C. Hasselluhn, Geou‐Yarh Liou, Peter Störz, Volker Ellenrieder, Daniel D. Billadeau, Alexander Otto König · 2015 · Stem Cells International
- Sesquiterpene Lactones as Promising Candidates for Cancer Therapy: Focus on Pancreatic CancerLaura Cecilia Laurella, Nadia Talin Mirakian, María Noé Garcia, Daniel Grasso, Valeria Patricia Sülsen, Daniela Laura Papademetrio · 2022 · Molecules
- Polycomb repressor complex 1 promotes gene silencing through H2AK119 mono-ubiquitination in acinar-to-ductal metaplasia and pancreatic cancer cellsSimone Benitz, Ivonne Regel, Tobias Reinhard, Anna Popp, Isabell Schäffer, Susanne Raulefs, Bo Kong, Iréne Esposito, Christoph W. Michalski, Jorg H. Kleeff · 2015 · Oncotarget
- Stress or injury induces cellular plasticity in salivary gland acinar cellsAndrew D. Shubin, Azmeer Sharipol, Timothy J. Felong, Pei‐Lun Weng, Brittany E. Schutrum, Debria S. Joe, Marit H. Aure, Danielle S. W. Benoit, Catherine E. Ovitt · 2020 · Cell and Tissue Research
- Serotonin-RhoA/ROCK axis promotes acinar-to-ductal metaplasia in caerulein-induced chronic pancreatitisXufeng Tao, Qing Chen, Ning Li, Hong Xiang, Yue Pan, Yueyang Qu, Dong Shang, Vay Liang W. Go, Jing Xue, Yongwei Sun et al. · 2020 · Biomedicine & Pharmacotherapy
- Transcriptional control of acinar development and homeostasis.Raymond J MacDonald, Galvin H. Swift, F. Real · 2010 · Progress in Molecular Biology and Translational Science
- Forgotten and novel aspects in pancreas developmentT. Pieler, Yong-Long Chen · 2006 · Biology of the Cell
- Challenges and advances in mouse modeling for human pancreatic tumorigenesis and metastasisWanglong Qiu, Gloria H. Su · 2012 · Cancer and Metastasis Reviews
- Xenopus Pancreas DevelopmentEsther J. Pearl, Cassandra K. Bilogan, S. Mukhi, Donald D. Brown, Marko E. Horb · 2009 · Developmental Dynamics
- Role of Cadherin-mediated Cell-Cell Adhesion in Pancreatic Exocrine-to-Endocrine TransdifferentiationKohtaro Minami, Hirotoshi Okano, Akinori Okumachi, Susumu Seino · 2008 · Journal of Biological Chemistry
- Early epigenetic downregulation of WNK2 kinase during pancreatic ductal adenocarcinoma developmentCéline Dutruel, Frank Bergmann, Ilse Rooman, Manuela Zucknick, Dieter Weichenhan, Lea Geiselhart, Thomas M. Kaffenberger, P. Sivaramakrishna Rachakonda, Andrea S. Bauer, N. Giese et al. · 2013 · Oncogene
- Pancreatic Ductal Deletion of Hnf1b Disrupts Exocrine Homeostasis, Leads to Pancreatitis, and Facilitates TumorigenesisEvans Quilichini, Mélanie Fabre, Thassadite Dirami, Aline Stedman, Matías G. De Vas, Özge Özgüç, Raymond C. Pasek, Silvia Cereghini, Lucie Morillon, Carmen E. Guerra et al. · 2019 · Cellular and Molecular Gastroenterology and Hepatology
- Characterization of Intestinal and Pancreatic Dysfunction in VPAC1-Null Mutant MouseDorit Fabricius, Bahri Karaçay, Damon C. Shutt, Whitney Leverich, Blanca Schafer, Erika J Takle, Daniel R. Thedens, Geetika Khanna, Sudhanshu P. Raikwar, Baoli Yang et al. · 2011 · Pancreas
- β-cell regeneration: Neogenesis, replication or both?Fred Levine, Pamela Itkin‐Ansari · 2007 · Journal of Molecular Medicine
- ST6GAL1 sialyltransferase promotes acinar to ductal metaplasia and pancreatic cancer progressionNikita Bhalerao, Asmi Chakraborty, Michael P. Marciel, Jihye Hwang, Colleen M. Britain, Austin D. Silva, Isam Eltoum, Robert B. Jones, Katie L. Alexander, Lesley E. Smythies et al. · 2023 · JCI Insight
- MECOM permits pancreatic acinar cell dedifferentiation avoiding cell death under stress conditionsElyne Backx, Elke Wauters, Jonathan Baldan, Mathias Van Bulck, Ellis Michiels, Yves Heremans, Diedert Luc De Paep, Mineo Kurokawa, Susumu Goyama, Luc Bouwens et al. · 2021 · Cell Death and Differentiation
- Suppression of mutant Kirsten-RAS (KRASG12D)-driven pancreatic carcinogenesis by dual-specificity MAP kinase phosphatases 5 and 6Andrew M. Kidger, Mark K. Saville, Linda K. Rushworth, Jane Davidson, Julia Stellzig, Motoharu Ono, Ludwig A. Kuebelsbeck, Klaus‐Peter Janssen, Bernhard Holzmann, Jennifer P. Morton et al. · 2022 · Oncogene
- Stimulating β-Cell Regeneration by Combining a GPR119 Agonist with a DPP-IV InhibitorMd Ansarullah, Yan Lu, Martha Holstein, DeRuyter Brittany, Alex Rabinovitch, Zhiguang Guo · 2013 · PLoS ONE
- Developmental Plasticity and Cellular Reprogramming in Caenorhabditis elegansJoel H. Rothman, Sophie Jarriault · 2019 · Genetics
- Transdifferentiation: a cell and molecular reprogramming processS. Sisakhtnezhad, M. Matin · 2012 · Cell and Tissue Research
- Dissecting the Cellular Origins of Pancreatic CancerBen Z. Stanger, Yuval Dor · 2005 · Cell Cycle
- Bmi1 Is Required for Regeneration of the Exocrine Pancreas in MiceAkihisa Fukuda, John P. Morris, Matthias Hebrok · 2012 · Gastroenterology
- Inflammation and Epithelial-Mesenchymal Transition in Pancreatic Ductal Adenocarcinoma: Fighting Against Multiple OpponentsFarid G. Khalafalla, Mohammad Wasim Khan · 2017 · Cancer Growth and Metastasis
- Weighing up β-cell mass in mice and humans: Self-renewal, progenitors or stem cells?Neil A. Hanley, Karen Piper Hanley, Päivi Johanna Miettinen, Timo Otonkoski · 2008 · Molecular and Cellular Endocrinology
- Dexamethasone Treatment Induces the Reprogramming of Pancreatic Acinar Cells to Hepatocytes and Ductal CellsAmani M. Al‐Adsani, Zoë D. Burke, Daniel Eberhard, Katherine L. Lawrence, Chia‐Ning Shen, Anil K. Rustgi, Hiroshi Sakaue, J. Mark Farrant, David Tosh · 2010 · PLoS ONE
- Pathogenesis of Pancreatic CancerLewis Charles Murtaugh · 2013 · Toxicologic Pathology
- REG3A/REG3B promotes acinar to ductal metaplasia through binding to EXTL3 and activating the RAS-RAF-MEK-ERK signaling pathwayHuairong Zhang, Andrea Liliam Gomez Corredor, Julia Messina‐Pacheco, Qing Li, George Zogopoulos, Nancy Kaddour, Yifan Wang, Bingyin Shi, Alex Gregorieff, Jun‐Li Liu et al. · 2021 · Communications Biology
- Acinar PlasticityMark A. Lipsett, Mauro L. Castellarin, Lawrence C. Rosenberg · 2007 · Pancreas
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- Pancreatic acinar-to-beta cell transdifferentiation in vitro.K. Minami, S. Seino · 2008 · Frontiers in Bioscience
- Therapeutic potential of targeting acinar cell reprogramming in pancreatic cancerChi Hin Wong, Youjia Li, Yangchao Chen · 2016 · World Journal of Gastroenterology
- Long-term in vitro expansion of a human fetal pancreas stem cell that generates all three pancreatic cell lineagesAmanda Andersson-Rolf, Kelvin Groot, Jeroen Korving, Harry Begthel, Maaike A. J. Hanegraaf, Michael A. VanInsberghe, Fredrik Salmén, Stieneke van den Brink, Carmen López‐Iglesias, Peter J. Peters et al. · 2024 · Cell
- Ligand-bound Thyroid Hormone Receptor Contributes to Reprogramming of Pancreatic Acinar Cells into Insulin-producing CellsFumihiko Furuya, Hiroki Shimura, Keiichi Asami, Sayaka Ichijo, Kazuya Takahashi, Masahiro Kaneshige, Yoichi Oikawa, Kaoru Aida, Toyoshi Endo, Tetsuro Kobayashi · 2013 · Journal of Biological Chemistry
- Class I histone deacetylase inhibition improves pancreatitis outcome by limiting leukocyte recruitment and acinar‐to‐ductal metaplasiaMarta Bombardo, Enrica Saponara, Ermanno Malagola, Rong Chen, Gitta Maria Seleznik, Cécile Haumaître, Evans Quilichini, Anja Zabel, Theresia Reding, Rolf Graf et al. · 2017 · British Journal of Pharmacology
- Acinar to ductal cell trans-differentiation: A prelude to dysplasia and pancreatic ductal adenocarcinomaSeema C. Parte, Rama Krishna Nimmakayala, Surinder K. Batra, Moorthy Palanimuthu Ponnusamy · 2021 · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
- Single-nucleus and spatial transcriptomics of archival pancreatic cancer reveals multi-compartment reprogramming after neoadjuvant treatmentWilliam L. Hwang, Karthik A. Jagadeesh, Jimmy A. Guo, Hannah I. Hoffman, Payman Yadollahpour, Rahul R. Mohan, Eugene Drokhlyansky, Nicholas Van Wittenberghe, Orr Ashenberg, Samouil L. Farhi et al. · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
- Pancreatic Ductal Adenocarcinoma: Cellular Origin, Signaling Pathways and Stroma ContributionInmaculada Hernńdez-Muñoz, Anouchka Skoudy, Francisco X. Real, Pilar Navarro · 2008 · Pancreatology
- PD2/Paf1 depletion in pancreatic acinar cells promotes acinar-to-ductal metaplasiaParama Dey, Satyanarayana Rachagani, Arokia Priyanka Vaz, Moorthy Palanimuthu Ponnusamy, Surinder K. Batra · 2014 · Oncotarget
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- Slow and steady is the key to β‐cell replicationKristen Brennand, Doug A. Melton · 2008 · Journal of Cellular and Molecular Medicine
- Upregulation of nestin in proximal tubules may participate in cell migration during renal repairDonghai Wen, Ni Li, Li You, Liying Zhang, Yong Gu, Chuan‐Ming Hao, Jing Chen · 2012 · American Journal of Physiology-Renal Physiology
- Isolation of rodent pancreatic acinar cells and acini by collagenase digestionJohn A. Williams · 2011
- Retinoid Signaling in Pancreatic Cancer, Injury and RegenerationEmily K. Colvin, Johana M. Susanto, James G. Kench, Vy Ong, Amanda Mawson, Mark Pinese, David Kuang-Fu Chang, Ilse Rooman, Sandra A O'Toole, Davendra Segara et al. · 2011 · PLoS ONE
- Acinar cells and the development of pancreatic fibrosisJianhong An, Tingting Jiang, Ling Qi, Keping Xie · 2023 · Cytokine & Growth Factor Reviews
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- Smad4 Loss Synergizes with TGFα Overexpression in Promoting Pancreatic Metaplasia, PanIN Development, and FibrosisDarío García‐Carracedo, Chih-Chieh Yu, Nathan Akhavan, Stuart A. Fine, Frank Schönleben, Naoki Maehara, Dillon C. Karg, Chuangao Xie, Wanglong Qiu, Robert Lance Fine et al. · 2015 · PLoS ONE
- Murine embryonic stem cell-derived pancreatic acinar cells recapitulate features of early pancreatic differentiation.M. Rovira, F. Delaspre, M. Massumi, S. Serra, M. Valverde, J. Lloreta, M. Dufresne, B. Payre, S. Konieczny, P. Savatier et al. · 2008 · Gastroenterology
- Stem cells and diabetes treatmentO. Madsen · 2005 · Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS)
- Dynamic Regulation of Expression of KRAS and Its Effectors Determines the Ability to Initiate Tumorigenesis in Pancreatic Acinar CellsMohamad Assi, Younès Achouri, Axelle E. Loriot, Nicolas Dauguet, Hajar Dahou, Jonathan Baldan, Maxime Libert, Jean S. Fain, Carmen E. Guerra, Luc Bouwens et al. · 2021 · Cancer Research
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- Emergent properties of collective gene-expression patterns in multicellular systemsMatthew Smart, Anton Zilman · 2023 · Cell Reports Physical Science
- Acinar cells in the neonatal pancreas grow by self-duplication and not by neogenesis from duct cellsIsabelle Houbracken, Luc Bouwens · 2017 · Scientific Reports
- Epidermal growth factor induces adult human islet cell dedifferentiationStephen C. Hanley, Béatrice Assouline-Thomas, Julia Makhlin, Lawrence C. Rosenberg · 2011 · Journal of Endocrinology
- Serotonin uptake is required for Rac1 activation in Kras‐induced acinar‐to‐ductal metaplasia in the pancreasEnrica Saponara, Michele Visentin, Francesco Baschieri, Gitta Maria Seleznik, Paola Martinelli, Iréne Esposito, Johanna Buschmann, Rong Chen, Rossella Parrotta, Nathalie Borgeaud et al. · 2018 · The Journal of Pathology
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- The potential benefit of non-purified islets preparations for islet transplantationM. Webb, A. Dennison, R. James · 2012 · Biotechnology & Genetic Engineering Reviews
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- KRAS above and beyond - EGFR in pancreatic cancerJens Thomas Siveke, Howard C. Crawford · 2012 · Oncotarget
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- Nestin expression throughout multistep pathogenesis of multiple myelomaHana Šváchová, Fedor Kryukov, Elena Kryukova, Sabina Ševčı́ková, Pavel Němec, Henrieta Grešlíková, Lucie Říhová, Lenka Kubiczková, Roman Hájek · 2013 · British Journal of Haematology