Stem cells, signals and vertebrate body axis extension
Open accessAbstract
The progressive generation of chick and mouse axial tissues – the spinal cord, skeleton and musculature of the body – has long been proposed to depend on the activity of multipotent stem cells. Here, we evaluate evidence for the existence and multipotency of axial stem cells. We show that although the data strongly support their existence, there is little definitive information about their multipotency or extent of contribution to the axis. We also review the location and molecular characteristics of these putative stem cells, along with their evolutionary conservation in vertebrates and the signalling mechanisms that regulate and arrest axis extension.
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ES cells are pluripotent cells that self-renew indefinitely and can differentiate in vitro into a larger variety of cell types, such as neuronal cells, in response to RA.
“Concerning ES cells, they are pluripotent cells that self-renew indefi nitely and can differentiate in vitro into a larger variety of cell types ( 137 ), such as neuronal cells, in response to RA ( 138 ).”
From Vitamin A and retinoid signaling: genomic and nongenomic effects (2013) · cites this paper as [137]
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Neural induction: old problem, new findings, yet more questions
Stern, C. D. (2005) · Development · doi:10.1242/dev.01794 · Cited by 421 · cited 1× · see citing works
“…cell fate in the Xenopus embryo (Delaune et al., 2005; Launay et al., 1996; Linker and Stern, 2004; Sasai et al., 1996), support the idea that high levels of or prolonged exposure to FGF signalling promotes mesoderm formation, whereas low levels elicit a neural fate (reviewed by Stern, 2005).”
BackgroundSpatial and temporal patterns of ERK signaling during mouse embryogenesis
Corson, L. B., Yamanaka, Y., Lai, K.-M. V., & Rossant, J. (2003) · Development · doi:10.1242/dev.00669 · Cited by 390 · see citing works
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Vitamin A in Reproduction and Development
Clagett-Dame, M., & Knutson, D. (2011) · Nutrients · doi:10.3390/nu3040385 · Cited by 439 · see citing works
“comprises the caudal end of the node and the rostral end of the primitive streak [186].”
BackgroundVitamin A and retinoid signaling: genomic and nongenomic effects
Al Tanoury, Z., Piskunov, A., & Rochette-Egly, C. (2013) · Journal of Lipid Research · doi:10.1194/jlr.r030833 · Cited by 408 · see citing works
Stavridis, M. P., Collins, B. J., & Storey, K. G. (2010) · Development · doi:10.1242/dev.043117 · Cited by 124 · see citing works
Self-citationCadherins in early neural development
Punovuori, K., Malaguti, M., & Lowell, S. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-021-03815-9 · Cited by 39 · see citing works
- Authors
- Wilson, V., Olivera-Martinez, I., & Storey, K. G.
- Affiliations
- MRC Centre for Regenerative Medicine (GB)
- Division of Cell and Developmental Biology, College of Life Sciences,University of Dundee, Dow Street, Dundee DD1 5EH, UK.
- University of Dundee (GB)
- Corresponding author
- Wilson, Valerie
- Storey, Kate G.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2009-05-15
- Volume
- 136
- Issue
- 10
- Pages
- 1591-1604
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2128103940
- Cited by
- 290
- References
- 2
- Citations by year
- 2026: 4 · 2025: 12 · 2024: 26 · 2023: 12 · 2022: 10 · 2021: 27 · 2020: 17 · 2019: 21 · 2018: 15 · 2017: 15 · 2016: 21 · 2015: 25 · 2014: 30 · 2013: 13 · 2012: 16
- FWCI
- 1.07
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Development (publishedVersion)
- PubMed (publishedVersion)
- Discovery Research Portal (University of Dundee) (submittedVersion)
- Funders
- Medical Research Council
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Keywords
- multipotency, spinal cord development, skeletal development, developmental signalling, evolutionary conservation, chick embryo, mouse embryo
- MeSH terms
- Animals, Chick Embryo, Spinal Cord, Stem Cells, Signal Transduction, Body Patterning, Multipotent Stem Cells, Musculoskeletal Development, Mice
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