The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
Pax2/8-regulated Gata3 expression is necessary for morphogenesis and guidance of the nephric duct in the developing kidney
Abstract
The mammalian pro- and mesonephros are transient embryonic kidneys essential for urogenital system development. The nephric (Wolffian) duct,which is a central constituent of both structures, elongates caudally along a stereotypical path to reach the hindlimb level where it induces metanephros(adult kidney) formation, while the remaining duct gives rise to the male genital tract (epidydimis, vas deferens). The transcription factors Pax2 and Pax8 are essential for the initiation of pro- and mesonephros development. In a cDNA microarray screen for genes specifically expressed in the pro/mesonephros and regulated by Pax proteins, we identified Gata3, a transcription factor gene associated with hypoparathyroidism, deafness and renal anomaly (HDR) syndrome. Gata3 is already expressed in the pronephric anlage, together with Pax2 and Pax8, suggesting that it may be a direct Pax2/8 target gene. Inactivation of Gata3 by insertion of an Ires-GFP reporter gene resulted in a massive increase in nephric duct cellularity, which was accompanied by enhanced cell proliferation and aberrant elongation of the nephric duct. Interestingly,however, the nephrogenic cord extended, with delayed kinetics, along the entire caudal path up to the level of the hindlimb bud, indicating that extension of the nephric duct and cord is controlled by different guidance cues. At the molecular level, the nephric duct of Gata3-/-embryos is characterized by the loss of Ret expression and signaling, which may contribute to the guidance defect of the nephric duct. Together, these results define Gata3 as a key regulator of nephric duct morphogenesis and guidance in the pro/mesonephric kidney.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Defects in the kidney and enteric nervous system of mice lacking the tyrosine kinase receptor Ret
Schuchardt, A., D'Agati, V., Larsson-Blomberg, L., Costantini, F., & Pachnis, V. (1994) · Nature · doi:10.1038/367380a0 · Cited by 1,614
Renal and neuronal abnormalities in mice lacking GDNF
Moore, M. W., Klein, R. D., Fariñas, I., Sauer, H., Armanini, M., Phillips, H., Reichardt, L. F., Ryan, A. M., Carver-Moore, K., & Rosenthal, A. (1996) · Nature · doi:10.1038/382076a0 · Cited by 1,271
Renal agenesis and the absence of enteric neurons in mice lacking GDNF
Sánchez, M. P., Silos-Santiago, I., Frisén, J., He, B., Lira, S. A., & Barbacid, M. (1996) · Nature · doi:10.1038/382070a0 · Cited by 1,216
Defects in enteric innervation and kidney development in mice lacking GDNF
Pichel, J. G., Shen, L., Sheng, H. Z., Granholm, A.-C., Drago, J., Grinberg, A., Lee, E. J., Huang, S. P., Saarma, M., Hoffer, B. J., et al. (1996) · Nature · doi:10.1038/382073a0 · Cited by 1,168
Saxen, L. (1987) · Cambridge University Press eBooks · doi:10.1017/cbo9780511565083 · Cited by 1,030
Expression of a Delta homologue in prospective neurons in the chick
Henrique, D., Adam, J., Myat, A., Chitnis, A., Lewis, J., & Ish-Horowicz, D. (1995) · Nature · doi:10.1038/375787a0 · Cited by 992
Pax-2 controls multiple steps of urogenital development
Torres, M., Gómez-Pardo, E., Dressler, G. R., & Gruss, P. (1995) · Development · doi:10.1242/dev.121.12.4057 · Cited by 897
Expression of the c-ret proto-oncogene during mouse embryogenesis
Pachnis, V., Mankoo, B., & Costantini, F. (1993) · Development · doi:10.1242/dev.119.4.1005 · Cited by 837
GATA3 haplo-insufficiency causes human HDR syndrome
Van Esch, H., Groenen, P., Nesbit, M. A., Schuffenhauer, S., Lichtner, P., Vanderlinden, G., Harding, B., Beetz, R., Bilous, R. W., Holdaway, I., et al. (2000) · Nature · doi:10.1038/35019088 · Cited by 643
Pandolfi, P. P., Roth, M. E., Karis, A., Leonard, M. W., Dzierzak, E., Grosveld, F. G., Engel, J. D., & Lindenbaum, M. H. (1995) · Nature Genetics · doi:10.1038/ng0995-40 · Cited by 630
Cited by
The microbiota regulates type 2 immunity through RORγt + T cells
Ohnmacht, C., Park, J.-H., Cording, S., Wing, J. B., Atarashi, K., Obata, Y., Gaboriau-Routhiau, V., Marques, R., Dulauroy, S., Fedoseeva, M., et al. (2015) · Science · doi:10.1126/science.aac4263 · Cited by 863
Self-citationGata-3 is an essential regulator of mammary-gland morphogenesis and luminal-cell differentiation
Asselin-Labat, M.-L., Sutherland, K. D., Barker, H., Thomas, R., Shackleton, M., Forrest, N. C., Hartley, L., Robb, L., Grosveld, F. G., van der Wees, J., et al. (2007) · Nature Cell Biology · doi:10.1038/ncb1530 · Cited by 840
The Transcription Factor GATA-3 Controls Cell Fate and Maintenance of Type 2 Innate Lymphoid Cells
Hoyler, T., Klose, C. S. N., Souabni, A., Turqueti-Neves, A., Pfeifer, D., Rawlins, E. L., Voehringer, D., Busslinger, M., & Diefenbach, A. (2012) · Immunity · doi:10.1016/j.immuni.2012.06.020 · Cited by 852
Self-citationGATA-3 Maintains the Differentiation of the Luminal Cell Fate in the Mammary Gland
Kouros-Mehr, H., Slorach, E. M., Sternlicht, M. D., & Werb, Z. (2006) · Cell · doi:10.1016/j.cell.2006.09.048 · Cited by 688
Direct regulation of Gata3 expression determines the T helper differentiation potential of Notch
Amsen, D., Antov, A., Jankovic, D., Sher, A., Radtke, F., Souabni, A., Busslinger, M., McCright, B., Gridley, T., & Flavell, R. A. (2007) · Immunity · doi:10.1016/j.immuni.2007.05.021 · Cited by 396
Self-citation
Metadata
- Authors
- Grote, D., Souabni, A., Busslinger, M., & Bouchard, M.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2006-01-01
- Volume
- 133
- Issue
- 1
- Pages
- 53-61
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2107664245
- Cited by
- 351
- References
- 44
- FWCI
- 4.38
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Pax2/8-regulated Gata3 expression is necessary for morphogenesis and guidance of the nephric duct in the developing kidney. https://app.cochat.ai/papers/10.1242/dev.02184
- The paper
- Grote, D., Souabni, A., Busslinger, M., & Bouchard, M. (2006). Pax2/8-regulated Gata3 expression is necessary for morphogenesis and guidance of the nephric duct in the developing kidney. Development. https://doi.org/10.1242/dev.02184
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
