Cited by 863T-cell and B-cell ImmunologyPsoriasis: Treatment and PathogenesisIL-33, ST2, and ILC Pathways

The microbiota regulates type 2 immunity through RORγt + T cells

Ohnmacht, Caspar, Park, Joo-Hong, Cording, Sascha, Wing, James B., Atarashi, Koji, Obata, Yuuki, Gaboriau-Routhiau, Valérie, Marques, Rute +10 more·2015·Science

Abstract

Gut microbes make T cells keep the peace: Our guts harbor trillions of microbial inhabitants, some of which regulate the types of immune cells that are present in the gut. For instance, Clostridium species of bacteria induce a type of T cell that promotes tolerance between the host and its microbial contents. Ohnmacht et al. and Sefik et al. characterized a population of gut regulatory T cells in mice, which required gut microbiota to survive. Multiple bacterial species of the microbiota could induce transcription factor–expressing regulatory T cells that helped maintain immune homeostasis. Mice engineered to lack these transcription factors exhibited enhanced susceptibility to colonic inflammation and had elevated amounts of proinflammatory molecules associated with allergies (see the Perspective by Hegazy and Powrie). Science , this issue pp. 989 and 993

Integrity signals

Registry

Crossref · 10.1126/science.aac4263

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53 of 53 references verified0 citation errors · 0 not checkable

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  • Helios, Nrp-1 or ROR-γt are widely accepted for the discrimination of tTreg and pTreg cells under homeostatic conditions.

    “Yet, Helios, Nrp-1 or ROR-γt are widely accepted for the discrimination of tTreg and pTreg cells under homeostatic conditions [364-366, 437-440].”
  • The gut microbiome regulates the activity of RORγ+ Treg cells, and dysregulation of these cells can lead to diseases such as colitis, food allergy, and colon cancer.

    “In addition, the gut microbiome regulates the activity of retinoic acid receptor-related orphan receptor gamma-positive (RORγ+) Treg cells, dysregulation of which can lead to diseases such as colitis, food allergy, and colon cancer.622,701–704”
  • Significantly reduced RORγt+ Tregs in GF or antibiotic-treated mice promote Th2 type-associated immune responses and inflammation upon helminth infection.

    “Significantly reduced RORγt+ Tregs in GF or antibiotic-treated mice promote Th2 type-associated immune responses and inflammation upon helminth infection.134”

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Authors
Ohnmacht, C., Park, J.-H., Cording, S., Wing, J. B., Atarashi, K., Obata, Y., Gaboriau-Routhiau, V., Marques, R., Dulauroy, S., Fedoseeva, M., Busslinger, M., Cerf-Bensussan, N., Boneca, I. G., Voehringer, D., Hase, K., Honda, K., Sakaguchi, S., & Eberl, G.
Affiliations
  • Institut Pasteur (FR)
  • Immunology Frontier Research Center, The University of Osaka (JP)
  • Japan Science and Technology Agency (JP)
  • Institute of Medical Science, The University of Tokyo (JP)
  • INSERM, U1163, Laboratory of Intestinal Immunity, Paris, France.
  • Helmholtz Munich (DE)
  • Research Institute of Molecular Pathology (AT)
  • Inserm (FR)
  • Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
  • Kyoto University (JP)
Corresponding author
  • Ohnmacht, Caspar
  • Park, Joo-Hong
  • Eberl, Gérard
Venue
Science
Published
2015-08-28
Volume
349
Issue
6251
Pages
989-993
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W2126657409
Cited by
863
References
53
Citations by year
2026: 55 · 2025: 84 · 2024: 59 · 2023: 86 · 2022: 88 · 2021: 96 · 2020: 87 · 2019: 87 · 2018: 78 · 2017: 68 · 2016: 65 · 2015: 10
FWCI
36.33
Type
journal article
Language
en
Open access
closed
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
  • mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich) (submittedVersion)
  • Site cant be reached (submittedVersion)
  • PuSH - Publication Server of Helmholtz Zentrum München (submittedVersion)
Funders
  • Boehringer Ingelheim
  • European Molecular Biology Organization
  • European Commission (MEXT-CT-2006-042374)
  • Agence Nationale de la Recherche (ANR 11 BSV3 020 01)
  • Japan Society for the Promotion of Science (15K19129)
  • Institut Pasteur
  • Fondation de la Recherche Medicale (DEq. 2010318246)
  • Fondation Simone e Cino Del Duca from the Institut de France
  • Integrative Biology of Emerging Infectious Diseases (ANR-10-LABX-62-IBEID)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
  • Life Sciences › Immunology and Microbiology › Immunology › IL-33, ST2, and ILC Pathways
Keywords
gut microbiota, Th2 immune response, RORγt, regulatory T cells, Th17 cells, Th2 cells, helminthiasis, allergic inflammation, mucosal immunity, nuclear receptors, intestinal immune regulation
MeSH terms
Animals, Colitis, Ulcerative, Colon, Germ-Free Life, Homeostasis, Intestinal Mucosa, Intestine, Small, Intestines, Nematospiroides dubius, Specific Pathogen-Free Organisms, Vitamin A, T-Lymphocyte Subsets, Strongylida Infections, Th2 Cells, Models, Immunological, Immunity, Mucosal, T-Lymphocytes, Regulatory, Mice, Nuclear Receptor Subfamily 1, Group F, Member 3, Th17 Cells, Microbiota

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