The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
The transcriptional foundation of pluripotency
Open accessAbstract
A fundamental goal in biology is to understand the molecular basis of cell identity. Pluripotent embryonic stem (ES) cell identity is governed by a set of transcription factors centred on the triumvirate of Oct4, Sox2 and Nanog. These proteins often bind to closely localised genomic sites. Recent studies have identified additional transcriptional modulators that bind to chromatin near sites occupied by Oct4, Sox2 and Nanog. This suggests that the combinatorial control of gene transcription might be fundamental to the ES cell state. Here we discuss how these observations advance our understanding of the transcription factor network that controls pluripotent identity and highlight unresolved issues that arise from these studies.
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Cites
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A bivalent chromatin structure marks key developmental genes in embryonic stem cells
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“Subsequent analyses have demonstrated that reduction in the level of Nanog increases the REVIEW Development 136 (14) Oct4 352 aa C-TADPOUSN-TAD POUHD Sox2 319 aa HMG TAD Nanog 305 aa WR CD2CD1HDNDA B C Fig.”
BackgroundInfluential
Cited by
The evolution of lncRNA repertoires and expression patterns in tetrapods
Necsulea, A., Soumillon, M., Warnefors, M., Liechti, A., Daish, T., Zeller, U., Baker, J. C., Grützner, F., & Kaessmann, H. (2014) · Nature · doi:10.1038/nature12943 · Cited by 984
Heddleston, J. M., Li, Z., McLendon, R. E., Hjelmeland, A. B., & Rich, J. N. (2009) · Cell Cycle · doi:10.4161/cc.8.20.9701 · Cited by 813
An Oct4-Centered Protein Interaction Network in Embryonic Stem Cells
van den Berg, D. L. C., Snoek, T., Mullin, N. P., Yates, A., Bezstarosti, K., Demmers, J., Chambers, I., & Poot, R. A. (2010) · Cell Stem Cell · doi:10.1016/j.stem.2010.02.014 · Cited by 542
Self-citationNanog, Pou5f1 and SoxB1 activate zygotic gene expression during the maternal-to-zygotic transition
Lee, M. T., Bonneau, A. R., Takacs, C. M., Bazzini, A. A., DiVito, K. R., Fleming, E. S., & Giraldez, A. J. (2013) · Nature · doi:10.1038/nature12632 · Cited by 503
Rigbolt, K. T. G., Prokhorova, T. A., Akimov, V., Henningsen, J., Johansen, P. T., Kratchmarova, I., Kassem, M., Mann, M., Olsen, J. V., & Blagoev, B. (2011) · Science Signaling · doi:10.1126/scisignal.2001570 · Cited by 451
Metadata
- Authors
- Chambers, I., & Tomlinson, S. R.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2009-07-15
- Volume
- 136
- Issue
- 14
- Pages
- 2311-2322
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2172215983
- Cited by
- 457
- References
- 4
- FWCI
- 15.12
- Type
- journal article
- Language
- en
- Open access
- green
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